GRB2 | ENSG00000177885 | NCBI 2885

Details for: GRB2

Gene ID: 2885

Symbol: GRB2

Ensembl ID: ENSG00000177885

Description: growth factor receptor bound protein 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Bacterial infection pathways
(R-HSA-9824439)
Cd28 co-stimulation
(R-HSA-389356)
Cell-cell communication
(R-HSA-1500931)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Costimulation by the cd28 family
(R-HSA-388841)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signal transduction
(R-HSA-186763)
Egfr downregulation
(R-HSA-182971)
Erythropoietin activates ras
(R-HSA-9027284)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling in disease
(R-HSA-9682385)
Gab1 signalosome
(R-HSA-180292)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Hemostasis
(R-HSA-109582)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Integrin signaling
(R-HSA-354192)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nervous system development
(R-HSA-9675108)
Parasitic infection pathways
(R-HSA-9824443)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of kit signaling
(R-HSA-1433559)
Rho gtpase effectors
(R-HSA-195258)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb4
(R-HSA-1236394)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr4 in disease
(R-HSA-5655291)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by gpcr
(R-HSA-372790)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by interleukins
(R-HSA-449147)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by ltk
(R-HSA-9842663)
Signaling by met
(R-HSA-6806834)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by pdgf
(R-HSA-186797)
Signaling by pdgfr in disease
(R-HSA-9671555)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by scf-kit
(R-HSA-1433557)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal regulatory protein family interactions
(R-HSA-391160)
Signal transduction
(R-HSA-162582)
Tie2 signaling
(R-HSA-210993)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 445.4010
Cell Significance Index: -69.2800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 262.5340
Cell Significance Index: -66.5900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 194.5150
Cell Significance Index: -80.1300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 166.7663
Cell Significance Index: -67.7500
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 163.8028
Cell Significance Index: -77.3400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 145.4649
Cell Significance Index: -74.8300
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 115.1899
Cell Significance Index: -77.3000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 72.1765
Cell Significance Index: -68.9100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 59.6047
Cell Significance Index: -73.4900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 25.6770
Cell Significance Index: -68.7900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 18.9405
Cell Significance Index: -74.7400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 18.8087
Cell Significance Index: -57.7700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.6892
Cell Significance Index: -29.9600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.7526
Cell Significance Index: 87.8400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.8586
Cell Significance Index: 76.3300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.7765
Cell Significance Index: 327.4300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.0546
Cell Significance Index: 132.5600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7756
Cell Significance Index: 352.3800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.6910
Cell Significance Index: 339.2100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.3116
Cell Significance Index: 142.6700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.3018
Cell Significance Index: 78.1500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.1676
Cell Significance Index: 143.5700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1297
Cell Significance Index: 203.6500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8348
Cell Significance Index: 299.4400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6672
Cell Significance Index: 364.4000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5689
Cell Significance Index: 393.4700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5418
Cell Significance Index: 53.6000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4917
Cell Significance Index: 67.5200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4376
Cell Significance Index: 193.4700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4281
Cell Significance Index: 22.3000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3619
Cell Significance Index: 17.0100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.3000
Cell Significance Index: 8.8100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2981
Cell Significance Index: 8.3300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2248
Cell Significance Index: 10.1900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1994
Cell Significance Index: 4.3200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1865
Cell Significance Index: 4.9900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1531
Cell Significance Index: 9.4100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0920
Cell Significance Index: 11.7900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0889
Cell Significance Index: 40.3700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0877
Cell Significance Index: 5.9000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0514
Cell Significance Index: 96.7000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0204
Cell Significance Index: 12.9300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0191
Cell Significance Index: 3.2600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0110
Cell Significance Index: 0.5800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0072
Cell Significance Index: -11.0800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0093
Cell Significance Index: -0.7200
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0128
Cell Significance Index: -23.7000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0279
Cell Significance Index: -20.6700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0296
Cell Significance Index: -18.4800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0315
Cell Significance Index: -28.4500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0378
Cell Significance Index: -7.2000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0418
Cell Significance Index: -30.6200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0438
Cell Significance Index: -59.5700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0600
Cell Significance Index: -45.4300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0724
Cell Significance Index: -40.8200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0862
Cell Significance Index: -8.8100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0877
Cell Significance Index: -4.0900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0992
Cell Significance Index: -5.5700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1019
