Details for: SERPINB8

Gene ID: 5271

Symbol: SERPINB8

Ensembl ID: ENSG00000166401

Description: serpin family B member 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 64.4186
    Cell Significance Index: -10.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.6262
    Cell Significance Index: -9.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.8243
    Cell Significance Index: -8.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.9134
    Cell Significance Index: -8.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.1593
    Cell Significance Index: -10.0600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.1986
    Cell Significance Index: 21.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5722
    Cell Significance Index: -10.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.2758
    Cell Significance Index: -6.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.9855
    Cell Significance Index: 53.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.9121
    Cell Significance Index: 363.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3816
    Cell Significance Index: 18.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2932
    Cell Significance Index: 67.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0316
    Cell Significance Index: 28.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7867
    Cell Significance Index: 14.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7203
    Cell Significance Index: 43.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4922
    Cell Significance Index: 48.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4875
    Cell Significance Index: 53.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4656
    Cell Significance Index: 420.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4518
    Cell Significance Index: 29.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4444
    Cell Significance Index: 12.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3694
    Cell Significance Index: 43.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3538
    Cell Significance Index: 7.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3466
    Cell Significance Index: 5.9400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3288
    Cell Significance Index: 4.6800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.3204
    Cell Significance Index: 3.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3003
    Cell Significance Index: 48.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2739
    Cell Significance Index: 18.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2226
    Cell Significance Index: 10.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1761
    Cell Significance Index: 3.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1569
    Cell Significance Index: 20.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1566
    Cell Significance Index: 11.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1372
    Cell Significance Index: 16.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1345
    Cell Significance Index: 24.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1085
    Cell Significance Index: 5.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1000
    Cell Significance Index: 44.2300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0986
    Cell Significance Index: 1.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0720
    Cell Significance Index: 9.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0655
    Cell Significance Index: 2.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0629
    Cell Significance Index: 34.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0525
    Cell Significance Index: 1.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0508
    Cell Significance Index: 10.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0488
    Cell Significance Index: 66.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0308
    Cell Significance Index: 0.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0297
    Cell Significance Index: 3.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0088
    Cell Significance Index: 0.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0087
    Cell Significance Index: 13.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0026
    Cell Significance Index: -0.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0029
    Cell Significance Index: -2.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0095
    Cell Significance Index: -6.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0116
    Cell Significance Index: -8.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0122
    Cell Significance Index: -8.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0166
    Cell Significance Index: -9.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0192
    Cell Significance Index: -8.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0192
    Cell Significance Index: -1.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0202
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0209
    Cell Significance Index: -2.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0215
    Cell Significance Index: -3.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0225
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0231
    Cell Significance Index: -3.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0242
    Cell Significance Index: -1.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0255
    Cell Significance Index: -7.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0258
    Cell Significance Index: -0.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0264
    Cell Significance Index: -5.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0380
    Cell Significance Index: -2.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0398
    Cell Significance Index: -0.6000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0444
    Cell Significance Index: -0.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0527
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0531
    Cell Significance Index: -11.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0593
    Cell Significance Index: -1.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0653
    Cell Significance Index: -1.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0939
    Cell Significance Index: -9.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1005
    Cell Significance Index: -2.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1079
    Cell Significance Index: -3.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1079
    Cell Significance Index: -1.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1080
    Cell Significance Index: -7.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1147
    Cell Significance Index: -9.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1226
    Cell Significance Index: -9.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1292
    Cell Significance Index: -1.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1391
    Cell Significance Index: -1.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1480
    Cell Significance Index: -9.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1561
    Cell Significance Index: -8.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1576
    Cell Significance Index: -9.9300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1600
    Cell Significance Index: -1.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1638
    Cell Significance Index: -10.0400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1774
    Cell Significance Index: -2.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1884
    Cell Significance Index: -6.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1971
    Cell Significance Index: -8.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2018
    Cell Significance Index: -7.0700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.2021
    Cell Significance Index: -1.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2024
    Cell Significance Index: -10.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2047
    Cell Significance Index: -10.7500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2086
    Cell Significance Index: -3.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2280
    Cell Significance Index: -7.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2307
    Cell Significance Index: -5.9300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2338
    Cell Significance Index: -5.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2366
    Cell Significance Index: -8.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2386
    Cell Significance Index: -8.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SERPINB8 is a 50-kDa protein that belongs to the serpin family, characterized by its ability to inhibit serine proteases, such as trypsin, thrombin, and plasmin. It is structurally similar to other serpins, including SERPINA1 (alpha-1 antitrypsin) and SERPINE1 (plasminogen activator inhibitor-1). SERPINB8 is primarily expressed in the cytosol and is localized to the extracellular space, where it can interact with other proteins and regulate cellular processes. **Pathways and Functions:** SERPINB8 is involved in several biological pathways, including: 1. **Hemostasis:** SERPINB8 plays a crucial role in regulating fibrinolysis by inhibiting plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator-1 (PA-1), thereby modulating the fibrinolytic process. 2. **Cellular Adhesion:** SERPINB8 interacts with integrins and other adhesion molecules to regulate cell-cell and cell-extracellular matrix interactions, which is essential for maintaining tissue homeostasis. 3. **Endopeptidase Regulation:** SERPINB8 inhibits endopeptidases, such as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase (ADAM) family members, which are involved in tissue remodeling and cellular migration. 4. **Extracellular Exosome Regulation:** SERPINB8 is also involved in regulating the extracellular exosome, which is a complex of proteins and lipids secreted by cells that can interact with other cells and regulate cellular processes. **Clinical Significance:** Dysregulation of SERPINB8 has been implicated in various diseases, including: 1. **Thrombotic Disorders:** SERPINB8 deficiency has been linked to increased risk of thrombosis, as it can lead to uncontrolled fibrinolysis and increased platelet activation. 2. **Cancer:** SERPINB8 is overexpressed in several types of cancer, including breast, lung, and colon cancer, where it can promote tumor progression and metastasis. 3. **Neurological Disorders:** SERPINB8 has been implicated in the regulation of GABAergic transmission in the cerebral cortex, and its dysregulation has been linked to neurological disorders, such as epilepsy and Alzheimer's disease. In conclusion, SERPINB8 is a key regulator of hemostasis, cellular adhesion, and endopeptidase activity, and its dysregulation has been implicated in various diseases. Further research is necessary to fully understand the mechanisms of SERPINB8 and its role in maintaining tissue homeostasis and regulating cellular interactions.

