Details for: CXCL5

Gene ID: 6374

Symbol: CXCL5

Ensembl ID: ENSG00000163735

Description: C-X-C motif chemokine ligand 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 43.2029
    Cell Significance Index: -6.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.4939
    Cell Significance Index: -6.7200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 3.8631
    Cell Significance Index: 23.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.2890
    Cell Significance Index: 383.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.9433
    Cell Significance Index: 62.2400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.7702
    Cell Significance Index: 29.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.7055
    Cell Significance Index: -6.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8473
    Cell Significance Index: 161.2400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.8392
    Cell Significance Index: 3.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5950
    Cell Significance Index: 324.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5657
    Cell Significance Index: 55.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4628
    Cell Significance Index: 417.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4014
    Cell Significance Index: 84.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3961
    Cell Significance Index: 8.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3054
    Cell Significance Index: 33.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2994
    Cell Significance Index: 48.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2214
    Cell Significance Index: 13.2900
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.1858
    Cell Significance Index: 2.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1383
    Cell Significance Index: 9.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1166
    Cell Significance Index: 15.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0634
    Cell Significance Index: 39.5900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.0623
    Cell Significance Index: 1.0700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0608
    Cell Significance Index: 0.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0332
    Cell Significance Index: 1.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0224
    Cell Significance Index: 1.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0051
    Cell Significance Index: 0.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0021
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -2.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0040
    Cell Significance Index: -1.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0046
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0052
    Cell Significance Index: -2.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0059
    Cell Significance Index: -0.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0060
    Cell Significance Index: -0.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0063
    Cell Significance Index: -4.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0066
    Cell Significance Index: -0.3300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0069
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0072
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0119
    Cell Significance Index: -2.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0120
    Cell Significance Index: -0.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0123
    Cell Significance Index: -3.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0129
    Cell Significance Index: -0.2800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0169
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0216
    Cell Significance Index: -2.4700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0265
    Cell Significance Index: -0.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0266
    Cell Significance Index: -0.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0267
    Cell Significance Index: -4.8100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0273
    Cell Significance Index: -0.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0276
    Cell Significance Index: -5.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0324
    Cell Significance Index: -0.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0329
    Cell Significance Index: -6.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0362
    Cell Significance Index: -0.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0460
    Cell Significance Index: -5.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0483
    Cell Significance Index: -1.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0534
    Cell Significance Index: -7.3300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0627
    Cell Significance Index: -0.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0661
    Cell Significance Index: -1.1300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0699
    Cell Significance Index: -0.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0792
    Cell Significance Index: -0.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0961
    Cell Significance Index: -6.4600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0974
    Cell Significance Index: -0.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1013
    Cell Significance Index: -7.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1049
    Cell Significance Index: -8.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1119
    Cell Significance Index: -0.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1188
    Cell Significance Index: -7.3100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1203
    Cell Significance Index: -1.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1210
    Cell Significance Index: -6.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1420
    Cell Significance Index: -4.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1646
    Cell Significance Index: -5.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1653
    Cell Significance Index: -8.5900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1656
    Cell Significance Index: -2.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1739
    Cell Significance Index: -3.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1787
    Cell Significance Index: -6.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1850
    Cell Significance Index: -6.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1861
    Cell Significance Index: -8.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1885
    Cell Significance Index: -2.8400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1903
    Cell Significance Index: -4.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2000
    Cell Significance Index: -6.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2006
    Cell Significance Index: -5.9100
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.2037
    Cell Significance Index: -2.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2039
    Cell Significance Index: -6.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2192
    Cell Significance Index: -8.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2264
    Cell Significance Index: -6.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2306
    Cell Significance Index: -6.1800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2342
    Cell Significance Index: -0.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2370
    Cell Significance Index: -6.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2564
    Cell Significance Index: -6.5500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2601
    Cell Significance Index: -2.6200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2675
    Cell Significance Index: -6.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2705
    Cell Significance Index: -5.0000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2746
    Cell Significance Index: -7.0000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2787
    Cell Significance Index: -3.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2791
    Cell Significance Index: -7.3400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2812
    Cell Significance Index: -4.1100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2871
    Cell Significance Index: -4.9500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2873
    Cell Significance Index: -4.8800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2890
    Cell Significance Index: -7.2100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3021
    Cell Significance Index: -4.0200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3070
    Cell Significance Index: -7.4900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3155
    Cell Significance Index: -3.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CXCL5 exhibits several key characteristics that enable it to perform its functions effectively. These include: 1. **Chemotactic properties**: CXCL5 is a potent chemotactic agent, capable of attracting immune cells to specific sites. 2. **Antimicrobial properties**: CXCL5 has been shown to exhibit antimicrobial activity, making it an important component of the innate immune response. 3. **Cell-cell signaling**: CXCL5 interacts with various chemokine receptors, including CXCR1 and CXCR2, to regulate cell-cell signaling and immune responses. 4. **Regulation of cell proliferation**: CXCL5 has been shown to regulate the proliferation of immune cells, including T lymphocytes and granulocytes. **Pathways and Functions** CXCL5 is involved in several key pathways and functions, including: 1. **Antimicrobial humoral immune response**: CXCL5 plays a crucial role in the recruitment of immune cells to sites of infection, where it helps to eliminate pathogens. 2. **Cell-cell signaling**: CXCL5 interacts with chemokine receptors to regulate cell-cell signaling and immune responses. 3. **Inflammatory response**: CXCL5 is involved in the regulation of the inflammatory response, including the recruitment of immune cells and the production of pro-inflammatory cytokines. 4. **Neutrophil chemotaxis**: CXCL5 is a potent chemoattractant for neutrophils, which are essential for the clearance of pathogens and the repair of tissue damage. **Clinical Significance** CXCL5 has significant clinical implications, particularly in the context of: 1. **Inflammatory bowel disease (IBD)**: CXCL5 has been implicated in the pathogenesis of IBD, including Crohn's disease and ulcerative colitis. 2. **Infections**: CXCL5 plays a crucial role in the recruitment of immune cells to sites of infection, making it an important target for the treatment of infections. 3. **Cancer**: CXCL5 has been shown to promote tumor growth and metastasis, highlighting its potential role in cancer progression. 4. **Neurological disorders**: CXCL5 has been implicated in the pathogenesis of neurological disorders, including multiple sclerosis and Alzheimer's disease. In conclusion, CXCL5 is a critical regulator of the immune response and cellular migration, playing a pivotal role in the regulation of inflammation, immune cell recruitment, and tissue repair. Its clinical significance is evident in its involvement in various diseases, including IBD, infections, cancer, and neurological disorders. Further research is needed to fully elucidate the mechanisms by which CXCL5 regulates the immune response and to explore its potential as a therapeutic target.

