Gene GRB2 - ENSG00000177885 | NCBI Gene ID: 2885

Details for: GRB2

Gene ID: 2885

Symbol: GRB2

Ensembl ID: ENSG00000177885

Description: growth factor receptor bound protein 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Bacterial infection pathways
(R-HSA-9824439)
Cd28 co-stimulation
(R-HSA-389356)
Cell-cell communication
(R-HSA-1500931)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Costimulation by the cd28 family
(R-HSA-388841)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signal transduction
(R-HSA-186763)
Egfr downregulation
(R-HSA-182971)
Erythropoietin activates ras
(R-HSA-9027284)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling in disease
(R-HSA-9682385)
Gab1 signalosome
(R-HSA-180292)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Hemostasis
(R-HSA-109582)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Integrin signaling
(R-HSA-354192)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Negative regulation of met activity
(R-HSA-6807004)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nervous system development
(R-HSA-9675108)
Parasitic infection pathways
(R-HSA-9824443)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of kit signaling
(R-HSA-1433559)
Rho gtpase effectors
(R-HSA-195258)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb4
(R-HSA-1236394)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr4 in disease
(R-HSA-5655291)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by gpcr
(R-HSA-372790)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by interleukins
(R-HSA-449147)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by met
(R-HSA-6806834)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by pdgf
(R-HSA-186797)
Signaling by pdgfr in disease
(R-HSA-9671555)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by scf-kit
(R-HSA-1433557)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal regulatory protein family interactions
(R-HSA-391160)
Signal transduction
(R-HSA-162582)
Tie2 signaling
(R-HSA-210993)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.2
Marker Score: 178926
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 3.02
Marker Score: 3643
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 2.81
Marker Score: 11703
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.69
Marker Score: 5248
Cell Name: blood cell (CL0000081)
Fold Change: 2.65
Marker Score: 30772
Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.52
Marker Score: 911.5
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 2.5
Marker Score: 5241
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.48
Marker Score: 7366
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.42
Marker Score: 2273
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.39
Marker Score: 2358
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.36
Marker Score: 1174
Cell Name: malignant cell (CL0001064)
Fold Change: 2.35
Marker Score: 31566
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.34
Marker Score: 1409
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.33
Marker Score: 952
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.32
Marker Score: 5779.5
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.31
Marker Score: 819
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.29
Marker Score: 2621
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.28
Marker Score: 949
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.24
Marker Score: 3898
Cell Name: microglial cell (CL0000129)
Fold Change: 2.22
Marker Score: 4043
Cell Name: memory B cell (CL0000787)
Fold Change: 2.21
Marker Score: 1675
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.21
Marker Score: 5330
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.18
Marker Score: 55836
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.14
Marker Score: 21734
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 2.12
Marker Score: 1245
Cell Name: centroblast (CL0009112)
Fold Change: 2.12
Marker Score: 1043
Cell Name: naive B cell (CL0000788)
Fold Change: 2.08
Marker Score: 1855
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.95
Marker Score: 1072
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.92
Marker Score: 11695
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.92
Marker Score: 458
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.91
Marker Score: 667
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.91
Marker Score: 1501
Cell Name: immature B cell (CL0000816)
Fold Change: 1.91
Marker Score: 1265
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.9
Marker Score: 662
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.88
Marker Score: 4862
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.87
Marker Score: 1874
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.87
Marker Score: 4102
Cell Name: centrocyte (CL0009111)
Fold Change: 1.86
Marker Score: 443
Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.86
Marker Score: 1133
Cell Name: plasmablast (CL0000980)
Fold Change: 1.86
Marker Score: 2470
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.84
Marker Score: 7130
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.83
Marker Score: 915
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.82
Marker Score: 7565
Cell Name: Unknown (CL0000548)
Fold Change: 1.81
Marker Score: 1316
Cell Name: neutrophil (CL0000775)
Fold Change: 1.8
Marker Score: 1097
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.8
Marker Score: 2481
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.79
Marker Score: 392.5
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.79
Marker Score: 1190
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.77
Marker Score: 7570
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.76
Marker Score: 1794
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.76
Marker Score: 4938
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.76
Marker Score: 393
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.74
Marker Score: 480
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.73
Marker Score: 1941
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.73
Marker Score: 597
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.72
Marker Score: 3080
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.72
Marker Score: 2428
Cell Name: erythroblast (CL0000765)
Fold Change: 1.7
Marker Score: 1060
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.7
Marker Score: 389
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.69
Marker Score: 821
Cell Name: mature T cell (CL0002419)
Fold Change: 1.69
Marker Score: 16719
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.69
Marker Score: 728
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.68
Marker Score: 1696
Cell Name: dendritic cell (CL0000451)
Fold Change: 1.68
Marker Score: 1149
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.67
Marker Score: 1137
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.65
Marker Score: 1451.5
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.65
Marker Score: 380
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.65
Marker Score: 1122
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.64
Marker Score: 322
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.64
Marker Score: 1787
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.64
Marker Score: 1508
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 1.64
Marker Score: 404
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.64
Marker Score: 86767
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 1.64
Marker Score: 3994
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.63
Marker Score: 1127
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.63
Marker Score: 665
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 1.62
Marker Score: 353
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 1.61
Marker Score: 402
Cell Name: tendon cell (CL0000388)
Fold Change: 1.61
Marker Score: 397
Cell Name: macrophage (CL0000235)
Fold Change: 1.61
Marker Score: 1795
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.61
Marker Score: 10298
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 1.61
Marker Score: 440
Cell Name: epidermal cell (CL0000362)
Fold Change: 1.6
Marker Score: 449.5
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 1.6
Marker Score: 423.5
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.6
Marker Score: 779
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.59
Marker Score: 15131
Cell Name: neuron (CL0000540)
Fold Change: 1.59
Marker Score: 6474
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 1.59
Marker Score: 455
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 1.58
Marker Score: 2331
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.58
Marker Score: 416
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.58
Marker Score: 489
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.57
Marker Score: 526
Cell Name: vasa recta descending limb cell (CL1001285)
Fold Change: 1.56
Marker Score: 428
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.56
Marker Score: 95797
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 1.56
Marker Score: 412
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.55
Marker Score: 383
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 1.55
Marker Score: 361
Cell Name: melanocyte (CL0000148)
Fold Change: 1.55
Marker Score: 628
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 1.54
Marker Score: 400
Cell Name: promonocyte (CL0000559)
Fold Change: 1.54
Marker Score: 993

