Details for: CD209

Gene ID: 30835

Symbol: CD209

Ensembl ID: ENSG00000090659

Description: CD209 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.6870
    Cell Significance Index: 26.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.5561
    Cell Significance Index: 23.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9767
    Cell Significance Index: 21.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8869
    Cell Significance Index: 22.1700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.5037
    Cell Significance Index: 6.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3759
    Cell Significance Index: 61.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3368
    Cell Significance Index: 20.2200
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.2748
    Cell Significance Index: 2.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2713
    Cell Significance Index: 26.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2543
    Cell Significance Index: 5.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1981
    Cell Significance Index: 37.6900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1533
    Cell Significance Index: 1.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1155
    Cell Significance Index: 12.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0369
    Cell Significance Index: 2.5600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0222
    Cell Significance Index: 0.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0020
    Cell Significance Index: 0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0052
    Cell Significance Index: -3.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0056
    Cell Significance Index: -1.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0060
    Cell Significance Index: -3.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0071
    Cell Significance Index: -4.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0076
    Cell Significance Index: -0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0100
    Cell Significance Index: -3.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0164
    Cell Significance Index: -1.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0172
    Cell Significance Index: -0.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0177
    Cell Significance Index: -3.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0199
    Cell Significance Index: -3.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0199
    Cell Significance Index: -4.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0205
    Cell Significance Index: -0.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0216
    Cell Significance Index: -2.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0217
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0231
    Cell Significance Index: -3.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0235
    Cell Significance Index: -1.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0254
    Cell Significance Index: -3.6900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0287
    Cell Significance Index: -0.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0307
    Cell Significance Index: -0.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0312
    Cell Significance Index: -3.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0342
    Cell Significance Index: -4.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0344
    Cell Significance Index: -4.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0345
    Cell Significance Index: -3.9500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0352
    Cell Significance Index: -1.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0371
    Cell Significance Index: -1.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0493
    Cell Significance Index: -1.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0545
    Cell Significance Index: -4.1800
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.0607
    Cell Significance Index: -0.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0642
    Cell Significance Index: -2.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0645
    Cell Significance Index: -4.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0656
    Cell Significance Index: -0.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0671
    Cell Significance Index: -4.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0747
    Cell Significance Index: -4.5900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0750
    Cell Significance Index: -1.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0776
    Cell Significance Index: -3.6500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0813
    Cell Significance Index: -1.0800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0861
    Cell Significance Index: -1.2500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0871
    Cell Significance Index: -1.4800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0905
    Cell Significance Index: -1.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0974
    Cell Significance Index: -2.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1063
    Cell Significance Index: -2.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1128
    Cell Significance Index: -3.9200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1139
    Cell Significance Index: -2.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1225
    Cell Significance Index: -4.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1252
    Cell Significance Index: -5.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1277
    Cell Significance Index: -3.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1297
    Cell Significance Index: -3.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1319
    Cell Significance Index: -4.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1344
    Cell Significance Index: -3.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1345
    Cell Significance Index: -4.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1358
    Cell Significance Index: -2.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1362
    Cell Significance Index: -2.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1460
    Cell Significance Index: -5.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1499
    Cell Significance Index: -3.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1514
    Cell Significance Index: -3.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1549
    Cell Significance Index: -4.4400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1585
    Cell Significance Index: -1.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1587
    Cell Significance Index: -4.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1615
    Cell Significance Index: -5.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1669
    Cell Significance Index: -7.7800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1704
    Cell Significance Index: -1.5400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1704
    Cell Significance Index: -4.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1719
    Cell Significance Index: -4.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1724
    Cell Significance Index: -1.7900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1728
    Cell Significance Index: -2.3700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1831
    Cell Significance Index: -2.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1942
    Cell Significance Index: -3.2500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1952
    Cell Significance Index: -2.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1968
    Cell Significance Index: -4.3100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1976
    Cell Significance Index: -4.1300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1978
    Cell Significance Index: -2.5600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1981
    Cell Significance Index: -3.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1989
    Cell Significance Index: -4.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2000
    Cell Significance Index: -4.3200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2019
    Cell Significance Index: -2.8700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2028
    Cell Significance Index: -2.0700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2044
    Cell Significance Index: -2.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2045
    Cell Significance Index: -4.3400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2062
    Cell Significance Index: -3.3400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2087
    Cell Significance Index: -3.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2107
    Cell Significance Index: -4.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CD209 is a member of the C-type lectin receptor family, characterized by its ability to bind carbohydrates on the surface of pathogens. It is expressed on the surface of myeloid leukocytes, which are involved in the innate immune response, as well as enterocytes and goblet cells in the colon and small intestine. CD209 has a unique structure, consisting of two C-type lectin domains and a cytoplasmic tail, which allows it to interact with other molecules and internalize pathogens. The expression of CD209 is regulated by various signaling pathways, including those involved in immune activation and cell-cell adhesion. **Pathways and Functions** CD209 plays a key role in the recognition and internalization of pathogens, including viruses and bacteria. It binds to carbohydrate antigens on the surface of pathogens, which triggers signaling pathways that lead to the activation of the adaptive immune response. CD209 is also involved in the presentation of antigens to T-cells, facilitating their activation and proliferation. Additionally, CD209 has been implicated in the regulation of cell-cell adhesion, influencing the interaction between immune cells and other cells in the tissue. The signaling pathways involved in CD209 function include: 1. **C-type lectin receptor signaling pathway**: CD209 binds to carbohydrate antigens on the surface of pathogens, triggering the activation of signaling pathways that lead to the activation of the adaptive immune response. 2. **JAK/STAT pathway**: CD209 signaling activates the JAK/STAT pathway, which is involved in the regulation of immune cell activation and proliferation. 3. **MAPK pathway**: CD209 signaling also activates the MAPK pathway, which is involved in the regulation of cell-cell adhesion and immune cell activation. **Clinical Significance** CD209 has been implicated in various diseases, including: 1. **Respiratory Syncytial Virus (RSV) infection**: CD209 has been shown to play a key role in the recognition and internalization of RSV, facilitating its presentation to T-cells and activation of the adaptive immune response. 2. **Infectious diseases**: CD209 has been implicated in the recognition and internalization of various pathogens, including bacteria and viruses, and has been shown to play a key role in the regulation of immune cell activation and proliferation. 3. **Autoimmune diseases**: CD209 has been implicated in the regulation of immune cell activation and proliferation, and has been shown to play a key role in the development of autoimmune diseases, such as rheumatoid arthritis. Therapeutic interventions targeting CD209 have been explored, including the use of antibodies and small molecules that inhibit CD209 signaling. These interventions have shown promise in preclinical studies, but further research is needed to fully understand the potential benefits and risks of CD209-targeted therapies. In conclusion, CD209 is a critical molecule involved in the recognition and internalization of pathogens, facilitating the activation of the adaptive immune response. Its dysregulation has been implicated in various diseases, including RSV infection and autoimmune diseases. Further research is needed to fully understand the role of CD209 in human health and disease, and to explore the potential of CD209-targeted therapies.

