Details for: MEOX1

Gene ID: 4222

Symbol: MEOX1

Ensembl ID: ENSG00000005102

Description: mesenchyme homeobox 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.4967
    Cell Significance Index: 86.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.4057
    Cell Significance Index: 27.3300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.4775
    Cell Significance Index: 26.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.3707
    Cell Significance Index: -4.2100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2081
    Cell Significance Index: 17.3800
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.8521
    Cell Significance Index: 7.2100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6084
    Cell Significance Index: 6.8000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.5565
    Cell Significance Index: 7.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3157
    Cell Significance Index: 9.3000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.2152
    Cell Significance Index: 1.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2072
    Cell Significance Index: 3.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0984
    Cell Significance Index: 1.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0984
    Cell Significance Index: 2.0600
  • Cell Name: vein endothelial cell of respiratory system (CL4033008)
    Fold Change: 0.0854
    Cell Significance Index: 0.5500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.0852
    Cell Significance Index: 0.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0368
    Cell Significance Index: 7.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0066
    Cell Significance Index: 2.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.4500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0014
    Cell Significance Index: -0.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0022
    Cell Significance Index: -3.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0026
    Cell Significance Index: -4.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0032
    Cell Significance Index: -0.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0062
    Cell Significance Index: -1.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0071
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0084
    Cell Significance Index: -5.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0089
    Cell Significance Index: -5.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0093
    Cell Significance Index: -4.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0109
    Cell Significance Index: -4.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0122
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0151
    Cell Significance Index: -2.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0161
    Cell Significance Index: -4.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0182
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0245
    Cell Significance Index: -5.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0288
    Cell Significance Index: -3.5400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0329
    Cell Significance Index: -0.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0372
    Cell Significance Index: -4.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0376
    Cell Significance Index: -5.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0409
    Cell Significance Index: -1.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0411
    Cell Significance Index: -3.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0451
    Cell Significance Index: -5.1700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0453
    Cell Significance Index: -0.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0467
    Cell Significance Index: -5.5100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0472
    Cell Significance Index: -2.0500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0488
    Cell Significance Index: -0.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0492
    Cell Significance Index: -5.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0494
    Cell Significance Index: -5.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0567
    Cell Significance Index: -3.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0596
    Cell Significance Index: -1.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0597
    Cell Significance Index: -2.6400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0605
    Cell Significance Index: -0.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0670
    Cell Significance Index: -4.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0779
    Cell Significance Index: -2.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0808
    Cell Significance Index: -4.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0843
    Cell Significance Index: -3.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0853
    Cell Significance Index: -5.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0859
    Cell Significance Index: -5.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0942
    Cell Significance Index: -2.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0986
    Cell Significance Index: -1.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0987
    Cell Significance Index: -3.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1003
    Cell Significance Index: -5.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1033
    Cell Significance Index: -3.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1069
    Cell Significance Index: -2.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1188
    Cell Significance Index: -3.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1255
    Cell Significance Index: -5.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1276
    Cell Significance Index: -6.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1362
    Cell Significance Index: -1.9500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.1405
    Cell Significance Index: -0.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1437
    Cell Significance Index: -3.8500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1458
    Cell Significance Index: -4.6100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1502
    Cell Significance Index: -0.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1564
    Cell Significance Index: -4.0200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1587
    Cell Significance Index: -2.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1588
    Cell Significance Index: -3.9600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1592
    Cell Significance Index: -3.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1617
    Cell Significance Index: -4.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1618
    Cell Significance Index: -5.9400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1619
    Cell Significance Index: -1.9900
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1639
    Cell Significance Index: -1.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1680
    Cell Significance Index: -3.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1693
    Cell Significance Index: -4.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1743
    Cell Significance Index: -4.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1771
    Cell Significance Index: -4.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1772
    Cell Significance Index: -4.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1790
    Cell Significance Index: -6.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1838
    Cell Significance Index: -3.6900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1941
    Cell Significance Index: -3.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1960
    Cell Significance Index: -4.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1998
    Cell Significance Index: -3.9500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2029
    Cell Significance Index: -2.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2119
    Cell Significance Index: -5.4000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2129
    Cell Significance Index: -4.1900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2153
    Cell Significance Index: -2.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2165
    Cell Significance Index: -4.7400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2170
    Cell Significance Index: -4.5300
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.2170
    Cell Significance Index: -1.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MEOX1 is a transcription factor that belongs to the homeobox gene family, which is known for its role in regulating embryonic development and tissue patterning. The gene encodes a protein with a high degree of sequence similarity to other homeobox genes, including the well-studied Hox genes. MEOX1 contains a conserved homeodomain, which is essential for its DNA-binding activity and transcriptional regulation. The gene is highly expressed in various cell types, including those of the nervous system, cardiovascular system, and retina. **Pathways and Functions:** MEOX1 is involved in multiple signaling pathways, including: 1. **Chromatin and DNA binding:** MEOX1 interacts with chromatin and DNA to regulate gene expression, with a high degree of specificity for its target genes. 2. **Hematopoietic stem cell differentiation:** MEOX1 plays a crucial role in regulating the differentiation of hematopoietic stem cells, influencing the production of blood cells. 3. **Somite development and specification:** MEOX1 is essential for the development and specification of somites, which are precursors to skeletal muscles, bones, and other tissues. 4. **Reticular and vascular development:** MEOX1 is involved in the development of reticular and vascular tissues, including the formation of cardiac endothelial cells. MEOX1's transcriptional activity is mediated through its interaction with RNA polymerase II, a key enzyme in the regulation of gene expression. The gene's ability to regulate transcriptional activity is critical for its role in cellular differentiation and development. **Clinical Significance:** MEOX1's dysregulation has been implicated in various diseases, including: 1. **Congenital heart defects:** Mutations in MEOX1 have been associated with congenital heart defects, highlighting the gene's importance in cardiac development. 2. **Neurological disorders:** MEOX1 has been implicated in the pathogenesis of neurological disorders, including autism spectrum disorder and schizophrenia. 3. **Cancer:** MEOX1's role in regulating cellular differentiation and proliferation makes it a potential target for cancer therapy. 4. **Retinal diseases:** MEOX1's involvement in retinal development and function makes it a potential therapeutic target for diseases affecting the retina, such as retinitis pigmentosa. In conclusion, MEOX1 is a critical transcription factor involved in various biological processes, including embryonic development, cell differentiation, and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms by which MEOX1 regulates gene expression and to explore its potential applications in disease treatment.

