Details for: LGALS1

Gene ID: 3956

Symbol: LGALS1

Ensembl ID: ENSG00000100097

Description: galectin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.69
    Marker Score: 7408
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.33
    Marker Score: 8210.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.44
    Marker Score: 151015
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.38
    Marker Score: 245024
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.16
    Marker Score: 2978
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.14
    Marker Score: 3528
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.11
    Marker Score: 11348.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.09
    Marker Score: 5054
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.09
    Marker Score: 2906
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.07
    Marker Score: 4342
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.02
    Marker Score: 3426
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.82
    Marker Score: 5257
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.74
    Marker Score: 4283
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.72
    Marker Score: 49095
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.63
    Marker Score: 9496
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.59
    Marker Score: 23343
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.57
    Marker Score: 5165
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.55
    Marker Score: 6667
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.52
    Marker Score: 20873
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.45
    Marker Score: 40068
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.44
    Marker Score: 1432
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.43
    Marker Score: 8286
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.36
    Marker Score: 6545.5
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.16
    Marker Score: 1359
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.16
    Marker Score: 7859
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.14
    Marker Score: 31067
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.12
    Marker Score: 35176
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.05
    Marker Score: 8904
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.98
    Marker Score: 1961
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.97
    Marker Score: 76005
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.95
    Marker Score: 2593.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.94
    Marker Score: 7627.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.93
    Marker Score: 2789.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.93
    Marker Score: 18705.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.92
    Marker Score: 12598.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.9
    Marker Score: 1099
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.89
    Marker Score: 1301
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.88
    Marker Score: 1684
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.82
    Marker Score: 11709
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.81
    Marker Score: 1603
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.81
    Marker Score: 1334
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.77
    Marker Score: 2675
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.74
    Marker Score: 879
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.73
    Marker Score: 1601
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.72
    Marker Score: 27590.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.71
    Marker Score: 2920
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.71
    Marker Score: 13296
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.68
    Marker Score: 16269
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.67
    Marker Score: 600
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.67
    Marker Score: 1112
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.65
    Marker Score: 965.5
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.64
    Marker Score: 747
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.62
    Marker Score: 3855
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.6
    Marker Score: 646.5
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.57
    Marker Score: 646.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.5
    Marker Score: 887
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.48
    Marker Score: 1369
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.46
    Marker Score: 1267
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.44
    Marker Score: 4874.5
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 2.44
    Marker Score: 1854
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.41
    Marker Score: 835
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.41
    Marker Score: 1519
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.4
    Marker Score: 813
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.4
    Marker Score: 1075
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.39
    Marker Score: 8855
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.39
    Marker Score: 677
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.38
    Marker Score: 5599
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.36
    Marker Score: 6008.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.34
    Marker Score: 538
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.31
    Marker Score: 587
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.29
    Marker Score: 1974
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.27
    Marker Score: 666
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.26
    Marker Score: 2653
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.26
    Marker Score: 2029
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.26
    Marker Score: 1639
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.23
    Marker Score: 1531
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.21
    Marker Score: 1215
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1518
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.2
    Marker Score: 543
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.19
    Marker Score: 9383
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.15
    Marker Score: 1626
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.15
    Marker Score: 3533
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.15
    Marker Score: 6792
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.14
    Marker Score: 1103
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.13
    Marker Score: 495
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.11
    Marker Score: 1991
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.11
    Marker Score: 2914
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.05
    Marker Score: 5579.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 2.04
    Marker Score: 2658
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.03
    Marker Score: 2253.5
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 2.02
    Marker Score: 1781
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.02
    Marker Score: 2929
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.99
    Marker Score: 972
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.98
    Marker Score: 3356
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.98
    Marker Score: 984
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.97
    Marker Score: 859
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.97
    Marker Score: 1128
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.96
    Marker Score: 2090
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.95
    Marker Score: 2350
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.95
    Marker Score: 424

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * LGALS1 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in tissues such as the uterus, skin, and mammary gland. * LGALS1 is a glycoprotein that is involved in cell adhesion and migration. * It is also a ligand for the integrin receptor α5β1. * It is a regulator of the apoptotic process, cell-cell adhesion, and inflammation. **Pathways and functions:** * LGALS1 is involved in cell adhesion and migration by binding to extracellular matrix proteins and to integrins on the cell surface. * It is also a ligand for the integrin receptor α5β1, which is expressed on endothelial cells. * LGALS1 is involved in cell signaling, where it can activate the MAPK signaling pathway. * It is also involved in the regulation of apoptosis, cell migration, and inflammation. **Clinical significance:** LGALS1 is a potential therapeutic target for a variety of diseases, including cancer and fibrosis. It is a target for the treatment of uterine fibroids, breast cancer, and liver cancer. LGALS1 is also a target for the treatment of inflammatory diseases, such as rheumatoid arthritis and Crohn's disease.

