Details for: CCN3

Gene ID: 4856

Symbol: CCN3

Ensembl ID: ENSG00000136999

Description: cellular communication network factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.9613
    Cell Significance Index: -9.3800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 24.1050
    Cell Significance Index: -9.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.8150
    Cell Significance Index: -8.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.3003
    Cell Significance Index: -8.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 7.1752
    Cell Significance Index: 192.2600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.3255
    Cell Significance Index: 51.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.4330
    Cell Significance Index: 52.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2039
    Cell Significance Index: 25.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9719
    Cell Significance Index: 44.0600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7081
    Cell Significance Index: 11.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6980
    Cell Significance Index: 19.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5508
    Cell Significance Index: 11.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4601
    Cell Significance Index: 87.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4410
    Cell Significance Index: 43.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3811
    Cell Significance Index: 5.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3803
    Cell Significance Index: 343.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3425
    Cell Significance Index: 37.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2561
    Cell Significance Index: 139.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2428
    Cell Significance Index: 39.5000
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: 0.1937
    Cell Significance Index: 1.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1817
    Cell Significance Index: 12.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1783
    Cell Significance Index: 35.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0932
    Cell Significance Index: 18.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0821
    Cell Significance Index: 10.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0589
    Cell Significance Index: 6.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0199
    Cell Significance Index: 8.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0198
    Cell Significance Index: 0.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0180
    Cell Significance Index: 0.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0148
    Cell Significance Index: 0.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0012
    Cell Significance Index: 0.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0047
    Cell Significance Index: -0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0048
    Cell Significance Index: -8.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0053
    Cell Significance Index: -0.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0103
    Cell Significance Index: -3.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0123
    Cell Significance Index: -1.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0127
    Cell Significance Index: -9.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0130
    Cell Significance Index: -0.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0136
    Cell Significance Index: -8.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0150
    Cell Significance Index: -8.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0187
    Cell Significance Index: -5.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0188
    Cell Significance Index: -3.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0227
    Cell Significance Index: -2.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0238
    Cell Significance Index: -0.2000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0285
    Cell Significance Index: -0.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0318
    Cell Significance Index: -3.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0326
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0326
    Cell Significance Index: -5.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0337
    Cell Significance Index: -3.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0489
    Cell Significance Index: -10.3100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0528
    Cell Significance Index: -0.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0545
    Cell Significance Index: -3.3500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0546
    Cell Significance Index: -0.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0579
    Cell Significance Index: -1.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0583
    Cell Significance Index: -8.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0583
    Cell Significance Index: -2.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0592
    Cell Significance Index: -0.9900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0647
    Cell Significance Index: -0.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0758
    Cell Significance Index: -3.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0779
    Cell Significance Index: -5.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0785
    Cell Significance Index: -3.6900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0792
    Cell Significance Index: -0.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0805
    Cell Significance Index: -0.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0822
    Cell Significance Index: -9.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0927
    Cell Significance Index: -9.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0954
    Cell Significance Index: -7.1100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0980
    Cell Significance Index: -1.3600
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0996
    Cell Significance Index: -0.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1134
    Cell Significance Index: -8.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1153
    Cell Significance Index: -5.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1169
    Cell Significance Index: -6.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1173
    Cell Significance Index: -3.0900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1241
    Cell Significance Index: -1.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1245
    Cell Significance Index: -3.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1252
    Cell Significance Index: -3.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1258
    Cell Significance Index: -9.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1445
    Cell Significance Index: -9.3300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1557
    Cell Significance Index: -2.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1643
    Cell Significance Index: -7.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1682
    Cell Significance Index: -9.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1774
    Cell Significance Index: -9.3100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1918
    Cell Significance Index: -2.7300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1966
    Cell Significance Index: -8.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2012
    Cell Significance Index: -8.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2013
    Cell Significance Index: -7.3900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2074
    Cell Significance Index: -4.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2092
    Cell Significance Index: -7.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2155
    Cell Significance Index: -4.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2217
    Cell Significance Index: -5.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2288
    Cell Significance Index: -7.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2321
    Cell Significance Index: -8.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2349
    Cell Significance Index: -6.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2351
    Cell Significance Index: -6.2900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2408
    Cell Significance Index: -6.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2434
    Cell Significance Index: -7.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2581
    Cell Significance Index: -6.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2716
    Cell Significance Index: -4.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCN3 exhibits a unique combination of characteristics that enable it to modulate various cellular processes. These include: 1. **Cell adhesion and migration**: CCN3 interacts with integrins and other adhesion molecules to regulate cell adhesion and migration, crucial processes in development, tissue repair, and disease. 2. **Differentiation and proliferation**: CCN3 modulates cell differentiation and proliferation by interacting with Notch signaling pathways and other transcriptional regulators. 3. **Inflammation and immune response**: CCN3 negatively regulates inflammatory responses by inhibiting the activity of various pro-inflammatory signaling pathways. 4. **Cell survival and apoptosis**: CCN3 promotes cell survival by regulating the activity of anti-apoptotic proteins and inhibiting pro-apoptotic signaling pathways. 5. **Extracellular matrix organization**: CCN3 interacts with collagen and other matrix components to regulate the organization and structure of the extracellular matrix. **Pathways and Functions** CCN3 participates in numerous signaling pathways, including: 1. **Notch signaling pathway**: CCN3 interacts with Notch receptors to regulate cell differentiation, proliferation, and survival. 2. **Wnt/β-catenin signaling pathway**: CCN3 modulates Wnt/β-catenin signaling to regulate cell proliferation and differentiation. 3. **PI3K/AKT signaling pathway**: CCN3 inhibits the PI3K/AKT pathway to regulate cell survival and apoptosis. 4. **MAPK/ERK signaling pathway**: CCN3 modulates MAPK/ERK signaling to regulate cell proliferation and differentiation. 5. **Integrin signaling pathway**: CCN3 interacts with integrins to regulate cell adhesion and migration. **Clinical Significance** CCN3 has been implicated in various diseases and disorders, including: 1. **Bone disorders**: CCN3 regulates bone formation and resorption, making it a potential therapeutic target for bone diseases such as osteoporosis. 2. **Neurological disorders**: CCN3 is involved in the development and maintenance of the nervous system, and its dysregulation has been implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: CCN3 has been shown to inhibit tumor growth and metastasis, making it a potential therapeutic target for cancer treatment. 4. **Inflammatory disorders**: CCN3 negatively regulates inflammatory responses, making it a potential therapeutic target for inflammatory diseases such as arthritis and asthma. In conclusion, CCN3 is a multifunctional protein that plays a crucial role in various cellular processes, including cell adhesion, differentiation, migration, and survival. Its dysregulation has been implicated in various diseases and disorders, making it a potential therapeutic target for the treatment of these conditions.

