Details for: GRM1

Gene ID: 2911

Symbol: GRM1

Ensembl ID: ENSG00000152822

Description: glutamate metabotropic receptor 1

Associated with

  • Class c/3 (metabotropic glutamate/pheromone receptors)
    (R-HSA-420499)
  • G alpha (q) signalling events
    (R-HSA-416476)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Neurexins and neuroligins
    (R-HSA-6794361)
  • Neuronal system
    (R-HSA-112316)
  • Protein-protein interactions at synapses
    (R-HSA-6794362)
  • Sensory perception
    (R-HSA-9709957)
  • Sensory perception of sweet, bitter, and umami (glutamate) taste
    (R-HSA-9717207)
  • Sensory perception of taste
    (R-HSA-9717189)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • Adenylate cyclase-inhibiting g protein-coupled glutamate receptor signaling pathway
    (GO:0007196)
  • Adenylate cyclase inhibiting g protein-coupled glutamate receptor activity
    (GO:0001640)
  • Cellular response to electrical stimulus
    (GO:0071257)
  • Chemical synaptic transmission
    (GO:0007268)
  • Dendrite
    (GO:0030425)
  • Glutamate receptor activity
    (GO:0008066)
  • Glutamatergic synapse
    (GO:0098978)
  • G protein-coupled glutamate receptor signaling pathway
    (GO:0007216)
  • G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
    (GO:0098872)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
    (GO:0099530)
  • G protein-coupled receptor dimeric complex
    (GO:0038037)
  • G protein-coupled receptor homodimeric complex
    (GO:0038038)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • L-glutamate import across plasma membrane
    (GO:0098712)
  • Locomotory behavior
    (GO:0007626)
  • Neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
    (GO:0099583)
  • Nucleus
    (GO:0005634)
  • Phospholipase c-activating g protein-coupled glutamate receptor signaling pathway
    (GO:0007206)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Postsynaptic density membrane
    (GO:0098839)
  • Protein binding
    (GO:0005515)
  • Regulation of postsynaptic cytosolic calcium ion concentration
    (GO:0099566)
  • Regulation of postsynaptic membrane potential
    (GO:0060078)
  • Regulation of sensory perception of pain
    (GO:0051930)
  • Regulation of synaptic transmission, glutamatergic
    (GO:0051966)
  • Schaffer collateral - ca1 synapse
    (GO:0098685)
  • Sensory perception of pain
    (GO:0019233)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.06
    Marker Score: 16462.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.82
    Marker Score: 8032
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.68
    Marker Score: 8971
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.44
    Marker Score: 48437
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.16
    Marker Score: 4084
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.06
    Marker Score: 15782
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.02
    Marker Score: 124320
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.79
    Marker Score: 752
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.7
    Marker Score: 3458.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.66
    Marker Score: 17175.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.66
    Marker Score: 6744
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.65
    Marker Score: 15683
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.64
    Marker Score: 2760
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2522
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167864
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.37
    Marker Score: 10331.5
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.33
    Marker Score: 641
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.3
    Marker Score: 779
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.26
    Marker Score: 48036
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.24
    Marker Score: 2841
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.22
    Marker Score: 4733
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 18044.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.14
    Marker Score: 311
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.13
    Marker Score: 38298
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7497
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.12
    Marker Score: 328
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.09
    Marker Score: 350
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.06
    Marker Score: 1170
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.01
    Marker Score: 451
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1
    Marker Score: 580
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2537
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.99
    Marker Score: 9267
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5331
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.92
    Marker Score: 7866
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.87
    Marker Score: 260
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.86
    Marker Score: 3974
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.84
    Marker Score: 383
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.77
    Marker Score: 2187
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7
    Marker Score: 269
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 324
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 447
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.67
    Marker Score: 14206
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.65
    Marker Score: 363
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1451
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 489
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.6
    Marker Score: 740
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.6
    Marker Score: 187
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 146
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.55
    Marker Score: 477
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.55
    Marker Score: 20303
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 213
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.5
    Marker Score: 627
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.48
    Marker Score: 212
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.46
    Marker Score: 6949
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.45
    Marker Score: 516
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.43
    Marker Score: 876
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.42
    Marker Score: 1757
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.42
    Marker Score: 219.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 372
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.39
    Marker Score: 388
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.39
    Marker Score: 255.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.38
    Marker Score: 1560
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.38
    Marker Score: 224
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.37
    Marker Score: 679
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.36
    Marker Score: 1892
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.36
    Marker Score: 95
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.34
    Marker Score: 339
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.33
    Marker Score: 3366
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.32
    Marker Score: 7093
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.32
    Marker Score: 300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.31
    Marker Score: 108
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.3
    Marker Score: 386
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.28
    Marker Score: 79
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.26
    Marker Score: 2230
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.26
    Marker Score: 246
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.25
    Marker Score: 190
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 72
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 382
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.23
    Marker Score: 272
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.22
    Marker Score: 592
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.21
    Marker Score: 427
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 102
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 194
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.17
    Marker Score: 99.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.17
    Marker Score: 69.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.17
    Marker Score: 405

