Details for: GAS1

Gene ID: 2619

Symbol: GAS1

Ensembl ID: ENSG00000180447

Description: growth arrest specific 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.4139
    Cell Significance Index: -15.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.7259
    Cell Significance Index: -15.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0116
    Cell Significance Index: -15.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.5505
    Cell Significance Index: 88.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.1975
    Cell Significance Index: 23.8900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.1858
    Cell Significance Index: 14.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.1102
    Cell Significance Index: 44.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2071
    Cell Significance Index: 23.5600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.0393
    Cell Significance Index: 10.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9266
    Cell Significance Index: 65.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9021
    Cell Significance Index: 25.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8793
    Cell Significance Index: 388.7400
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.8603
    Cell Significance Index: 5.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6687
    Cell Significance Index: 127.2500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.6324
    Cell Significance Index: 5.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5200
    Cell Significance Index: 8.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5183
    Cell Significance Index: 71.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4582
    Cell Significance Index: 27.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4308
    Cell Significance Index: 55.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3258
    Cell Significance Index: 9.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2948
    Cell Significance Index: 29.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2850
    Cell Significance Index: 31.0000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.2521
    Cell Significance Index: 1.4800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1879
    Cell Significance Index: 1.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1763
    Cell Significance Index: 28.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1592
    Cell Significance Index: 143.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1092
    Cell Significance Index: 7.5500
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.0822
    Cell Significance Index: 0.4000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.0722
    Cell Significance Index: 0.3800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0552
    Cell Significance Index: 0.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0526
    Cell Significance Index: 0.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0469
    Cell Significance Index: 2.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0083
    Cell Significance Index: 15.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0028
    Cell Significance Index: 0.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0036
    Cell Significance Index: -0.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0046
    Cell Significance Index: -0.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0046
    Cell Significance Index: -0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0048
    Cell Significance Index: -8.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0089
    Cell Significance Index: -0.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0117
    Cell Significance Index: -17.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0127
    Cell Significance Index: -9.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0153
    Cell Significance Index: -8.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0171
    Cell Significance Index: -23.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0186
    Cell Significance Index: -11.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0203
    Cell Significance Index: -7.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0205
    Cell Significance Index: -15.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0243
    Cell Significance Index: -15.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0244
    Cell Significance Index: -18.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0257
    Cell Significance Index: -5.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0322
    Cell Significance Index: -14.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0327
    Cell Significance Index: -18.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0334
    Cell Significance Index: -6.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0340
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0345
    Cell Significance Index: -5.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0411
    Cell Significance Index: -2.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0419
    Cell Significance Index: -12.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0450
    Cell Significance Index: -6.5400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0539
    Cell Significance Index: -0.5200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0542
    Cell Significance Index: -0.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0551
    Cell Significance Index: -1.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0599
    Cell Significance Index: -1.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0693
    Cell Significance Index: -1.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0695
    Cell Significance Index: -13.7900
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.0749
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0849
    Cell Significance Index: -9.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0863
    Cell Significance Index: -18.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0904
    Cell Significance Index: -11.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0926
    Cell Significance Index: -10.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0946
    Cell Significance Index: -12.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0950
    Cell Significance Index: -4.4700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1045
    Cell Significance Index: -1.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1125
    Cell Significance Index: -11.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1280
    Cell Significance Index: -15.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1518
    Cell Significance Index: -15.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1610
    Cell Significance Index: -12.7500
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.1808
    Cell Significance Index: -0.9800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1855
    Cell Significance Index: -2.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1894
    Cell Significance Index: -12.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1990
    Cell Significance Index: -15.2700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2008
    Cell Significance Index: -1.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2021
    Cell Significance Index: -15.0600
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.2051
    Cell Significance Index: -2.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2054
    Cell Significance Index: -12.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2068
    Cell Significance Index: -10.8600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2077
    Cell Significance Index: -1.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2125
    Cell Significance Index: -4.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2190
    Cell Significance Index: -13.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2219
    Cell Significance Index: -14.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2362
    Cell Significance Index: -6.4300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2426
    Cell Significance Index: -5.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2632
    Cell Significance Index: -12.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2688
    Cell Significance Index: -6.9100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2787
    Cell Significance Index: -4.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2917
    Cell Significance Index: -7.7900
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.2968
    Cell Significance Index: -1.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2981
    Cell Significance Index: -8.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3395
    Cell Significance Index: -13.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3721
    Cell Significance Index: -16.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3817
    Cell Significance Index: -19.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3825
    Cell Significance Index: -10.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** GAS1 is expressed in a wide range of cell types, including respiratory basal cells, decidual cells, smooth muscle cells, keratocytes, and enterocytes. 2. **Cellular Functions:** GAS1 is involved in cell fate commitment, apoptosis, and regulation of the Hedgehog signaling pathway. 3. **Signaling Pathways:** GAS1 interacts with various signaling pathways, including the Hedgehog pathway, Smoothened signaling pathway, and ligand-receptor interactions. 4. **Protein Binding:** GAS1 binds to several proteins, including those involved in Hedgehog signaling and cell cycle regulation. **Pathways and Functions:** 1. **Hedgehog Signaling Pathway:** GAS1 is involved in the regulation of the Hedgehog signaling pathway, which is crucial for development, growth, and differentiation. 2. **Cell Cycle Regulation:** GAS1 regulates the cell cycle, particularly in the negative regulation of mitotic cell cycle and negative regulation of protein processing. 3. **Apoptosis:** GAS1 is involved in the regulation of apoptotic processes, which is essential for maintaining tissue homeostasis. 4. **Cell Fate Commitment:** GAS1 plays a crucial role in cell fate commitment, which is essential for the development and differentiation of cells. **Clinical Significance:** GAS1's involvement in various cellular processes makes it a potential target for the treatment of several diseases, including: 1. **Cancer:** GAS1's role in apoptosis and cell fate commitment makes it a potential target for cancer therapy. 2. **Neurological Disorders:** GAS1's involvement in Hedgehog signaling pathway makes it a potential target for the treatment of neurological disorders, such as spinal muscular atrophy. 3. **Cardiovascular Diseases:** GAS1's role in vascular endothelial growth factor (VEGF) signaling pathway makes it a potential target for the treatment of cardiovascular diseases. In conclusion, GAS1 is a multifaceted gene that plays a crucial role in various cellular processes, including cell fate commitment, apoptosis, and Hedgehog signaling. Its involvement in these processes makes it a potential target for the treatment of several diseases, including cancer, neurological disorders, and cardiovascular diseases.

Genular Protein ID: 1642038318

Symbol: GAS1_HUMAN

Name: Growth arrest-specific protein 1

UniProtKB Accession Codes:

P54826 B9EGM4 Q6B086

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 1 Ensembl 1 GO 12 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8127893

Title: Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene.

PubMed ID: 8127893

DOI: 10.1073/pnas.91.5.1848

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 345
  • Mass: 35693
  • Checksum: 31A0CBEEC3632F82
  • Sequence:
    • MVAALLGGGG EARGGTVPGA WLCLMALLQL LGSAPRGSGL AHGRRLICWQ ALLQCQGEPE 
CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS SRWRCPSHCI SALIQLNHTR 
RGPALEDCDC AQDENCKSTK RAIEPCLPRT SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN 
LALSRYLTYC GKVFNGLRCT DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA 
RLCFGAELGN GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA 
AASGGRGDLP YGPGRRSSGG GGRLAPRGAW TPLASILLLL LGPLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.