Details for: TLL2

Gene ID: 7093

Symbol: TLL2

Ensembl ID: ENSG00000095587

Description: tolloid like 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.7
    Marker Score: 7659
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.51
    Marker Score: 2853
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169588
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.32
    Marker Score: 2299
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18829
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.03
    Marker Score: 2093
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.96
    Marker Score: 2257
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.93
    Marker Score: 631.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.88
    Marker Score: 5286
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.75
    Marker Score: 14935
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3102.5
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.71
    Marker Score: 6008
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.67
    Marker Score: 968
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 216
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.61
    Marker Score: 192
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 354
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 230
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 349
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.51
    Marker Score: 132
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.51
    Marker Score: 11304
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.5
    Marker Score: 239
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.5
    Marker Score: 223
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.47
    Marker Score: 594
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.41
    Marker Score: 182
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.37
    Marker Score: 245
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.36
    Marker Score: 105
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.35
    Marker Score: 380
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.35
    Marker Score: 1253
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.35
    Marker Score: 834
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.34
    Marker Score: 141
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.31
    Marker Score: 354
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.29
    Marker Score: 135
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.25
    Marker Score: 313
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.24
    Marker Score: 982
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.21
    Marker Score: 324
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.2
    Marker Score: 161
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.2
    Marker Score: 218
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.19
    Marker Score: 70
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.19
    Marker Score: 1807
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 109
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.18
    Marker Score: 1844
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.18
    Marker Score: 74
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.18
    Marker Score: 66
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.18
    Marker Score: 10858
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.18
    Marker Score: 85
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.17
    Marker Score: 277
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.17
    Marker Score: 145
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.17
    Marker Score: 79
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.16
    Marker Score: 199
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.15
    Marker Score: 172
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.15
    Marker Score: 191
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.15
    Marker Score: 346
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.15
    Marker Score: 87
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 55
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.15
    Marker Score: 1396
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.14
    Marker Score: 1241
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.14
    Marker Score: 190
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.14
    Marker Score: 4840
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.14
    Marker Score: 48
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 124
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.14
    Marker Score: 342
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.13
    Marker Score: 68
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 119
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.12
    Marker Score: 176
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.12
    Marker Score: 165
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.12
    Marker Score: 121
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.12
    Marker Score: 344
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.12
    Marker Score: 144
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.12
    Marker Score: 132
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.12
    Marker Score: 84
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.11
    Marker Score: 346

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Other Information

**Key Characteristics:** TLL2 is a member of the tolloid family of enzymes, which are known for their ability to cleave and process various proteins. The TLL2 protein is a metalloendopeptidase, containing a zinc-binding motif that is essential for its enzymatic activity. The protein is highly expressed in various cell types, including epithelial cells, endothelial cells, and immune cells. Its expression is also observed in developing tissues, such as the kidney, heart, and brain. **Pathways and Functions:** TLL2 is involved in multiple biological pathways, including: 1. **Anchoring fibril formation:** TLL2 plays a crucial role in the formation of anchoring fibrils, which are essential for the integrity of the extracellular matrix. 2. **Collagen biosynthesis and modifying enzymes:** TLL2 is involved in the processing of collagen, a key component of the extracellular matrix. 3. **Collagen fibril organization:** TLL2 helps to organize collagen fibrils, which is essential for maintaining tissue structure and function. 4. **Cell differentiation:** TLL2 is involved in the differentiation of various cell types, including immune cells and epithelial cells. 5. **Metalloendopeptidase activity:** TLL2 has metalloendopeptidase activity, which allows it to cleave and process various proteins. **Clinical Significance:** TLL2 has been implicated in various diseases and disorders, including: 1. **Musculoskeletal disorders:** Mutations in the TLL2 gene have been associated with musculoskeletal disorders, such as osteogenesis imperfecta and Ehlers-Danlos syndrome. 2. **Immune system disorders:** TLL2 has been implicated in immune system disorders, such as rheumatoid arthritis and lupus. 3. **Cancer:** TLL2 has been found to be overexpressed in various types of cancer, including breast and lung cancer. 4. **Neurological disorders:** TLL2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TLL2 is a versatile gene involved in multiple biological processes, including extracellular matrix organization, cell differentiation, and metalloendopeptidase activity. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the role of TLL2 in human health and disease. **Future Directions:** Further research is needed to fully understand the role of TLL2 in human health and disease. This includes: 1. **Functional studies:** Investigating the functional role of TLL2 in various cellular processes. 2. **Disease modeling:** Developing disease models using TLL2-deficient mice to study the effects of TLL2 dysregulation on human disease. 3. **Therapeutic targeting:** Identifying potential therapeutic targets for TLL2-related diseases. By advancing our understanding of TLL2, we can better understand the underlying mechanisms of human disease and develop effective therapeutic strategies to treat TLL2-related disorders.

