Details for: NCAM2

Gene ID: 4685

Symbol: NCAM2

Ensembl ID: ENSG00000154654

Description: neural cell adhesion molecule 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 7.01
    Marker Score: 23496
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 6.27
    Marker Score: 7564
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 6.09
    Marker Score: 7584
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.28
    Marker Score: 178418
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.84
    Marker Score: 25393
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 4.8
    Marker Score: 1587
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 4.78
    Marker Score: 3147
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.77
    Marker Score: 11411
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.64
    Marker Score: 6531.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.51
    Marker Score: 2021
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.1
    Marker Score: 2281.5
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.89
    Marker Score: 32918.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.71
    Marker Score: 6757.5
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.52
    Marker Score: 26565
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.41
    Marker Score: 1637
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.21
    Marker Score: 68427.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.18
    Marker Score: 9071
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 3
    Marker Score: 5037
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.94
    Marker Score: 13622
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.9
    Marker Score: 8313.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22066.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.79
    Marker Score: 49479
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.78
    Marker Score: 14915
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.56
    Marker Score: 2221
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.56
    Marker Score: 97065.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.51
    Marker Score: 37553.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.41
    Marker Score: 2986
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3
    Marker Score: 8891
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.26
    Marker Score: 870
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.11
    Marker Score: 19873
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 2.08
    Marker Score: 631
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.06
    Marker Score: 40981.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.05
    Marker Score: 8511
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.03
    Marker Score: 125090
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.97
    Marker Score: 1296
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.94
    Marker Score: 1090
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.9
    Marker Score: 7742.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18024
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.89
    Marker Score: 69670
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.79
    Marker Score: 2064
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.67
    Marker Score: 17252
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.67
    Marker Score: 14306
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2548
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.58
    Marker Score: 3205
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.53
    Marker Score: 1904
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.49
    Marker Score: 518
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.48
    Marker Score: 891
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.48
    Marker Score: 1116
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.47
    Marker Score: 614
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167748
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.34
    Marker Score: 778
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.3
    Marker Score: 436
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.29
    Marker Score: 771
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.25
    Marker Score: 511
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.2
    Marker Score: 2753
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.19
    Marker Score: 949
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.17
    Marker Score: 635
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4805
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.09
    Marker Score: 395
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.08
    Marker Score: 4502
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.06
    Marker Score: 1858
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.05
    Marker Score: 397
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16300.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.03
    Marker Score: 2428
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.03
    Marker Score: 427
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.03
    Marker Score: 495
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.02
    Marker Score: 6112
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.01
    Marker Score: 1136
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.01
    Marker Score: 4201
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71799
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48024.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.97
    Marker Score: 890
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.96
    Marker Score: 442
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5328
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.9
    Marker Score: 259
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.88
    Marker Score: 1084
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.86
    Marker Score: 13848
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.86
    Marker Score: 480
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 641
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.83
    Marker Score: 283
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.82
    Marker Score: 393
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.78
    Marker Score: 244
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.77
    Marker Score: 340
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.74
    Marker Score: 170
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.74
    Marker Score: 524
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.71
    Marker Score: 298

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Other Information

**Key Characteristics:** 1. **Transmembrane glycoprotein**: NCAM2 is a transmembrane protein, consisting of a large extracellular domain, a transmembrane domain, and a cytoplasmic tail. This structure allows for interaction with other cells and molecules, facilitating cell-cell adhesion and signaling. 2. **Axon guidance**: NCAM2 plays a critical role in axon guidance during neuronal development, promoting the formation of specific neural connections and preventing aberrant axon growth. 3. **Cell-cell adhesion**: NCAM2 mediates cell-cell adhesion, enabling neurons to interact with each other and with other cell types, such as glial cells and epithelial cells. 4. **Neuronal communication**: NCAM2 is involved in neuronal communication, including synaptic transmission and neurotrophic support. **Pathways and Functions:** 1. **Axon fasciculation**: NCAM2 regulates axon fasciculation, the process by which axons converge and form specific neural connections. 2. **Neuronal communication**: NCAM2 facilitates neuronal communication through interaction with other molecules, such as NCAM1, L1CAM, and N-CAM. 3. **Cell-cell adhesion**: NCAM2 mediates cell-cell adhesion through interaction with integrins, cadherins, and other adhesion molecules. 4. **Signaling pathways**: NCAM2 is involved in various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which regulate cell survival, proliferation, and differentiation. **Clinical Significance:** 1. **Neurological disorders**: Alterations in NCAM2 expression have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Neurodevelopmental disorders**: NCAM2 dysfunction has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Cancer**: NCAM2 has been identified as a potential biomarker for cancer, particularly in glioblastoma and melanoma. 4. **Neuroplasticity**: NCAM2 plays a critical role in neuroplasticity, the brain's ability to reorganize and adapt in response to injury or experience. In conclusion, NCAM2 is a multifaceted gene that plays a crucial role in neural cell adhesion, communication, and development. Its dysregulation has been implicated in various neurological and non-neurological disorders, highlighting the importance of further research into the mechanisms and therapeutic potential of NCAM2.

Genular Protein ID: 1342654721

Symbol: NCAM2_HUMAN

Name: Neural cell adhesion molecule 2

UniProtKB Accession Codes:

O15394 A8MQ06 B7Z841 Q7Z7F2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 5 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 9 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9226371

Title: Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome.

PubMed ID: 9226371

DOI: 10.1006/geno.1997.4782

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

Sequence Information:

  • Length: 837
  • Mass: 93046
  • Checksum: 878EC1110562B3F3
  • Sequence:
    • MSLLLSFYLL GLLVSSGQAL LQVTISLSKV ELSVGESKFF TCTAIGEPES IDWYNPQGEK 
IISTQRVVVQ KEGVRSRLTI YNANIEDAGI YRCQATDAKG QTQEATVVLE IYQKLTFREV 
VSPQEFKQGE DAEVVCRVSS SPAPAVSWLY HNEEVTTISD NRFAMLANNN LQILNINKSD 
EGIYRCEGRV EARGEIDFRD IIVIVNVPPA ISMPQKSFNA TAERGEEMTF SCRASGSPEP 
AISWFRNGKL IEENEKYILK GSNTELTVRN IINSDGGPYV CRATNKAGED EKQAFLQVFV 
QPHIIQLKNE TTYENGQVTL VCDAEGEPIP EITWKRAVDG FTFTEGDKSL DGRIEVKGQH 
GSSSLHIKDV KLSDSGRYDC EAASRIGGHQ KSMYLDIEYA PKFISNQTIY YSWEGNPINI 
SCDVKSNPPA SIHWRRDKLV LPAKNTTNLK TYSTGRKMIL EIAPTSDNDF GRYNCTATNH 
IGTRFQEYIL ALADVPSSPY GVKIIELSQT TAKVSFNKPD SHGGVPIHHY QVDVKEVASE 
IWKIVRSHGV QTMVVLNNLE PNTTYEIRVA AVNGKGQGDY SKIEIFQTLP VREPSPPSIH 
GQPSSGKSFK LSITKQDDGG APILEYIVKY RSKDKEDQWL EKKVQGNKDH IILEHLQWTM 
GYEVQITAAN RLGYSEPTVY EFSMPPKPNI IKDTLFNGLG LGAVIGLGVA ALLLILVVTD 
VSCFFIRQCG LLMCITRRMC GKKSGSSGKS KELEEGKAAY LKDGSKEPIV EMRTEDERVT 
NHEDGSPVNE PNETTPLTEP EKLPLKEEDG KEALNPETIE IKVSNDIIQS KEDDSKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.