Details for: SLPI

Gene ID: 6590

Symbol: SLPI

Ensembl ID: ENSG00000124107

Description: secretory leukocyte peptidase inhibitor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.4
    Marker Score: 10028
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 4.24
    Marker Score: 1548
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.1
    Marker Score: 30503
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.07
    Marker Score: 7433.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.91
    Marker Score: 25462
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.82
    Marker Score: 2553
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.81
    Marker Score: 20018
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.58
    Marker Score: 1429
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.53
    Marker Score: 30668
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.48
    Marker Score: 3100.5
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 3.43
    Marker Score: 940
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.37
    Marker Score: 2658
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 3.31
    Marker Score: 1048
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 3.29
    Marker Score: 1623
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 3.23
    Marker Score: 5192
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.14
    Marker Score: 2141
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.11
    Marker Score: 107806
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 3.05
    Marker Score: 1426
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 3.04
    Marker Score: 1109.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.96
    Marker Score: 39819
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.87
    Marker Score: 9877
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.86
    Marker Score: 24617
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.82
    Marker Score: 3292
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.76
    Marker Score: 17608
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.71
    Marker Score: 21148
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.64
    Marker Score: 937
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.55
    Marker Score: 2688
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.55
    Marker Score: 5787
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.5
    Marker Score: 4756
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.5
    Marker Score: 721
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.42
    Marker Score: 38813
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.29
    Marker Score: 527
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.11
    Marker Score: 2141
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.06
    Marker Score: 3650
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.04
    Marker Score: 492
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.98
    Marker Score: 3142
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.97
    Marker Score: 2370
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.94
    Marker Score: 871
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.92
    Marker Score: 2832
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.91
    Marker Score: 984
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9
    Marker Score: 4652
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.86
    Marker Score: 1291
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.82
    Marker Score: 583
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.77
    Marker Score: 451
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.73
    Marker Score: 595
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.64
    Marker Score: 2112
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.46
    Marker Score: 294
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.43
    Marker Score: 1012
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.4
    Marker Score: 1205
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.4
    Marker Score: 2291
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.38
    Marker Score: 553
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.36
    Marker Score: 336
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.35
    Marker Score: 642
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.34
    Marker Score: 1117.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.31
    Marker Score: 1305
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.21
    Marker Score: 3791
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.18
    Marker Score: 3101
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.17
    Marker Score: 683
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.16
    Marker Score: 4490
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.15
    Marker Score: 330
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.1
    Marker Score: 2614
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.08
    Marker Score: 2736
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.07
    Marker Score: 307
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.07
    Marker Score: 4115
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.06
    Marker Score: 2047
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.06
    Marker Score: 1142
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.04
    Marker Score: 924
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 788
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.02
    Marker Score: 2650
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1
    Marker Score: 459
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71745
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47972
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.99
    Marker Score: 620
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.99
    Marker Score: 237
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.98
    Marker Score: 610
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.98
    Marker Score: 1504
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.97
    Marker Score: 330
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.95
    Marker Score: 10676
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.95
    Marker Score: 953
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.9
    Marker Score: 930
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.89
    Marker Score: 563
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.88
    Marker Score: 2225
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5267
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.86
    Marker Score: 345
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.86
    Marker Score: 228
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.85
    Marker Score: 369
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.85
    Marker Score: 1464
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.84
    Marker Score: 223
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1329
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.8
    Marker Score: 412
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.77
    Marker Score: 449
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.77
    Marker Score: 747
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3214.5