Genular Protein ID: 3497147025

Symbol: CD209_HUMAN

Name: CD209 antigen

UniProtKB Accession Codes:

Q9NNX6 A8KAM4 A8MVQ9 G5E9C4 Q2TB19 Q96QP7 Q96QP8 Q96QP9 Q96QQ0 Q96QQ1 Q96QQ2 Q96QQ3 Q96QQ4 Q96QQ5 Q96QQ6 Q96QQ7 Q96QQ8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CTD 1 ChEBI 6 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 24 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 13 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 3 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1518869

Title: Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp 120.

PubMed ID: 1518869

DOI: 10.1073/pnas.89.17.8356

PubMed ID: 10975799

Title: DC-SIGN, a related gene, DC-SIGNR, and CD23 form a cluster on 19p13.

PubMed ID: 10975799

DOI: 10.4049/jimmunol.165.6.2937

PubMed ID: 11257134

Title: A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection.

PubMed ID: 11257134

DOI: 10.1084/jem.193.6.671

PubMed ID: 11337487

Title: Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts.

PubMed ID: 11337487

DOI: 10.1074/jbc.m009807200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10721995

Title: DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.

PubMed ID: 10721995

DOI: 10.1016/s0092-8674(00)80694-7

PubMed ID: 11017109

Title: DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking.

PubMed ID: 11017109

DOI: 10.1038/79815

PubMed ID: 11384997

Title: A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands.

PubMed ID: 11384997

DOI: 10.1074/jbc.m104565200

PubMed ID: 12433371

Title: Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection.

PubMed ID: 12433371

DOI: 10.1016/s1074-7613(02)00447-8

PubMed ID: 11799126

Title: Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1.

PubMed ID: 11799126

DOI: 10.1074/jbc.m111532200

PubMed ID: 11859097

Title: The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells.

PubMed ID: 11859097

DOI: 10.4049/jimmunol.168.5.2118

PubMed ID: 11825572

Title: DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection.