Cell Significance Index: -2.9400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1033
Cell Significance Index: -1.7700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1488
Cell Significance Index: -6.5800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1650
Cell Significance Index: -11.6700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2211
Cell Significance Index: -28.5700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2253
Cell Significance Index: -47.4600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2303
Cell Significance Index: -66.2600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2342
Cell Significance Index: -8.2300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2500
Cell Significance Index: -18.6300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2514
Cell Significance Index: -29.3000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2928
Cell Significance Index: -42.5700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.3329
Cell Significance Index: -54.1500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3539
Cell Significance Index: -40.5500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3580
Cell Significance Index: -13.5600
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.4281
Cell Significance Index: -2.6600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4354
Cell Significance Index: -49.7000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4714
Cell Significance Index: -16.3800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4788
Cell Significance Index: -24.8700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6290
Cell Significance Index: -65.4900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6994
Cell Significance Index: -14.9000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7736
Cell Significance Index: -61.2700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.8331
Cell Significance Index: -52.5100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8616
Cell Significance Index: -22.0100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.9504
Cell Significance Index: -25.8700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.9731
Cell Significance Index: -27.7700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.0138
Cell Significance Index: -26.0600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.0465
Cell Significance Index: -30.0000
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.0942
Cell Significance Index: -28.7700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.0944
Cell Significance Index: -18.3200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.1175
Cell Significance Index: -29.9500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2495
Cell Significance Index: -76.6100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.3445
Cell Significance Index: -33.6100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.4070
Cell Significance Index: -29.4500
Cell Name: preadipocyte (CL0002334)
Fold Change: -1.4088
Cell Significance Index: -27.5000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.4212
Cell Significance Index: -19.3900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.4944
Cell Significance Index: -35.8400
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.5360
Cell Significance Index: -9.2800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.5790
Cell Significance Index: -50.2900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.6231
Cell Significance Index: -53.1400
Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.6698
Cell Significance Index: -19.9100
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.6833
Cell Significance Index: -58.9700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.7172
Cell Significance Index: -50.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** GRB2 is a 186-kDa protein that belongs to the SH2 domain-containing protein family. It is characterized by its ability to interact with a wide range of signaling molecules, including growth factor receptors, tyrosine kinases, and adaptors. GRB2's unique structure and high affinity for phosphotyrosine residues enable it to bind to various signaling molecules, thereby facilitating the activation of downstream pathways. **Pathways and Functions:** GRB2 is involved in numerous signaling pathways, including: 1. **Cell-cell communication**: GRB2 mediates interactions between cells, facilitating the exchange of signals and information between different cell types. 2. **Adaptive immune system**: GRB2 plays a crucial role in the adaptive immune response, particularly in the activation of T cells and B cells. 3. **Cytokine signaling**: GRB2 is involved in the regulation of cytokine signaling, including the activation of JAK/STAT pathways. 4. **Cell surface interactions**: GRB2 mediates interactions between cells and the extracellular matrix, influencing cell migration, adhesion, and proliferation. 5. **Signaling by growth factor receptors**: GRB2 is a key adapter protein in the signaling cascade initiated by growth factor receptors, such as EGFR, ERBB2, and FGFR. **Clinical Significance:** GRB2's involvement in various diseases highlights its potential as a therapeutic target. Some of the clinical significance of GRB2 includes: 1. **Cancer**: GRB2 is overexpressed in several types of cancer, including breast, lung, and colon cancer, making it a potential target for cancer therapy. 2. **Autoimmune disorders**: GRB2 is implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it may contribute to the dysregulation of immune responses. 3. **Infectious diseases**: GRB2 is involved in the regulation of immune responses to viral infections, such as HIV and influenza. 4. **Neurological disorders**: GRB2 is expressed in the nervous system and has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. **Conclusion:** In conclusion, GRB2 is a multifaceted protein that plays a crucial role in various cellular processes, including immune response, cell signaling, and disease. Its involvement in numerous diseases highlights its potential as a therapeutic target, and further research is needed to fully understand the mechanisms underlying GRB2's functions and its implications in human disease. **Recommendations:** 1. Further research is needed to elucidate the specific mechanisms underlying GRB2's functions in immune response and disease. 2. GRB2 should be considered as a potential therapeutic target for various diseases, including cancer, autoimmune disorders, and infectious diseases. 3. The development of GRB2-specific inhibitors or antibodies may provide a novel approach to treating diseases associated with GRB2 dysregulation. **Limitations:** 1. The complexity of GRB2's functions and pathways may limit the development of specific therapies targeting this protein. 2. Further research is needed to fully understand the mechanisms underlying GRB2's involvement in various diseases. **Future Directions:** 1. Elucidation of GRB2's specific mechanisms in immune response and disease. 2. Development of GRB2-specific inhibitors or antibodies for therapeutic applications. 3. Investigation of GRB2's role in various diseases, including cancer, autoimmune disorders, and infectious diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Growth factor receptor-bound protein 2

