Details for: SLPI

Gene ID: 6590

Symbol: SLPI

Ensembl ID: ENSG00000124107

Description: secretory leukocyte peptidase inhibitor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 290.7836
    Cell Significance Index: -45.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.6761
    Cell Significance Index: -45.2200
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 32.9389
    Cell Significance Index: 183.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 20.6173
    Cell Significance Index: 476.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 19.9564
    Cell Significance Index: 930.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.6829
    Cell Significance Index: -47.3700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 17.3305
    Cell Significance Index: 361.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.5636
    Cell Significance Index: -41.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4824
    Cell Significance Index: -45.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 7.2622
    Cell Significance Index: 5496.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.3495
    Cell Significance Index: 2921.4800
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 4.6873
    Cell Significance Index: 31.3000
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 4.6139
    Cell Significance Index: 32.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.1026
    Cell Significance Index: 530.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.3456
    Cell Significance Index: 91.0700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.0938
    Cell Significance Index: 26.5900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.8575
    Cell Significance Index: 44.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.8280
    Cell Significance Index: 132.9200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.8240
    Cell Significance Index: 29.1300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.0295
    Cell Significance Index: 12.5600
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.5884
    Cell Significance Index: 13.1300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.5259
    Cell Significance Index: 3.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0512
    Cell Significance Index: 9.6800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.9593
    Cell Significance Index: 6.5000
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.9402
    Cell Significance Index: 6.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9109
    Cell Significance Index: 90.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8901
    Cell Significance Index: 803.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7908
    Cell Significance Index: 11.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7785
    Cell Significance Index: 40.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7196
    Cell Significance Index: 20.1100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.6699
    Cell Significance Index: 5.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6540
    Cell Significance Index: 106.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6462
    Cell Significance Index: 48.1600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.6159
    Cell Significance Index: 3.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4200
    Cell Significance Index: 5.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3873
    Cell Significance Index: 8.3900
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.2755
    Cell Significance Index: 2.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2601
    Cell Significance Index: 17.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2341
    Cell Significance Index: 44.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2218
    Cell Significance Index: 27.2700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.0768
    Cell Significance Index: 0.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0685
    Cell Significance Index: 12.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0035
    Cell Significance Index: 0.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0097
    Cell Significance Index: -0.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0147
    Cell Significance Index: -10.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0228
    Cell Significance Index: -42.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0254
    Cell Significance Index: -46.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0293
    Cell Significance Index: -21.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0301
    Cell Significance Index: -3.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0305
    Cell Significance Index: -46.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0381
    Cell Significance Index: -23.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0413
    Cell Significance Index: -2.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0451
    Cell Significance Index: -1.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0470
    Cell Significance Index: -5.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0525
    Cell Significance Index: -8.9600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0528
    Cell Significance Index: -0.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0601
    Cell Significance Index: -33.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0605
    Cell Significance Index: -38.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0649
    Cell Significance Index: -8.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0856
    Cell Significance Index: -9.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0924
    Cell Significance Index: -41.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0988
    Cell Significance Index: -43.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1104
    Cell Significance Index: -23.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1211
    Cell Significance Index: -3.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1385
    Cell Significance Index: -17.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1563
    Cell Significance Index: -9.5800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1596
    Cell Significance Index: -1.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1659
    Cell Significance Index: -47.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1692
    Cell Significance Index: -17.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2108
    Cell Significance Index: -42.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2220
    Cell Significance Index: -44.0500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2906
    Cell Significance Index: -2.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2915
    Cell Significance Index: -42.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2961
    Cell Significance Index: -13.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3099
    Cell Significance Index: -6.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3868
    Cell Significance Index: -9.6700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3905
    Cell Significance Index: -5.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4413
    Cell Significance Index: -45.9500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.4777
    Cell Significance Index: -4.7800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.5784
    Cell Significance Index: -6.3400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.6163
    Cell Significance Index: -6.0300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6234
    Cell Significance Index: -15.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6725
    Cell Significance Index: -51.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7073
    Cell Significance Index: -44.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7100
    Cell Significance Index: -47.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7306
    Cell Significance Index: -26.8200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.7493
    Cell Significance Index: -7.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7707
    Cell Significance Index: -54.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8065
    Cell Significance Index: -49.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9135
    Cell Significance Index: -51.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9411
    Cell Significance Index: -27.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9550
    Cell Significance Index: -19.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0001
    Cell Significance Index: -52.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0019
    Cell Significance Index: -35.1000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.0526
    Cell Significance Index: -16.7000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -1.0877
    Cell Significance Index: -7.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0968
    Cell Significance Index: -35.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1534
    Cell Significance Index: -11.9400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.1688
    Cell Significance Index: -16.9700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1724
    Cell Significance Index: -25.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine protease inhibitor**: SLPI is a serine protease inhibitor, which means it binds to and inhibits the activity of serine proteases, including leukocyte elastase. 2. **Broad tissue expression**: SLPI is expressed in multiple tissues, including the salivary gland, trachea, lung, and nasal mucosa, suggesting a wide range of biological functions. 3. **Antileukoproteinase activity**: SLPI has been shown to inhibit the proteolytic activity of leukocyte elastase, a key enzyme involved in inflammatory responses. 4. **Innate immune response**: SLPI is involved in the innate immune response, regulating the activity of neutrophils and other immune cells. **Pathways and Functions:** 1. **Antibacterial humoral response**: SLPI has been shown to have antimicrobial activity, inhibiting the growth of certain bacteria and viruses. 2. **Collagen-containing extracellular matrix**: SLPI is involved in the regulation of collagen synthesis and degradation, which is essential for tissue repair and remodeling. 3. **Endopeptidase inhibitor activity**: SLPI inhibits the activity of endopeptidases, which are enzymes involved in protein degradation and processing. 4. **Golgi apparatus**: SLPI is transported to the Golgi apparatus, where it is processed and secreted into the extracellular space. 5. **Immune response**: SLPI regulates the activity of immune cells, including neutrophils and macrophages, and modulates the production of pro-inflammatory cytokines. **Clinical Significance:** 1. **Inflammatory diseases**: SLPI has been implicated in the pathogenesis of various inflammatory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and rheumatoid arthritis. 2. **Cancer**: SLPI has been shown to have antitumor activity, inhibiting the growth of certain cancer cells and inducing apoptosis. 3. **Neurological disorders**: SLPI has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Antimicrobial resistance**: SLPI has been shown to have antimicrobial activity, which may contribute to the development of antimicrobial resistance. In conclusion, SLPI is a multifunctional protein that plays a critical role in regulating the immune response and protecting against various diseases. Its antileukoproteinase activity, antimicrobial activity, and involvement in inflammatory responses make it an important target for the development of novel therapeutic strategies for a range of diseases.