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**Key characteristics:** - GRB2 is a type I transmembrane receptor that is expressed on the surface of immune cells. - It is a member of the GRB family of cell surface receptors, which are known for their ability to bind to growth factors and regulate their activity. - GRB2 is a highly conserved protein that is found in mammals, birds, and fish. - It is a multi-functional protein that has been shown to play a role in a variety of cellular processes, including cell growth, differentiation, and migration. **Pathways and functions:** - GRB2 is a key regulator of cell growth and differentiation. - It is involved in the regulation of lymphocyte differentiation and activation. - It is also involved in the regulation of inflammation and cell migration. - GRB2 is a potential therapeutic target for a variety of diseases, including cancer and autoimmune disorders. **Clinical significance:** - Mutations in the GRB2 gene have been linked to a number of human diseases, including cancer, autoimmune disorders, and developmental disorders. - GRB2 is a target for immunotherapy in several human cancers. - The development of targeted therapies that block GRB2 signaling has shown promise in improving the outcomes of cancer patients.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Growth factor receptor-bound protein 2

Genular Protein ID: 610317879

Symbol: GRB2_HUMAN

Name: Growth factor receptor-bound protein 2

UniProtKB Accession Codes:

P62993 P29354 Q14450 Q63057 Q63059

Database IDs:

Citations:

PubMed ID: 1322798

Title: The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.

PubMed ID: 1322798

DOI: 10.1016/0092-8674(92)90167-b

PubMed ID: 1384039

Title: Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.

PubMed ID: 1384039

DOI: 10.1073/pnas.89.19.9015

PubMed ID: 8178156

Title: Cloning of a Grb2 isoform with apoptotic properties.

