Details for: STAC

Gene ID: 6769

Symbol: STAC

Ensembl ID: ENSG00000144681

Description: SH3 and cysteine rich domain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 48.2818
    Cell Significance Index: -7.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.0709
    Cell Significance Index: -7.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 7.8858
    Cell Significance Index: 172.6700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.3307
    Cell Significance Index: 11.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.1431
    Cell Significance Index: 19.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3820
    Cell Significance Index: 10.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3168
    Cell Significance Index: 4.5100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.2074
    Cell Significance Index: 2.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2009
    Cell Significance Index: 138.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1899
    Cell Significance Index: 68.1200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.1436
    Cell Significance Index: 1.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0938
    Cell Significance Index: 2.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0841
    Cell Significance Index: 4.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0566
    Cell Significance Index: 2.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0554
    Cell Significance Index: 1.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0517
    Cell Significance Index: 95.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0421
    Cell Significance Index: 26.7600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0416
    Cell Significance Index: 0.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0363
    Cell Significance Index: 68.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0313
    Cell Significance Index: 42.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0302
    Cell Significance Index: 6.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0096
    Cell Significance Index: 14.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0077
    Cell Significance Index: 0.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0035
    Cell Significance Index: 0.7000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0024
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0048
    Cell Significance Index: -2.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0071
    Cell Significance Index: -5.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0087
    Cell Significance Index: -4.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0104
    Cell Significance Index: -1.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0106
    Cell Significance Index: -0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0126
    Cell Significance Index: -5.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0128
    Cell Significance Index: -8.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0179
    Cell Significance Index: -5.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0231
    Cell Significance Index: -1.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0286
    Cell Significance Index: -3.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0300
    Cell Significance Index: -5.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0302
    Cell Significance Index: -4.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0310
    Cell Significance Index: -6.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0350
    Cell Significance Index: -3.5800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0380
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0404
    Cell Significance Index: -6.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0434
    Cell Significance Index: -5.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0440
    Cell Significance Index: -2.0500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0441
    Cell Significance Index: -0.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0462
    Cell Significance Index: -6.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0483
    Cell Significance Index: -5.9400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0515
    Cell Significance Index: -0.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0552
    Cell Significance Index: -0.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0593
    Cell Significance Index: -6.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0629
    Cell Significance Index: -7.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0680
    Cell Significance Index: -7.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0773
    Cell Significance Index: -4.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0809
    Cell Significance Index: -6.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0920
    Cell Significance Index: -7.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0921
    Cell Significance Index: -6.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0924
    Cell Significance Index: -6.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0943
    Cell Significance Index: -2.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0969
    Cell Significance Index: -3.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1051
    Cell Significance Index: -2.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1087
    Cell Significance Index: -5.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1234
    Cell Significance Index: -5.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1362
    Cell Significance Index: -7.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1371
    Cell Significance Index: -7.1200
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1426
    Cell Significance Index: -1.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1500
    Cell Significance Index: -6.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1717
    Cell Significance Index: -5.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1736
    Cell Significance Index: -6.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1743
    Cell Significance Index: -6.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1807
    Cell Significance Index: -6.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1838
    Cell Significance Index: -3.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1851
    Cell Significance Index: -4.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1881
    Cell Significance Index: -1.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1896
    Cell Significance Index: -6.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1951
    Cell Significance Index: -5.2200
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.2031
    Cell Significance Index: -2.1500
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2049
    Cell Significance Index: -1.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2092
    Cell Significance Index: -7.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2113
    Cell Significance Index: -6.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2124
    Cell Significance Index: -6.0900
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.2150
    Cell Significance Index: -2.2100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2239
    Cell Significance Index: -7.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2240
    Cell Significance Index: -5.8900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2259
    Cell Significance Index: -2.7500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2276
    Cell Significance Index: -2.4800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2316
    Cell Significance Index: -2.2000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2331
    Cell Significance Index: -2.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2333
    Cell Significance Index: -6.2300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2344
    Cell Significance Index: -2.8300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2359
    Cell Significance Index: -1.4000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2362
    Cell Significance Index: -2.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2404
    Cell Significance Index: -7.0600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2527
    Cell Significance Index: -2.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2551
    Cell Significance Index: -7.3500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2552
    Cell Significance Index: -2.3000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2562
    Cell Significance Index: -6.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2602
    Cell Significance Index: -6.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2615
    Cell Significance Index: -5.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2717
    Cell Significance Index: -4.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **SH3 and cysteine-rich domain:** The STAC protein contains a unique SH3 and cysteine-rich domain, which is responsible for its interactions with other proteins and regulation of cellular processes. 2. **Cellular localization:** STAC is primarily found in the cytosol and plasma membrane, where it regulates protein localization and signal transduction. 3. **Expression profile:** STAC is highly expressed in specific cell types, including chromaffin cells, Purkinje cells, and skeletal muscle cells. 4. **Pathway involvement:** STAC is involved in various signaling pathways, including cellular response to heat, positive regulation of cation channel activity, and positive regulation of voltage-gated calcium channel activity. **Pathways and Functions:** 1. **Cellular response to heat:** STAC is involved in the regulation of cellular response to heat stress, which is essential for maintaining cellular homeostasis. 2. **Skeletal muscle contraction:** STAC regulates skeletal muscle contraction by modulating the activity of voltage-gated calcium channels. 3. **Signal transduction:** STAC is involved in the regulation of signal transduction pathways, including the activation of cation channels and voltage-gated calcium channels. 4. **Protein localization:** STAC regulates protein localization to the plasma membrane, which is essential for maintaining cellular homeostasis. **Clinical Significance:** 1. **Dysregulation in diseases:** Dysregulation of STAC has been implicated in various diseases, including muscular dystrophy, cardiovascular disease, and neurodegenerative disorders. 2. **Therapeutic potential:** Targeting STAC may provide a novel therapeutic approach for the treatment of these diseases. 3. **Cancer association:** STAC has been associated with cancer progression and metastasis, suggesting its potential as a prognostic marker. 4. **Neurological disorders:** STAC is highly expressed in the brain and may play a role in the regulation of neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, STAC is a multifunctional gene that plays a crucial role in various cellular processes, including cellular response to heat, skeletal muscle contraction, and signal transduction. Its dysregulation may contribute to various diseases, and targeting STAC may provide a novel therapeutic approach for the treatment of these diseases. Further research is needed to fully understand the role of STAC in human disease and to explore its therapeutic potential.

