Details for: CCL8

Gene ID: 6355

Symbol: CCL8

Ensembl ID: ENSG00000108700

Description: C-C motif chemokine ligand 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 4.28
    Marker Score: 5290
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2547
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.89
    Marker Score: 370
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.79
    Marker Score: 273
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1599.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.78
    Marker Score: 612
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 569
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 382
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.58
    Marker Score: 1092
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 189
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 181
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.4
    Marker Score: 191
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.33
    Marker Score: 1442
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.33
    Marker Score: 331
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.32
    Marker Score: 539
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.31
    Marker Score: 178
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.3
    Marker Score: 139
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3
    Marker Score: 4725
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.29
    Marker Score: 289
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.25
    Marker Score: 146
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.25
    Marker Score: 767
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.23
    Marker Score: 1559
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.22
    Marker Score: 158
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.21
    Marker Score: 333
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.2
    Marker Score: 46
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.19
    Marker Score: 107
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 164
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.18
    Marker Score: 199
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.17
    Marker Score: 104
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.17
    Marker Score: 197
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.17
    Marker Score: 96
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.17
    Marker Score: 217
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.17
    Marker Score: 9329
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 113
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.16
    Marker Score: 306
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 69
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 147
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.15
    Marker Score: 231
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.15
    Marker Score: 144
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.14
    Marker Score: 61
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.13
    Marker Score: 4555
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.13
    Marker Score: 333
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.13
    Marker Score: 279
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.13
    Marker Score: 158
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.13
    Marker Score: 161
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.12
    Marker Score: 121
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.12
    Marker Score: 61
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.11
    Marker Score: 216
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.11
    Marker Score: 79
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1
    Marker Score: 1152
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 119
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1
    Marker Score: 80
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.1
    Marker Score: 98
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.08
    Marker Score: 57
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 87
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.07
    Marker Score: 76
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.07
    Marker Score: 127
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.07
    Marker Score: 421
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.07
    Marker Score: 53
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.07
    Marker Score: 18

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Other Information

**Key characteristics:** - The CCL8 gene is located on chromosome 19p13.1. - It is a member of the chemokine family of proteins. - It is a type I transmembrane protein with a conserved C-C chemokine domain. - It is expressed in high levels in the central nervous system. **Pathways and functions:** - CCL8 is a key regulator of immune responses. - It is involved in the regulation of inflammation, cell migration, and chemotaxis. - It is expressed in cells that are activated by inflammatory stimuli. - It helps to recruit immune cells to sites of infection or injury. **Clinical significance:** - Mutations in the CCL8 gene have been linked to a number of autoimmune diseases, including multiple sclerosis and Crohn's disease. - Targeting CCL8 has been shown to be an effective treatment for these diseases. **Other important points:** - CCL8 is a highly conserved protein, with a similar protein found in other mammals. - It is a relatively new protein, with the gene first identified in humans in 2002. - It is a promising target for the development of new treatments for autoimmune diseases.

Genular Protein ID: 2720196867

Symbol: CCL8_HUMAN

Name: C-C motif chemokine 8

UniProtKB Accession Codes:

P80075 A0AV77 P78388

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9119400

Title: The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2.

PubMed ID: 9119400

DOI: 10.1006/geno.1996.4594

PubMed ID: 9070881

Title: Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells.

PubMed ID: 9070881

DOI: 10.1006/bbrc.1997.6177

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2518726

Title: Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family.

PubMed ID: 2518726

DOI: 10.1093/intimm/1.4.388

PubMed ID: 1613466

Title: Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.

PubMed ID: 1613466

DOI: 10.1084/jem.176.1.59

PubMed ID: 8898111

Title: Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3.

PubMed ID: 8898111

DOI: 10.1016/0014-5793(96)01024-1

PubMed ID: 9558113

Title: Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP-2(6-76) as a natural chemokine inhibitor.

PubMed ID: 9558113

PubMed ID: 11087354

Title: Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors.

PubMed ID: 11087354

DOI: 10.1021/bi0009340

Sequence Information:

  • Length: 99
  • Mass: 11246
  • Checksum: 9D67976BB9422F2A
  • Sequence:
    • MKVSAALLCL LLMAATFSPQ GLAQPDSVSI PITCCFNVIN RKIPIQRLES YTRITNIQCP 
KEAVIFKTKR GKEVCADPKE RWVRDSMKHL DQIFQNLKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.