Details for: FLNC AS1

Gene ID: 110806300

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: FLNC AS1

Ensembl ID: ENSG00000242902

Description: FLNC antisense RNA 1

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cardiac muscle cell CL0000746
    CSI 2.85
    rCSI 4.09%
    PRS 99.76
  • regular ventricular cardiac myocyte CL0002131
    CSI 1.13
    rCSI 7.06%
    PRS 99.81

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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  • Node Color (Target Cell CSI, relative to current network):
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    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [FLNC AS1](/details-gene/110806300) is a non-coding RNA (ncRNA) located on chromosome 7q32.1. As its name implies, it is an antisense RNA transcribed from the locus of the *FLNC* gene, which encodes the cytoskeletal protein Filamin C. Expression data indicates that [FLNC AS1](/details-gene/110806300) is a highly specific marker for cardiac muscle tissue, suggesting a primary role in the regulation of cardiomyocyte biology and heart function, likely through modulation of its sense-strand counterpart. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [FLNC AS1](/details-gene/110806300) demonstrates a remarkably high degree of tissue specificity. The gene's significance is almost exclusively confined to cells of the cardiac lineage. Its highest significance is observed in the [cardiac muscle cell](/details-cell/CL0000746) population (CSI: 2.85), indicating it serves as a strong and defining marker for this cell type. This is further supported by its significant, though lower, expression in [regular ventricular cardiac myocytes](/details-cell/CL0002131) (CSI: 1.13). The highly restricted expression pattern suggests that the function of [FLNC AS1](/details-gene/110806300) is tightly coupled to the unique physiological demands and molecular architecture of heart muscle. ## Pathways and Molecular Function While specific pathway annotations are not provided, the identity of [FLNC AS1](/details-gene/110806300) as an antisense transcript provides a strong basis for inferring its molecular function. It is expected to be involved in the post-transcriptional regulation of the *FLNC* gene. The protein product of *FLNC*, Filamin C, is a critical component of the Z-disc in cardiac and skeletal muscle, playing a vital role in myofibrillar integrity, force transmission, and mechanosensing. Therefore, by controlling the expression of *FLNC*, [FLNC AS1](/details-gene/110806300) may be an important regulator of cardiomyocyte structure and function. ## Research Directions Given the specific expression of [FLNC AS1](/details-gene/110806300) in cardiac tissue and its relationship with the cardiomyopathy-associated gene *FLNC*, further investigation into its role in both cardiac homeostasis and disease is warranted. ### Testable Hypotheses 1. **Negative Regulation of Filamin C:** [FLNC AS1](/details-gene/110806300) acts as a negative regulator of *FLNC* mRNA stability or translation in [cardiac muscle cells](/details-cell/CL0000746). Increased expression of the antisense RNA leads to reduced Filamin C protein levels, thereby influencing myofibrillar organization. 2. **Role in Pathological Remodeling:** The expression of [FLNC AS1](/details-gene/110806300) is altered in response to pathological stimuli, such as ischemic injury or pressure overload. This dysregulation contributes to adverse cardiac remodeling by disrupting the precise stoichiometric balance of Filamin C and other Z-disc proteins. ### Proposed Experiments To test the hypothesis that [FLNC AS1](/details-gene/110806300) negatively regulates *FLNC*, one could utilize an in vitro model of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). A loss-of-function experiment could be performed by transfecting iPSC-CMs with antisense oligonucleotides (ASOs) or siRNA designed to specifically degrade [FLNC AS1](/details-gene/110806300). The subsequent impact on *FLNC* mRNA levels would be quantified by qRT-PCR, while changes in Filamin C protein levels and its localization at the Z-disc would be assessed by Western blot and immunofluorescence microscopy, respectively. ### Therapeutic Potential The high cardiac specificity of [FLNC AS1](/details-gene/110806300) makes it an attractive therapeutic target. Mutations in *FLNC* are known to cause various forms of cardiomyopathy. If certain pathologies are driven by an overexpression of [FLNC AS1](/details-gene/110806300) that leads to insufficient Filamin C (haploinsufficiency), a therapeutic strategy involving the targeted **inhibition** of this ncRNA could be beneficial. ASO-based therapies designed to reduce [FLNC AS1](/details-gene/110806300) levels could restore normal Filamin C expression. The tissue-restricted expression pattern suggests that such a therapy would have a low risk of off-target effects in non-cardiac tissues.