Genular Protein ID: 2420473547

Symbol: STAC_HUMAN

Name: SH3 and cysteine-rich domain-containing protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8954993

Title: Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains.

PubMed ID: 8954993

DOI: 10.1006/bbrc.1996.1900

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 29078335

Title: Structural insights into binding of STAC proteins to voltage-gated calcium channels.

PubMed ID: 29078335

DOI: 10.1073/pnas.1708852114

Sequence Information:

  • Length: 402
  • Mass: 44554
  • Checksum: 211688D178E4F905
  • Sequence:
  • MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK SLRSKSADNF 
    FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG LHPGGKAHAF QEYIFKKPTF 
    CDVCNHMIVG TNAKHGLRCK ACKMSIHHKC TDGLAPQRCM GKLPKGFRRY YSSPLLIHEQ 
    FGCIKEVMPI ACGNKVDPVY ETLRFGTSLA QRTKKGSSGS GSDSPHRTST SDLVEVPEEA 
    NGPGGGYDLR KRSNSVFTYP ENGTDDFRDP AKNINHQGSL SKDPLQMNTY VALYKFVPQE 
    NEDLEMRPGD IITLLEDSNE DWWKGKIQDR IGFFPANFVQ RLQQNEKIFR CVRTFIGCKE 
    QGQITLKENQ ICVSSEEEQD GFIRVLSGKK KGLIPLDVLE NI

