Details for: HSD17B11

Gene ID: 51170

Symbol: HSD17B11

Ensembl ID: ENSG00000198189

Description: hydroxysteroid 17-beta dehydrogenase 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 179.4333
    Cell Significance Index: -27.9100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 97.8765
    Cell Significance Index: -40.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.6076
    Cell Significance Index: -36.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 84.3107
    Cell Significance Index: -39.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 79.9401
    Cell Significance Index: -41.1200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 59.5882
    Cell Significance Index: -39.9900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.2252
    Cell Significance Index: -37.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.8969
    Cell Significance Index: -9.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.2110
    Cell Significance Index: -33.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.4336
    Cell Significance Index: -28.9800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3850
    Cell Significance Index: -20.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.3585
    Cell Significance Index: -25.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.2498
    Cell Significance Index: -36.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.5482
    Cell Significance Index: 413.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.4887
    Cell Significance Index: 93.4800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.4483
    Cell Significance Index: 60.9400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.1981
    Cell Significance Index: 36.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.1512
    Cell Significance Index: 39.7600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.7617
    Cell Significance Index: 10.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6948
    Cell Significance Index: 336.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3229
    Cell Significance Index: 28.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2217
    Cell Significance Index: 120.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0923
    Cell Significance Index: 31.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0177
    Cell Significance Index: 65.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9036
    Cell Significance Index: 13.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8530
    Cell Significance Index: 44.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8130
    Cell Significance Index: 36.8500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.8099
    Cell Significance Index: 8.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7542
    Cell Significance Index: 103.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6756
    Cell Significance Index: 135.5200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5981
    Cell Significance Index: 10.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5772
    Cell Significance Index: 521.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5571
    Cell Significance Index: 71.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4507
    Cell Significance Index: 5.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3592
    Cell Significance Index: 7.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3299
    Cell Significance Index: 62.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3161
    Cell Significance Index: 56.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3151
    Cell Significance Index: 15.9200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3051
    Cell Significance Index: 2.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2674
    Cell Significance Index: 95.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2632
    Cell Significance Index: 8.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2262
    Cell Significance Index: 5.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2245
    Cell Significance Index: 15.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2118
    Cell Significance Index: 36.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1828
    Cell Significance Index: 99.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1432
    Cell Significance Index: 16.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1327
    Cell Significance Index: 91.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1309
    Cell Significance Index: 16.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1199
    Cell Significance Index: 6.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1062
    Cell Significance Index: 3.7300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0952
    Cell Significance Index: 0.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0593
    Cell Significance Index: 1.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0460
    Cell Significance Index: 2.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0203
    Cell Significance Index: 15.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0006
    Cell Significance Index: 0.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0033
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0124
    Cell Significance Index: -23.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0160
    Cell Significance Index: -11.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0163
    Cell Significance Index: -30.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0201
    Cell Significance Index: -30.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0230
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0257
    Cell Significance Index: -16.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0284
    Cell Significance Index: -38.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0451
    Cell Significance Index: -33.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0474
    Cell Significance Index: -1.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0495
    Cell Significance Index: -27.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0516
    Cell Significance Index: -32.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0526
    Cell Significance Index: -23.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0621
    Cell Significance Index: -1.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0636
    Cell Significance Index: -1.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0731
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0927
    Cell Significance Index: -19.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1120
    Cell Significance Index: -32.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1230
    Cell Significance Index: -14.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1245
    Cell Significance Index: -14.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1516
    Cell Significance Index: -3.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1594
    Cell Significance Index: -5.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1980
    Cell Significance Index: -5.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2166
    Cell Significance Index: -31.4800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2396
    Cell Significance Index: -2.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2754
    Cell Significance Index: -35.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2992
    Cell Significance Index: -17.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3094
    Cell Significance Index: -19.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3183
    Cell Significance Index: -8.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3184
    Cell Significance Index: -23.7300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3305
    Cell Significance Index: -2.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3433
    Cell Significance Index: -35.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3480
    Cell Significance Index: -18.2700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3543
    Cell Significance Index: -5.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3753
    Cell Significance Index: -5.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3897
    Cell Significance Index: -27.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4041
    Cell Significance Index: -31.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4520
    Cell Significance Index: -12.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4534
    Cell Significance Index: -12.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4758
    Cell Significance Index: -37.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4862
    Cell Significance Index: -22.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5016
    Cell Significance Index: -30.7500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5082
    Cell Significance Index: -8.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5137
    Cell Significance Index: -23.9500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5583
    Cell Significance Index: -6.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSD17B11 is a member of the hydroxysteroid dehydrogenase family, which consists of enzymes that catalyze the reduction or oxidation of hydroxysteroid hormones. The gene is primarily expressed in cells involved in steroid hormone metabolism, including polychromatophilic erythroblasts, embryonic stem cells, and smooth muscle fibers. HSD17B11 exhibits a unique substrate specificity, primarily converting estradiol to estrone, a process that is crucial for maintaining the delicate balance of estrogen levels in the body. **Pathways and Functions:** The primary function of HSD17B11 is to participate in the androgen catabolic process, where it converts testosterone to dihydrotestosterone (DHT). This process is essential for regulating androgen-dependent gene expression, particularly in tissues such as the prostate and skin. Additionally, HSD17B11 is involved in estrogen biosynthesis, where it converts estrone to estradiol, a process that is critical for maintaining estrogen homeostasis. Furthermore, the gene plays a role in lipid metabolism, where it is involved in the regulation of cholesterol and fatty acid metabolism. **Clinical Significance:** Abnormal expression of HSD17B11 has been implicated in various diseases, including prostate cancer, where elevated levels of DHT contribute to tumor growth and progression. Additionally, HSD17B11 has been linked to metabolic disorders, such as obesity, where dysregulation of lipid metabolism contributes to the development of insulin resistance and type 2 diabetes. Furthermore, the gene's role in estrogen biosynthesis has significant implications for the treatment of estrogen-related disorders, such as breast cancer and osteoporosis. In conclusion, HSD17B11 is a crucial gene that plays a pivotal role in various cellular processes, including androgen catabolism, estrogen biosynthesis, and lipid metabolism. Further research is necessary to fully elucidate the functional implications of this enigmatic gene and its role in human disease.