PubMed ID: 8178156

DOI: 10.1126/science.8178156

PubMed ID: 10051406

Title: The gene structure of the human growth factor bound protein GRB2.

PubMed ID: 10051406

DOI: 10.1006/geno.1998.5692

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8262059

Title: Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts.

PubMed ID: 8262059

DOI: 10.1002/j.1460-2075.1993.tb06211.x

PubMed ID: 8388384

Title: Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2.

PubMed ID: 8388384

DOI: 10.1016/s0021-9258(18)82106-8

PubMed ID: 8491186

Title: The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

PubMed ID: 8491186

DOI: 10.1002/j.1460-2075.1993.tb05842.x

PubMed ID: 8493579

Title: Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

PubMed ID: 8493579

DOI: 10.1126/science.8493579

PubMed ID: 7664271

Title: Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.

PubMed ID: 7664271

PubMed ID: 8723348

Title: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.

PubMed ID: 8723348

DOI: 10.1016/s0960-9822(02)00511-0

PubMed ID: 8798570

Title: Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.

PubMed ID: 8798570

DOI: 10.1074/jbc.271.38.23588

PubMed ID: 9108392

Title: Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.

PubMed ID: 9108392

PubMed ID: 9148935

Title: Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src.

PubMed ID: 9148935

DOI: 10.1074/jbc.272.20.13189

PubMed ID: 9062191

Title: A family of proteins that inhibit signalling through tyrosine kinase receptors.

PubMed ID: 9062191

DOI: 10.1038/386181a0

PubMed ID: 9178760

Title: Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.

PubMed ID: 9178760

DOI: 10.1038/sj.onc.1201123

PubMed ID: 9233773

Title: Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.

PubMed ID: 9233773

DOI: 10.1038/sj.onc.1201163

PubMed ID: 9489702

Title: LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.

PubMed ID: 9489702

DOI: 10.1016/s0092-8674(00)80901-0

PubMed ID: 9422736

Title: Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral.

PubMed ID: 9422736

DOI: 10.1074/jbc.273.2.814

PubMed ID: 9553137

Title: Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells.

PubMed ID: 9553137

DOI: 10.1074/jbc.273.17.10726

PubMed ID: 9484780

Title: Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.

PubMed ID: 9484780

DOI: 10.1038/sj.onc.1201607

PubMed ID: 10026169

Title: Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.

PubMed ID: 10026169

DOI: 10.1074/jbc.274.9.5542

PubMed ID: 10022120

Title: Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.

PubMed ID: 10022120

DOI: 10.1038/sj.onc.1202411

PubMed ID: 10086340

Title: cbl-b inhibits epidermal growth factor receptor signaling.

PubMed ID: 10086340

DOI: 10.1038/sj.onc.1202499

PubMed ID: 10318918

Title: NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling.

PubMed ID: 10318918

DOI: 10.1073/pnas.96.10.5533

PubMed ID: 10747847

Title: Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.

PubMed ID: 10747847

DOI: 10.1074/jbc.c000085200

PubMed ID: 10867024

Title: Ligand discrimination in signaling through an ErbB4 receptor homodimer.

PubMed ID: 10867024

DOI: 10.1074/jbc.c901015199

PubMed ID: 10942756

Title: Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.

PubMed ID: 10942756

DOI: 10.1074/jbc.m001439200

PubMed ID: 10980613

Title: Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control.

PubMed ID: 10980613

DOI: 10.1038/sj.onc.1203790

PubMed ID: 11433379

Title: Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).

PubMed ID: 11433379

DOI: 10.1002/1521-4141(200106)31:6<1825::aid-immu1825>3.0.co;2-v

PubMed ID: 11518702

Title: The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.

PubMed ID: 11518702

DOI: 10.1074/jbc.m101546200

PubMed ID: 11533253

Title: Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2.

PubMed ID: 11533253

DOI: 10.1128/mcb.21.19.6660-6667.2001

PubMed ID: 11912194

Title: Insulin receptor substrate 4 associates with the protein IRAS.