PubMed ID: 11825572

DOI: 10.1016/s1074-7613(02)00259-5

PubMed ID: 12502850

Title: Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR.

PubMed ID: 12502850

DOI: 10.1128/jvi.77.2.1337-1346.2003

PubMed ID: 12682107

Title: DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells.

PubMed ID: 12682107

DOI: 10.1084/jem.20021840

PubMed ID: 12692233

Title: Inhibition of human immunodeficiency virus type 1 Env-mediated fusion by DC-SIGN.

PubMed ID: 12692233

DOI: 10.1128/jvi.77.9.5313-5323.2003

PubMed ID: 12574325

Title: Carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells.

PubMed ID: 12574325

DOI: 10.4049/jimmunol.170.4.1635

PubMed ID: 12949494

Title: DC-SIGN: escape mechanism for pathogens.

PubMed ID: 12949494

DOI: 10.1038/nri1182

PubMed ID: 12960229

Title: The role of dendritic cell C-type lectin receptors in HIV pathogenesis.

PubMed ID: 12960229

DOI: 10.1189/jlb.0503208

PubMed ID: 12504546

Title: DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells.

PubMed ID: 12504546

DOI: 10.1006/viro.2002.1730

PubMed ID: 15371595

Title: L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus.

PubMed ID: 15371595

DOI: 10.1073/pnas.0405695101

PubMed ID: 15140961

Title: pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN.

PubMed ID: 15140961

DOI: 10.1128/jvi.78.11.5642-5650.2004

PubMed ID: 15479853

Title: DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus.

PubMed ID: 15479853

DOI: 10.1128/jvi.78.21.12090-12095.2004

PubMed ID: 16246332

Title: Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils.

PubMed ID: 16246332

DOI: 10.1016/j.febslet.2005.09.089

PubMed ID: 15838506

Title: A variant in the CD209 promoter is associated with severity of dengue disease.

PubMed ID: 15838506

DOI: 10.1038/ng1550

PubMed ID: 16092920

Title: Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity.

PubMed ID: 16092920

DOI: 10.1042/bj20050709

PubMed ID: 16379498

Title: Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.

PubMed ID: 16379498

DOI: 10.1371/journal.pmed.0030020

PubMed ID: 16537615

Title: Measles virus targets DC-SIGN to enhance dendritic cell infection.

PubMed ID: 16537615

DOI: 10.1128/jvi.80.7.3477-3486.2006

PubMed ID: 16415006

Title: West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection.

PubMed ID: 16415006

DOI: 10.1128/jvi.80.3.1290-1301.2006

PubMed ID: 16816373

Title: Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles.

PubMed ID: 16816373

DOI: 10.2353/ajpath.2006.051191

PubMed ID: 21203928

Title: Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG.

PubMed ID: 21203928

DOI: 10.1007/s13238-010-0101-3

PubMed ID: 22700724

Title: DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.

PubMed ID: 22700724

DOI: 10.1182/blood-2011-07-369728

PubMed ID: 18796707

Title: Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN.

PubMed ID: 18796707

DOI: 10.1099/vir.0.2008/003129-0

PubMed ID: 21191006

Title: N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN.

PubMed ID: 21191006

DOI: 10.1128/jvi.01705-10

PubMed ID: 21767814

Title: DC-SIGN as a receptor for phleboviruses.

PubMed ID: 21767814

DOI: 10.1016/j.chom.2011.06.007

PubMed ID: 11739956

Title: Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.

PubMed ID: 11739956

DOI: 10.1126/science.1066371

PubMed ID: 22496863

Title: Human cytomegalovirus entry into dendritic cells occurs via a macropinocytosis-like pathway in a pH-independent and cholesterol-dependent manner.

PubMed ID: 22496863

DOI: 10.1371/journal.pone.0034795

PubMed ID: 22090124

Title: Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2.

PubMed ID: 22090124

DOI: 10.1128/jvi.06096-11

PubMed ID: 24623090

Title: Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin.

PubMed ID: 24623090

DOI: 10.1007/s00705-014-2042-2

PubMed ID: 23966408

Title: Role of DC-SIGN in Lassa virus entry into human dendritic cells.

PubMed ID: 23966408

DOI: 10.1128/jvi.01893-13

PubMed ID: 22440960

Title: Virus entry: old viruses, new receptors.