Genular Protein ID: 3338516297

Symbol: CXCL5_HUMAN

Name: C-X-C motif chemokine 5

UniProtKB Accession Codes:

P42830 Q96QE1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7828901

Title: Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets.

PubMed ID: 7828901

DOI: 10.1016/0378-1119(94)90682-3

PubMed ID: 7929219

Title: Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene.

PubMed ID: 7929219

DOI: 10.1016/s0021-9258(18)47243-2

PubMed ID: 7999089

Title: Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78).

PubMed ID: 7999089

DOI: 10.1006/bbrc.1994.2709

PubMed ID: 11468158

Title: Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus.

PubMed ID: 11468158

DOI: 10.1182/blood.v98.3.610

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1744577

Title: Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8.

PubMed ID: 1744577

DOI: 10.1084/jem.174.6.1355

PubMed ID: 10095777

Title: Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms.

PubMed ID: 10095777

DOI: 10.1046/j.1432-1327.1999.00166.x

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 14711052

Title: Regulation of the immune response by the interaction of chemokines and proteases.

PubMed ID: 14711052

DOI: 10.1016/s0065-2776(03)81001-5

PubMed ID: 24695525

Title: Solution structure of CXCL5--a novel chemokine and adipokine implicated in inflammation and obesity.

PubMed ID: 24695525

DOI: 10.1371/journal.pone.0093228

Sequence Information:

  • Length: 114
  • Mass: 11972
  • Checksum: 56B21EE86AE952D3
  • Sequence:
    • MSLLSSRAAR VPGPSSSLCA LLVLLLLLTQ PGPIASAGPA AAVLRELRCV CLQTTQGVHP 
KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.