Genular Protein ID: 610317879

Symbol: GRB2_HUMAN

Name: Growth factor receptor-bound protein 2

UniProtKB Accession Codes:

P62993 P29354 Q14450 Q63057 Q63059

Database IDs:

Citations:

PubMed ID: 1322798

Title: The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.

PubMed ID: 1322798

DOI: 10.1016/0092-8674(92)90167-b

PubMed ID: 1384039

Title: Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.

PubMed ID: 1384039

DOI: 10.1073/pnas.89.19.9015

PubMed ID: 8178156

Title: Cloning of a Grb2 isoform with apoptotic properties.

PubMed ID: 8178156

DOI: 10.1126/science.8178156

PubMed ID: 10051406

Title: The gene structure of the human growth factor bound protein GRB2.

PubMed ID: 10051406

DOI: 10.1006/geno.1998.5692

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8262059

Title: Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts.

PubMed ID: 8262059

DOI: 10.1002/j.1460-2075.1993.tb06211.x

PubMed ID: 8388384

Title: Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2.

PubMed ID: 8388384

DOI: 10.1016/s0021-9258(18)82106-8

PubMed ID: 8491186

Title: The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

PubMed ID: 8491186

DOI: 10.1002/j.1460-2075.1993.tb05842.x

PubMed ID: 8493579

Title: Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

PubMed ID: 8493579

DOI: 10.1126/science.8493579

PubMed ID: 7568038

Title: p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

PubMed ID: 7568038

DOI: 10.1073/pnas.92.19.8891

PubMed ID: 7664271

Title: Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.

PubMed ID: 7664271

PubMed ID: 8723348

Title: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.

PubMed ID: 8723348

DOI: 10.1016/s0960-9822(02)00511-0

PubMed ID: 8798570

Title: Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.

PubMed ID: 8798570

DOI: 10.1074/jbc.271.38.23588

PubMed ID: 9108392

Title: Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.

PubMed ID: 9108392

PubMed ID: 9148935

Title: Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src.

PubMed ID: 9148935

DOI: 10.1074/jbc.272.20.13189

PubMed ID: 9062191

Title: A family of proteins that inhibit signalling through tyrosine kinase receptors.

PubMed ID: 9062191

DOI: 10.1038/386181a0

PubMed ID: 9178760

Title: Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.

PubMed ID: 9178760

DOI: 10.1038/sj.onc.1201123

PubMed ID: 9233773

Title: Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.

PubMed ID: 9233773

DOI: 10.1038/sj.onc.1201163

PubMed ID: 9489702

Title: LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.

PubMed ID: 9489702

DOI: 10.1016/s0092-8674(00)80901-0

PubMed ID: 9422736

Title: Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral.

PubMed ID: 9422736

DOI: 10.1074/jbc.273.2.814

PubMed ID: 9553137

Title: Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells.

PubMed ID: 9553137

DOI: 10.1074/jbc.273.17.10726

PubMed ID: 9484780

Title: Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.

