Details for: CCL13

Gene ID: 6357

Symbol: CCL13

Ensembl ID: ENSG00000181374

Description: C-C motif chemokine ligand 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 9.6035
    Cell Significance Index: 336.4300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 8.6818
    Cell Significance Index: 97.0300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 8.0780
    Cell Significance Index: 168.6000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 7.3920
    Cell Significance Index: 110.5900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 5.6512
    Cell Significance Index: 114.9900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.7819
    Cell Significance Index: 14.5300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.9999
    Cell Significance Index: 15.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4082
    Cell Significance Index: 10.9200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0976
    Cell Significance Index: 0.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.4300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0056
    Cell Significance Index: -0.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0058
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0063
    Cell Significance Index: -4.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0105
    Cell Significance Index: -5.9400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0112
    Cell Significance Index: -0.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0133
    Cell Significance Index: -6.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0139
    Cell Significance Index: -0.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0180
    Cell Significance Index: -0.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0225
    Cell Significance Index: -4.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0272
    Cell Significance Index: -5.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0292
    Cell Significance Index: -5.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0328
    Cell Significance Index: -5.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0394
    Cell Significance Index: -5.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0398
    Cell Significance Index: -1.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0425
    Cell Significance Index: -1.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0453
    Cell Significance Index: -1.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0468
    Cell Significance Index: -5.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0483
    Cell Significance Index: -4.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0496
    Cell Significance Index: -6.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0502
    Cell Significance Index: -1.0500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0508
    Cell Significance Index: -1.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0538
    Cell Significance Index: -2.3400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0658
    Cell Significance Index: -1.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0781
    Cell Significance Index: -5.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0805
    Cell Significance Index: -3.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0826
    Cell Significance Index: -0.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0852
    Cell Significance Index: -6.3500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0863
    Cell Significance Index: -1.7200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0872
    Cell Significance Index: -1.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0889
    Cell Significance Index: -2.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0938
    Cell Significance Index: -1.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0977
    Cell Significance Index: -2.1100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1001
    Cell Significance Index: -0.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1036
    Cell Significance Index: -5.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1041
    Cell Significance Index: -6.3800
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1069
    Cell Significance Index: -1.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1119
    Cell Significance Index: -5.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1231
    Cell Significance Index: -4.0300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1371
    Cell Significance Index: -1.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1386
    Cell Significance Index: -6.5200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1408
    Cell Significance Index: -0.6500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1473
    Cell Significance Index: -2.0200
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.1491
    Cell Significance Index: -1.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1673
    Cell Significance Index: -6.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1702
    Cell Significance Index: -5.9800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1810
    Cell Significance Index: -2.1300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1845
    Cell Significance Index: -1.1300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1925
    Cell Significance Index: -5.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1959
    Cell Significance Index: -3.6200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2005
    Cell Significance Index: -2.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2029
    Cell Significance Index: -5.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2038
    Cell Significance Index: -4.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2071
    Cell Significance Index: -5.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2096
    Cell Significance Index: -6.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2134
    Cell Significance Index: -4.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2191
    Cell Significance Index: -6.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2227
    Cell Significance Index: -4.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2241
    Cell Significance Index: -3.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2286
    Cell Significance Index: -5.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2373
    Cell Significance Index: -6.9700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2410
    Cell Significance Index: -6.1400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2567
    Cell Significance Index: -2.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2575
