Details for: ADAM20

Gene ID: 8748

Symbol: ADAM20

Ensembl ID: ENSG00000134007

Description: ADAM metallopeptidase domain 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.6265
    Cell Significance Index: -6.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.7659
    Cell Significance Index: -4.7800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 3.6708
    Cell Significance Index: 43.2600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.5943
    Cell Significance Index: 36.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4754
    Cell Significance Index: 10.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3737
    Cell Significance Index: 11.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2834
    Cell Significance Index: 7.6000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1324
    Cell Significance Index: 1.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1211
    Cell Significance Index: 7.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1194
    Cell Significance Index: 23.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1129
    Cell Significance Index: 1.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1052
    Cell Significance Index: 30.2600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.0893
    Cell Significance Index: 1.1700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0733
    Cell Significance Index: 0.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0639
    Cell Significance Index: 22.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0479
    Cell Significance Index: 2.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0426
    Cell Significance Index: 29.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0339
    Cell Significance Index: 0.5700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0317
    Cell Significance Index: 0.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0144
    Cell Significance Index: 1.6800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0007
    Cell Significance Index: -0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0086
    Cell Significance Index: -6.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0094
    Cell Significance Index: -5.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0097
    Cell Significance Index: -7.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0097
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0129
    Cell Significance Index: -7.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0160
    Cell Significance Index: -0.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0191
    Cell Significance Index: -3.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0220
    Cell Significance Index: -3.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0227
    Cell Significance Index: -1.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0267
    Cell Significance Index: -1.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0334
    Cell Significance Index: -2.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0339
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0349
    Cell Significance Index: -7.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0365
    Cell Significance Index: -4.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0371
    Cell Significance Index: -6.3400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0375
    Cell Significance Index: -0.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0390
    Cell Significance Index: -5.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0415
    Cell Significance Index: -1.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0419
    Cell Significance Index: -5.7500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0435
    Cell Significance Index: -0.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0462
    Cell Significance Index: -4.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0468
    Cell Significance Index: -5.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0492
    Cell Significance Index: -1.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0501
    Cell Significance Index: -1.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0577
    Cell Significance Index: -1.4400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0591
    Cell Significance Index: -2.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0592
    Cell Significance Index: -6.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0597
    Cell Significance Index: -1.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0617
    Cell Significance Index: -4.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0646
    Cell Significance Index: -1.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0655
    Cell Significance Index: -1.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0667
    Cell Significance Index: -1.4400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0667
    Cell Significance Index: -0.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0722
    Cell Significance Index: -3.7900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0732
    Cell Significance Index: -1.4700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0733
    Cell Significance Index: -0.9400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0750
    Cell Significance Index: -1.1900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0776
    Cell Significance Index: -1.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0833
    Cell Significance Index: -5.0000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0836
    Cell Significance Index: -1.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0892
    Cell Significance Index: -1.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0895
    Cell Significance Index: -5.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0904
    Cell Significance Index: -5.8400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0911
    Cell Significance Index: -1.2300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0953
    Cell Significance Index: -1.3100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0956
    Cell Significance Index: -2.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0988
    Cell Significance Index: -4.6500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1006
    Cell Significance Index: -1.7400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1174
    Cell Significance Index: -2.4500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1178
    Cell Significance Index: -1.6800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1279
    Cell Significance Index: -1.3900
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1296
    Cell Significance Index: -1.4700
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1305
    Cell Significance Index: -1.5100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1319
    Cell Significance Index: -1.3700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1367
    Cell Significance Index: -2.6900
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1391
    Cell Significance Index: -1.4900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1395
    Cell Significance Index: -1.7600
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1430
    Cell Significance Index: -1.5800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1446
    Cell Significance Index: -0.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1453
    Cell Significance Index: -5.0500
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.1454
    Cell Significance Index: -1.5400
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1466
    Cell Significance Index: -1.6400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1539
    Cell Significance Index: -1.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1540
    Cell Significance Index: -6.3100
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.1574
    Cell Significance Index: -1.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1577
    Cell Significance Index: -4.2100
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.1582
    Cell Significance Index: -1.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1610
    Cell Significance Index: -4.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1686
    Cell Significance Index: -2.0100
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1695
    Cell Significance Index: -1.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1723
    Cell Significance Index: -4.9400
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1740
    Cell Significance Index: -1.7100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1758
    Cell Significance Index: -4.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1762
    Cell Significance Index: -4.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1765
    Cell Significance Index: -5.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1793
    Cell Significance Index: -6.3000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1809
    Cell Significance Index: -2.0700
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1817
    Cell Significance Index: -1.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADAM20 exhibits a unique combination of functional domains, including a metalloprotease domain, a disintegrin domain, and a type II transmembrane domain. This gene is characterized by its ability to interact with various cellular components, including the plasma membrane, cumulus cells, and the zona pellucida, playing a critical role in fertilization and male gonad development. ADAM20 is also involved in metal ion binding and metalloendopeptidase activity, highlighting its potential role in regulating proteolytic processes. **Pathways and Functions:** ADAM20 is implicated in several key pathways, including: 1. **External side of plasma membrane:** ADAM20 interacts with the plasma membrane, influencing cell-cell interactions and signaling. 2. **Fertilization:** This gene plays a crucial role in the interaction between the sperm head plasma membrane and the zona pellucida, facilitating fertilization. 3. **Interaction with cumulus cells and the zona pellucida:** ADAM20 mediates the interaction between cumulus cells and the zona pellucida, essential for successful fertilization. 4. **Male gonad development:** ADAM20 is involved in the regulation of male gonad development, highlighting its role in reproductive processes. 5. **Metal ion binding:** This gene binds metal ions, influencing metalloendopeptidase activity and proteolytic processes. 6. **Proteolysis:** ADAM20 is involved in proteolytic processes, regulating the degradation of proteins and influencing cellular signaling. **Clinical Significance:** ADAM20 has significant implications in various diseases and disorders, including: 1. **Reproductive disorders:** Impaired ADAM20 function has been linked to male infertility and reproductive disorders. 2. **Immunological disorders:** ADAM20 plays a role in regulating immune responses, and dysregulation of this gene has been implicated in autoimmune diseases. 3. **Neurological disorders:** ADAM20 expression has been observed in GABAergic neurons, highlighting its potential role in neurological disorders, such as epilepsy and schizophrenia. In conclusion, ADAM20 is a multifaceted gene with significant implications in various physiological and pathological processes. Its role in regulating cell-cell interactions, proteolysis, and metal ion binding highlights its importance in maintaining tissue homeostasis and regulating immune responses. Further research is necessary to fully elucidate the complexities of ADAM20 and its role in human diseases.