Genular Protein ID: 628468921

Symbol: CCN3_HUMAN

Name: Insulin-like growth factor-binding protein 9

UniProtKB Accession Codes:

P48745 B2R5X7 Q6I9S3 Q96BY5 Q9UDE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 40 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7520150

Title: Structural analysis of the human nov proto-oncogene and expression in Wilms tumor.

PubMed ID: 7520150

PubMed ID: 8622864

Title: Regulation of nov by WT1: a potential role for nov in nephrogenesis.

PubMed ID: 8622864

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1756408

Title: Expression of a gene encoding a novel potential IGF binding protein in human tissues.

PubMed ID: 1756408

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9927660

Title: The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling.

PubMed ID: 9927660

DOI: 10.1073/pnas.96.3.869

PubMed ID: 12050162

Title: The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.

PubMed ID: 12050162

DOI: 10.1074/jbc.m203727200

PubMed ID: 12695522

Title: CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family.

PubMed ID: 12695522

DOI: 10.1074/jbc.m302028200

PubMed ID: 12665631

Title: Proposal for a unified CCN nomenclature.

PubMed ID: 12665631

DOI: 10.1136/mp.56.2.127

PubMed ID: 15181016

Title: Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells.

PubMed ID: 15181016

DOI: 10.1074/jbc.m404073200

PubMed ID: 15213231

Title: CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression.

PubMed ID: 15213231

DOI: 10.1074/jbc.m403952200

PubMed ID: 15611078

Title: Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing.

PubMed ID: 15611078

DOI: 10.1074/jbc.m404903200

PubMed ID: 17463287

Title: NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells.

PubMed ID: 17463287

DOI: 10.1126/science.1136031

PubMed ID: 20139355

Title: CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration.

PubMed ID: 20139355

DOI: 10.1161/atvbaha.110.203356

PubMed ID: 21063504

Title: A novel role of CCN3 in regulating endothelial inflammation.

PubMed ID: 21063504

DOI: 10.1007/s12079-010-0095-x

PubMed ID: 21871891

Title: Novel effects of CCN3 that may direct the differentiation of chondrocytes.

PubMed ID: 21871891

DOI: 10.1016/j.febslet.2011.08.024

PubMed ID: 21344378

Title: CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin-dependent pathway.

PubMed ID: 21344378

DOI: 10.1002/jcp.22672

PubMed ID: 24722330

Title: Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-deficient mice.

PubMed ID: 24722330

DOI: 10.1371/journal.pone.0094912

Sequence Information:

  • Length: 357
  • Mass: 39162
  • Checksum: 035D5BF4576BD85B
  • Sequence:
    • MQSVQSTSFC LRKQCLCLTF LLLHLLGQVA ATQRCPPQCP GRCPATPPTC APGVRAVLDG 
CSCCLVCARQ RGESCSDLEP CDESSGLYCD RSADPSNQTG ICTAVEGDNC VFDGVIYRSG 
EKFQPSCKFQ CTCRDGQIGC VPRCQLDVLL PEPNCPAPRK VEVPGECCEK WICGPDEEDS 
LGGLTLAAYR PEATLGVEVS DSSVNCIEQT TEWTACSKSC GMGFSTRVTN RNRQCEMLKQ 
TRLCMVRPCE QEPEQPTDKK GKKCLRTKKS LKAIHLQFKN CTSLHTYKPR FCGVCSDGRC 
CTPHNTKTIQ AEFQCSPGQI VKKPVMVIGT CTCHTNCPKN NEAFLQELEL KTTRGKM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.