Genular Protein ID: 3105962491

Symbol: MEOX1_HUMAN

Name: Homeobox protein MOX-1

UniProtKB Accession Codes:

P50221 A8K524 A8MWF9 Q15069

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7987315

Title: Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture.

PubMed ID: 7987315

DOI: 10.1093/hmg/3.8.1359

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23290072

Title: Mutations in MEOX1, encoding mesenchyme homeobox 1, cause Klippel-Feil anomaly.

PubMed ID: 23290072

DOI: 10.1016/j.ajhg.2012.11.016

PubMed ID: 24073994

Title: Mutation in MEOX1 gene causes a recessive Klippel-Feil syndrome subtype.

PubMed ID: 24073994

DOI: 10.1186/1471-2156-14-95

Sequence Information:

  • Length: 254
  • Mass: 27997
  • Checksum: A53724BF77C02166
  • Sequence:
    • MDPAASSCMR SLQPPAPVWG CLRNPHSEGN GASGLPHYPP TPFSFHQKPD FLATATAAYP 
DFSASCLAAT PHSLPQEEHI FTEQHPAFPQ SPNWHFPVSD ARRRPNSGPA GGSKEMGTSS 
LGLVDTTGGP GDDYGVLGST ANETEKKSSR RRKESSDNQE NRGKPEGSSK ARKERTAFTK 
EQLRELEAEF AHHNYLTRLR RYEIAVNLDL SERQVKVWFQ NRRMKWKRVK GGQPISPNGQ 
DPEDGDSTAS PSSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.