Genular Protein ID: 2495925437

Symbol: SPB8_HUMAN

Name: Serpin B8

UniProtKB Accession Codes:

P50452 B4DTW2 Q7Z2V6 Q8N178

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530382

Title: Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors.

PubMed ID: 8530382

DOI: 10.1074/jbc.270.50.29854

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27476651

Title: Loss-of-function mutations in SERPINB8 linked to exfoliative ichthyosis with impaired mechanical stability of intercellular adhesions.

PubMed ID: 27476651

DOI: 10.1016/j.ajhg.2016.06.004

Sequence Information:

  • Length: 374
  • Mass: 42767
  • Checksum: 7235A033519AC612
  • Sequence:
    • MDDLCEANGT FAISLFKILG EEDNSRNVFF SPMSISSALA MVFMGAKGST AAQMSQALCL 
YKDGDIHRGF QSLLSEVNRT GTQYLLRTAN RLFGEKTCDF LPDFKEYCQK FYQAELEELS 
FAEDTEECRK HINDWVAEKT EGKISEVLDA GTVDPLTKLV LVNAIYFKGK WNEQFDRKYT 
RGMLFKTNEE KKTVQMMFKE AKFKMGYADE VHTQVLELPY VEEELSMVIL LPDDNTDLAV 
VEKALTYEKF KAWTNSEKLT KSKVQVFLPR LKLEESYDLE PFLRRLGMID AFDEAKADFS 
GMSTEKNVPL SKVAHKCFVE VNEEGTEAAA ATAVVRNSRC SRMEPRFCAD HPFLFFIRHH 
KTNCILFCGR FSSP

Genular Protein ID: 2578140797

Symbol: A0A1B0GU38_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1B0GU38

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 RuleBase 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 259
  • Mass: 29515
  • Checksum: 32FE6A23C2D03CD3
  • Sequence:
    • MDDLCEANGT FAISLFKILG EEDNSRNVFF SPMSISSALA MVFMGAKGST AAQMSQALCL 
YKDGDIHRGF QSLLSEVNRT GTQYLLRTAN RLFGEKTCDF LPDFKEYCQK FYQAELEELS 
FAEDTEECRK HINDWVAEKT EGKISEVLDA GTVDPLTKLV LVNAIYFKGK WNEQFDRKYT 
RGMLFKTNEE KKTVQMMFKE AKFKMGYADE VHTQVLELPY VEEELSMVIL LPDDNTDLAV 
DTLRSTSFFC DILANIIST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.