Details for: FABP3

Gene ID: 2170

Symbol: FABP3

Ensembl ID: ENSG00000121769

Description: fatty acid binding protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.9914
    Cell Significance Index: -13.2200
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 33.3217
    Cell Significance Index: 143.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.7303
    Cell Significance Index: -13.2300
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 10.3008
    Cell Significance Index: 29.5200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.6882
    Cell Significance Index: 114.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.6990
    Cell Significance Index: 54.6100
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 2.5045
    Cell Significance Index: 13.9400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.4933
    Cell Significance Index: 40.2300
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.3052
    Cell Significance Index: 11.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.2564
    Cell Significance Index: 173.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9498
    Cell Significance Index: 102.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4782
    Cell Significance Index: 29.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4764
    Cell Significance Index: 61.5500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3917
    Cell Significance Index: 3.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3649
    Cell Significance Index: 9.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3617
    Cell Significance Index: 72.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3130
    Cell Significance Index: 8.2300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.2049
    Cell Significance Index: 2.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1949
    Cell Significance Index: 22.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1870
    Cell Significance Index: 35.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1850
    Cell Significance Index: 66.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1796
    Cell Significance Index: 8.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1475
    Cell Significance Index: 4.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1317
    Cell Significance Index: 3.5300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1293
    Cell Significance Index: 2.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1285
    Cell Significance Index: 10.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1099
    Cell Significance Index: 80.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0778
    Cell Significance Index: 5.2300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.0699
    Cell Significance Index: 0.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0604
    Cell Significance Index: 54.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0472
    Cell Significance Index: 32.6700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0267
    Cell Significance Index: 0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0092
    Cell Significance Index: 16.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0092
    Cell Significance Index: 14.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0021
    Cell Significance Index: 3.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0051
    Cell Significance Index: -0.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0058
    Cell Significance Index: -1.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0068
    Cell Significance Index: -1.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0070
    Cell Significance Index: -0.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0143
    Cell Significance Index: -9.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0150
    Cell Significance Index: -11.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0178
    Cell Significance Index: -13.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0187
    Cell Significance Index: -8.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0196
    Cell Significance Index: -10.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0208
    Cell Significance Index: -2.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0228
    Cell Significance Index: -12.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0229
    Cell Significance Index: -14.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0295
    Cell Significance Index: -5.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0305
    Cell Significance Index: -0.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0366
    Cell Significance Index: -0.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0366
    Cell Significance Index: -0.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0369
    Cell Significance Index: -4.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0370
    Cell Significance Index: -10.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0506
    Cell Significance Index: -7.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0554
    Cell Significance Index: -7.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0603
    Cell Significance Index: -7.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0663
    Cell Significance Index: -13.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0693
    Cell Significance Index: -3.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0701
    Cell Significance Index: -4.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0704
    Cell Significance Index: -9.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0726
    Cell Significance Index: -4.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0777
    Cell Significance Index: -13.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0778
    Cell Significance Index: -4.7800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0890
    Cell Significance Index: -1.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0974
    Cell Significance Index: -2.1100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0996
    Cell Significance Index: -1.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1206
    Cell Significance Index: -12.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1207
    Cell Significance Index: -14.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1210
    Cell Significance Index: -13.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1216
    Cell Significance Index: -8.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1271
    Cell Significance Index: -1.8200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1348
    Cell Significance Index: -1.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1419
    Cell Significance Index: -1.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1432
    Cell Significance Index: -3.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1447
    Cell Significance Index: -9.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1481
    Cell Significance Index: -11.0400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1700
    Cell Significance Index: -2.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1701
    Cell Significance Index: -7.5300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1790
    Cell Significance Index: -1.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1856
    Cell Significance Index: -7.0300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1862
    Cell Significance Index: -2.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1884
    Cell Significance Index: -10.5700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1895
    Cell Significance Index: -2.4300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1899
    Cell Significance Index: -3.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1900
    Cell Significance Index: -9.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1972
    Cell Significance Index: -6.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2048
    Cell Significance Index: -3.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2167
    Cell Significance Index: -4.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2184
    Cell Significance Index: -14.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2303
    Cell Significance Index: -7.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2316
    Cell Significance Index: -4.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2569
    Cell Significance Index: -9.0000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2577
    Cell Significance Index: -2.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2735
    Cell Significance Index: -6.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2754
    Cell Significance Index: -5.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2772
    Cell Significance Index: -5.9900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2845
    Cell Significance Index: -12.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2887
    Cell Significance Index: -13.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue Expression:** FABP3 is widely expressed in various tissues, including cardiac muscle cells, enterocytes, kidney epithelial cells, and other cell types. 2. **Lipid Binding:** FABP3 is a long-chain fatty acid-binding protein, capable of binding and transporting fatty acids, phospholipids, and cholesterol. 3. **Regulatory Functions:** FABP3 is involved in the regulation of fatty acid oxidation, phospholipid biosynthesis, and cholesterol homeostasis, as well as negative regulation of cell population proliferation and positive regulation of fatty acid import into cells. 4. **Cellular Localization:** FABP3 is primarily localized to the cytosol, where it interacts with other proteins to regulate lipid metabolism. **Pathways and Functions:** 1. **Long-chain Fatty Acid Binding and Transport:** FABP3 plays a crucial role in the binding, transport, and oxidation of long-chain fatty acids, which is essential for energy production and lipid metabolism. 2. **Phospholipid Homeostasis:** FABP3 is involved in the regulation of phospholipid biosynthesis and homeostasis, which is critical for maintaining cellular membrane structure and function. 3. **Cholesterol Homeostasis:** FABP3 has been implicated in the regulation of cholesterol homeostasis, which is essential for maintaining proper lipid metabolism and preventing cardiovascular diseases. 4. **Brown Fat Cell Differentiation:** FABP3 is involved in the regulation of brown fat cell differentiation, which is critical for thermogenesis and energy expenditure. 5. **Negative Regulation of Cell Population Proliferation:** FABP3 has been shown to negatively regulate cell population proliferation, which is essential for maintaining tissue homeostasis and preventing cancer. **Clinical Significance:** 1. **Cardiovascular Diseases:** Alterations in FABP3 expression have been linked to various cardiovascular diseases, including heart failure, coronary artery disease, and atherosclerosis. 2. **Metabolic Disorders:** FABP3 has been implicated in the regulation of lipid metabolism and has been linked to metabolic disorders, such as obesity, type 2 diabetes, and dyslipidemia. 3. **Cancer:** FABP3 has been shown to play a role in the regulation of cell population proliferation and has been implicated in the development and progression of certain cancers. 4. **Therapeutic Applications:** FABP3 has been identified as a potential therapeutic target for the treatment of various metabolic and cardiovascular diseases. In conclusion, FABP3 plays a critical role in regulating lipid metabolism and cellular function, and its dysregulation has been linked to various diseases. Further research is needed to fully elucidate the mechanisms by which FABP3 regulates lipid metabolism and to explore its therapeutic potential.