Genular Protein ID: 2330560813

Symbol: LEG1_HUMAN

Name: Galectin-1

UniProtKB Accession Codes:

P09382 B2R5E8 Q9UDK5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 7 CPTC 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 5 EMBL 13 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 38 PDBsum 36 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniLectin 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2719964

Title: Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin.

PubMed ID: 2719964

DOI: 10.1016/0167-4781(89)90173-5

PubMed ID: 2910856

Title: Molecular cloning, characterization, and expression of a human 14-kDa lectin.

PubMed ID: 2910856

DOI: 10.1016/s0021-9258(19)85087-1

PubMed ID: 2719646

Title: Evidence that the 14 kDa soluble beta-galactoside-binding lectin in man is encoded by a single gene.

PubMed ID: 2719646

DOI: 10.1042/bj2590291

PubMed ID: 18824694

Title: Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance.

PubMed ID: 18824694

DOI: 10.1073/pnas.0807606105

PubMed ID: 1988031

Title: Genomic sequence and organization of two members of a human lectin gene family.

PubMed ID: 1988031

DOI: 10.1021/bi00215a013

PubMed ID: 12761501

Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

PubMed ID: 12761501

DOI: 10.1038/sj.onc.1206406

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3065332

Title: Complete amino acid sequence of a beta-galactoside-binding lectin from human placenta.

PubMed ID: 3065332

DOI: 10.1093/oxfordjournals.jbchem.a122401

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 3611046

Title: Further characterization and structural studies on human placenta lectin.

PubMed ID: 3611046

DOI: 10.1093/oxfordjournals.jbchem.a121968

PubMed ID: 1386213

Title: Identification of a 14-kDa laminin binding protein (HLBP14) in human melanoma cells that is identical to the 14-kDa galactoside binding lectin.

PubMed ID: 1386213

DOI: 10.1016/0003-9861(92)90650-l

PubMed ID: 2383549

Title: Human splenic galaptin: physicochemical characterization.

PubMed ID: 2383549

DOI: 10.1021/bi00474a014

PubMed ID: 7501023

Title: Apoptosis of T cells mediated by galectin-1.

PubMed ID: 7501023

DOI: 10.1038/378736a0

PubMed ID: 10369126

Title: Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45.

PubMed ID: 10369126

DOI: 10.1016/s0165-2478(99)00012-7

PubMed ID: 10764829

Title: Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells.

PubMed ID: 10764829

DOI: 10.1093/glycob/10.4.413

PubMed ID: 11146440

Title: Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation.

PubMed ID: 11146440

DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1022>3.3.co;2-q

PubMed ID: 14617626

Title: Presentation of galectin-1 by extracellular matrix triggers T cell death.

PubMed ID: 14617626

DOI: 10.1074/jbc.m311183200

PubMed ID: 19497882

Title: A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.

PubMed ID: 19497882

DOI: 10.1073/pnas.0903568106

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23131994

Title: Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis.

PubMed ID: 23131994

DOI: 10.1158/1541-7786.mcr-12-0501-t

PubMed ID: 24945728

Title: Modulation of CD6 function through interaction with galectin-1 and -3.

PubMed ID: 24945728

DOI: 10.1016/j.febslet.2014.05.064

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 15476813

Title: Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding.

PubMed ID: 15476813

DOI: 10.1016/j.jmb.2004.08.078

PubMed ID: 18796645

Title: Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1.

PubMed ID: 18796645

DOI: 10.1093/glycob/cwn089

PubMed ID: 19128029

Title: Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose.

PubMed ID: 19128029

DOI: 10.1021/bi801855g

Sequence Information:

  • Length: 135
  • Mass: 14716
  • Checksum: 2FBB8D7A1FC0F1F9
  • Sequence:
    • MACGLVASNL NLKPGECLRV RGEVAPDAKS FVLNLGKDSN NLCLHFNPRF NAHGDANTIV 
CNSKDGGAWG TEQREAVFPF QPGSVAEVCI TFDQANLTVK LPDGYEFKFP NRLNLEAINY 
MAADGDFKIK CVAFD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.