PubMed ID: 11912194

DOI: 10.1074/jbc.m111838200

PubMed ID: 12171928

Title: SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation.

PubMed ID: 12171928

DOI: 10.1074/jbc.m206023200

PubMed ID: 12359715

Title: Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling.

PubMed ID: 12359715

DOI: 10.1074/jbc.m208946200

PubMed ID: 12486104

Title: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.

PubMed ID: 12486104

DOI: 10.1084/jem.20021405

PubMed ID: 12475979

Title: Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.

PubMed ID: 12475979

DOI: 10.1074/jbc.m210656200

PubMed ID: 12925710

Title: EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.

PubMed ID: 12925710

DOI: 10.1083/jcb.200302073

PubMed ID: 12514734

Title: LAB: a new membrane-associated adaptor molecule in B cell activation.

PubMed ID: 12514734

DOI: 10.1038/ni882

PubMed ID: 15488758

Title: TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.

PubMed ID: 15488758

DOI: 10.1016/j.ccr.2004.09.011

PubMed ID: 15102829

Title: Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.

PubMed ID: 15102829

DOI: 10.1074/jbc.m314015200

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 15302586

Title: The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.

PubMed ID: 15302586

DOI: 10.1016/j.yexcr.2004.05.010

PubMed ID: 16129412

Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

PubMed ID: 16129412

DOI: 10.1016/j.bbrc.2005.08.055

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16582911

Title: NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.

PubMed ID: 16582911

DOI: 10.1038/ni1325

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 18559951

Title: Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.

PubMed ID: 18559951

DOI: 10.1189/jlb.0208087

PubMed ID: 18296648

Title: Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.

PubMed ID: 18296648

DOI: 10.1158/1541-7786.mcr-07-2028

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19836242

Title: An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.

PubMed ID: 19836242

DOI: 10.1016/j.cub.2009.09.048

PubMed ID: 19815557

Title: Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.

PubMed ID: 19815557

DOI: 10.1074/jbc.m109.072660

PubMed ID: 19914172

Title: KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.

PubMed ID: 19914172

DOI: 10.1016/j.cell.2009.10.023

PubMed ID: 19509291

Title: GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.

PubMed ID: 19509291

DOI: 10.1074/jbc.m109.021139

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20521079

Title: Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells.

PubMed ID: 20521079

DOI: 10.1007/s00018-010-0411-x

PubMed ID: 21179510

Title: Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL.

PubMed ID: 21179510

DOI: 10.1371/journal.pone.0014339

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20933011

Title: FCRL6 receptor: expression and associated proteins.

PubMed ID: 20933011

DOI: 10.1016/j.imlet.2010.09.023

PubMed ID: 22027826

Title: ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration.

PubMed ID: 22027826

DOI: 10.1074/jbc.m111.278770

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

PubMed ID: 22561606

Title: Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.

PubMed ID: 22561606

DOI: 10.1038/ni.2301

PubMed ID: 31462771

Title: Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.

PubMed ID: 31462771

DOI: 10.1038/s41586-019-1511-x

PubMed ID: 32555452

Title:

PubMed ID: 32555452

DOI: 10.1038/s41586-020-2414-6

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23946459

Title: Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc.

PubMed ID: 23946459

DOI: 10.1128/jvi.01702-13

PubMed ID: 25092874

Title: RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.

PubMed ID: 25092874

DOI: 10.1084/jem.20130624

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27041574

Title: PRR14 is a novel activator of the PI3K pathway promoting lung carcinogenesis.

PubMed ID: 27041574

DOI: 10.1038/onc.2016.93

PubMed ID: 29030480

Title: Intersectin-s interaction with DENND2B facilitates recycling of epidermal growth factor receptor.

PubMed ID: 29030480

DOI: 10.15252/embr.201744034

PubMed ID: 35687021

Title: PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.

PubMed ID: 35687021

DOI: 10.1083/jcb.202108027

PubMed ID: 8794768

Title: Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain.

PubMed ID: 8794768

DOI: 10.1021/bi952615s

PubMed ID: 7881903

Title: Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2.

