Details for: TESK1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 93.3491
Cell Significance Index: -14.5200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 56.1418
Cell Significance Index: -14.2400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 30.0733
Cell Significance Index: -12.2200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 12.7993
Cell Significance Index: -12.2200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 11.9510
Cell Significance Index: -14.7400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.2186
Cell Significance Index: -13.9800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 4.4799
Cell Significance Index: 120.0400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.7531
Cell Significance Index: -14.8100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0893
Cell Significance Index: 983.5600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7624
Cell Significance Index: 45.7700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7031
Cell Significance Index: 114.3500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5283
Cell Significance Index: 15.2200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5116
Cell Significance Index: 23.1900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.5006
Cell Significance Index: 31.5500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4353
Cell Significance Index: 30.1100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3800
Cell Significance Index: 37.5900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3736
Cell Significance Index: 10.1700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3604
Cell Significance Index: 18.7200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2964
Cell Significance Index: 59.4500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2903
Cell Significance Index: 20.5300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2529
Cell Significance Index: 5.4800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2104
Cell Significance Index: 10.9600 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.2038
Cell Significance Index: 3.2700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1982
Cell Significance Index: 9.2400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1978
Cell Significance Index: 24.3200 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.1941
Cell Significance Index: 1.6300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1919
Cell Significance Index: 5.5000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1838
Cell Significance Index: 33.1400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1749
Cell Significance Index: 77.3100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1645
Cell Significance Index: 10.6200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1505
Cell Significance Index: 53.9800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1413
Cell Significance Index: 77.1600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1382
Cell Significance Index: 4.8600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1355
Cell Significance Index: 18.6100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1301
Cell Significance Index: 24.7600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1296
Cell Significance Index: 6.0900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1261
Cell Significance Index: 1.8900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0914
Cell Significance Index: 18.1400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0890
Cell Significance Index: 61.5300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0812
Cell Significance Index: 2.0300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0619
Cell Significance Index: 1.7300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0197
Cell Significance Index: 2.5300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0048
Cell Significance Index: 9.1300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0027
Cell Significance Index: -4.8900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0055
Cell Significance Index: -3.4700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0061
Cell Significance Index: -9.4300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0082
Cell Significance Index: -11.1700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0089
Cell Significance Index: -6.7400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0095
Cell Significance Index: -6.9500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0106
Cell Significance Index: -0.2200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0125
Cell Significance Index: -1.4800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0129
Cell Significance Index: -9.5700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0144
Cell Significance Index: -1.8700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0193
Cell Significance Index: -3.2900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0195
Cell Significance Index: -1.4500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0211
Cell Significance Index: -0.4500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0216
Cell Significance Index: -9.8200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0224
Cell Significance Index: -12.6200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0244
Cell Significance Index: -2.5000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0269
Cell Significance Index: -3.9100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0271
Cell Significance Index: -16.9400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0340
Cell Significance Index: -3.8900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0406
Cell Significance Index: -1.1600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0415
Cell Significance Index: -11.9300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0431
Cell Significance Index: -5.0200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0708
Cell Significance Index: -4.3500 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.0758
Cell Significance Index: -0.3300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0767
Cell Significance Index: -16.1600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0867
Cell Significance Index: -5.8300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0927
Cell Significance Index: -2.0300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1187
Cell Significance Index: -1.6200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1283
Cell Significance Index: -9.8500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1299
Cell Significance Index: -6.8200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1322
Cell Significance Index: -13.7700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1463
Cell Significance Index: -11.5900 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.1672
Cell Significance Index: -1.0900 - Cell Name: peg cell (CL4033014)
Fold Change: -0.1697
Cell Significance Index: -3.9200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1716
Cell Significance Index: -10.5200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1970
Cell Significance Index: -5.2600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2101
Cell Significance Index: -5.6200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2164
Cell Significance Index: -5.6900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2220
Cell Significance Index: -12.4600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2268
Cell Significance Index: -10.0300 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2342
Cell Significance Index: -1.9100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2345
Cell Significance Index: -8.1500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2379
Cell Significance Index: -7.6200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2390
Cell Significance Index: -4.0000 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2497
Cell Significance Index: -2.5900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2741
Cell Significance Index: -10.3800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2910
Cell Significance Index: -7.4800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3058
Cell Significance Index: -6.4000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3092
Cell Significance Index: -15.6300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3226
Cell Significance Index: -11.3000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3250
Cell Significance Index: -11.9300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3259
Cell Significance Index: -7.8200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3374
Cell Significance Index: -7.1600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3429
Cell Significance Index: -10.9200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3473
Cell Significance Index: -11.3700 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.3664
Cell Significance Index: -5.2500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3704
Cell Significance Index: -5.3100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2602278254
Symbol: TESK1_HUMAN
Name: Dual specificity testis-specific protein kinase 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8537404
Title: Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells.