Genular Protein ID: 498915222

Symbol: B4DR96_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 341
  • Mass: 37668
  • Checksum: A7F22AA787DCDD38
  • Sequence:
  • MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK SLRSKSADNF 
    FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG LHPGGKAHAF QEYIFKKPTF 
    CDVCNHMIVA CGNKVDPVYE TLRFGTSPAQ RTKKGSSGSG SDSPHRTSTS DLVEVPEEAN 
    GPGGGYDLRK RSNSVFTYPE NGTDDFRDPA KNINHQGSLS KDPLQMNTYV ALYKFVPQEN 
    EDLEMRPGDI ITLLEDSNED WWKGKIQDRI GFFPANFVQR LQQNEKIFRC VRTFIGCKEQ 
    GQITLKENQI CVSSEEEQDG FIRVLSGKKK GLIPLDVLEN I

Genular Protein ID: 4168900317

Symbol: E9PEA7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 341
  • Mass: 37684
  • Checksum: BC9516ECB0BBE178
  • Sequence:
  • MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK SLRSKSADNF 
    FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG LHPGGKAHAF QEYIFKKPTF 
    CDVCNHMIVA CGNKVDPVYE TLRFGTSLAQ RTKKGSSGSG SDSPHRTSTS DLVEVPEEAN 
    GPGGGYDLRK RSNSVFTYPE NGTDDFRDPA KNINHQGSLS KDPLQMNTYV ALYKFVPQEN 
    EDLEMRPGDI ITLLEDSNED WWKGKIQDRI GFFPANFVQR LQQNEKIFRC VRTFIGCKEQ 
    GQITLKENQI CVSSEEEQDG FIRVLSGKKK GLIPLDVLEN I

Genular Protein ID: 3100270331

Symbol: Q8WUK8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 402
  • Mass: 44563
  • Checksum: F39CAD24A73601FD
  • Sequence:
  • MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK SLRSKSADNF 
    FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG LHPGGKAHAF HEYIFKKPTF 
    CDVCNHMIVG TNAKHGLRCK ACKMSIHHKC TDGLAPQRCM GKLPKGFRRY YSSPLLIHEQ 
    FGCIKEVMPI ACGNKVDPVY ETLRFGTSLA QRTKKGSSGS GSDSPHRTST SDLVEVPEEA 
    NGPGGGYDLR KRSNSVFTYP ENGTDDFRDP AKNINHQGSL SKDPLQMNTY VALYKFVPQE 
    NEDLEMRPGD IITLLEDSNE DWWKGKIQDR IGFFPANFVQ RLQQNEKIFR CVRTFIGCKE 
    QGQITLKENQ ICVSSEEEQD GFIRVLSGKK KGLIPLDVLE NI

Genular Protein ID: 367785068

Symbol: B4DZ13_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 334
  • Mass: 37164
  • Checksum: 35F7BA991E669F72
  • Sequence:
  • MKLQAHMVAE ISPSSSPLPA PGSLTSTPAR AGLHPGGKAH AFQEYIFKKP TFCDVCNHMI 
    VGTNAKHGLR CKACKMSIHH KCTDGLAPQR CMGKLPKGFR RYYSSPLLIH EQFGCIKEVM 
    PIACGNKVDP VYETLRFGTS LAQRTKKGSS GSGSDSPHRT STSDLVEVPE EANGPGGGYD 
    LRKRSNSVFT YPENGTDDFR DPAKNINHQG SLSKDPLQMN TYVALYKFVP QENEDLEMRP 
    GDIITLLEDS NEDWWKGKIQ DRIGFFPANF VQRLQQNEKI FRCVRTFIGC KEQGQITLKE 
    NQICVSSEEE QDGFIRVLSG KKKGLIPLDV LENI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.