Details for: SERPINB1

Gene ID: 1992

Symbol: SERPINB1

Ensembl ID: ENSG00000021355

Description: serpin family B member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 289.2406
    Cell Significance Index: -44.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 113.5980
    Cell Significance Index: -46.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.1710
    Cell Significance Index: -51.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 99.3030
    Cell Significance Index: -51.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.6160
    Cell Significance Index: -50.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.1182
    Cell Significance Index: -47.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.8197
    Cell Significance Index: -46.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 12.5951
    Cell Significance Index: 336.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.3896
    Cell Significance Index: -48.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.8446
    Cell Significance Index: -31.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.7469
    Cell Significance Index: -36.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.5730
    Cell Significance Index: -23.1400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 7.7338
    Cell Significance Index: 49.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.6796
    Cell Significance Index: 141.9400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 7.2780
    Cell Significance Index: 62.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.1253
    Cell Significance Index: -1.3000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 4.6532
    Cell Significance Index: 30.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.2774
    Cell Significance Index: 275.9600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.2621
    Cell Significance Index: 57.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7679
    Cell Significance Index: 965.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6143
    Cell Significance Index: 83.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5746
    Cell Significance Index: 256.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5064
    Cell Significance Index: 44.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.4498
    Cell Significance Index: 16.4700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.3950
    Cell Significance Index: 23.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3549
    Cell Significance Index: 63.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2968
    Cell Significance Index: 96.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2793
    Cell Significance Index: 139.1500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.2114
    Cell Significance Index: 8.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1629
    Cell Significance Index: 115.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1275
    Cell Significance Index: 132.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.0848
    Cell Significance Index: 185.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9905
    Cell Significance Index: 46.1800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.9590
    Cell Significance Index: 5.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8889
    Cell Significance Index: 13.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8165
    Cell Significance Index: 42.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8101
    Cell Significance Index: 18.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7855
    Cell Significance Index: 21.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6963
    Cell Significance Index: 85.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5961
    Cell Significance Index: 107.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5579
    Cell Significance Index: 72.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5337
    Cell Significance Index: 68.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3991
    Cell Significance Index: 10.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3822
    Cell Significance Index: 10.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3798
    Cell Significance Index: 52.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3560
    Cell Significance Index: 67.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3420
    Cell Significance Index: 151.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2919
    Cell Significance Index: 7.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2829
    Cell Significance Index: 8.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2690
    Cell Significance Index: 19.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1912
    Cell Significance Index: 37.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1664
    Cell Significance Index: 125.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1187
    Cell Significance Index: 4.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0860
    Cell Significance Index: 4.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0724
    Cell Significance Index: 8.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0183
    Cell Significance Index: 33.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0070
    Cell Significance Index: 13.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0058
    Cell Significance Index: 3.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0054
    Cell Significance Index: 0.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0047
    Cell Significance Index: -7.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0143
    Cell Significance Index: -8.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0263
    Cell Significance Index: -3.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0277
    Cell Significance Index: -37.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0386
    Cell Significance Index: -28.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0478
    Cell Significance Index: -33.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0629
    Cell Significance Index: -35.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0757
    Cell Significance Index: -34.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1022
    Cell Significance Index: -7.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1037
    Cell Significance Index: -2.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1107
    Cell Significance Index: -23.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1166
    Cell Significance Index: -41.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1244
    Cell Significance Index: -14.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1271
    Cell Significance Index: -36.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1360
    Cell Significance Index: -27.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1547
    Cell Significance Index: -2.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1928
    Cell Significance Index: -1.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2129
    Cell Significance Index: -6.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2662
    Cell Significance Index: -10.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2981
    Cell Significance Index: -34.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3268
    Cell Significance Index: -8.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3282
    Cell Significance Index: -7.1100
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.3561
    Cell Significance Index: -2.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3692
    Cell Significance Index: -23.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4600
    Cell Significance Index: -47.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4818
    Cell Significance Index: -12.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5409
    Cell Significance Index: -42.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6356
    Cell Significance Index: -28.8100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.6373
    Cell Significance Index: -3.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6516
    Cell Significance Index: -6.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7022
    Cell Significance Index: -43.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7318
    Cell Significance Index: -49.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7392
    Cell Significance Index: -21.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7406
    Cell Significance Index: -45.5200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8719
    Cell Significance Index: -15.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8732
    Cell Significance Index: -49.0000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.9144
    Cell Significance Index: -19.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9258
    Cell Significance Index: -48.6100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9861
    Cell Significance Index: -24.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9866
    Cell Significance Index: -25.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SERPINB1 is a serpin protein that exhibits a unique structure, consisting of a single chain of approximately 89 amino acids. This protein is characterized by its ability to inhibit serine proteases, such as leukocyte elastase, trypsin, and chymotrypsin, through a covalent binding mechanism. SERPINB1 is also capable of modulating the activity of other proteins, including interleukin-1 beta (IL-1β) and neutrophil elastase, thereby influencing immune responses and tissue damage. **Pathways and Functions:** SERPINB1 is involved in various cellular pathways, including: 1. **Negative regulation of endopeptidase activity**: SERPINB1 inhibits the activity of serine proteases, such as leukocyte elastase, which are involved in tissue damage and inflammation. 2. **Negative regulation of interleukin-1 beta production**: SERPINB1 modulates the activity of IL-1β, a key pro-inflammatory cytokine, thereby influencing immune responses. 3. **Neutrophil degranulation**: SERPINB1 inhibits the release of neutrophil granules, which contain serine proteases, thereby reducing tissue damage. 4. **Protein binding**: SERPINB1 interacts with various proteins, including cytokines, chemokines, and growth factors, modulating their activity and function. 5. **Secretory granule lumen**: SERPINB1 is localized to the lumen of secretory granules, where it regulates the activity of enzymes involved in cellular signaling. **Clinical Significance:** SERPINB1 has significant implications in various diseases, including: 1. **Inflammatory disorders**: SERPINB1 is involved in the regulation of inflammatory responses, making it a potential therapeutic target for treating inflammatory conditions, such as rheumatoid arthritis and asthma. 2. **Cancer**: SERPINB1 has been implicated in the regulation of tumor growth and metastasis, suggesting its potential as a biomarker or therapeutic target in cancer therapy. 3. **Neurological disorders**: SERPINB1 has been linked to the regulation of neuronal function and survival, making it a potential therapeutic target for treating neurological conditions, such as Alzheimer's disease and Parkinson's disease. 4. **Viral infections**: SERPINB1 has been shown to inhibit the activity of certain viruses, such as HIV, suggesting its potential as an antiviral agent. In conclusion, SERPINB1 is a crucial regulator of immune response and cellular homeostasis. Its involvement in various cellular pathways and its clinical significance make it an attractive target for therapeutic intervention in various diseases. Further studies are needed to fully elucidate the functional significance of SERPINB1 and its potential as a therapeutic agent.

