Details for: TESK1

Gene ID: 7016

Symbol: TESK1

Ensembl ID: ENSG00000107140

Description: testis associated actin remodelling kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.3491
    Cell Significance Index: -14.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.1418
    Cell Significance Index: -14.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.0733
    Cell Significance Index: -12.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.7993
    Cell Significance Index: -12.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.9510
    Cell Significance Index: -14.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2186
    Cell Significance Index: -13.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.4799
    Cell Significance Index: 120.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7531
    Cell Significance Index: -14.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0893
    Cell Significance Index: 983.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7624
    Cell Significance Index: 45.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7031
    Cell Significance Index: 114.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5283
    Cell Significance Index: 15.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5116
    Cell Significance Index: 23.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5006
    Cell Significance Index: 31.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4353
    Cell Significance Index: 30.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3800
    Cell Significance Index: 37.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3736
    Cell Significance Index: 10.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3604
    Cell Significance Index: 18.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2964
    Cell Significance Index: 59.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2903
    Cell Significance Index: 20.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2529
    Cell Significance Index: 5.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2104
    Cell Significance Index: 10.9600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2038
    Cell Significance Index: 3.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1982
    Cell Significance Index: 9.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1978
    Cell Significance Index: 24.3200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1941
    Cell Significance Index: 1.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1919
    Cell Significance Index: 5.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1838
    Cell Significance Index: 33.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1749
    Cell Significance Index: 77.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1645
    Cell Significance Index: 10.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1505
    Cell Significance Index: 53.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1413
    Cell Significance Index: 77.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1382
    Cell Significance Index: 4.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1355
    Cell Significance Index: 18.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1301
    Cell Significance Index: 24.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1296
    Cell Significance Index: 6.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1261
    Cell Significance Index: 1.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0914
    Cell Significance Index: 18.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0890
    Cell Significance Index: 61.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0812
    Cell Significance Index: 2.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0619
    Cell Significance Index: 1.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0197
    Cell Significance Index: 2.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0048
    Cell Significance Index: 9.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -4.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0055
    Cell Significance Index: -3.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0061
    Cell Significance Index: -9.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0082
    Cell Significance Index: -11.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0089
    Cell Significance Index: -6.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0106
    Cell Significance Index: -0.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0125
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0144
    Cell Significance Index: -1.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0193
    Cell Significance Index: -3.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0195
    Cell Significance Index: -1.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0211
    Cell Significance Index: -0.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0216
    Cell Significance Index: -9.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0224
    Cell Significance Index: -12.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0244
    Cell Significance Index: -2.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0269
    Cell Significance Index: -3.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0271
    Cell Significance Index: -16.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0340
    Cell Significance Index: -3.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0406
    Cell Significance Index: -1.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0415
    Cell Significance Index: -11.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0431
    Cell Significance Index: -5.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0708
    Cell Significance Index: -4.3500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0758
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0767
    Cell Significance Index: -16.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0867
    Cell Significance Index: -5.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0927
    Cell Significance Index: -2.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1187
    Cell Significance Index: -1.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1283
    Cell Significance Index: -9.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1299
    Cell Significance Index: -6.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1322
    Cell Significance Index: -13.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1463
    Cell Significance Index: -11.5900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1672
    Cell Significance Index: -1.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1697
    Cell Significance Index: -3.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1716
    Cell Significance Index: -10.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1970
    Cell Significance Index: -5.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2101
    Cell Significance Index: -5.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2164
    Cell Significance Index: -5.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2220
    Cell Significance Index: -12.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2268
    Cell Significance Index: -10.0300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2342
    Cell Significance Index: -1.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2345
    Cell Significance Index: -8.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2379
    Cell Significance Index: -7.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2390
    Cell Significance Index: -4.0000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2497
    Cell Significance Index: -2.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2741
    Cell Significance Index: -10.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2910
    Cell Significance Index: -7.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3058
    Cell Significance Index: -6.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3092
    Cell Significance Index: -15.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3226
    Cell Significance Index: -11.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3250
    Cell Significance Index: -11.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3259
    Cell Significance Index: -7.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3374
    Cell Significance Index: -7.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3429
    Cell Significance Index: -10.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3473
    Cell Significance Index: -11.3700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3664
    Cell Significance Index: -5.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3704
    Cell Significance Index: -5.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TESK1 is a serine/threonine kinase enzyme that belongs to the testis-specific protein kinase family. It is characterized by its ability to phosphorylate specific amino acid residues on target proteins, leading to various cellular responses. Some key characteristics of TESK1 include: 1. **Dual specificity kinase**: TESK1 has dual specificity kinase activity, allowing it to phosphorylate both serine and threonine residues on target proteins. 2. **Testis-specific expression**: TESK1 is predominantly expressed in testicular cells, suggesting its importance in spermatogenesis and male fertility. 3. **Regulation of actin cytoskeleton organization**: TESK1 has been shown to regulate actin cytoskeleton organization, which is essential for maintaining cellular shape, movement, and division. 4. **Cell-cell and cell-extracellular matrix interactions**: TESK1 is involved in regulating cell-cell and cell-extracellular matrix interactions, which are critical for maintaining tissue structure and function. **Pathways and Functions** TESK1 is involved in various cellular pathways, including: 1. **Actin cytoskeleton organization**: TESK1 regulates the organization of the actin cytoskeleton, which is essential for maintaining cellular shape, movement, and division. 2. **Cell-cell communication**: TESK1 is involved in regulating cell-cell communication, which is critical for maintaining tissue structure and function. 3. **Cell-extracellular matrix interactions**: TESK1 regulates cell-extracellular matrix interactions, which are essential for maintaining tissue structure and function. 4. **Spermatogenesis**: TESK1 is involved in regulating spermatogenesis, which is the process of sperm development and maturation. **Clinical Significance** TESK1 has been implicated in various diseases and disorders, including: 1. **Infertility**: TESK1 has been shown to play a critical role in spermatogenesis, and its dysfunction has been linked to male infertility. 2. **Cancer**: TESK1 has been implicated in the regulation of cell growth, migration, and invasion, making it a potential target for cancer therapy. 3. **Neurological disorders**: TESK1 has been shown to play a role in regulating neuronal function and synaptic plasticity, making it a potential target for treating neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, TESK1 is a critical enzyme involved in regulating various cellular processes, including actin cytoskeleton organization, cell-cell communication, and cell-extracellular matrix interactions. Its expression and function are crucial for maintaining cellular homeostasis and normal cellular processes, and its dysfunction has been linked to various diseases and disorders. Further research is needed to fully understand the role of TESK1 in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 2602278254

