Details for: SLCO4A1

Gene ID: 28231

Symbol: SLCO4A1

Ensembl ID: ENSG00000101187

Description: solute carrier organic anion transporter family member 4A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.7973
    Cell Significance Index: -10.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.4792
    Cell Significance Index: -9.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.1873
    Cell Significance Index: -9.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.4877
    Cell Significance Index: -10.4700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.9150
    Cell Significance Index: 97.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6812
    Cell Significance Index: -10.5800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.4942
    Cell Significance Index: 15.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.1716
    Cell Significance Index: -6.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0881
    Cell Significance Index: 397.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7314
    Cell Significance Index: 201.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5754
    Cell Significance Index: 155.8400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.5734
    Cell Significance Index: 11.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.4579
    Cell Significance Index: 211.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.4342
    Cell Significance Index: 25.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2043
    Cell Significance Index: 1087.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1619
    Cell Significance Index: 13.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9583
    Cell Significance Index: 60.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9184
    Cell Significance Index: -2.0100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9094
    Cell Significance Index: 13.0800
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.9004
    Cell Significance Index: 6.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8498
    Cell Significance Index: 138.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8236
    Cell Significance Index: 89.5900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.7171
    Cell Significance Index: 9.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5795
    Cell Significance Index: 34.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5790
    Cell Significance Index: 7.9000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.5057
    Cell Significance Index: 1.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4474
    Cell Significance Index: 12.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3524
    Cell Significance Index: 24.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3333
    Cell Significance Index: 7.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3199
    Cell Significance Index: 174.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3047
    Cell Significance Index: 8.9500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2883
    Cell Significance Index: 2.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2817
    Cell Significance Index: 12.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2581
    Cell Significance Index: 51.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2538
    Cell Significance Index: 50.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2395
    Cell Significance Index: 152.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2268
    Cell Significance Index: 11.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1989
    Cell Significance Index: 2.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1367
    Cell Significance Index: 2.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1057
    Cell Significance Index: 199.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1028
    Cell Significance Index: 2.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0919
    Cell Significance Index: 3.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0874
    Cell Significance Index: 15.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0655
    Cell Significance Index: 23.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0560
    Cell Significance Index: 1.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0547
    Cell Significance Index: 6.7300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0466
    Cell Significance Index: 0.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0365
    Cell Significance Index: 1.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0221
    Cell Significance Index: 15.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0220
    Cell Significance Index: 2.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0195
    Cell Significance Index: 29.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0186
    Cell Significance Index: 34.2300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0066
    Cell Significance Index: 0.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0030
    Cell Significance Index: -0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0077
    Cell Significance Index: -3.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0108
    Cell Significance Index: -7.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0119
    Cell Significance Index: -1.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0131
    Cell Significance Index: -5.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0140
    Cell Significance Index: -10.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0151
    Cell Significance Index: -11.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0181
    Cell Significance Index: -10.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0187
    Cell Significance Index: -5.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0358
    Cell Significance Index: -4.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0408
    Cell Significance Index: -1.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0417
    Cell Significance Index: -5.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0422
    Cell Significance Index: -5.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0468
    Cell Significance Index: -1.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0471
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0523
    Cell Significance Index: -11.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0534
    Cell Significance Index: -9.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0558
    Cell Significance Index: -1.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0577
    Cell Significance Index: -3.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0635
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0656
    Cell Significance Index: -7.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0677
    Cell Significance Index: -0.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0758
    Cell Significance Index: -5.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0796
    Cell Significance Index: -3.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0920
    Cell Significance Index: -6.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0978
    Cell Significance Index: -10.1800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1007
    Cell Significance Index: -1.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1202
    Cell Significance Index: -4.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1203
    Cell Significance Index: -6.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1218
    Cell Significance Index: -9.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1261
    Cell Significance Index: -9.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1315
    Cell Significance Index: -9.8000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1365
    Cell Significance Index: -0.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1385
    Cell Significance Index: -7.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1506
    Cell Significance Index: -8.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1545
    Cell Significance Index: -4.4300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1593
    Cell Significance Index: -6.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1601
    Cell Significance Index: -9.8400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1618
    Cell Significance Index: -2.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1649
    Cell Significance Index: -8.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1661
    Cell Significance Index: -5.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1664
    Cell Significance Index: -10.2000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1674
    Cell Significance Index: -1.2900
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.1678
    Cell Significance Index: -1.4200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1691
    Cell Significance Index: -7.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1859
    Cell Significance Index: -5.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLCO4A1 is a member of the solute carrier organic anion transporter family, which is involved in the transport of organic anions across cellular membranes. The gene is characterized by its ability to transport a wide range of organic anions, including prostaglandins, thyroid hormones, vitamins, nucleosides, and related molecules. SLCO4A1 is also known to be involved in the transport of small molecules, such as urea and creatinine, which are essential for maintaining proper kidney function. **Pathways and Functions:** SLCO4A1 is involved in various cellular pathways, including: 1. **Basolateral plasma membrane transport**: SLCO4A1 plays a crucial role in the transport of organic anions across the basolateral plasma membrane, which is essential for maintaining proper ion and solute balance in the body. 2. **Organic anion transmembrane transporter activity**: SLCO4A1 is involved in the transport of organic anions across the plasma membrane, which is essential for maintaining proper cellular homeostasis. 3. **Prostaglandin transport**: SLCO4A1 is involved in the transport of prostaglandins, which are essential for regulating inflammation and immune responses. 4. **Thyroid hormone transport**: SLCO4A1 is involved in the transport of thyroid hormones, which are essential for regulating metabolism and growth. **Clinical Significance:** SLCO4A1 has been implicated in various diseases, including: 1. **Genetic disorders**: Mutations in the SLCO4A1 gene have been associated with genetic disorders, such as familial hypercholesterolemia and familial hyperuricosuria. 2. **Cancer**: SLCO4A1 has been shown to play a role in the transport of cancer biomarkers, such as prostaglandins, which are involved in tumor growth and metastasis. 3. **Neurological disorders**: SLCO4A1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where impaired organic anion transport can lead to neuroinflammation and oxidative stress. 4. **Kidney disease**: SLCO4A1 has been shown to play a role in the transport of urea and creatinine, which are essential for maintaining proper kidney function. In conclusion, SLCO4A1 is a crucial gene involved in the transport of organic anions across cellular membranes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its functions and clinical significance.