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Other Information

**Key characteristics:** * GRM1 is a transmembrane protein that is expressed in a variety of cell types. * It is a member of the Class c/3 subfamily of glutamate receptors. * GRM1 is a ligand-gated ion channel, which means that it opens or closes in response to the binding of a specific ligand. * The GRM1 channel is permeable to glutamate, a neurotransmitter that is involved in a variety of synaptic processes. * GRM1 is a key regulator of synaptic plasticity, which is the ability of the brain to change its structure and function in response to experience. **Pathways and functions:** * GRM1 is involved in a variety of cellular processes, including synaptic transmission, neurotransmitter release, and calcium signaling. * In synaptic transmission, GRM1 is expressed on the surface of postsynaptic neurons and binds to glutamate released by presynaptic neurons. * This binding activates the channel, which allows calcium ions to enter the postsynaptic neuron. * Calcium ions can then trigger a variety of intracellular events that lead to the postsynaptic neuron firing an action potential. * GRM1 is also involved in neurotransmitter release. * In some brain regions, GRM1 is expressed on the surface of astrocytes, which are star-shaped glial cells that help to maintain the integrity of the blood-brain barrier. * Binding of glutamate to GRM1 on astrocytes can inhibit their activity, which can lead to a decrease in blood-brain barrier permeability and an increase in the flow of nutrients and ions from the blood into the brain. **Clinical significance:** * Mutations in the GRM1 gene have been linked to a number of neurological disorders, including epilepsy, schizophrenia, and autism. * These disorders are characterized by abnormal synaptic plasticity, which is the ability of the brain to change its structure and function in response to experience. * GRM1 is a potential target for therapeutic interventions in these disorders. **Additional information:** * The GRM1 gene is located on chromosome 15q21.1. * It is a single-exon gene, which means that it has a single coding region. * GRM1 is a highly conserved gene, which means that it is found in organisms from flies to humans.

Genular Protein ID: 865678979

Symbol: GRM1_HUMAN

Name: Metabotropic glutamate receptor 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7476890

Title: Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter.

PubMed ID: 7476890

PubMed ID: 9076744

Title: Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants.

PubMed ID: 9076744

DOI: 10.1016/s0028-3908(96)00108-6

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22901947

Title: Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1.

PubMed ID: 22901947

DOI: 10.1016/j.ajhg.2012.07.019

PubMed ID: 28886343

Title: Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44.

PubMed ID: 28886343

DOI: 10.1016/j.ajhg.2017.08.005

PubMed ID: 24603153

Title: Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.

PubMed ID: 24603153

DOI: 10.1126/science.1249489

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 26308914

Title: The role of a novel TRMT1 gene mutation and rare grm1 gene defect in intellectual disability in two azeri families.

