Details for: CCL24

Gene ID: 6369

Symbol: CCL24

Ensembl ID: ENSG00000106178

Description: C-C motif chemokine ligand 24

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 3.5593
    Cell Significance Index: 39.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.1806
    Cell Significance Index: 101.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.9435
    Cell Significance Index: 180.4700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.9664
    Cell Significance Index: 26.9700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.2033
    Cell Significance Index: 17.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8194
    Cell Significance Index: 155.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4677
    Cell Significance Index: 9.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4612
    Cell Significance Index: 45.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4282
    Cell Significance Index: 386.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3946
    Cell Significance Index: 10.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3098
    Cell Significance Index: 33.7000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2753
    Cell Significance Index: 6.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2747
    Cell Significance Index: 44.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2627
    Cell Significance Index: 15.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2077
    Cell Significance Index: 7.3000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2020
    Cell Significance Index: 2.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1805
    Cell Significance Index: 12.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0750
    Cell Significance Index: 1.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0668
    Cell Significance Index: 1.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0472
    Cell Significance Index: 1.3600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0245
    Cell Significance Index: 0.2000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0159
    Cell Significance Index: 0.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0118
    Cell Significance Index: 1.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0111
    Cell Significance Index: 0.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0074
    Cell Significance Index: 0.1600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0071
    Cell Significance Index: 0.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0055
    Cell Significance Index: 0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -4.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0053
    Cell Significance Index: -2.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0058
    Cell Significance Index: -3.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0072
    Cell Significance Index: -2.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0086
    Cell Significance Index: -3.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0103
    Cell Significance Index: -2.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0110
    Cell Significance Index: -0.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0128
    Cell Significance Index: -0.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0131
    Cell Significance Index: -0.6600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0136
    Cell Significance Index: -0.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0143
    Cell Significance Index: -0.2800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0148
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0150
    Cell Significance Index: -2.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0162
    Cell Significance Index: -3.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0169
    Cell Significance Index: -3.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0201
    Cell Significance Index: -3.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0202
    Cell Significance Index: -2.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0221
    Cell Significance Index: -0.5900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0227
    Cell Significance Index: -0.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0245
    Cell Significance Index: -3.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0261
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0263
    Cell Significance Index: -3.0100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0279
    Cell Significance Index: -0.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0306
    Cell Significance Index: -3.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0357
    Cell Significance Index: -4.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0471
    Cell Significance Index: -5.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0491
    Cell Significance Index: -3.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0495
    Cell Significance Index: -1.7400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0495
    Cell Significance Index: -0.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0504
    Cell Significance Index: -3.3900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0512
    Cell Significance Index: -0.5300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0513
    Cell Significance Index: -0.7500
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0539
    Cell Significance Index: -0.6900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0539
    Cell Significance Index: -0.4700
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0554
    Cell Significance Index: -0.5300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0556
    Cell Significance Index: -0.9500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0558
    Cell Significance Index: -0.6600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0563
    Cell Significance Index: -0.7500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0596
    Cell Significance Index: -0.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0607