Genular Protein ID: 1900121545

Symbol: FABPH_HUMAN

Name: Fatty acid-binding protein, heart

UniProtKB Accession Codes:

P05413 B2RAB6 Q5VV93 Q99957

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 65 PDBsum 65 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1710107

Title: Cloning of the cDNA encoding human skeletal-muscle fatty-acid-binding protein, its peptide sequence and chromosomal localization.

PubMed ID: 1710107

DOI: 10.1042/bj2760203

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3421901

Title: Characterization and amino acid sequence of a fatty acid-binding protein from human heart.

PubMed ID: 3421901

DOI: 10.1042/bj2520191

PubMed ID: 2266954

Title: Revision of the amino acid sequence of human heart fatty acid-binding protein.

PubMed ID: 2266954

DOI: 10.1007/bf00231376

PubMed ID: 8262516

Title: Localization of the gene for human heart fatty acid binding protein to chromosome 1p32-1p33.

PubMed ID: 8262516

DOI: 10.1007/bf00420939

PubMed ID: 7498159

Title: The major protein expression profile and two-dimensional protein database of human heart.

PubMed ID: 7498159

DOI: 10.1002/elps.11501601192

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 1526991

Title: Three-dimensional structure of recombinant human muscle fatty acid-binding protein.

PubMed ID: 1526991

DOI: 10.2210/pdb2hmb/pdb

PubMed ID: 7922029

Title: Structural studies on human muscle fatty acid binding protein at 1.4-A resolution: binding interactions with three C18 fatty acids.

PubMed ID: 7922029

DOI: 10.1016/s0969-2126(00)00052-6

PubMed ID: 11171102

Title: Spin-system heterogeneities indicate a selected-fit mechanism in fatty acid binding to heart-type fatty acid-binding protein (H-FABP).

PubMed ID: 11171102

DOI: 10.1042/0264-6021:3540259

Sequence Information:

  • Length: 133
  • Mass: 14858
  • Checksum: 5FD396B1BE538A3C
  • Sequence:
    • MVDAFLGTWK LVDSKNFDDY MKSLGVGFAT RQVASMTKPT TIIEKNGDIL TLKTHSTFKN 
TEISFKLGVE FDETTADDRK VKSIVTLDGG KLVHLQKWDG QETTLVRELI DGKLILTLTH 
GTAVCTRTYE KEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.