Details for: LOC105370792

Gene ID: 105370792

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LOC105370792

Ensembl ID: ENSG00000174171

Description: uncharacterized LOC105370792

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • mucosal invariant T cell CL0000940
    CSI 5.09
    rCSI 4.12%
    PRS 99.96
  • Mueller cell CL0000636
    CSI 3.43
    rCSI 7.83%
    PRS 99.31
  • cardiac muscle cell CL0000746
    CSI 2.37
    rCSI 3.41%
    PRS 98.97
  • regular atrial cardiac myocyte CL0002129
    CSI 2.06
    rCSI 6.63%
    PRS 99.38
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.97
    rCSI 6.06%
    PRS 99.07

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LOC105370792](/details-gene/105370792) is an uncharacterized non-coding RNA (ncRNA) located on human chromosome 15q15.1. Its function is currently unknown. Expression analysis reveals a highly specific and unusual pattern, with its most significant expression observed in disparate cell types, including immune [mucosal invariant T cell](/details-cell/CL0000940)s, retinal [Mueller cell](/details-cell/CL0000636)s, and [cardiac muscle cell](/details-cell/CL0000746)s. This unique distribution suggests it may play a specialized regulatory role within these distinct cellular environments, although the biological processes it governs have yet to be elucidated. ## Cellular Roles and Expression Landscape The expression profile of [LOC105370792](/details-gene/105370792) is marked by high specificity in a diverse set of tissues. **Overall**, its most significant expression is found in [mucosal invariant T cell](/details-cell/CL0000940) (CSI: 5.09), an innate-like T lymphocyte population, pointing towards a potential role in immune surveillance or response. Strikingly, [LOC105370792](/details-gene/105370792) also shows high significance in non-hematopoietic lineages. It is a prominent transcript in [Mueller cell](/details-cell/CL0000636) (CSI: 3.43), the principal glial cell of the retina, suggesting a possible function in retinal homeostasis or neuronal support. Furthermore, it is significantly expressed in [cardiac muscle cell](/details-cell/CL0000746) (CSI: 2.37), including both [regular atrial cardiac myocyte](/details-cell/CL0002129) and [regular ventricular cardiac myocyte](/details-cell/CL0002131). This restricted yet varied expression pattern across immune, neural, and muscle tissues is unusual and implies that [LOC105370792](/details-gene/105370792) may be involved in a fundamental cellular process common to these specialized, high-energy-demand cells. ## Pathways and Molecular Function The molecular function of [LOC105370792](/details-gene/105370792) remains uncharacterized. As a non-coding RNA, it is hypothesized to function as a regulatory molecule, potentially a long non-coding RNA (lncRNA). Such molecules can influence gene expression through various mechanisms, including chromatin remodeling, transcriptional regulation, or post-transcriptional modification of target mRNAs. Currently, there are no established Gene Ontology (GO) or Reactome pathway annotations associated with this gene. Its functional role is inferred only from its specific expression pattern. ## Research Directions The distinct expression of [LOC105370792](/details-gene/105370792) in MAIT cells, Mueller cells, and cardiomyocytes presents a compelling biological puzzle. Future research should focus on elucidating its function and regulation in these diverse contexts. **Proposed Hypotheses:** 1. [LOC105370792](/details-gene/105370792) may be part of a shared transcriptional program activated in response to high metabolic demand or specific cellular stress. The three primary cell types where it is expressed—[mucosal invariant T cell](/details-cell/CL0000940)s, [Mueller cell](/details-cell/CL0000636)s, and [cardiac muscle cell](/details-cell/CL0000746)s—are all characterized by high energy expenditure and unique metabolic requirements. 2. The ncRNA produced by the [LOC105370792](/details-gene/105370792) locus may have distinct interacting partners or molecular targets in each cell type, leading to context-dependent functions. For instance, it could regulate immune effector functions in MAIT cells while being involved in metabolic homeostasis or structural integrity in cardiac and retinal cells. **Key Experimental Approach:** To test the hypothesis of a role in a shared metabolic stress response, one could use a combination of primary cells and in-vitro models. Primary human [mucosal invariant T cell](/details-cell/CL0000940)s, iPSC-derived [cardiac muscle cell](/details-cell/CL0000746)s, and retinal organoids containing [Mueller cell](/details-cell/CL0000636)s could be subjected to metabolic stressors such as hypoxia or glucose starvation. The expression of [LOC105370792](/details-gene/105370792) could then be quantified by qRT-PCR. Coordinated upregulation of the ncRNA across all three cell models in response to a specific stressor would provide strong evidence for a conserved role in cellular stress pathways. **Therapeutic Potential:** The therapeutic potential of [LOC105370792](/details-gene/105370792) is speculative but intriguing due to its cell-type specificity. If it is found to be a critical regulator of MAIT cell function, it could become a target for modulating the activity of this cell type in autoimmune diseases, infectious diseases, or cancer. A therapeutic strategy would likely involve **inhibition** using RNA-targeting modalities like antisense oligonucleotides (ASOs). However, its significant expression in cardiac and retinal cells presents a major safety consideration, and any therapeutic development would require a thorough assessment of on-target toxicities in these vital tissues.