    Cell Significance Index: -1.3300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0621
    Cell Significance Index: -0.5900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0697
    Cell Significance Index: -1.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0722
    Cell Significance Index: -2.3700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0731
    Cell Significance Index: -0.8600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0764
    Cell Significance Index: -1.1600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0811
    Cell Significance Index: -0.7200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0820
    Cell Significance Index: -0.5900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0821
    Cell Significance Index: -1.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0855
    Cell Significance Index: -4.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0867
    Cell Significance Index: -2.7600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0880
    Cell Significance Index: -0.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0894
    Cell Significance Index: -0.5400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0946
    Cell Significance Index: -2.3600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0949
    Cell Significance Index: -0.6300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0950
    Cell Significance Index: -1.3600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0951
    Cell Significance Index: -0.6200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0964
    Cell Significance Index: -0.6500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0966
    Cell Significance Index: -0.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1013
    Cell Significance Index: -4.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1056
    Cell Significance Index: -2.6900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1068
    Cell Significance Index: -0.2400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1102
    Cell Significance Index: -1.4000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1102
    Cell Significance Index: -0.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1126
    Cell Significance Index: -2.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1164
    Cell Significance Index: -2.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1179
    Cell Significance Index: -2.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1191
    Cell Significance Index: -4.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chemokine Structure:** CCL24 is a small, secreted protein that belongs to the C-C chemokine family. It consists of four conserved cysteine residues and exhibits a characteristic amphipathic structure. 2. **Receptor Binding:** CCL24 interacts with CCR3, a G-protein coupled receptor, to mediate its biological effects. 3. **Cellular Expression:** CCL24 is expressed in various cell types, including double-negative thymocytes, erythrocytes, hematopoietic stem cells, megakaryocytes, and colon goblet cells. 4. **Signaling Pathways:** CCL24 activates multiple signaling pathways, including cell-cell signaling, cellular response to interleukin-1, and chemokine-mediated signaling pathway. **Pathways and Functions:** 1. **Chemotaxis:** CCL24 is a potent chemoattractant for eosinophils, neutrophils, and lymphocytes, playing a crucial role in the recruitment of these cells to sites of inflammation and immune response. 2. **Immune Response:** CCL24 modulates the immune response by regulating the activation, proliferation, and differentiation of immune cells, including eosinophils, neutrophils, and lymphocytes. 3. **Angiogenesis:** CCL24 promotes angiogenesis by regulating the expression of angiogenic factors and endothelial cell proliferation. 4. **Cell Migration:** CCL24 facilitates cell migration by regulating the expression of adhesion molecules and cytoskeletal proteins. **Clinical Significance:** 1. **Allergic Diseases:** CCL24 is implicated in the pathogenesis of allergic diseases, such as asthma, rhinitis, and atopic dermatitis, where it contributes to eosinophilic inflammation and airway hyperresponsiveness. 2. **Cancer:** CCL24 is overexpressed in various types of cancer, including lung, breast, and colon cancer, where it promotes tumor growth, angiogenesis, and metastasis. 3. **Inflammatory Disorders:** CCL24 is involved in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease, where it contributes to the recruitment and activation of immune cells. 4. **Immunodeficiency:** CCL24 is also involved in the regulation of the immune response in immunodeficiency disorders, such as chronic granulomatous disease and hyper IgE syndrome. In conclusion, CCL24 is a multifunctional chemokine that plays a crucial role in regulating immune responses, chemotaxis, and cellular signaling pathways. Its dysregulation is implicated in various immune-related disorders, including allergic diseases, cancer, inflammatory disorders, and immunodeficiency. Further studies are necessary to fully elucidate the mechanisms of CCL24 and its clinical significance in human diseases.

Genular Protein ID: 2664697870

Symbol: CCL24_HUMAN

Name: C-C motif chemokine 24

UniProtKB Accession Codes:

O00175 B2R5K2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9104803

Title: Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors.

PubMed ID: 9104803

DOI: 10.1084/jem.185.7.1163

PubMed ID: 9365122

Title: Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils.

PubMed ID: 9365122

DOI: 10.1002/jlb.62.5.667

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10913244

Title: NMR solution structure and receptor peptide binding of the CC chemokine eotaxin-2.

PubMed ID: 10913244

DOI: 10.1021/bi000523j

Sequence Information:

  • Length: 119
  • Mass: 13134
  • Checksum: 6CAACA61731FB393
  • Sequence:
    • MAGLMTIVTS LLFLGVCAHH IIPTGSVVIP SPCCMFFVSK RIPENRVVSY QLSSRSTCLK 
AGVIFTTKKG QQFCGDPKQE WVQRYMKNLD AKQKKASPRA RAVAVKGPVQ RYPGNQTTC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.