Details for: SERPINB1

Gene ID: 1992

Symbol: SERPINB1

Ensembl ID: ENSG00000021355

Description: serpin family B member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.58
    Marker Score: 200315
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.37
    Marker Score: 2547
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.13
    Marker Score: 4528
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.12
    Marker Score: 24398
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.11
    Marker Score: 36105
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.85
    Marker Score: 3445
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.84
    Marker Score: 7075
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.77
    Marker Score: 6278
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.76
    Marker Score: 23790
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.76
    Marker Score: 2302
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.74
    Marker Score: 1983
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.74
    Marker Score: 2157
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.71
    Marker Score: 11076
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.66
    Marker Score: 8342
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.58
    Marker Score: 5024
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.54
    Marker Score: 25745
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.44
    Marker Score: 11705
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.43
    Marker Score: 15478
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.34
    Marker Score: 1111
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.31
    Marker Score: 5865
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.26
    Marker Score: 57834
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.23
    Marker Score: 19395
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.18
    Marker Score: 2488.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.17
    Marker Score: 3447
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.16
    Marker Score: 74841
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.16
    Marker Score: 2069
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.15
    Marker Score: 1063
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.15
    Marker Score: 2512
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.14
    Marker Score: 3907
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 2.14
    Marker Score: 748.5
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 2.12
    Marker Score: 681
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.12
    Marker Score: 950
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.11
    Marker Score: 1113
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.1
    Marker Score: 3717
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.09
    Marker Score: 5044
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.09
    Marker Score: 1423
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.06
    Marker Score: 2172.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.03
    Marker Score: 2995
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.03
    Marker Score: 13219
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.03
    Marker Score: 849
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.02
    Marker Score: 10602
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.01
    Marker Score: 5213
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.99
    Marker Score: 5494
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.99
    Marker Score: 830
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.92
    Marker Score: 827
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.92
    Marker Score: 4551
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.89
    Marker Score: 1822
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.88
    Marker Score: 3022
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.88
    Marker Score: 891
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.88
    Marker Score: 18569
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.86
    Marker Score: 1273
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.86
    Marker Score: 698.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.85
    Marker Score: 3903
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.83
    Marker Score: 792
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.79
    Marker Score: 518
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.78
    Marker Score: 1782
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.75
    Marker Score: 2965
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 1.75
    Marker Score: 987
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.74
    Marker Score: 5084
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.74
    Marker Score: 3403.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.73
    Marker Score: 2838
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.71
    Marker Score: 10949
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.71
    Marker Score: 412
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.71
    Marker Score: 5385
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.7
    Marker Score: 1736
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.7
    Marker Score: 1240
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.7
    Marker Score: 7049
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.7
    Marker Score: 361
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.69
    Marker Score: 1032
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.69
    Marker Score: 600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.68
    Marker Score: 822
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.68
    Marker Score: 12524
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.67
    Marker Score: 698
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.67
    Marker Score: 578
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.67
    Marker Score: 2578
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.67
    Marker Score: 3176
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.67
    Marker Score: 621
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.66
    Marker Score: 6416
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.66
    Marker Score: 1459
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.66
    Marker Score: 1770
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.65
    Marker Score: 6503
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.65
    Marker Score: 771
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.65
    Marker Score: 568
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.63
    Marker Score: 2405
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.63
    Marker Score: 1122
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.62
    Marker Score: 893
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.62
    Marker Score: 401
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.61
    Marker Score: 85258
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.6
    Marker Score: 9738
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.6
    Marker Score: 1312
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.6
    Marker Score: 829
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.58
    Marker Score: 402
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.57
    Marker Score: 1398
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.53
    Marker Score: 1847
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.53
    Marker Score: 4549
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.53
    Marker Score: 755
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.53
    Marker Score: 2531
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.51
    Marker Score: 1421
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.51
    Marker Score: 5192
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.5
    Marker Score: 1047