Genular Protein ID: 3872838428

Symbol: ADA20_HUMAN

Name: Disintegrin and metalloproteinase domain-containing protein 20

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9469942

Title: ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha.

PubMed ID: 9469942

DOI: 10.1016/s0378-1119(97)00597-0

PubMed ID: 10524237

Title: The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries.

PubMed ID: 10524237

DOI: 10.1016/s0378-1119(99)00302-9

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 726
  • Mass: 81603
  • Checksum: 7DB864FA1796A9B0
  • Sequence:
  • MAVGEPLVHI RVTLLLLWFG MFLSISGHSQ ARPSQYFTSP EVVIPLKVIS RGRGAKAPGW 
    LSYSLRFGGQ RYIVHMRVNK LLFAAHLPVF TYTEQHALLQ DQPFIQDDCY YHGYVEGVPE 
    SLVALSTCSG GFLGMLQIND LVYEIKPISV SATFEHLVYK IDSDDTQFPP MRCGLTEEKI 
    AHQMELQLSY NFTLKQSSFV GWWTHQRFVE LVVVVDNIRY LFSQSNATTV QHEVFNVVNI 
    VDSFYHPLEV DVILTGIDIW TASNPLPTSG DLDNVLEDFS IWKNYNLNNR LQHDVAHLFI 
    KDTQGMKLGV AYVKGICQNP FNTGVDVFED NRLVVFAITL GHELGHNLGM QHDTQWCVCE 
    LQWCIMHAYR KVTTKFSNCS YAQYWDSTIS SGLCIQPPPY PGNIFRLKYC GNLVVEEGEE 
    CDCGTIRQCA KDPCCLLNCT LHPGAACAFG ICCKDCKFLP SGTLCRQQVG ECDLPEWCNG 
    TSHQCPDDVY VQDGISCNVN AFCYEKTCNN HDIQCKEIFG QDARSASQSC YQEINTQGNR 
    FGHCGIVGTT YVKCWTPDIM CGRVQCENVG VIPNLIEHST VQQFHLNDTT CWGTDYHLGM 
    AIPDIGEVKD GTVCGPEKIC IRKKCASMVH LSQACQPKTC NMRGICNNKQ HCHCNHEWAP 
    PYCKDKGYGG SADSGPPPKN NMEGLNVMGK LRYLSLLCLL PLVAFLLFCL HVLFKKRTKS 
    KEDEEG

Genular Protein ID: 656644860

Symbol: A0A494C0E3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 776
  • Mass: 87099
  • Checksum: 209B956C2F1BBF21
  • Sequence:
  • MVQLHQDTDP QIPKGQPCTL NSSEGGARPA VPHTLFSSAL DRWLHNDSFI MAVGEPLVHI 
    RVTLLLLWFG MFLSISGHSQ ARPSQYFTSP EVVIPLKVIS RGRGAKAPGW LSYSLRFGGQ 
    RYIVHMRVNK LLFAAHLPVF TYTEQHALLQ DQPFIQDDCY YHGYVEGVPE SLVALSTCSG 
    GFLGMLQIND LVYEIKPISV SATFEHLVYK IDSDDTQFPP MRCGLTEEKI AHQMELQLSY 
    NFTLKQSSFV GWWTHQRFVE LVVVVDNIRY LFSQSNATTV QHEVFNVVNI VDSFYHPLEV 
    DVILTGIDIW TASNPLPTSG DLDNVLEDFS IWKNYNLNNR LQHDVAHLFI KDTQGMKLGV 
    AYVKGICQNP FNTGVDVFED NRLVVFAITL GHELGHNLGM QHDTQWCVCE LQWCIMHAYR 
    KVTTKFSNCS YAQYWDSTIS SGLCIQPPPY PGNIFRLKYC GNLVVEEGEE CDCGTIRQCA 
    KDPCCLLNCT LHPGAACAFG ICCKDCKFLP SGTLCRQQVG ECDLPEWCNG TSHQCPDDVY 
    VQDGISCNVN AFCYEKTCNN HDIQCKEIFG QDARSASQSC YQEINTQGNR FGHCGIVGTT 
    YVKCWTPDIM CGRVQCENVG VIPNLIEHST VQQFHLNDTT CWGTDYHLGM AIPDIGEVKD 
    GTVCGPEKIC IRKKCASMVH LSQACQPKTC NMRGICNNKQ HCHCNHEWAP PYCKDKGYGG 
    SADSGPPPKN NMEGLNVMGK LRYLSLLCLL PLVAFLLFCL HVLFKKRTKS KEDEEG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.