Genular Protein ID: 3385625377

Symbol: ILEU_HUMAN

Name: Leukocyte elastase inhibitor

UniProtKB Accession Codes:

P30740 A8K5L2 B4DNT0 Q53FB9 Q5W0E1 Q9UDF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1376927

Title: Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor.

PubMed ID: 1376927

DOI: 10.1073/pnas.89.12.5635

PubMed ID: 9630619

Title: Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene.

PubMed ID: 9630619

DOI: 10.1016/s0378-1119(98)00189-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 7578269

Title: A serpin from human tumor cells with direct lymphoid immunomodulatory activity: mitogenic stimulation of human tumor-infiltrating lymphocytes.

PubMed ID: 7578269

DOI: 10.1016/0167-4889(95)00113-7

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 11747453

Title: The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites.

PubMed ID: 11747453

DOI: 10.1021/bi0113925

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21248149

Title: SerpinB1 protects the mature neutrophil reserve in the bone marrow.

PubMed ID: 21248149

DOI: 10.1189/jlb.0810461

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26701651

Title: SerpinB1 Promotes Pancreatic beta Cell Proliferation.

PubMed ID: 26701651

DOI: 10.1016/j.cmet.2015.12.001

PubMed ID: 30692621

Title: SERPINB1-mediated checkpoint of inflammatory caspase activation.

PubMed ID: 30692621

DOI: 10.1038/s41590-018-0303-z

PubMed ID: 23269243

Title: Identification of SERPINB1 as a physiological inhibitor of human granzyme H.

PubMed ID: 23269243

DOI: 10.4049/jimmunol.1202542

Sequence Information:

  • Length: 379
  • Mass: 42742
  • Checksum: BAAE08DFCBCD8CD3
  • Sequence:
    • MEQLSSANTR FALDLFLALS ENNPAGNIFI SPFSISSAMA MVFLGTRGNT AAQLSKTFHF 
NTVEEVHSRF QSLNADINKR GASYILKLAN RLYGEKTYNF LPEFLVSTQK TYGADLASVD 
FQHASEDARK TINQWVKGQT EGKIPELLAS GMVDNMTKLV LVNAIYFKGN WKDKFMKEAT 
TNAPFRLNKK DRKTVKMMYQ KKKFAYGYIE DLKCRVLELP YQGEELSMVI LLPDDIEDES 
TGLKKIEEQL TLEKLHEWTK PENLDFIEVN VSLPRFKLEE SYTLNSDLAR LGVQDLFNSS 
KADLSGMSGA RDIFISKIVH KSFVEVNEEG TEAAAATAGI ATFCMLMPEE NFTADHPFLF 
FIRHNSSGSI LFLGRFSSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.