Gene GAS1 - ENSG00000180447 | NCBI Gene ID: 2619

Details for: GAS1

Gene ID: 2619

Symbol: GAS1

Ensembl ID: ENSG00000180447

Description: growth arrest specific 1

Associated with

Activation of smo
(R-HSA-5635838)
Hedgehog 'on' state
(R-HSA-5632684)
Ligand-receptor interactions
(R-HSA-5632681)
Signaling by hedgehog
(R-HSA-5358351)
Signal transduction
(R-HSA-162582)
Cell cycle
(GO:0007049)
Cell fate commitment
(GO:0045165)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Developmental growth
(GO:0048589)
Membrane
(GO:0016020)
Negative regulation of mitotic cell cycle
(GO:0045930)
Negative regulation of protein processing
(GO:0010955)
Oxysterol binding
(GO:0008142)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of apoptotic process
(GO:0042981)
Regulation of er to golgi vesicle-mediated transport
(GO:0060628)
Regulation of smoothened signaling pathway
(GO:0008589)
Side of membrane
(GO:0098552)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: respiratory basal cell (CL0002633)
Fold Change: 2.59
Marker Score: 3719.5
Cell Name: decidual cell (CL2000002)
Fold Change: 2.01
Marker Score: 8667
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.89
Marker Score: 715
Cell Name: keratocyte (CL0002363)
Fold Change: 1.82
Marker Score: 419
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1162
Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169360
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.37
Marker Score: 1361
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.34
Marker Score: 332
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.31
Marker Score: 3076.5
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.28
Marker Score: 412
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.27
Marker Score: 4718
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.26
Marker Score: 3299
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.12
Marker Score: 3053
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.11
Marker Score: 1546
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.08
Marker Score: 713
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.07
Marker Score: 1139
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.05
Marker Score: 236
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71815
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48039
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.99
Marker Score: 280
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 504
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 457
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 0.95
Marker Score: 1234
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 369
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5203
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 321
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.87
Marker Score: 8798
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5283
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.85
Marker Score: 479
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.85
Marker Score: 1301.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.81
Marker Score: 27695
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.79
Marker Score: 4733
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.78
Marker Score: 313
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1256
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 704
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.76
Marker Score: 374
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 576.5
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.75
Marker Score: 1573
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.74
Marker Score: 498
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.73
Marker Score: 1010
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.73
Marker Score: 231
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.72
Marker Score: 3028
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.71
Marker Score: 457
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.71
Marker Score: 650.5
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7
Marker Score: 11000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.69
Marker Score: 1168.5
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.65
Marker Score: 2511
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.63
Marker Score: 161
Cell Name: fibroblast (CL0000057)
Fold Change: 0.62
Marker Score: 602
Cell Name: supporting cell (CL0000630)
Fold Change: 0.6
Marker Score: 1129
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.6
Marker Score: 7915
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.59
Marker Score: 1200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.58
Marker Score: 2293
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 171
Cell Name: kidney cell (CL1000497)
Fold Change: 0.54
Marker Score: 360
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.52
Marker Score: 542
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.52
Marker Score: 162
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.51
Marker Score: 5800
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.5
Marker Score: 1409
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.5
Marker Score: 378
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.5
Marker Score: 598
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.49
Marker Score: 240
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.47
Marker Score: 123
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.47
Marker Score: 768.5
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.46
Marker Score: 2981
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 273
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.44
Marker Score: 930
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.44
Marker Score: 467
Cell Name: tendon cell (CL0000388)
Fold Change: 0.43
Marker Score: 106
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.42
Marker Score: 202
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.42
Marker Score: 519
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.42
Marker Score: 989
Cell Name: smooth muscle cell of small intestine (CL1000275)
Fold Change: 0.4
Marker Score: 105
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.39
Marker Score: 415
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.39
Marker Score: 96
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.39
Marker Score: 227
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.38
Marker Score: 230
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.38
Marker Score: 1857.5
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.37
Marker Score: 394.5
Cell Name: reticular cell (CL0000432)
Fold Change: 0.37
Marker Score: 136
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.37
Marker Score: 128
Cell Name: Unknown (CL0002371)
Fold Change: 0.37
Marker Score: 390
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.37
Marker Score: 345
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.37
Marker Score: 312
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.36
Marker Score: 117
Cell Name: inflammatory cell (CL0009002)
Fold Change: 0.36
Marker Score: 154
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.35
Marker Score: 160
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.35
Marker Score: 478
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.34
Marker Score: 2538
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.33
Marker Score: 206
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.32
Marker Score: 75
Cell Name: podocyte (CL0000653)
Fold Change: 0.31
Marker Score: 114
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.3
Marker Score: 109
Cell Name: neural cell (CL0002319)
Fold Change: 0.3
Marker Score: 144

Hover over a box to see details here...

**Key characteristics:** * The GAS1 gene is located on chromosome 17p13.1. * It is a member of the Gas family of cell surface receptors. * GAS1 is a key regulator of cell cycle arrest and growth. * It binds to the Gas-associated protein (GAP) and is involved in the regulation of the cell cycle. * Gas1 signaling is also involved in the regulation of apoptosis, cell migration, and tissue development. **Pathways and functions:** * GAS1 signaling is involved in the regulation of cell cycle arrest and growth. * It is a key regulator of the cell cycle in normal cells. * In cancer cells, GAS1 signaling is often overactive, leading to cell proliferation and tumor formation. * Targeting GAS1 signaling has been shown to be a potential therapeutic strategy for cancer. **Clinical significance:** * Mutations in the GAS1 gene have been linked to a number of human cancers, including lung cancer, breast cancer, and colon cancer. * Targeting GAS1 signaling has shown to be a promising therapeutic strategy for cancer. * Clinical trials of GAS1 inhibitors are currently underway to evaluate their potential for cancer treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Growth arrest-specific protein 1

Genular Protein ID: 1642038318

Symbol: GAS1_HUMAN

Name: Growth arrest-specific protein 1

UniProtKB Accession Codes:

P54826 B9EGM4 Q6B086

Database IDs:

Citations:

PubMed ID: 8127893

Title: Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene.

PubMed ID: 8127893

DOI: 10.1073/pnas.91.5.1848

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 345
Mass: 35693
Checksum: 31A0CBEEC3632F82
Sequence:

MVAALLGGGG EARGGTVPGA WLCLMALLQL LGSAPRGSGL AHGRRLICWQ ALLQCQGEPE 
CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS SRWRCPSHCI SALIQLNHTR 
RGPALEDCDC AQDENCKSTK RAIEPCLPRT SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN 
LALSRYLTYC GKVFNGLRCT DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA 
RLCFGAELGN GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA 
AASGGRGDLP YGPGRRSSGG GGRLAPRGAW TPLASILLLL LGPLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.