PubMed ID: 22440960

DOI: 10.1016/j.coviro.2011.12.005

Sequence Information:

  • Length: 404
  • Mass: 45775
  • Checksum: A23FA246014533C0
  • Sequence:
    • MSDSKEPRLQ QLGLLEEEQL RGLGFRQTRG YKSLAGCLGH GPLVLQLLSF TLLAGLLVQV 
SKVPSSISQE QSRQDAIYQN LTQLKAAVGE LSEKSKLQEI YQELTQLKAA VGELPEKSKL 
QEIYQELTRL KAAVGELPEK SKLQEIYQEL TWLKAAVGEL PEKSKMQEIY QELTRLKAAV 
GELPEKSKQQ EIYQELTRLK AAVGELPEKS KQQEIYQELT RLKAAVGELP EKSKQQEIYQ 
ELTQLKAAVE RLCHPCPWEW TFFQGNCYFM SNSQRNWHDS ITACKEVGAQ LVVIKSAEEQ 
NFLQLQSSRS NRFTWMGLSD LNQEGTWQWV DGSPLLPSFK QYWNRGEPNN VGEEDCAEFS 
GNGWNDDKCN LAKFWICKKS AASCSRDEEQ FLSPAPATPN PPPA

Genular Protein ID: 3156101372

Symbol: B2R907_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R907

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 7 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 404
  • Mass: 45776
  • Checksum: A23FA1F0014535E0
  • Sequence:
    • MSDSKEPRLQ QLGLLEEEQL RGLGFRQTRG YKSLAGCLGH GPLVLQLLSF TLLAGLLVQV 
SKVPSSISQE QSRQDAIYQN LTQLKAAVGE LSEKSKLQEI YQELTQLKAA VGELPEKSKL 
QEIYQELTRL KAAVGELPEK SKLQEIYQEL TWLEAAVGEL PEKSKMQEIY QELTRLKAAV 
GELPEKSKQQ EIYQELTRLK AAVGELPEKS KQQEIYQELT RLKAAVGELP EKSKQQEIYQ 
ELTQLKAAVE RLCHPCPWEW TFFQGNCYFM SNSQRNWHDS ITACKEVGAQ LVVIKSAEEQ 
NFLQLQSSRS NRFTWMGLSD LNQEGTWQWV DGSPLLPSFK QYWNRGEPNN VGEEDCAEFS 
GNGWNDDKCN LAKFWICKKS AASCSRDEEQ FLSPAPATPN PPPA

Genular Protein ID: 2396592200

Symbol: B4E2A8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E2A8

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 135
  • Mass: 15186
  • Checksum: 5BAFCEDE6E84250A
  • Sequence:
    • MSNSQRNWHD SITACKEVGA QLVVIKSAEE QNFLQLQSSR SNRFTWMGLS DLNQEGTWQW 
VDGSPLLPSF KQYWNRGEPN NVGEEDCAEF SGNGWNDDKC NLAKFWICKK SAASCSRDEE 
QFLSPAPATP NPPPA

Genular Protein ID: 3045680543

Symbol: X6RB12_HUMAN

Name: N/A

UniProtKB Accession Codes:

X6RB12

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 243
  • Mass: 27366
  • Checksum: E2DD8A5F2B3B7AF6
  • Sequence:
    • MSDSKEPRLQ QLGLLEEEQL RGLGFRQTRG YKSLAGCLGH GPLVLQLLSF TLLAGLLVQV 
SKVPSSISQE QSRQDAIYQN LTQLKAAVER LCHPCPWEWT FFQGNCYFMS NSQRNWHDSI 
TACKEVGAQL VVIKSAEEQN FLQLQSSRSN RFTWMGLSDL NQEGTWQWVD GSPLLPSFKQ 
YWNRGEPNNV GEEDCAEFSG NGWNDDKCNL AKFWICKKSA ASCSRDEEQF LSPAPATPNP 
PPA

Genular Protein ID: 3869453355

Symbol: M0R0P0_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0R0P0

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 268
  • Mass: 30470
  • Checksum: BB89AF2DA0CC3A72
  • Sequence:
    • MSDSKEPRLQ QLGLLVSKVP SSISQEQSRQ DAIYQNLTQL KAAVGELSEK SKLQEIYQEL 
TQLKAAVGEL PEKSKLQEIY QELTRLKAAV GELPEKSKLQ EIYQELTWLK AAVERLCHPC 
PWEWTFFQGN CYFMSNSQRN WHDSITACKE VGAQLVVIKS AEEQNFLQLQ SSRSNRFTWM 
GLSDLNQEGT WQWVDGSPLL PSFKQYWNRG EPNNVGEEDC AEFSGNGWND DKCNLAKFWI 
CKKSAASCSR DEEQFLSPAP ATPNPPPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.