Genular Protein ID: 3148468287

Symbol: TLL2_HUMAN

Name: Tolloid-like protein 2

UniProtKB Accession Codes:

Q9Y6L7 A6NDK0 Q2M1H1 Q6PJN5 Q9UQ00

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 9 Ensembl 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10479448

Title: Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.

PubMed ID: 10479448

DOI: 10.1006/dbio.1999.9383

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11313359

Title: Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures.

PubMed ID: 11313359

DOI: 10.1074/jbc.m102352200

Sequence Information:

  • Length: 1015
  • Mass: 113557
  • Checksum: 25F5B23065861593
  • Sequence:
    • MPRATALGAL VSLLLLLPLP RGAGGLGERP DATADYSELD GEEGTEQQLE HYHDPCKAAV 
FWGDIALDED DLKLFHIDKA RDWTKQTVGA TGHSTGGLEE QASESSPDTT AMDTGTKEAG 
KDGRENTTLL HSPGTLHAAA KTFSPRVRRA TTSRTERIWP GGVIPYVIGG NFTGSQRAIF 
KQAMRHWEKH TCVTFIERTD EESFIVFSYR TCGCCSYVGR RGGGPQAISI GKNCDKFGIV 
AHELGHVVGF WHEHTRPDRD QHVTIIRENI QPGQEYNFLK MEAGEVSSLG ETYDFDSIMH 
YARNTFSRGV FLDTILPRQD DNGVRPTIGQ RVRLSQGDIA QARKLYKCPA CGETLQDTTG 
NFSAPGFPNG YPSYSHCVWR ISVTPGEKIV LNFTSMDLFK SRLCWYDYVE VRDGYWRKAP 
LLGRFCGDKI PEPLVSTDSR LWVEFRSSSN ILGKGFFAAY EATCGGDMNK DAGQIQSPNY 
PDDYRPSKEC VWRITVSEGF HVGLTFQAFE IERHDSCAYD YLEVRDGPTE ESALIGHFCG 
YEKPEDVKSS SNRLWMKFVS DGSINKAGFA ANFFKEVDEC SWPDHGGCEH RCVNTLGSYK 
CACDPGYELA ADKKMCEVAC GGFITKLNGT ITSPGWPKEY PTNKNCVWQV VAPAQYRISL 
QFEVFELEGN DVCKYDFVEV RSGLSPDAKL HGRFCGSETP EVITSQSNNM RVEFKSDNTV 
SKRGFRAHFF SDKDECAKDN GGCQHECVNT FGSYLCRCRN GYWLHENGHD CKEAGCAHKI 
SSVEGTLASP NWPDKYPSRR ECTWNISSTA GHRVKLTFNE FEIEQHQECA YDHLEMYDGP 
DSLAPILGRF CGSKKPDPTV ASGSSMFLRF YSDASVQRKG FQAVHSTECG GRLKAEVQTK 
ELYSHAQFGD NNYPSEARCD WVIVAEDGYG VELTFRTFEV EEEADCGYDY MEAYDGYDSS 
APRLGRFCGS GPLEEIYSAG DSLMIRFRTD DTINKKGFHA RYTSTKFQDA LHMKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.