Details for: PCOLCE2

Gene ID: 26577

Symbol: PCOLCE2

Ensembl ID: ENSG00000163710

Description: procollagen C-endopeptidase enhancer 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.2638
    Cell Significance Index: -13.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1416
    Cell Significance Index: -15.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 6.7446
    Cell Significance Index: 180.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.1730
    Cell Significance Index: 255.8500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 4.0732
    Cell Significance Index: 51.2900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 3.4446
    Cell Significance Index: 49.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.2567
    Cell Significance Index: 71.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.9226
    Cell Significance Index: 57.0400
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 2.5754
    Cell Significance Index: 25.9900
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.1338
    Cell Significance Index: 10.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0715
    Cell Significance Index: 212.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0455
    Cell Significance Index: 198.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9375
    Cell Significance Index: 20.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8024
    Cell Significance Index: 79.3800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.7236
    Cell Significance Index: 11.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6906
    Cell Significance Index: 623.5300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.5549
    Cell Significance Index: 3.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5514
    Cell Significance Index: 42.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4475
    Cell Significance Index: 22.6100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.4411
    Cell Significance Index: 1.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3217
    Cell Significance Index: 52.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2438
    Cell Significance Index: 26.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1199
    Cell Significance Index: 8.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1049
    Cell Significance Index: 2.8100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1003
    Cell Significance Index: 0.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0920
    Cell Significance Index: 1.9600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0418
    Cell Significance Index: 0.2600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0200
    Cell Significance Index: 0.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0195
    Cell Significance Index: 0.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0191
    Cell Significance Index: 8.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0154
    Cell Significance Index: 0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0123
    Cell Significance Index: 2.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0095
    Cell Significance Index: 6.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0059
    Cell Significance Index: 2.1100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0021
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0048
    Cell Significance Index: -0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0058
    Cell Significance Index: -10.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0068
    Cell Significance Index: -10.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0097
    Cell Significance Index: -4.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0107
    Cell Significance Index: -14.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0112
    Cell Significance Index: -1.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0138
    Cell Significance Index: -8.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0164
    Cell Significance Index: -12.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0176
    Cell Significance Index: -0.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0183
    Cell Significance Index: -13.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0208
    Cell Significance Index: -15.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0210
    Cell Significance Index: -11.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0211
    Cell Significance Index: -2.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0226
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0238
    Cell Significance Index: -14.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0270
    Cell Significance Index: -2.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0273
    Cell Significance Index: -15.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0375
    Cell Significance Index: -10.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0484
    Cell Significance Index: -6.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0664
    Cell Significance Index: -8.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0712
    Cell Significance Index: -12.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0762
    Cell Significance Index: -16.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1036
    Cell Significance Index: -6.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1080
    Cell Significance Index: -12.5900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1090
    Cell Significance Index: -1.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1124
    Cell Significance Index: -6.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1149
    Cell Significance Index: -14.8500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1245
    Cell Significance Index: -1.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1290
    Cell Significance Index: -13.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1325
    Cell Significance Index: -1.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1326
    Cell Significance Index: -15.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1377
    Cell Significance Index: -15.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1382
    Cell Significance Index: -2.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1394
    Cell Significance Index: -8.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1429
    Cell Significance Index: -10.1100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1474
    Cell Significance Index: -2.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1618
    Cell Significance Index: -4.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1638
    Cell Significance Index: -5.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1687
    Cell Significance Index: -7.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1828
    Cell Significance Index: -11.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1978
    Cell Significance Index: -14.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2065
    Cell Significance Index: -6.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2228
    Cell Significance Index: -12.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2291
    Cell Significance Index: -4.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2333
    Cell Significance Index: -12.1500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2474
    Cell Significance Index: -2.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2524
    Cell Significance Index: -13.2500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2735
    Cell Significance Index: -2.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2838
    Cell Significance Index: -14.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2853
    Cell Significance Index: -12.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3253
    Cell Significance Index: -10.3600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3267
    Cell Significance Index: -3.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3314
    Cell Significance Index: -12.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3332
    Cell Significance Index: -11.5800
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.3470
    Cell Significance Index: -1.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3619
    Cell Significance Index: -10.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3622
    Cell Significance Index: -12.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3679
    Cell Significance Index: -13.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3717
    Cell Significance Index: -10.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3718
    Cell Significance Index: -17.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3847
    Cell Significance Index: -7.9800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4083
    Cell Significance Index: -5.2400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4143
    Cell Significance Index: -10.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCOLCE2 is a non-coding gene, meaning it does not encode a protein but rather regulates the expression of nearby genes. Its enhancer region is crucial for its function, as it modulates the transcription of genes involved in collagen biosynthesis and modifying enzymes. The gene's expression is tightly regulated, with notable variations in its expression levels across different tissues and cell types. This suggests that PCOLCE2 plays a significant role in tissue-specific processes and may be involved in the regulation of cell differentiation and survival. **Pathways and Functions:** PCOLCE2's involvement in various biological pathways highlights its multifaceted function: 1. **Cellular response to leukemia inhibitory factor (LIF):** PCOLCE2's expression is induced by LIF, a cytokine involved in the regulation of immune responses and tissue homeostasis. This suggests that PCOLCE2 may play a role in modulating the immune response to LIF. 2. **Collagen biosynthesis and modifying enzymes:** PCOLCE2 regulates the expression of genes involved in collagen synthesis and modification, highlighting its importance in tissue structure and development. 3. **Extracellular matrix organization:** PCOLCE2's expression is required for the proper organization of the extracellular matrix, which is essential for tissue architecture and function. 4. **Heparin binding:** PCOLCE2's interaction with heparin, a polysaccharide involved in various biological processes, suggests its involvement in the regulation of heparin-dependent signaling pathways. **Significance in Clinical Context:** The study of PCOLCE2's role in human disease is an area of active research. Its involvement in various biological pathways and its expression in specific cell types make it a potential target for therapeutic interventions: 1. **Immune-related disorders:** PCOLCE2's role in regulating the immune response to LIF and its expression in immune cells suggest its potential involvement in immune-related disorders, such as autoimmune diseases or inflammatory conditions. 2. **Cancer:** The gene's expression in various types of cancer cells, including alveolar macrophages and granulocyte monocyte progenitor cells, highlights its potential role in cancer progression and metastasis. 3. **Connective tissue disorders:** PCOLCE2's involvement in collagen biosynthesis and modifying enzymes makes it a potential target for the treatment of connective tissue disorders, such as osteoarthritis or fibrosis. In conclusion, PCOLCE2 is a gene of multifaceted function, playing a crucial role in regulating various biological processes, including collagen biosynthesis, extracellular matrix organization, and immune response. Its significance in the clinical context is an area of active research, with potential implications for the treatment of immune-related disorders, cancer, and connective tissue disorders. Further studies are needed to fully elucidate the role of PCOLCE2 in human disease and to explore its therapeutic potential.