    Cell Significance Index: -7.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2762
    Cell Significance Index: -5.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2816
    Cell Significance Index: -6.8200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2824
    Cell Significance Index: -6.8900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2831
    Cell Significance Index: -4.1400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2953
    Cell Significance Index: -1.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2982
    Cell Significance Index: -6.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2987
    Cell Significance Index: -6.9000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2988
    Cell Significance Index: -3.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3080
    Cell Significance Index: -6.3900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3141
    Cell Significance Index: -4.0700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3186
    Cell Significance Index: -6.2300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3201
    Cell Significance Index: -3.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3256
    Cell Significance Index: -5.4500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3289
    Cell Significance Index: -4.3700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3297
    Cell Significance Index: -5.3400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3334
    Cell Significance Index: -5.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3415
    Cell Significance Index: -4.8900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3418
    Cell Significance Index: -4.4700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3486
    Cell Significance Index: -5.9200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3486
    Cell Significance Index: -4.3900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3490
    Cell Significance Index: -5.8700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3506
    Cell Significance Index: -3.7700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3691
    Cell Significance Index: -4.3400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3769
    Cell Significance Index: -3.3000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.3887
    Cell Significance Index: -6.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCL13 shares several key characteristics with other chemokines, including: 1. **Chemotactic activity**: CCL13 exhibits chemotactic activity towards specific immune cells, such as granulocytes, monocytes, and T lymphocytes, promoting their migration towards sites of inflammation or infection. 2. **Receptor binding**: CCL13 binds to its specific receptor, CCR6, a G-protein coupled receptor that mediates its downstream signaling events. 3. **Cell signaling**: The binding of CCL13 to CCR6 triggers a signaling cascade that regulates various cellular processes, including cell migration, proliferation, and survival. 4. **Antimicrobial activity**: CCL13 has been shown to exhibit antimicrobial activity against certain pathogens, suggesting its potential role in the innate immune response. **Pathways and Functions** CCL13 is involved in several signaling pathways, including: 1. **Antimicrobial humoral immune response**: CCL13 mediates the recruitment of immune cells to sites of infection, promoting the elimination of pathogens. 2. **Cell-cell signaling**: CCL13 interacts with its receptor, CCR6, to regulate cell-cell communication and the coordination of immune responses. 3. **Cellular response to cytokines**: CCL13 is responsive to cytokines, such as IL-1β and TNF-α, which are key players in the regulation of immune responses. 4. **Chemokine-mediated signaling pathway**: CCL13 is involved in the regulation of chemokine-mediated signaling pathways, which are critical for the recruitment and migration of immune cells. The functions of CCL13 include: 1. **Immune cell recruitment**: CCL13 promotes the recruitment of immune cells, such as granulocytes and monocytes, to sites of inflammation or infection. 2. **Inflammation regulation**: CCL13 regulates the intensity and duration of inflammatory responses, preventing excessive tissue damage. 3. **Cell migration**: CCL13 mediates the migration of immune cells towards sites of inflammation or infection. 4. **Tissue repair**: CCL13 has been implicated in the regulation of tissue repair processes, including the recruitment of stem cells and the promotion of tissue regeneration. **Clinical Significance** CCL13 has been implicated in various diseases, including: 1. **Inflammatory bowel disease**: CCL13 has been shown to play a role in the pathogenesis of inflammatory bowel disease, including Crohn's disease and ulcerative colitis. 2. **Allergic diseases**: CCL13 has been implicated in the regulation of allergic responses, including asthma and atopic dermatitis. 3. **Cancer**: CCL13 has been shown to promote tumor progression and metastasis, highlighting its potential role as a prognostic biomarker. 4. **Neurological disorders**: CCL13 has been implicated in the regulation of neuroinflammation and neurodegeneration, including multiple sclerosis and Alzheimer's disease. In conclusion, CCL13 is a critical chemokine that plays a key role in the regulation of immune responses, inflammation, and cell migration. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms and clinical significance of CCL13.

Genular Protein ID: 548228404

Symbol: CCL13_HUMAN

Name: C-C motif chemokine 13

UniProtKB Accession Codes:

Q99616 O95689 Q6ICQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8955214

Title: Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3.

PubMed ID: 8955214

PubMed ID: 8642349

Title: Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin.

PubMed ID: 8642349

DOI: 10.1084/jem.183.5.2379

PubMed ID: 9195948

Title: Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B.

PubMed ID: 9195948

DOI: 10.1074/jbc.272.26.16404

PubMed ID: 9060459

Title: Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2.

PubMed ID: 9060459

DOI: 10.1002/jlb.61.3.353

PubMed ID: 10049733

Title: Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines.

PubMed ID: 10049733

DOI: 10.1006/bbrc.1999.0216

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18323622

Title: Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13).

PubMed ID: 18323622

DOI: 10.1107/s0907444907066164

Sequence Information:

  • Length: 98
  • Mass: 10986
  • Checksum: 612688DFCD308873
  • Sequence:
    • MKVSAVLLCL LLMTAAFNPQ GLAQPDALNV PSTCCFTFSS KKISLQRLKS YVITTSRCPQ 
KAVIFRTKLG KEICADPKEK WVQNYMKHLG RKAHTLKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.