PubMed ID: 9484780

DOI: 10.1038/sj.onc.1201607

PubMed ID: 10026169

Title: Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.

PubMed ID: 10026169

DOI: 10.1074/jbc.274.9.5542

PubMed ID: 10022120

Title: Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.

PubMed ID: 10022120

DOI: 10.1038/sj.onc.1202411

PubMed ID: 10086340

Title: cbl-b inhibits epidermal growth factor receptor signaling.

PubMed ID: 10086340

DOI: 10.1038/sj.onc.1202499

PubMed ID: 10318918

Title: NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling.

PubMed ID: 10318918

DOI: 10.1073/pnas.96.10.5533

PubMed ID: 10747847

Title: Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.

PubMed ID: 10747847

DOI: 10.1074/jbc.c000085200

PubMed ID: 10867024

Title: Ligand discrimination in signaling through an ErbB4 receptor homodimer.

PubMed ID: 10867024

DOI: 10.1074/jbc.c901015199

PubMed ID: 10942756

Title: Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.

PubMed ID: 10942756

DOI: 10.1074/jbc.m001439200

PubMed ID: 10980613

Title: Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control.

PubMed ID: 10980613

DOI: 10.1038/sj.onc.1203790

PubMed ID: 11433379

Title: Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).

PubMed ID: 11433379

DOI: 10.1002/1521-4141(200106)31:6<1825::aid-immu1825>3.0.co;2-v

PubMed ID: 11518702

Title: The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.

PubMed ID: 11518702

DOI: 10.1074/jbc.m101546200

PubMed ID: 11533253

Title: Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2.

PubMed ID: 11533253

DOI: 10.1128/mcb.21.19.6660-6667.2001

PubMed ID: 11726515

Title: Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling.

PubMed ID: 11726515

DOI: 10.1093/emboj/20.23.6793

PubMed ID: 11912194

Title: Insulin receptor substrate 4 associates with the protein IRAS.

PubMed ID: 11912194

DOI: 10.1074/jbc.m111838200

PubMed ID: 12171928

Title: SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation.

PubMed ID: 12171928

DOI: 10.1074/jbc.m206023200

PubMed ID: 12359715

Title: Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling.

PubMed ID: 12359715

DOI: 10.1074/jbc.m208946200

PubMed ID: 12486104

Title: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.

PubMed ID: 12486104

DOI: 10.1084/jem.20021405

PubMed ID: 12475979

Title: Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.

PubMed ID: 12475979

DOI: 10.1074/jbc.m210656200

PubMed ID: 12925710

Title: EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.

PubMed ID: 12925710

DOI: 10.1083/jcb.200302073

PubMed ID: 12514734

Title: LAB: a new membrane-associated adaptor molecule in B cell activation.

PubMed ID: 12514734

DOI: 10.1038/ni882

PubMed ID: 15488758

Title: TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.

PubMed ID: 15488758

DOI: 10.1016/j.ccr.2004.09.011

PubMed ID: 15102829

Title: Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.

PubMed ID: 15102829

DOI: 10.1074/jbc.m314015200

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 15302586

Title: The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.

PubMed ID: 15302586

DOI: 10.1016/j.yexcr.2004.05.010

PubMed ID: 16129412

Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

PubMed ID: 16129412

DOI: 10.1016/j.bbrc.2005.08.055

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16582911

Title: NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.

PubMed ID: 16582911

DOI: 10.1038/ni1325

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 18559951

Title: Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.

PubMed ID: 18559951

DOI: 10.1189/jlb.0208087

PubMed ID: 18296648

Title: Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.

PubMed ID: 18296648

DOI: 10.1158/1541-7786.mcr-07-2028

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19836242

Title: An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.

PubMed ID: 19836242

DOI: 10.1016/j.cub.2009.09.048

PubMed ID: 19815557

Title: Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.

PubMed ID: 19815557

DOI: 10.1074/jbc.m109.072660

PubMed ID: 19914172

Title: KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.

PubMed ID: 19914172

DOI: 10.1016/j.cell.2009.10.023

PubMed ID: 19509291

Title: GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.

