Details for: CCL7

Gene ID: 6354

Symbol: CCL7

Ensembl ID: ENSG00000108688

Description: C-C motif chemokine ligand 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3684
    Cell Significance Index: 5.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0836
    Cell Significance Index: 2.2800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0590
    Cell Significance Index: 0.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0008
    Cell Significance Index: -0.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0011
    Cell Significance Index: -0.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0071
    Cell Significance Index: -0.1700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0082
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0091
    Cell Significance Index: -6.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0110
    Cell Significance Index: -8.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0130
    Cell Significance Index: -7.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0144
    Cell Significance Index: -8.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0338
    Cell Significance Index: -6.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0405
    Cell Significance Index: -5.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0433
    Cell Significance Index: -7.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0488
    Cell Significance Index: -6.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0493
    Cell Significance Index: -5.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0505
    Cell Significance Index: -6.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0549
    Cell Significance Index: -5.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0554
    Cell Significance Index: -1.4600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0731
    Cell Significance Index: -3.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0960
    Cell Significance Index: -7.3700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0960
    Cell Significance Index: -2.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1072
    Cell Significance Index: -7.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1190
    Cell Significance Index: -6.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1190
    Cell Significance Index: -2.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1210
    Cell Significance Index: -7.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1227
    Cell Significance Index: -6.3900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1238
    Cell Significance Index: -1.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1467
    Cell Significance Index: -6.9000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1469
    Cell Significance Index: -1.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1562
    Cell Significance Index: -7.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1771
    Cell Significance Index: -6.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1775
    Cell Significance Index: -4.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1831
    Cell Significance Index: -6.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1868
    Cell Significance Index: -8.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1953
    Cell Significance Index: -3.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2132
    Cell Significance Index: -5.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2256
    Cell Significance Index: -7.3900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2346
    Cell Significance Index: -2.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2399
    Cell Significance Index: -7.6400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2491
    Cell Significance Index: -3.5400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2505
    Cell Significance Index: -2.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2522
    Cell Significance Index: -7.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2722
    Cell Significance Index: -2.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2881
    Cell Significance Index: -7.3400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3080
    Cell Significance Index: -4.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3268
    Cell Significance Index: -7.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3290
    Cell Significance Index: -7.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3322
    Cell Significance Index: -7.0500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3422
    Cell Significance Index: -6.6900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3480
    Cell Significance Index: -5.9100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3626
    Cell Significance Index: -7.1700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3683
    Cell Significance Index: -4.4800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3701
    Cell Significance Index: -7.4300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3803
    Cell Significance Index: -4.4900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.3833
    Cell Significance Index: -4.8500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3868
    Cell Significance Index: -6.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3875
    Cell Significance Index: -6.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3986
    Cell Significance Index: -7.7800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4112
    Cell Significance Index: -4.4800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4158
    Cell Significance Index: -7.1900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.4163
    Cell Significance Index: -2.5500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4199
    Cell Significance Index: -5.5800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.4286
    Cell Significance Index: -5.1800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4341
    Cell Significance Index: -7.4200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4359
    Cell Significance Index: -6.6200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4499
    Cell Significance Index: -7.9500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.4564
    Cell Significance Index: -5.5100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.4590
    Cell Significance Index: -7.3800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4649
    Cell Significance Index: -4.3700
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.4705
    Cell Significance Index: -2.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4745
    Cell Significance Index: -7.1100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4824
    Cell Significance Index: -4.9300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.4855
    Cell Significance Index: -5.3100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.4881
    Cell Significance Index: -6.3700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.4959
    Cell Significance Index: -3.8200
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.5042
    Cell Significance Index: -4.7600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.5052
    Cell Significance Index: -5.9400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5073
    Cell Significance Index: -7.4900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.5084
    Cell Significance Index: -7.4100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5216
    Cell Significance Index: -7.4900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5242
    Cell Significance Index: -7.5400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.5272
    Cell Significance Index: -7.7100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5411
    Cell Significance Index: -6.7600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5414
    Cell Significance Index: -6.2300
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.5422
    Cell Significance Index: -6.2200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.5437
    Cell Significance Index: -7.5400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5508
    Cell Significance Index: -6.9500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.5509
    Cell Significance Index: -7.2500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.5523
    Cell Significance Index: -7.2100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.5524
    Cell Significance Index: -6.9800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.5597
    Cell Significance Index: -7.3200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.5629
    Cell Significance Index: -4.5600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.5630
    Cell Significance Index: -6.9200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5640
    Cell Significance Index: -6.6700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.5695
    Cell Significance Index: -6.7300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.5723
    Cell Significance Index: -7.5100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5729
    Cell Significance Index: -8.0300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.5740
    Cell Significance Index: -7.7400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.5741
    Cell Significance Index: -7.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCL7 exhibits several key characteristics that distinguish it from other chemokines: 1. **Chemotactic activity**: CCL7 is a potent chemotactic agent, capable of attracting immune cells to specific sites of inflammation or injury. 2. **Receptor specificity**: CCL7 interacts with specific receptors on the surface of immune cells, including CCR1, CCR2, and CCR5. 3. **Tissue-specific expression**: CCL7 is expressed in various tissues, including the brain, spinal cord, and immune organs, such as the spleen and lymph nodes. 4. **Regulation of immune responses**: CCL7 plays a role in regulating immune responses, including the activation of immune cells, the promotion of inflammation, and the suppression of immune responses. **Pathways and Functions** CCL7 is involved in several signaling pathways that regulate immune responses, inflammation, and cell migration: 1. **Chemokine-mediated signaling pathway**: CCL7 interacts with its receptors, triggering the activation of downstream signaling pathways, including the MAPK/ERK and PI3K/Akt pathways. 2. **Cell-cell signaling**: CCL7 regulates cell-cell interactions, including the adhesion and migration of immune cells. 3. **Cellular response to ethanol**: CCL7 is upregulated in response to ethanol exposure, contributing to the development of liver injury and inflammation. 4. **Cellular response to cytokines**: CCL7 is involved in the regulation of immune responses to cytokines, such as IL-1β and TNF-α. **Clinical Significance** CCL7 has significant clinical implications in various diseases, including: 1. **Inflammatory diseases**: CCL7 is upregulated in inflammatory conditions, such as rheumatoid arthritis, asthma, and inflammatory bowel disease. 2. **Cancer**: CCL7 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and contributes to the development of metastasis. 3. **Neurodegenerative disorders**: CCL7 is involved in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and multiple sclerosis. 4. **Infectious diseases**: CCL7 plays a role in the recruitment of immune cells to sites of infection, such as the lungs and brain. In conclusion, CCL7 is a crucial chemokine that regulates immune responses, inflammation, and cell migration. Its dysregulation has significant clinical implications in various diseases, making it an important target for therapeutic intervention.