PubMed ID: 7881903

DOI: 10.1016/s0969-2126(94)00106-5

PubMed ID: 7716522

Title: Crystal structure of the mammalian Grb2 adaptor.

PubMed ID: 7716522

DOI: 10.1126/science.7716522

PubMed ID: 9642078

Title: Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands.

PubMed ID: 9642078

DOI: 10.1006/jmbi.1998.1790

PubMed ID: 10090780

Title: Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).

PubMed ID: 10090780

DOI: 10.1021/jm9811007

PubMed ID: 10395476

Title: Structure-based design, synthesis, and X-ray crystallography of a high- affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.

PubMed ID: 10395476

DOI: 10.1021/jm991013u

PubMed ID: 11063574

Title: Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.

PubMed ID: 11063574

DOI: 10.1021/bi0012336

PubMed ID: 11827484

Title: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.

PubMed ID: 11827484

DOI: 10.1006/jmbi.2001.5299

PubMed ID: 19523899

Title: Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.

PubMed ID: 19523899

DOI: 10.1016/j.str.2009.03.017

PubMed ID: 24098653

Title: High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28.

PubMed ID: 24098653

DOI: 10.1371/journal.pone.0074482

Sequence Information:

Length: 217
Mass: 25206
Checksum: 83A4B0BA1B248DC4
Sequence:

MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG 
DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GRB2

Associated with

Cells (max top 100)

Other Information

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. PubMed ID: 1322798

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries. PubMed ID: 1384039

Cloning of a Grb2 isoform with apoptotic properties. PubMed ID: 8178156

The gene structure of the human growth factor bound protein GRB2. PubMed ID: 10051406

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts. PubMed ID: 8262059

Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2. PubMed ID: 8388384

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. PubMed ID: 8491186

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. PubMed ID: 8493579

Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. PubMed ID: 7664271

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. PubMed ID: 8723348

Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells. PubMed ID: 8798570

Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl. PubMed ID: 9108392

Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. PubMed ID: 9148935

A family of proteins that inhibit signalling through tyrosine kinase receptors. PubMed ID: 9062191

Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site. PubMed ID: 9178760

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation. PubMed ID: 9233773

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. PubMed ID: 9489702

Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. PubMed ID: 9422736

Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells. PubMed ID: 9553137

Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. PubMed ID: 9484780

Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. PubMed ID: 10026169

Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. PubMed ID: 10022120

cbl-b inhibits epidermal growth factor receptor signaling. PubMed ID: 10086340

NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling. PubMed ID: 10318918

Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. PubMed ID: 10747847

Ligand discrimination in signaling through an ErbB4 receptor homodimer. PubMed ID: 10867024

Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin. PubMed ID: 10942756

Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control. PubMed ID: 10980613

Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). PubMed ID: 11433379

The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK. PubMed ID: 11518702

Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. PubMed ID: 11533253

Insulin receptor substrate 4 associates with the protein IRAS. PubMed ID: 11912194

SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation. PubMed ID: 12171928

Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. PubMed ID: 12359715

Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. PubMed ID: 12486104

Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. PubMed ID: 12475979

EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. PubMed ID: 12925710

LAB: a new membrane-associated adaptor molecule in B cell activation. PubMed ID: 12514734

TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. PubMed ID: 15488758

Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress. PubMed ID: 15102829

Signal transduction via the stem cell factor receptor/c-Kit. PubMed ID: 15526160

The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner. PubMed ID: 15302586

Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. PubMed ID: 16129412

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. PubMed ID: 16582911

Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. PubMed ID: 17974561

Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells. PubMed ID: 18559951

Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. PubMed ID: 18296648

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. PubMed ID: 19836242

Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling. PubMed ID: 19815557

KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development. PubMed ID: 19914172

GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling. PubMed ID: 19509291

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells. PubMed ID: 20521079

Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL. PubMed ID: 21179510

Initial characterization of the human central proteome. PubMed ID: 21269460

FCRL6 receptor: expression and associated proteins. PubMed ID: 20933011

ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration. PubMed ID: 22027826

SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling. PubMed ID: 21930792

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. PubMed ID: 22561606

Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation. PubMed ID: 31462771