PubMed ID: 19509291

DOI: 10.1074/jbc.m109.021139

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20521079

Title: Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells.

PubMed ID: 20521079

DOI: 10.1007/s00018-010-0411-x

PubMed ID: 21179510

Title: Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL.

PubMed ID: 21179510

DOI: 10.1371/journal.pone.0014339

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20933011

Title: FCRL6 receptor: expression and associated proteins.

PubMed ID: 20933011

DOI: 10.1016/j.imlet.2010.09.023

PubMed ID: 22027826

Title: ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration.

PubMed ID: 22027826

DOI: 10.1074/jbc.m111.278770

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

PubMed ID: 22561606

Title: Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.

PubMed ID: 22561606

DOI: 10.1038/ni.2301

PubMed ID: 31462771

Title: Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.

PubMed ID: 31462771

DOI: 10.1038/s41586-019-1511-x

PubMed ID: 32555452

Title:

PubMed ID: 32555452

DOI: 10.1038/s41586-020-2414-6

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23946459

Title: Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc.

PubMed ID: 23946459

DOI: 10.1128/jvi.01702-13

PubMed ID: 25092874

Title: RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.

PubMed ID: 25092874

DOI: 10.1084/jem.20130624

PubMed ID: 25413232

Title: The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module.

PubMed ID: 25413232

DOI: 10.1038/ncomms6456

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25870599

Title: GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-gamma1 Activation and Cytokine Production.

PubMed ID: 25870599

DOI: 10.3389/fimmu.2015.00141

PubMed ID: 27041574

Title: PRR14 is a novel activator of the PI3K pathway promoting lung carcinogenesis.

PubMed ID: 27041574

DOI: 10.1038/onc.2016.93

PubMed ID: 29030480

Title: Intersectin-s interaction with DENND2B facilitates recycling of epidermal growth factor receptor.

PubMed ID: 29030480

DOI: 10.15252/embr.201744034

PubMed ID: 29523808

Title: Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells.

PubMed ID: 29523808

DOI: 10.1038/s41598-018-22544-x

PubMed ID: 30282717

Title: The 11-Kilodalton Nonstructural Protein of Human Parvovirus B19 Facilitates Viral DNA Replication by Interacting with Grb2 through Its Proline-Rich Motifs.

PubMed ID: 30282717

DOI: 10.1128/jvi.01464-18

PubMed ID: 34348893

Title: GRB2 enforces homology-directed repair initiation by MRE11.

PubMed ID: 34348893

DOI: 10.1126/sciadv.abe9254

PubMed ID: 35687021

Title: PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.

PubMed ID: 35687021

DOI: 10.1083/jcb.202108027

PubMed ID: 36171279

Title: The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation.

PubMed ID: 36171279

DOI: 10.1038/s42003-022-03985-7

PubMed ID: 35831301

Title: Grb2 interacts with necrosome components and is involved in rasfonin-induced necroptosis.

PubMed ID: 35831301

DOI: 10.1038/s41420-022-01106-1

PubMed ID: 36864087

Title: GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production.

PubMed ID: 36864087

DOI: 10.1038/s41598-023-30562-7

PubMed ID: 37328606

Title: Regulation of microRNA expression by the adaptor protein GRB2.

PubMed ID: 37328606

DOI: 10.1038/s41598-023-36996-3

PubMed ID: 37626338

Title: RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma.

PubMed ID: 37626338

DOI: 10.1186/s12964-023-01241-x

PubMed ID: 38459011

Title: GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer.

PubMed ID: 38459011

DOI: 10.1038/s41467-024-46283-y

PubMed ID: 38182563

Title: GRB2 is a BECN1 interacting protein that regulates autophagy.

PubMed ID: 38182563

DOI: 10.1038/s41419-023-06387-7

PubMed ID: 8794768

Title: Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain.

PubMed ID: 8794768

DOI: 10.1021/bi952615s

PubMed ID: 7881903

Title: Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2.

PubMed ID: 7881903

DOI: 10.1016/s0969-2126(94)00106-5

PubMed ID: 7716522

Title: Crystal structure of the mammalian Grb2 adaptor.

