Details for: TESK1

Gene ID: 7016

Symbol: TESK1

Ensembl ID: ENSG00000107140

Description: testis associated actin remodelling kinase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.49
    Marker Score: 26514
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71770
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47995
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14895
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5035
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5260
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.86
    Marker Score: 277
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.85
    Marker Score: 1996
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.79
    Marker Score: 248
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.76
    Marker Score: 1552
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.76
    Marker Score: 457
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 551.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 281
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.69
    Marker Score: 1462
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2826.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 612
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.67
    Marker Score: 6915
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.65
    Marker Score: 167
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.59
    Marker Score: 280
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.58
    Marker Score: 2362
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.56
    Marker Score: 19190
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.56
    Marker Score: 205
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.55
    Marker Score: 811
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.55
    Marker Score: 124
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.54
    Marker Score: 840
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.54
    Marker Score: 3291
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.54
    Marker Score: 218
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 424
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.53
    Marker Score: 275
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.53
    Marker Score: 231
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.48
    Marker Score: 323
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.47
    Marker Score: 1068
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.47
    Marker Score: 227
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.46
    Marker Score: 1121
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.45
    Marker Score: 470
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.45
    Marker Score: 134
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.44
    Marker Score: 181
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.43
    Marker Score: 26461
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.43
    Marker Score: 269
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 281.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.42
    Marker Score: 447
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.42
    Marker Score: 2545
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.41
    Marker Score: 2035
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.41
    Marker Score: 496
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.41
    Marker Score: 571
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.41
    Marker Score: 14951
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.4
    Marker Score: 105
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.4
    Marker Score: 3430
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.4
    Marker Score: 195
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.39
    Marker Score: 104
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.39
    Marker Score: 248
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.39
    Marker Score: 458
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.39
    Marker Score: 98
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.38
    Marker Score: 14593
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.38
    Marker Score: 352
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.38
    Marker Score: 469
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.38
    Marker Score: 1473
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.38
    Marker Score: 663
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.38
    Marker Score: 109
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.38
    Marker Score: 214
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 166
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.37
    Marker Score: 3511
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.36
    Marker Score: 3430
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.36
    Marker Score: 905
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.36
    Marker Score: 103
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.36
    Marker Score: 3618
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.36
    Marker Score: 166
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.36
    Marker Score: 148
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.35
    Marker Score: 227
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.35
    Marker Score: 1113
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.35
    Marker Score: 79
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.35
    Marker Score: 2242
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.35
    Marker Score: 2289.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.35
    Marker Score: 199
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.35
    Marker Score: 3042
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.35
    Marker Score: 573
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.35
    Marker Score: 201
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.35
    Marker Score: 107
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.34
    Marker Score: 550
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.34
    Marker Score: 361
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.34
    Marker Score: 78
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.34
    Marker Score: 338
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.34
    Marker Score: 302
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.33
    Marker Score: 222
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.33
    Marker Score: 115
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.33
    Marker Score: 331.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.33
    Marker Score: 330
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.32
    Marker Score: 113
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.32
    Marker Score: 136
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.32
    Marker Score: 389.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.32
    Marker Score: 1143
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.32
    Marker Score: 359

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Other Information

**Key Characteristics** TESK1 is a serine/threonine kinase enzyme that belongs to the testis-specific protein kinase family. It is characterized by its ability to phosphorylate specific amino acid residues on target proteins, leading to various cellular responses. Some key characteristics of TESK1 include: 1. **Dual specificity kinase**: TESK1 has dual specificity kinase activity, allowing it to phosphorylate both serine and threonine residues on target proteins. 2. **Testis-specific expression**: TESK1 is predominantly expressed in testicular cells, suggesting its importance in spermatogenesis and male fertility. 3. **Regulation of actin cytoskeleton organization**: TESK1 has been shown to regulate actin cytoskeleton organization, which is essential for maintaining cellular shape, movement, and division. 4. **Cell-cell and cell-extracellular matrix interactions**: TESK1 is involved in regulating cell-cell and cell-extracellular matrix interactions, which are critical for maintaining tissue structure and function. **Pathways and Functions** TESK1 is involved in various cellular pathways, including: 1. **Actin cytoskeleton organization**: TESK1 regulates the organization of the actin cytoskeleton, which is essential for maintaining cellular shape, movement, and division. 2. **Cell-cell communication**: TESK1 is involved in regulating cell-cell communication, which is critical for maintaining tissue structure and function. 3. **Cell-extracellular matrix interactions**: TESK1 regulates cell-extracellular matrix interactions, which are essential for maintaining tissue structure and function. 4. **Spermatogenesis**: TESK1 is involved in regulating spermatogenesis, which is the process of sperm development and maturation. **Clinical Significance** TESK1 has been implicated in various diseases and disorders, including: 1. **Infertility**: TESK1 has been shown to play a critical role in spermatogenesis, and its dysfunction has been linked to male infertility. 2. **Cancer**: TESK1 has been implicated in the regulation of cell growth, migration, and invasion, making it a potential target for cancer therapy. 3. **Neurological disorders**: TESK1 has been shown to play a role in regulating neuronal function and synaptic plasticity, making it a potential target for treating neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, TESK1 is a critical enzyme involved in regulating various cellular processes, including actin cytoskeleton organization, cell-cell communication, and cell-extracellular matrix interactions. Its expression and function are crucial for maintaining cellular homeostasis and normal cellular processes, and its dysfunction has been linked to various diseases and disorders. Further research is needed to fully understand the role of TESK1 in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 2602278254