Genular Protein ID: 134960606

Symbol: DHB11_HUMAN

Name: Estradiol 17-beta-dehydrogenase 11

UniProtKB Accession Codes:

Q8NBQ5 Q96HF6 Q9UKU4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 3 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10800688

Title: Short-chain dehydrogenases/reductases in retina.

PubMed ID: 10800688

DOI: 10.1016/s0076-6879(00)16736-9

PubMed ID: 14996095

Title: SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.

PubMed ID: 14996095

DOI: 10.1111/j.1365-2133.2004.05651.x

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9888557

Title: Cloning and expression of a novel tissue specific 17beta-hydroxysteroid dehydrogenase.

PubMed ID: 9888557

DOI: 10.3109/07435809809032667

PubMed ID: 11165019

Title: Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung.

PubMed ID: 11165019

DOI: 10.1016/s0303-7207(00)00417-2

PubMed ID: 12697717

Title: 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells.

PubMed ID: 12697717

DOI: 10.1210/en.2002-221030

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 300
  • Mass: 32964
  • Checksum: 51DC0EAA205EBE86
  • Sequence:
    • MKFLLDILLL LPLLIVCSLE SFVKLFIPKR RKSVTGEIVL ITGAGHGIGR LTAYEFAKLK 
SKLVLWDINK HGLEETAAKC KGLGAKVHTF VVDCSNREDI YSSAKKVKAE IGDVSILVNN 
AGVVYTSDLF ATQDPQIEKT FEVNVLAHFW TTKAFLPAMT KNNHGHIVTV ASAAGHVSVP 
FLLAYCSSKF AAVGFHKTLT DELAALQITG VKTTCLCPNF VNTGFIKNPS TSLGPTLEPE 
EVVNRLMHGI LTEQKMIFIP SSIAFLTTLE RILPERFLAV LKRKISVKFD AVIGYKMKAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.