Symbol: TESK1_HUMAN

Name: Dual specificity testis-specific protein kinase 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8537404

Title: Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells.

PubMed ID: 8537404

DOI: 10.1074/jbc.270.52.31331

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11555644

Title: Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1.

PubMed ID: 11555644

DOI: 10.1074/jbc.m104620200

PubMed ID: 12027893

Title: Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1.

PubMed ID: 12027893

DOI: 10.1046/j.1432-1033.2002.02921.x

PubMed ID: 15584898

Title: Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase.

PubMed ID: 15584898

DOI: 10.1042/bj20041181

PubMed ID: 15817463

Title: Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.

PubMed ID: 15817463

DOI: 10.1074/jbc.m500752200

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 18216281

Title: Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.

PubMed ID: 18216281

DOI: 10.1091/mbc.e07-07-0730

PubMed ID: 25849865

Title: Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.

PubMed ID: 25849865

DOI: 10.1038/ncomms7781

PubMed ID: 30115939

Title: Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1).

PubMed ID: 30115939

DOI: 10.1038/s41598-018-30115-3

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 626
  • Mass: 67684
  • Checksum: 32F78E5E6AEDB0E5
  • Sequence:
  • MAGERPPLRG PGPGPGEVPG EGPPGPGGTG GGPGRGRPSS YRALRSAVSS LARVDDFHCA 
    EKIGAGFFSE VYKVRHRQSG QVMVLKMNKL PSNRGNTLRE VQLMNRLRHP NILRFMGVCV 
    HQGQLHALTE YMNGGTLEQL LSSPEPLSWP VRLHLALDIA RGLRYLHSKG VFHRDLTSKN 
    CLVRREDRGF TAVVGDFGLA EKIPVYREGA RKEPLAVVGS PYWMAPEVLR GELYDEKADV 
    FAFGIVLCEL IARVPADPDY LPRTEDFGLD VPAFRTLVGD DCPLPFLLLA IHCCNLEPST 
    RAPFTEITQH LEWILEQLPE PAPLTRTALT HNQGSVARGG PSATLPRPDP RLSRSRSDLF 
    LPPSPESPPN WGDNLTRVNP FSLREDLRGG KIKLLDTPSK PVLPLVPPSP FPSTQLPLVT 
    TPETLVQPGT PARRCRSLPS SPELPRRMET ALPGPGPPAV GPSAEEKMEC EGSSPEPEPP 
    GPAPQLPLAV ATDNFISTCS SASQPWSPRS GPVLNNNPPA VVVNSPQGWA GEPWNRAQHS 
    LPRAAALERT EPSPPPSAPR EPDEGLPCPG CCLGPFSFGF LSMCPRPTPA VARYRNLNCE 
    AGSLLCHRGH HAKPPTPSLQ LPGARS

Genular Protein ID: 1815303584

Symbol: Q8NFJ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 244
  • Mass: 27496
  • Checksum: C4D3C99A2E64EF7D
  • Sequence:
  • LKMNKLPSNR GNTLREVQLM NRLRHPNILR FMGVCVHQGQ LHALTEYMNG GTLEXLLSSP 
    EPLSWPVRLH LALDIARGLR YLHSKGVFHR DLTSKNCLVR REDRGFTAVV GDFGLAEKIP 
    VYREGARKEP LAVVGSPYWM APEVLRGELY DEKADVFAFG IVLCELIARV PADPDYLPRT 
    EDFGLDVPAF RTLVGDDCPL PFLLLAIHCC NLEPSTRAPF TEITQHLEWI LEQLPEPAPL 
    TXTA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.