Details for: TLL2

Gene ID: 7093

Symbol: TLL2

Ensembl ID: ENSG00000095587

Description: tolloid like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 35.8095
    Cell Significance Index: -5.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.2580
    Cell Significance Index: -5.0200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.9461
    Cell Significance Index: 6.4100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6567
    Cell Significance Index: 9.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5817
    Cell Significance Index: 110.7000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5449
    Cell Significance Index: 8.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3746
    Cell Significance Index: 74.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3274
    Cell Significance Index: 32.3900
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.3186
    Cell Significance Index: 1.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2918
    Cell Significance Index: 263.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2858
    Cell Significance Index: 3.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2629
    Cell Significance Index: 5.6000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2501
    Cell Significance Index: 3.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2421
    Cell Significance Index: 18.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1930
    Cell Significance Index: 20.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1833
    Cell Significance Index: 126.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1829
    Cell Significance Index: 10.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1729
    Cell Significance Index: 28.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1663
    Cell Significance Index: 4.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1569
    Cell Significance Index: 3.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1022
    Cell Significance Index: 7.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0918
    Cell Significance Index: 4.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0890
    Cell Significance Index: 17.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0743
    Cell Significance Index: 40.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0664
    Cell Significance Index: 1.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0529
    Cell Significance Index: 1.8600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0477
    Cell Significance Index: 0.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0405
    Cell Significance Index: 0.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0400
    Cell Significance Index: 4.9200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0372
    Cell Significance Index: 0.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0355
    Cell Significance Index: 6.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0282
    Cell Significance Index: 1.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0268
    Cell Significance Index: 1.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0263
    Cell Significance Index: 9.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0200
    Cell Significance Index: 0.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0063
    Cell Significance Index: 0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0059
    Cell Significance Index: 10.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0055
    Cell Significance Index: 8.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0034
    Cell Significance Index: 0.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0029
    Cell Significance Index: 0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0016
    Cell Significance Index: 1.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0038
    Cell Significance Index: -0.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0052
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0074
    Cell Significance Index: -5.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0077
    Cell Significance Index: -5.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0090
    Cell Significance Index: -5.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0094
    Cell Significance Index: -5.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0105
    Cell Significance Index: -4.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0114
    Cell Significance Index: -0.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0135
    Cell Significance Index: -0.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0146
    Cell Significance Index: -4.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0147
    Cell Significance Index: -0.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0226
    Cell Significance Index: -1.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0270
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0278
    Cell Significance Index: -5.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0283
    Cell Significance Index: -0.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0299
    Cell Significance Index: -3.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0317
    Cell Significance Index: -4.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0338
    Cell Significance Index: -0.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0340
    Cell Significance Index: -4.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0363
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0389
    Cell Significance Index: -4.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0407
    Cell Significance Index: -1.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0423
    Cell Significance Index: -5.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0483
    Cell Significance Index: -1.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0487
    Cell Significance Index: -1.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0496
    Cell Significance Index: -5.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0514
    Cell Significance Index: -0.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0544
    Cell Significance Index: -5.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0647
    Cell Significance Index: -0.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0670
    Cell Significance Index: -3.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0714
    Cell Significance Index: -2.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0717
    Cell Significance Index: -4.5200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0727
    Cell Significance Index: -3.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0743
    Cell Significance Index: -5.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0751
    Cell Significance Index: -1.9300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0763
    Cell Significance Index: -0.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0804
    Cell Significance Index: -5.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0862
    Cell Significance Index: -4.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0907
    Cell Significance Index: -4.7600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0946
    Cell Significance Index: -2.3600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0961
    Cell Significance Index: -2.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1006
    Cell Significance Index: -2.8700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1037
    Cell Significance Index: -1.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1038
    Cell Significance Index: -4.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1068
    Cell Significance Index: -3.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1082
    Cell Significance Index: -2.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1091
    Cell Significance Index: -3.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1152
    Cell Significance Index: -3.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1283
    Cell Significance Index: -4.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1287
    Cell Significance Index: -3.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1293
    Cell Significance Index: -3.1000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1320
    Cell Significance Index: -1.4200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1449
    Cell Significance Index: -0.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1457
    Cell Significance Index: -3.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1465
    Cell Significance Index: -3.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1469
    Cell Significance Index: -3.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TLL2 is a member of the tolloid family of enzymes, which are known for their ability to cleave and process various proteins. The TLL2 protein is a metalloendopeptidase, containing a zinc-binding motif that is essential for its enzymatic activity. The protein is highly expressed in various cell types, including epithelial cells, endothelial cells, and immune cells. Its expression is also observed in developing tissues, such as the kidney, heart, and brain. **Pathways and Functions:** TLL2 is involved in multiple biological pathways, including: 1. **Anchoring fibril formation:** TLL2 plays a crucial role in the formation of anchoring fibrils, which are essential for the integrity of the extracellular matrix. 2. **Collagen biosynthesis and modifying enzymes:** TLL2 is involved in the processing of collagen, a key component of the extracellular matrix. 3. **Collagen fibril organization:** TLL2 helps to organize collagen fibrils, which is essential for maintaining tissue structure and function. 4. **Cell differentiation:** TLL2 is involved in the differentiation of various cell types, including immune cells and epithelial cells. 5. **Metalloendopeptidase activity:** TLL2 has metalloendopeptidase activity, which allows it to cleave and process various proteins. **Clinical Significance:** TLL2 has been implicated in various diseases and disorders, including: 1. **Musculoskeletal disorders:** Mutations in the TLL2 gene have been associated with musculoskeletal disorders, such as osteogenesis imperfecta and Ehlers-Danlos syndrome. 2. **Immune system disorders:** TLL2 has been implicated in immune system disorders, such as rheumatoid arthritis and lupus. 3. **Cancer:** TLL2 has been found to be overexpressed in various types of cancer, including breast and lung cancer. 4. **Neurological disorders:** TLL2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TLL2 is a versatile gene involved in multiple biological processes, including extracellular matrix organization, cell differentiation, and metalloendopeptidase activity. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the role of TLL2 in human health and disease. **Future Directions:** Further research is needed to fully understand the role of TLL2 in human health and disease. This includes: 1. **Functional studies:** Investigating the functional role of TLL2 in various cellular processes. 2. **Disease modeling:** Developing disease models using TLL2-deficient mice to study the effects of TLL2 dysregulation on human disease. 3. **Therapeutic targeting:** Identifying potential therapeutic targets for TLL2-related diseases. By advancing our understanding of TLL2, we can better understand the underlying mechanisms of human disease and develop effective therapeutic strategies to treat TLL2-related disorders.