Genular Protein ID: 2331861848

Symbol: CCL7_HUMAN

Name: C-C motif chemokine 7

UniProtKB Accession Codes:

P80098 Q569J6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8461011

Title: Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines.

PubMed ID: 8461011

DOI: 10.1006/bbrc.1993.1251

PubMed ID: 7916328

Title: The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12.

PubMed ID: 7916328

DOI: 10.1006/geno.1994.1283

PubMed ID: 8318676

Title: Molecular cloning of the MCP-3 chemokine gene and regulation of its expression.

PubMed ID: 8318676

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1613466

Title: Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.

PubMed ID: 1613466

DOI: 10.1084/jem.176.1.59

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 27044744

Title: The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.

PubMed ID: 27044744

DOI: 10.1074/jbc.m116.720953

PubMed ID: 8898111

Title: Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3.

PubMed ID: 8898111

DOI: 10.1016/0014-5793(96)01024-1

PubMed ID: 9109648

Title: Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy.

PubMed ID: 9109648

DOI: 10.1021/bi9627929

Sequence Information:

  • Length: 99
  • Mass: 11200
  • Checksum: 96048B371C25D00E
  • Sequence:
    • MKASAALLCL LLTAAAFSPQ GLAQPVGINT STTCCYRFIN KKIPKQRLES YRRTTSSHCP 
REAVIFKTKL DKEICADPTQ KWVQDFMKHL DKKTQTPKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.