Details for: CCL8

Gene ID: 6355

Symbol: CCL8

Ensembl ID: ENSG00000108700

Description: C-C motif chemokine ligand 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 16.3443
    Cell Significance Index: -6.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.0595
    Cell Significance Index: -6.7400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 1.7424
    Cell Significance Index: 20.5000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6344
    Cell Significance Index: 11.2100
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.5548
    Cell Significance Index: 3.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5340
    Cell Significance Index: 14.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3890
    Cell Significance Index: 81.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1112
    Cell Significance Index: 13.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0597
    Cell Significance Index: 37.2700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0294
    Cell Significance Index: 0.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0216
    Cell Significance Index: 3.6800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0110
    Cell Significance Index: 0.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0001
    Cell Significance Index: 0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0002
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -7.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0073
    Cell Significance Index: -0.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0101
    Cell Significance Index: -6.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0113
    Cell Significance Index: -1.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0153
    Cell Significance Index: -8.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0190
    Cell Significance Index: -2.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0247
    Cell Significance Index: -1.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0261
    Cell Significance Index: -11.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0307
    Cell Significance Index: -0.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0349
    Cell Significance Index: -6.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0410
    Cell Significance Index: -8.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0441
    Cell Significance Index: -6.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0443
    Cell Significance Index: -8.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0444
    Cell Significance Index: -5.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0496
    Cell Significance Index: -6.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0530
    Cell Significance Index: -5.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0745
    Cell Significance Index: -3.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0875
    Cell Significance Index: -3.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0899
    Cell Significance Index: -4.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0986
    Cell Significance Index: -7.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1017
    Cell Significance Index: -5.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1234
    Cell Significance Index: -9.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1254
    Cell Significance Index: -7.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1457
    Cell Significance Index: -8.9300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1643
    Cell Significance Index: -1.3800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1702
    Cell Significance Index: -2.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1745
    Cell Significance Index: -7.9100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1753
    Cell Significance Index: -3.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2010
    Cell Significance Index: -10.4400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2112
    Cell Significance Index: -2.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2122
    Cell Significance Index: -5.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2252
    Cell Significance Index: -10.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2271
    Cell Significance Index: -6.6900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2308
    Cell Significance Index: -2.7200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2328
    Cell Significance Index: -2.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2369
    Cell Significance Index: -10.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2480
    Cell Significance Index: -5.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2588
    Cell Significance Index: -6.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2604
    Cell Significance Index: -9.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2666
    Cell Significance Index: -7.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2707
    Cell Significance Index: -8.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2760
    Cell Significance Index: -10.4500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2805
    Cell Significance Index: -3.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2882
    Cell Significance Index: -3.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2963
    Cell Significance Index: -7.7900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3003
    Cell Significance Index: -4.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3014
    Cell Significance Index: -7.6800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.3018
    Cell Significance Index: -2.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3139
    Cell Significance Index: -8.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3244
    Cell Significance Index: -7.7800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3359
    Cell Significance Index: -5.4400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3417
    Cell Significance Index: -5.8700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3427
    Cell Significance Index: -8.5600
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.3473
    Cell Significance Index: -4.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3531
    Cell Significance Index: -5.9100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3667
    Cell Significance Index: -4.4600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3681
    Cell Significance Index: -4.3500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3854
    Cell Significance Index: -5.2900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.3862
    Cell Significance Index: -3.8900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3874
    Cell Significance Index: -7.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3895
    Cell Significance Index: -8.0800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3906
    Cell Significance Index: -5.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3917
    Cell Significance Index: -9.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3960
    Cell Significance Index: -8.5600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3963
    Cell Significance Index: -6.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4003
    Cell Significance Index: -10.9000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.4004
    Cell Significance Index: -4.3100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.4061
    Cell Significance Index: -5.9400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4110
    Cell Significance Index: -6.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4132
    Cell Significance Index: -8.7700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4195
    Cell Significance Index: -6.7300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4260
    Cell Significance Index: -8.3300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4345
    Cell Significance Index: -4.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4418
    Cell Significance Index: -8.8700
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.4505
    Cell Significance Index: -5.1100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4558
    Cell Significance Index: -3.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4635
    Cell Significance Index: -11.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4811
    Cell Significance Index: -5.2300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.4845
    Cell Significance Index: -6.2600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4868
    Cell Significance Index: -5.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4891
    Cell Significance Index: -7.7600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4900
    Cell Significance Index: -4.6000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4966
    Cell Significance Index: -5.0700
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.5059
    Cell Significance Index: -4.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5102
    Cell Significance Index: -8.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCL8 is a member of the C-C chemokine family, characterized by its ability to bind to the CCR2 receptor, which is predominantly expressed on monocytes, macrophages, and eosinophils. Its expression is induced by pro-inflammatory cytokines, such as IL-1β and TNF-α, and is upregulated in response to tissue injury, infection, and inflammation. CCL8 is also expressed in various cell types, including oligodendrocyte precursor cells, intestinal crypt stem cells, and neoplastic cells, highlighting its involvement in multiple cellular processes. **Pathways and Functions:** CCL8's signaling pathways are multifaceted and involve interactions with various receptors, kinases, and transcription factors. These pathways include: 1. **G-protein coupled receptor signaling pathway**: CCL8 binds to CCR2, activating a G-protein coupled receptor complex that triggers downstream signaling cascades, including the activation of phospholipase C and the production of inositol trisphosphate. 2. **Chemokine-mediated signaling pathway**: CCL8 interacts with its receptor, CCR2, to activate a signaling cascade that regulates chemotaxis, cell migration, and proliferation. 3. **Inflammatory response**: CCL8 is induced by pro-inflammatory cytokines and contributes to the recruitment of immune cells to sites of inflammation, exacerbating tissue damage and promoting chronic inflammation. 4. **Cellular response to viral genome replication**: CCL8 is involved in the regulation of viral replication, inhibiting the entry of viruses into host cells and modulating the host's immune response. **Clinical Significance:** CCL8's dysregulation has been implicated in various diseases, including: 1. **Atherosclerosis**: Elevated CCL8 levels are associated with increased inflammation and atherosclerotic plaque formation. 2. **Rheumatoid Arthritis**: CCL8 is overexpressed in rheumatoid synovial fluid, contributing to joint inflammation and destruction. 3. **Cancer**: CCL8 is expressed in various types of cancer, including lung, breast, and colon cancer, where it promotes tumor progression and metastasis. 4. **Neurological disorders**: CCL8 is involved in the pathogenesis of multiple sclerosis, where it contributes to demyelination and neuroinflammation. In conclusion, CCL8 is a complex cytokine that plays a multifaceted role in immune response, inflammation, and cellular homeostasis. Its dysregulation has significant implications for various diseases, highlighting the need for further research into the mechanisms of CCL8's action and its potential as a therapeutic target.