Genular Protein ID: 3148468287

Symbol: TLL2_HUMAN

Name: Tolloid-like protein 2

UniProtKB Accession Codes:

Q9Y6L7 A6NDK0 Q2M1H1 Q6PJN5 Q9UQ00

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 9 Ensembl 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10479448

Title: Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.

PubMed ID: 10479448

DOI: 10.1006/dbio.1999.9383

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11313359

Title: Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures.

PubMed ID: 11313359

DOI: 10.1074/jbc.m102352200

Sequence Information:

  • Length: 1015
  • Mass: 113557
  • Checksum: 25F5B23065861593
  • Sequence:
    • MPRATALGAL VSLLLLLPLP RGAGGLGERP DATADYSELD GEEGTEQQLE HYHDPCKAAV 
FWGDIALDED DLKLFHIDKA RDWTKQTVGA TGHSTGGLEE QASESSPDTT AMDTGTKEAG 
KDGRENTTLL HSPGTLHAAA KTFSPRVRRA TTSRTERIWP GGVIPYVIGG NFTGSQRAIF 
KQAMRHWEKH TCVTFIERTD EESFIVFSYR TCGCCSYVGR RGGGPQAISI GKNCDKFGIV 
AHELGHVVGF WHEHTRPDRD QHVTIIRENI QPGQEYNFLK MEAGEVSSLG ETYDFDSIMH 
YARNTFSRGV FLDTILPRQD DNGVRPTIGQ RVRLSQGDIA QARKLYKCPA CGETLQDTTG 
NFSAPGFPNG YPSYSHCVWR ISVTPGEKIV LNFTSMDLFK SRLCWYDYVE VRDGYWRKAP 
LLGRFCGDKI PEPLVSTDSR LWVEFRSSSN ILGKGFFAAY EATCGGDMNK DAGQIQSPNY 
PDDYRPSKEC VWRITVSEGF HVGLTFQAFE IERHDSCAYD YLEVRDGPTE ESALIGHFCG 
YEKPEDVKSS SNRLWMKFVS DGSINKAGFA ANFFKEVDEC SWPDHGGCEH RCVNTLGSYK 
CACDPGYELA ADKKMCEVAC GGFITKLNGT ITSPGWPKEY PTNKNCVWQV VAPAQYRISL 
QFEVFELEGN DVCKYDFVEV RSGLSPDAKL HGRFCGSETP EVITSQSNNM RVEFKSDNTV 
SKRGFRAHFF SDKDECAKDN GGCQHECVNT FGSYLCRCRN GYWLHENGHD CKEAGCAHKI 
SSVEGTLASP NWPDKYPSRR ECTWNISSTA GHRVKLTFNE FEIEQHQECA YDHLEMYDGP 
DSLAPILGRF CGSKKPDPTV ASGSSMFLRF YSDASVQRKG FQAVHSTECG GRLKAEVQTK 
ELYSHAQFGD NNYPSEARCD WVIVAEDGYG VELTFRTFEV EEEADCGYDY MEAYDGYDSS 
APRLGRFCGS GPLEEIYSAG DSLMIRFRTD DTINKKGFHA RYTSTKFQDA LHMKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.