PubMed ID: 7716522

DOI: 10.1126/science.7716522

PubMed ID: 9642078

Title: Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands.

PubMed ID: 9642078

DOI: 10.1006/jmbi.1998.1790

PubMed ID: 10090780

Title: Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).

PubMed ID: 10090780

DOI: 10.1021/jm9811007

PubMed ID: 10395476

Title: Structure-based design, synthesis, and X-ray crystallography of a high- affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.

PubMed ID: 10395476

DOI: 10.1021/jm991013u

PubMed ID: 11063574

Title: Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.

PubMed ID: 11063574

DOI: 10.1021/bi0012336

PubMed ID: 11827484

Title: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.

PubMed ID: 11827484

DOI: 10.1006/jmbi.2001.5299

PubMed ID: 19523899

Title: Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.

PubMed ID: 19523899

DOI: 10.1016/j.str.2009.03.017

PubMed ID: 24098653

Title: High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28.

PubMed ID: 24098653

DOI: 10.1371/journal.pone.0074482

Sequence Information:

Length: 217
Mass: 25206
Checksum: 83A4B0BA1B248DC4
Sequence:

MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG 
DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GRB2

Associated with

Cells (max top 100)

Other Information

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. PubMed ID: 1322798

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries. PubMed ID: 1384039

Cloning of a Grb2 isoform with apoptotic properties. PubMed ID: 8178156

The gene structure of the human growth factor bound protein GRB2. PubMed ID: 10051406

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts. PubMed ID: 8262059

Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2. PubMed ID: 8388384

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. PubMed ID: 8491186

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. PubMed ID: 8493579

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. PubMed ID: 7568038

Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. PubMed ID: 7664271

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. PubMed ID: 8723348

Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells. PubMed ID: 8798570

Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl. PubMed ID: 9108392

Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. PubMed ID: 9148935

A family of proteins that inhibit signalling through tyrosine kinase receptors. PubMed ID: 9062191

Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site. PubMed ID: 9178760

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation. PubMed ID: 9233773

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. PubMed ID: 9489702

Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. PubMed ID: 9422736

Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells. PubMed ID: 9553137

Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. PubMed ID: 9484780

Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. PubMed ID: 10026169

Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. PubMed ID: 10022120

cbl-b inhibits epidermal growth factor receptor signaling. PubMed ID: 10086340

NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling. PubMed ID: 10318918

Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. PubMed ID: 10747847

Ligand discrimination in signaling through an ErbB4 receptor homodimer. PubMed ID: 10867024

Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin. PubMed ID: 10942756

Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control. PubMed ID: 10980613

Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). PubMed ID: 11433379

The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK. PubMed ID: 11518702

Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. PubMed ID: 11533253

Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling. PubMed ID: 11726515

Insulin receptor substrate 4 associates with the protein IRAS. PubMed ID: 11912194

SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation. PubMed ID: 12171928

Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. PubMed ID: 12359715

Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. PubMed ID: 12486104

Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. PubMed ID: 12475979

EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. PubMed ID: 12925710

LAB: a new membrane-associated adaptor molecule in B cell activation. PubMed ID: 12514734

TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. PubMed ID: 15488758

Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress. PubMed ID: 15102829

Signal transduction via the stem cell factor receptor/c-Kit. PubMed ID: 15526160

The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner. PubMed ID: 15302586

Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. PubMed ID: 16129412

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. PubMed ID: 16582911

Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. PubMed ID: 17974561

Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells. PubMed ID: 18559951

Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. PubMed ID: 18296648

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. PubMed ID: 19836242

Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling. PubMed ID: 19815557

KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development. PubMed ID: 19914172

GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling. PubMed ID: 19509291

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells. PubMed ID: 20521079

Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL. PubMed ID: 21179510

Initial characterization of the human central proteome. PubMed ID: 21269460

FCRL6 receptor: expression and associated proteins. PubMed ID: 20933011

ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration. PubMed ID: 22027826

SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling. PubMed ID: 21930792

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. PubMed ID: 22561606

Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation. PubMed ID: 31462771