Symbol: TESK1_HUMAN

Name: Dual specificity testis-specific protein kinase 1

UniProtKB Accession Codes:

Q15569 Q8IXZ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 4 EMBL 5 EPD 1 Ensembl 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 9 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8537404

Title: Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells.

PubMed ID: 8537404

DOI: 10.1074/jbc.270.52.31331

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11555644

Title: Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1.

PubMed ID: 11555644

DOI: 10.1074/jbc.m104620200

PubMed ID: 12027893

Title: Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1.

PubMed ID: 12027893

DOI: 10.1046/j.1432-1033.2002.02921.x

PubMed ID: 15584898

Title: Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase.

PubMed ID: 15584898

DOI: 10.1042/bj20041181

PubMed ID: 15817463

Title: Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.

PubMed ID: 15817463

DOI: 10.1074/jbc.m500752200

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 18216281

Title: Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.

PubMed ID: 18216281

DOI: 10.1091/mbc.e07-07-0730

PubMed ID: 25849865

Title: Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.

PubMed ID: 25849865

DOI: 10.1038/ncomms7781

PubMed ID: 30115939

Title: Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1).

PubMed ID: 30115939

DOI: 10.1038/s41598-018-30115-3

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 626
  • Mass: 67684
  • Checksum: 32F78E5E6AEDB0E5
  • Sequence:
    • MAGERPPLRG PGPGPGEVPG EGPPGPGGTG GGPGRGRPSS YRALRSAVSS LARVDDFHCA 
EKIGAGFFSE VYKVRHRQSG QVMVLKMNKL PSNRGNTLRE VQLMNRLRHP NILRFMGVCV 
HQGQLHALTE YMNGGTLEQL LSSPEPLSWP VRLHLALDIA RGLRYLHSKG VFHRDLTSKN 
CLVRREDRGF TAVVGDFGLA EKIPVYREGA RKEPLAVVGS PYWMAPEVLR GELYDEKADV 
FAFGIVLCEL IARVPADPDY LPRTEDFGLD VPAFRTLVGD DCPLPFLLLA IHCCNLEPST 
RAPFTEITQH LEWILEQLPE PAPLTRTALT HNQGSVARGG PSATLPRPDP RLSRSRSDLF 
LPPSPESPPN WGDNLTRVNP FSLREDLRGG KIKLLDTPSK PVLPLVPPSP FPSTQLPLVT 
TPETLVQPGT PARRCRSLPS SPELPRRMET ALPGPGPPAV GPSAEEKMEC EGSSPEPEPP 
GPAPQLPLAV ATDNFISTCS SASQPWSPRS GPVLNNNPPA VVVNSPQGWA GEPWNRAQHS 
LPRAAALERT EPSPPPSAPR EPDEGLPCPG CCLGPFSFGF LSMCPRPTPA VARYRNLNCE 
AGSLLCHRGH HAKPPTPSLQ LPGARS

Genular Protein ID: 1815303584

Symbol: Q8NFJ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NFJ4

Database IDs:

ARBA 8 BioGRID-ORCS 1 CTD 1 ChEBI 17 DNASU 1 EC 3 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 9 SUPFAM 1

Sequence Information:

  • Length: 244
  • Mass: 27496
  • Checksum: C4D3C99A2E64EF7D
  • Sequence:
    • LKMNKLPSNR GNTLREVQLM NRLRHPNILR FMGVCVHQGQ LHALTEYMNG GTLEXLLSSP 
EPLSWPVRLH LALDIARGLR YLHSKGVFHR DLTSKNCLVR REDRGFTAVV GDFGLAEKIP 
VYREGARKEP LAVVGSPYWM APEVLRGELY DEKADVFAFG IVLCELIARV PADPDYLPRT 
EDFGLDVPAF RTLVGDDCPL PFLLLAIHCC NLEPSTRAPF TEITQHLEWI LEQLPEPAPL 
TXTA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.