PubMed ID: 8537404
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11555644
Title: Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1.
PubMed ID: 11555644
PubMed ID: 12027893
Title: Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1.
PubMed ID: 12027893
PubMed ID: 15584898
Title: Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase.
PubMed ID: 15584898
DOI: 10.1042/bj20041181
PubMed ID: 15817463
Title: Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.
PubMed ID: 15817463
PubMed ID: 17974561
Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
PubMed ID: 17974561
PubMed ID: 18216281
Title: Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.
PubMed ID: 18216281
PubMed ID: 25849865
Title: Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.
PubMed ID: 25849865
DOI: 10.1038/ncomms7781
PubMed ID: 30115939
Title: Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1).
PubMed ID: 30115939
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 626
- Mass: 67684
- Checksum: 32F78E5E6AEDB0E5
- Sequence:
MAGERPPLRG PGPGPGEVPG EGPPGPGGTG GGPGRGRPSS YRALRSAVSS LARVDDFHCA EKIGAGFFSE VYKVRHRQSG QVMVLKMNKL PSNRGNTLRE VQLMNRLRHP NILRFMGVCV HQGQLHALTE YMNGGTLEQL LSSPEPLSWP VRLHLALDIA RGLRYLHSKG VFHRDLTSKN CLVRREDRGF TAVVGDFGLA EKIPVYREGA RKEPLAVVGS PYWMAPEVLR GELYDEKADV FAFGIVLCEL IARVPADPDY LPRTEDFGLD VPAFRTLVGD DCPLPFLLLA IHCCNLEPST RAPFTEITQH LEWILEQLPE PAPLTRTALT HNQGSVARGG PSATLPRPDP RLSRSRSDLF LPPSPESPPN WGDNLTRVNP FSLREDLRGG KIKLLDTPSK PVLPLVPPSP FPSTQLPLVT TPETLVQPGT PARRCRSLPS SPELPRRMET ALPGPGPPAV GPSAEEKMEC EGSSPEPEPP GPAPQLPLAV ATDNFISTCS SASQPWSPRS GPVLNNNPPA VVVNSPQGWA GEPWNRAQHS LPRAAALERT EPSPPPSAPR EPDEGLPCPG CCLGPFSFGF LSMCPRPTPA VARYRNLNCE AGSLLCHRGH HAKPPTPSLQ LPGARS
Genular Protein ID: 1815303584
Symbol: Q8NFJ4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 244
- Mass: 27496
- Checksum: C4D3C99A2E64EF7D
- Sequence:
LKMNKLPSNR GNTLREVQLM NRLRHPNILR FMGVCVHQGQ LHALTEYMNG GTLEXLLSSP EPLSWPVRLH LALDIARGLR YLHSKGVFHR DLTSKNCLVR REDRGFTAVV GDFGLAEKIP VYREGARKEP LAVVGSPYWM APEVLRGELY DEKADVFAFG IVLCELIARV PADPDYLPRT EDFGLDVPAF RTLVGDDCPL PFLLLAIHCC NLEPSTRAPF TEITQHLEWI LEQLPEPAPL TXTA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.