Genular Protein ID: 2073599774

Symbol: SLPI_HUMAN

Name: Antileukoproteinase

UniProtKB Accession Codes:

P03973 B2R5H8 P07757

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3533531

Title: Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus.

PubMed ID: 3533531

DOI: 10.1111/j.1432-1033.1986.tb09940.x

PubMed ID: 3640338

Title: Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases.

PubMed ID: 3640338

DOI: 10.1093/nar/14.20.7883

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3485543

Title: The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red sea turtle proteinase inhibitor.

PubMed ID: 3485543

DOI: 10.1016/0014-5793(86)81220-0

PubMed ID: 3462719

Title: Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase.

PubMed ID: 3462719

DOI: 10.1073/pnas.83.18.6692

PubMed ID: 2039600

Title: Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor.

PubMed ID: 2039600

DOI: 10.1515/bchm3.1991.372.1.13

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 2110563

Title: Location of the protease-inhibitory region of secretory leukocyte protease inhibitor.

PubMed ID: 2110563

DOI: 10.1016/s0021-9258(19)39026-x

PubMed ID: 10702419

Title: Anti-inflammatory effects of mutant forms of secretory leukocyte protease inhibitor.

PubMed ID: 10702419

DOI: 10.1016/s0002-9440(10)64971-1

PubMed ID: 12526812

Title: Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair.

PubMed ID: 12526812

DOI: 10.1016/s0092-8674(02)01141-8

PubMed ID: 24352879

Title: A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.

PubMed ID: 24352879

DOI: 10.1182/blood-2013-06-508887

PubMed ID: 3366116

Title: The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin.

PubMed ID: 3366116

DOI: 10.1002/j.1460-2075.1988.tb02819.x

PubMed ID: 18421166

Title: Complex of human neutrophil elastase with 1/2SLPI.

PubMed ID: 18421166

DOI: 10.1107/s0909049507060670

PubMed ID: 24121345

Title: Structure basis 1/2SLPI and porcine pancreas trypsin interaction.

PubMed ID: 24121345

DOI: 10.1107/s090904951302133x

Sequence Information:

  • Length: 132
  • Mass: 14326
  • Checksum: B62F3221E0903D90
  • Sequence:
    • MKSSGLFPFL VLLALGTLAP WAVEGSGKSF KAGVCPPKKS AQCLRYKKPE CQSDWQCPGK 
KRCCPDTCGI KCLDPVDTPN PTRRKPGKCP VTYGQCLMLN PPNFCEMDGQ CKRDLKCCMG 
MCGKSCVSPV KA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.