Genular Protein ID: 2720196867

Symbol: CCL8_HUMAN

Name: C-C motif chemokine 8

UniProtKB Accession Codes:

P80075 A0AV77 P78388

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9119400

Title: The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2.

PubMed ID: 9119400

DOI: 10.1006/geno.1996.4594

PubMed ID: 9070881

Title: Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells.

PubMed ID: 9070881

DOI: 10.1006/bbrc.1997.6177

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2518726

Title: Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family.

PubMed ID: 2518726

DOI: 10.1093/intimm/1.4.388

PubMed ID: 1613466

Title: Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.

PubMed ID: 1613466

DOI: 10.1084/jem.176.1.59

PubMed ID: 8898111

Title: Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3.

PubMed ID: 8898111

DOI: 10.1016/0014-5793(96)01024-1

PubMed ID: 9558113

Title: Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP-2(6-76) as a natural chemokine inhibitor.

PubMed ID: 9558113

PubMed ID: 11087354

Title: Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors.

PubMed ID: 11087354

DOI: 10.1021/bi0009340

Sequence Information:

  • Length: 99
  • Mass: 11246
  • Checksum: 9D67976BB9422F2A
  • Sequence:
    • MKVSAALLCL LLMAATFSPQ GLAQPDSVSI PITCCFNVIN RKIPIQRLES YTRITNIQCP 
KEAVIFKTKR GKEVCADPKE RWVRDSMKHL DQIFQNLKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.