Details for: NCAM2

Gene ID: 4685

Symbol: NCAM2

Ensembl ID: ENSG00000154654

Description: neural cell adhesion molecule 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.2004
    Cell Significance Index: -111.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.9966
    Cell Significance Index: -35.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 8.3106
    Cell Significance Index: 558.8100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 5.3413
    Cell Significance Index: 74.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.8904
    Cell Significance Index: 1754.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.5450
    Cell Significance Index: 129.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.8346
    Cell Significance Index: 2652.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.6848
    Cell Significance Index: 226.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.6684
    Cell Significance Index: 735.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.1731
    Cell Significance Index: 76.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.7550
    Cell Significance Index: 121.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.4458
    Cell Significance Index: 92.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8908
    Cell Significance Index: 19.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2695
    Cell Significance Index: 15.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1189
    Cell Significance Index: 223.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0658
    Cell Significance Index: 59.3900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0607
    Cell Significance Index: 0.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0237
    Cell Significance Index: -15.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0446
    Cell Significance Index: -8.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0633
    Cell Significance Index: -116.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0807
    Cell Significance Index: -124.3100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0836
    Cell Significance Index: -1.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0923
    Cell Significance Index: -125.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1317
    Cell Significance Index: -96.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1513
    Cell Significance Index: -112.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1704
    Cell Significance Index: -77.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1754
    Cell Significance Index: -132.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.2093
    Cell Significance Index: -114.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2133
    Cell Significance Index: -133.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2567
    Cell Significance Index: -144.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2785
    Cell Significance Index: -40.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.2811
    Cell Significance Index: -124.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3143
    Cell Significance Index: -90.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.4322
    Cell Significance Index: -77.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.5154
    Cell Significance Index: -83.8300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5554
    Cell Significance Index: -7.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.5834
    Cell Significance Index: -115.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.6805
    Cell Significance Index: -83.6700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6821
    Cell Significance Index: -6.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.6935
    Cell Significance Index: -95.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7035
    Cell Significance Index: -148.1800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.7055
    Cell Significance Index: -8.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.7161
    Cell Significance Index: -70.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.7965
    Cell Significance Index: -86.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.8126
    Cell Significance Index: -104.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.8372
    Cell Significance Index: -142.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.8814
    Cell Significance Index: -103.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.9624
    Cell Significance Index: -98.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.0166
    Cell Significance Index: -118.4700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.0259
    Cell Significance Index: -11.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0721
    Cell Significance Index: -111.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0873
    Cell Significance Index: -66.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -1.0985
    Cell Significance Index: -140.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.2276
    Cell Significance Index: -43.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.2333
    Cell Significance Index: -141.3000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.2869
    Cell Significance Index: -14.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.2908
    Cell Significance Index: -22.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.3233
    Cell Significance Index: -101.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.3364
    Cell Significance Index: -99.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.4257
    Cell Significance Index: -64.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.5605
    Cell Significance Index: -43.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.5708
    Cell Significance Index: -94.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.5894
    Cell Significance Index: -109.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.6409
    Cell Significance Index: -85.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.6410
    Cell Significance Index: -105.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.8939
    Cell Significance Index: -60.3200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -2.0655
    Cell Significance Index: -23.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -2.0684
    Cell Significance Index: -108.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.0913
    Cell Significance Index: -68.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -2.1026
    Cell Significance Index: -91.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -2.1474
    Cell Significance Index: -100.9300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -2.1661
    Cell Significance Index: -42.8300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -2.2437
    Cell Significance Index: -45.0500
  • Cell Name: neuron (CL0000540)
    Fold Change: -2.3573
    Cell Significance Index: -22.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.4410
    Cell Significance Index: -70.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -2.4705
    Cell Significance Index: -35.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.5066
    Cell Significance Index: -87.8100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.6188
    Cell Significance Index: -45.2800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -2.7873
    Cell Significance Index: -59.5800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -2.8455
    Cell Significance Index: -19.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.8515
    Cell Significance Index: -91.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.9127
    Cell Significance Index: -101.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -3.0153
    Cell Significance Index: -80.8000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -3.0672
    Cell Significance Index: -76.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -3.1072
    Cell Significance Index: -195.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -3.1116
    Cell Significance Index: -66.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -3.1636
    Cell Significance Index: -68.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.1857
    Cell Significance Index: -79.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -3.2905
    Cell Significance Index: -153.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.4409
    Cell Significance Index: -101.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.5076
    Cell Significance Index: -128.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -3.6036
    Cell Significance Index: -103.3000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -3.6083
    Cell Significance Index: -89.9800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -3.6144
    Cell Significance Index: -45.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -3.6769
    Cell Significance Index: -107.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -3.8961
    Cell Significance Index: -202.3900
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -3.9950
    Cell Significance Index: -29.0500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -4.0059
    Cell Significance Index: -78.8500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -4.0588
    Cell Significance Index: -84.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -4.0854
    Cell Significance Index: -109.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane glycoprotein**: NCAM2 is a transmembrane protein, consisting of a large extracellular domain, a transmembrane domain, and a cytoplasmic tail. This structure allows for interaction with other cells and molecules, facilitating cell-cell adhesion and signaling. 2. **Axon guidance**: NCAM2 plays a critical role in axon guidance during neuronal development, promoting the formation of specific neural connections and preventing aberrant axon growth. 3. **Cell-cell adhesion**: NCAM2 mediates cell-cell adhesion, enabling neurons to interact with each other and with other cell types, such as glial cells and epithelial cells. 4. **Neuronal communication**: NCAM2 is involved in neuronal communication, including synaptic transmission and neurotrophic support. **Pathways and Functions:** 1. **Axon fasciculation**: NCAM2 regulates axon fasciculation, the process by which axons converge and form specific neural connections. 2. **Neuronal communication**: NCAM2 facilitates neuronal communication through interaction with other molecules, such as NCAM1, L1CAM, and N-CAM. 3. **Cell-cell adhesion**: NCAM2 mediates cell-cell adhesion through interaction with integrins, cadherins, and other adhesion molecules. 4. **Signaling pathways**: NCAM2 is involved in various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which regulate cell survival, proliferation, and differentiation. **Clinical Significance:** 1. **Neurological disorders**: Alterations in NCAM2 expression have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Neurodevelopmental disorders**: NCAM2 dysfunction has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Cancer**: NCAM2 has been identified as a potential biomarker for cancer, particularly in glioblastoma and melanoma. 4. **Neuroplasticity**: NCAM2 plays a critical role in neuroplasticity, the brain's ability to reorganize and adapt in response to injury or experience. In conclusion, NCAM2 is a multifaceted gene that plays a crucial role in neural cell adhesion, communication, and development. Its dysregulation has been implicated in various neurological and non-neurological disorders, highlighting the importance of further research into the mechanisms and therapeutic potential of NCAM2.