PubMed ID: 26308914

DOI: 10.1371/journal.pone.0129631

Sequence Information:

  • Length: 1194
  • Mass: 132357
  • Checksum: 0A633505F6D51909
  • Sequence:
  • MVGLLLFFFP AIFLEVSLLP RSPGRKVLLA GASSQRSVAR MDGDVIIGAL FSVHHQPPAE 
    KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT LGSEIRDSCW HSSVALEQSI 
    EFIRDSLISI RDEKDGINRC LPDGQSLPPG RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI 
    PQIAYSATSI DLSDKTLYKY FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG 
    MDAFKELAAQ EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL 
    SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF DDYFLKLRLD 
    TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KRICTGNESL EENYVQDSKM GFVINAIYAM 
    AHGLQNMHHA LCPGHVGLCD AMKPIDGSKL LDFLIKSSFI GVSGEEVWFD EKGDAPGRYD 
    IMNLQYTEAN RYDYVHVGTW HEGVLNIDDY KIQMNKSGVV RSVCSEPCLK GQIKVIRKGE 
    VSCCWICTAC KENEYVQDEF TCKACDLGWW PNADLTGCEP IPVRYLEWSN IESIIAIAFS 
    CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA KPTTTSCYLQ 
    RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF MSAWAQVIIA SILISVQLTL 
    VVTLIIMEPP MPILSYPSIK EVYLICNTSN LGVVAPLGYN GLLIMSCTYY AFKTRNVPAN 
    FNEAKYIAFT MYTTCIIWLA FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA 
    KPERNVRSAF TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK AGAGNANSNG KSVSWSEPGG 
    GQVPKGQHMW HRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDTS TKTLYNVEEE 
    EDAQPIRFSP PGSPSMVVHR RVPSAATTPP LPSHLTAEET PLFLAEPALP KGLPPPLQQQ 
    QQPPPQQKSL MDQLQGVVSN FSTAIPDFHA VLAGPGGPGN GLRSLYPPPP PPQHLQMLPL 
    QLSTFGEELV SPPADDDDDS ERFKLLQEYV YEHEREGNTE EDELEEEEED LQAASKLTPD 
    DSPALTPPSP FRDSVASGSS VPSSPVSESV LCTPPNVSYA SVILRDYKQS SSTL

Genular Protein ID: 2676243081

Symbol: Q59HC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 901
  • Mass: 100881
  • Checksum: 511EC22B381DE455
  • Sequence:
  • LFFFPAIFLE VSLLPRSPGR KVLLAGASSQ RSVARMDGDV IIGALFSVHH QPPAEKVPER 
    KCGEIREQYG IQRVEAMFHT LDKINADPVL LPNITLGSEI RDSCWHSSVA LEQSIEFIRD 
    SLISIRDEKD GINRCLPDGQ SLPPGRTKKP IAGVIGPGSS SVAIQVQNLL QLFDIPQIAY 
    SATSIDLSDK TLYKYFLRVV PSDTLQARAM LDIVKRYNWT YVSAVHTEGN YGESGMDAFK 
    ELAAQEGLCI AHSDKIYSNA GEKSFDRLLR KLRERLPKAR VVVCFCEGMT VRGLLSAMRR 
    LGVVGEFSLI GSDGWADRDE VIEGYEVEAN GGITIKLQSP EVRSFDDYFL KLRLDTNTRN 
    PWFPEFWQHR FQCRLPGHLL ENPNFKRICT GNESLEENYV QDSKMGFVIN AIYAMAHGLQ 
    NMHHALCPGH VGLCDAMKPI DGSKLLDFLI KSSFIGVSGE EVWFDEKGDA PGRYDIMNLQ 
    YTEANRYDYV HVGTWHEGVL NIDDYKIQMN KSGVVRSVCS EPCLKGQIKV IRKGEVSCCW 
    ICTACKENEY VQDEFTCKAC DLGWWPNADL TGCEPIPVRY LEWSNIESII AIAFSCLGIL 
    VTLFVTLIFV LYRDTPVVKS SSRELCYIIL AGIFLGYVCP FTLIAKPTTT SCYLQRLLVG 
    LSSAMCYSAL VTKTNRIARI LAGSKKKICT RKPRFMSAWA QVIIASILIS VQLTLVVTLI 
    IMEPPMPILS YPSIKEVYLI CNTSNLGVVA PLGYNGLLIM SCTYYAFKTR NVPANFNEAK 
    YIAFTMYTTC IIWLAFVPIY FGSNYKIITT CFAVSLSVTV ALGCMFTPKM YIIIAKPERN 
    VRSAFTTSDV VRMHVGDGKL PCRSNTFLNI FRRKKAGAEN AKKRQPEFSP TSQCPSAHVQ 
    L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.