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Other Information

**Key Characteristics:** 1. **Serine protease inhibitor**: SLPI is a serine protease inhibitor, which means it binds to and inhibits the activity of serine proteases, including leukocyte elastase. 2. **Broad tissue expression**: SLPI is expressed in multiple tissues, including the salivary gland, trachea, lung, and nasal mucosa, suggesting a wide range of biological functions. 3. **Antileukoproteinase activity**: SLPI has been shown to inhibit the proteolytic activity of leukocyte elastase, a key enzyme involved in inflammatory responses. 4. **Innate immune response**: SLPI is involved in the innate immune response, regulating the activity of neutrophils and other immune cells. **Pathways and Functions:** 1. **Antibacterial humoral response**: SLPI has been shown to have antimicrobial activity, inhibiting the growth of certain bacteria and viruses. 2. **Collagen-containing extracellular matrix**: SLPI is involved in the regulation of collagen synthesis and degradation, which is essential for tissue repair and remodeling. 3. **Endopeptidase inhibitor activity**: SLPI inhibits the activity of endopeptidases, which are enzymes involved in protein degradation and processing. 4. **Golgi apparatus**: SLPI is transported to the Golgi apparatus, where it is processed and secreted into the extracellular space. 5. **Immune response**: SLPI regulates the activity of immune cells, including neutrophils and macrophages, and modulates the production of pro-inflammatory cytokines. **Clinical Significance:** 1. **Inflammatory diseases**: SLPI has been implicated in the pathogenesis of various inflammatory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and rheumatoid arthritis. 2. **Cancer**: SLPI has been shown to have antitumor activity, inhibiting the growth of certain cancer cells and inducing apoptosis. 3. **Neurological disorders**: SLPI has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Antimicrobial resistance**: SLPI has been shown to have antimicrobial activity, which may contribute to the development of antimicrobial resistance. In conclusion, SLPI is a multifunctional protein that plays a critical role in regulating the immune response and protecting against various diseases. Its antileukoproteinase activity, antimicrobial activity, and involvement in inflammatory responses make it an important target for the development of novel therapeutic strategies for a range of diseases.

Genular Protein ID: 2073599774

Symbol: SLPI_HUMAN

Name: Antileukoproteinase

UniProtKB Accession Codes:

P03973 B2R5H8 P07757

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3533531

Title: Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus.

PubMed ID: 3533531

DOI: 10.1111/j.1432-1033.1986.tb09940.x

PubMed ID: 3640338

Title: Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases.

PubMed ID: 3640338

DOI: 10.1093/nar/14.20.7883

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3485543

Title: The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red sea turtle proteinase inhibitor.

PubMed ID: 3485543

DOI: 10.1016/0014-5793(86)81220-0

PubMed ID: 3462719

Title: Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase.

PubMed ID: 3462719

DOI: 10.1073/pnas.83.18.6692

PubMed ID: 2039600

Title: Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor.

PubMed ID: 2039600

DOI: 10.1515/bchm3.1991.372.1.13

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 2110563

Title: Location of the protease-inhibitory region of secretory leukocyte protease inhibitor.

PubMed ID: 2110563

DOI: 10.1016/s0021-9258(19)39026-x

PubMed ID: 10702419

Title: Anti-inflammatory effects of mutant forms of secretory leukocyte protease inhibitor.

PubMed ID: 10702419

DOI: 10.1016/s0002-9440(10)64971-1

PubMed ID: 12526812

Title: Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair.

PubMed ID: 12526812

DOI: 10.1016/s0092-8674(02)01141-8

PubMed ID: 24352879

Title: A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.

PubMed ID: 24352879

DOI: 10.1182/blood-2013-06-508887

PubMed ID: 3366116

Title: The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin.

PubMed ID: 3366116

DOI: 10.1002/j.1460-2075.1988.tb02819.x

PubMed ID: 18421166

Title: Complex of human neutrophil elastase with 1/2SLPI.

PubMed ID: 18421166

DOI: 10.1107/s0909049507060670

PubMed ID: 24121345

Title: Structure basis 1/2SLPI and porcine pancreas trypsin interaction.

PubMed ID: 24121345

DOI: 10.1107/s090904951302133x

Sequence Information:

  • Length: 132
  • Mass: 14326
  • Checksum: B62F3221E0903D90
  • Sequence:
    • MKSSGLFPFL VLLALGTLAP WAVEGSGKSF KAGVCPPKKS AQCLRYKKPE CQSDWQCPGK 
KRCCPDTCGI KCLDPVDTPN PTRRKPGKCP VTYGQCLMLN PPNFCEMDGQ CKRDLKCCMG 
MCGKSCVSPV KA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.