Genular Protein ID: 1342654721

Symbol: NCAM2_HUMAN

Name: Neural cell adhesion molecule 2

UniProtKB Accession Codes:

O15394 A8MQ06 B7Z841 Q7Z7F2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 5 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9226371

Title: Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome.

PubMed ID: 9226371

DOI: 10.1006/geno.1997.4782

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

Sequence Information:

  • Length: 837
  • Mass: 93046
  • Checksum: 878EC1110562B3F3
  • Sequence:
    • MSLLLSFYLL GLLVSSGQAL LQVTISLSKV ELSVGESKFF TCTAIGEPES IDWYNPQGEK 
IISTQRVVVQ KEGVRSRLTI YNANIEDAGI YRCQATDAKG QTQEATVVLE IYQKLTFREV 
VSPQEFKQGE DAEVVCRVSS SPAPAVSWLY HNEEVTTISD NRFAMLANNN LQILNINKSD 
EGIYRCEGRV EARGEIDFRD IIVIVNVPPA ISMPQKSFNA TAERGEEMTF SCRASGSPEP 
AISWFRNGKL IEENEKYILK GSNTELTVRN IINSDGGPYV CRATNKAGED EKQAFLQVFV 
QPHIIQLKNE TTYENGQVTL VCDAEGEPIP EITWKRAVDG FTFTEGDKSL DGRIEVKGQH 
GSSSLHIKDV KLSDSGRYDC EAASRIGGHQ KSMYLDIEYA PKFISNQTIY YSWEGNPINI 
SCDVKSNPPA SIHWRRDKLV LPAKNTTNLK TYSTGRKMIL EIAPTSDNDF GRYNCTATNH 
IGTRFQEYIL ALADVPSSPY GVKIIELSQT TAKVSFNKPD SHGGVPIHHY QVDVKEVASE 
IWKIVRSHGV QTMVVLNNLE PNTTYEIRVA AVNGKGQGDY SKIEIFQTLP VREPSPPSIH 
GQPSSGKSFK LSITKQDDGG APILEYIVKY RSKDKEDQWL EKKVQGNKDH IILEHLQWTM 
GYEVQITAAN RLGYSEPTVY EFSMPPKPNI IKDTLFNGLG LGAVIGLGVA ALLLILVVTD 
VSCFFIRQCG LLMCITRRMC GKKSGSSGKS KELEEGKAAY LKDGSKEPIV EMRTEDERVT 
NHEDGSPVNE PNETTPLTEP EKLPLKEEDG KEALNPETIE IKVSNDIIQS KEDDSKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.