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Other Information

**Key characteristics:** * SERPINB1 is a secreted protein that is produced by a variety of cell types, including immune cells, endothelial cells, and cancer cells. * It is a potent inhibitor of serine proteases, which are enzymes that break down proteins. * SERPINB1 works by binding to serine proteases and preventing them from binding to their substrates. * This inhibition reduces the activity of the proteases and helps to regulate the activity of the immune system. **Pathways and functions:** * SERPINB1 is involved in a variety of immune pathways, including the regulation of inflammation, the activation of the innate immune system, and the regulation of cell proliferation. * It is involved in the regulation of inflammation by inhibiting the activity of serine proteases that are involved in the production of inflammatory cytokines. * It is also involved in the activation of the innate immune system by binding to toll-like receptors (TLRs) and triggering the production of inflammatory cytokines. * SERPINB1 also plays a role in the regulation of cell proliferation by binding to type b pancreatic cells and inhibiting their proliferation. **Clinical significance:** SERPINB1 is a promising target for the treatment of inflammatory diseases and cancer. It is a safe and well-tolerated drug that has been shown to be effective in reducing inflammation and cancer growth. **Additional information:** * SERPINB1 is a member of the SERPIN family of serine proteases. * It is expressed in high levels in the blood of patients with inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. * SERPINB1 is also expressed in high levels in cancer cells. * It is a potential target for the treatment of cancer, as it can inhibit the growth and spread of cancer cells.

Genular Protein ID: 3385625377

Symbol: ILEU_HUMAN

Name: Leukocyte elastase inhibitor

UniProtKB Accession Codes:

P30740 A8K5L2 B4DNT0 Q53FB9 Q5W0E1 Q9UDF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1376927

Title: Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor.

PubMed ID: 1376927

DOI: 10.1073/pnas.89.12.5635

PubMed ID: 9630619

Title: Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene.

PubMed ID: 9630619

DOI: 10.1016/s0378-1119(98)00189-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 7578269

Title: A serpin from human tumor cells with direct lymphoid immunomodulatory activity: mitogenic stimulation of human tumor-infiltrating lymphocytes.

PubMed ID: 7578269

DOI: 10.1016/0167-4889(95)00113-7

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 11747453

Title: The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites.

PubMed ID: 11747453

DOI: 10.1021/bi0113925

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21248149

Title: SerpinB1 protects the mature neutrophil reserve in the bone marrow.

PubMed ID: 21248149

DOI: 10.1189/jlb.0810461

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26701651

Title: SerpinB1 Promotes Pancreatic beta Cell Proliferation.

PubMed ID: 26701651

DOI: 10.1016/j.cmet.2015.12.001

PubMed ID: 30692621

Title: SERPINB1-mediated checkpoint of inflammatory caspase activation.

PubMed ID: 30692621

DOI: 10.1038/s41590-018-0303-z

PubMed ID: 23269243

Title: Identification of SERPINB1 as a physiological inhibitor of human granzyme H.

PubMed ID: 23269243

DOI: 10.4049/jimmunol.1202542

Sequence Information:

  • Length: 379
  • Mass: 42742
  • Checksum: BAAE08DFCBCD8CD3
  • Sequence:
    • MEQLSSANTR FALDLFLALS ENNPAGNIFI SPFSISSAMA MVFLGTRGNT AAQLSKTFHF 
NTVEEVHSRF QSLNADINKR GASYILKLAN RLYGEKTYNF LPEFLVSTQK TYGADLASVD 
FQHASEDARK TINQWVKGQT EGKIPELLAS GMVDNMTKLV LVNAIYFKGN WKDKFMKEAT 
TNAPFRLNKK DRKTVKMMYQ KKKFAYGYIE DLKCRVLELP YQGEELSMVI LLPDDIEDES 
TGLKKIEEQL TLEKLHEWTK PENLDFIEVN VSLPRFKLEE SYTLNSDLAR LGVQDLFNSS 
KADLSGMSGA RDIFISKIVH KSFVEVNEEG TEAAAATAGI ATFCMLMPEE NFTADHPFLF 
FIRHNSSGSI LFLGRFSSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.