Genular Protein ID: 485422637

Symbol: PCOC2_HUMAN

Name: Procollagen C-endopeptidase enhancer 2

UniProtKB Accession Codes:

Q9UKZ9 B2RCH9 D3DNG4 Q9BRH3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10873381

Title: Identification and expression of a novel type I procollagen C-proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24.

PubMed ID: 10873381

DOI: 10.1006/geno.2000.6229

PubMed ID: 11597177

Title: Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.

PubMed ID: 11597177

DOI: 10.1053/joca.2001.0421

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12393877

Title: PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1.

PubMed ID: 12393877

DOI: 10.1074/jbc.m209891200

Sequence Information:

  • Length: 415
  • Mass: 45717
  • Checksum: B9AA87FD9AAF7A5B
  • Sequence:
    • MRGANAWAPL CLLLAAATQL SRQQSPERPV FTCGGILTGE SGFIGSEGFP GVYPPNSKCT 
WKITVPEGKV VVLNFRFIDL ESDNLCRYDF VDVYNGHANG QRIGRFCGTF RPGALVSSGN 
KMMVQMISDA NTAGNGFMAM FSAAEPNERG DQYCGGLLDR PSGSFKTPNW PDRDYPAGVT 
CVWHIVAPKN QLIELKFEKF DVERDNYCRY DYVAVFNGGE VNDARRIGKY CGDSPPAPIV 
SERNELLIQF LSDLSLTADG FIGHYIFRPK KLPTTTEQPV TTTFPVTTGL KPTVALCQQK 
CRRTGTLEGN YCSSDFVLAG TVITTITRDG SLHATVSIIN IYKEGNLAIQ QAGKNMSARL 
TVVCKQCPLL RRGLNYIIMG QVGEDGRGKI MPNSFIMMFK TKNQKLLDAL KNKQC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.