Genular Protein ID: 3717434208

Symbol: SO4A1_HUMAN

Name: Solute carrier organic anion transporter family member 4A1

UniProtKB Accession Codes:

Q96BD0 Q9H4T7 Q9H4T8 Q9H8P2 Q9NWX8 Q9UI35 Q9UIG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 14 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 22 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10873595

Title: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.

PubMed ID: 10873595

DOI: 10.1006/bbrc.2000.2922

PubMed ID: 11316767

Title: Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner.

PubMed ID: 11316767

DOI: 10.1210/endo.142.5.8115

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12409283

Title: Characterization and identification of steroid sulfate transporters of human placenta.

PubMed ID: 12409283

DOI: 10.1152/ajpendo.00257.2002

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19129463

Title: Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.

PubMed ID: 19129463

DOI: 10.1152/ajpcell.00436.2008

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30343886

Title: Estrone sulphate uptake by the microvillous membrane of placental syncytiotrophoblast is coupled to glutamate efflux.

PubMed ID: 30343886

DOI: 10.1016/j.bbrc.2018.10.074

PubMed ID: 35307651

Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

PubMed ID: 35307651

DOI: 10.1124/dmd.121.000748

Sequence Information:

  • Length: 722
  • Mass: 77193
  • Checksum: DD8F0C10E4BCD255
  • Sequence:
    • MPLHQLGDKP LTFPSPNSAM ENGLDHTPPS RRASPGTPLS PGSLRSAAHS PLDTSKQPLC 
QLWAEKHGAR GTHEVRYVSA GQSVACGWWA FAPPCLQVLN TPKGILFFLC AAAFLQGMTV 
NGFINTVITS LERRYDLHSY QSGLIASSYD IAACLCLTFV SYFGGSGHKP RWLGWGVLLM 
GTGSLVFALP HFTAGRYEVE LDAGVRTCPA NPGAVCADST SGLSRYQLVF MLGQFLHGVG 
ATPLYTLGVT YLDENVKSSC SPVYIAIFYT AAILGPAAGY LIGGALLNIY TEMGRRTELT 
TESPLWVGAW WVGFLGSGAA AFFTAVPILG YPRQLPGSQR YAVMRAAEMH QLKDSSRGEA 
SNPDFGKTIR DLPLSIWLLL KNPTFILLCL AGATEATLIT GMSTFSPKFL ESQFSLSASE 
AATLFGYLVV PAGGGGTFLG GFFVNKLRLR GSAVIKFCLF CTVVSLLGIL VFSLHCPSVP 
MAGVTASYGG SLLPEGHLNL TAPCNAACSC QPEHYSPVCG SDGLMYFSLC HAGCPAATET 
NVDGQKVYRD CSCIPQNLSS GFGHATAGKC TSTCQRKPLL LVFIFVVIFF TFLSSIPALT 
ATLRCVRDPQ RSFALGIQWI VVRILGGIPG PIAFGWVIDK ACLLWQDQCG QQGSCLVYQN 
SAMSRYILIM GLLYKVLGVL FFAIACFLYK PLSESSDGLE TCLPSQSSAP DSATDSQLQS 
SV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.