Details for: MEOX2

Gene ID: 4223

Symbol: MEOX2

Ensembl ID: ENSG00000106511

Description: mesenchyme homeobox 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 29.2464
    Cell Significance Index: 180.9400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.0799
    Cell Significance Index: 34.2700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.6650
    Cell Significance Index: 38.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 2.0457
    Cell Significance Index: 12.3600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1.1107
    Cell Significance Index: 6.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0924
    Cell Significance Index: 21.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4949
    Cell Significance Index: 10.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4759
    Cell Significance Index: 8.4100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1880
    Cell Significance Index: 2.7000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1811
    Cell Significance Index: 3.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1168
    Cell Significance Index: 80.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1141
    Cell Significance Index: 5.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0997
    Cell Significance Index: 20.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0399
    Cell Significance Index: 14.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0063
    Cell Significance Index: -11.8400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0065
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0115
    Cell Significance Index: -21.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0143
    Cell Significance Index: -21.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0162
    Cell Significance Index: -22.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0187
    Cell Significance Index: -5.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0239
    Cell Significance Index: -15.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0246
    Cell Significance Index: -18.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0250
    Cell Significance Index: -18.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0323
    Cell Significance Index: -6.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0324
    Cell Significance Index: -18.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0394
    Cell Significance Index: -17.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0661
    Cell Significance Index: -11.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0859
    Cell Significance Index: -18.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0868
    Cell Significance Index: -11.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0881
    Cell Significance Index: -12.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0884
    Cell Significance Index: -9.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0959
    Cell Significance Index: -16.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1218
    Cell Significance Index: -15.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1226
    Cell Significance Index: -15.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1397
    Cell Significance Index: -16.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1493
    Cell Significance Index: -11.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1601
    Cell Significance Index: -18.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1776
    Cell Significance Index: -18.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1841
    Cell Significance Index: -12.3800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2070
    Cell Significance Index: -2.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2127
    Cell Significance Index: -15.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2339
    Cell Significance Index: -3.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2817
    Cell Significance Index: -13.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2932
    Cell Significance Index: -18.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3072
    Cell Significance Index: -17.2400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3139
    Cell Significance Index: -4.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3334
    Cell Significance Index: -8.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3346
    Cell Significance Index: -14.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3457
    Cell Significance Index: -11.0100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3532
    Cell Significance Index: -3.8400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3694
    Cell Significance Index: -3.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3715
    Cell Significance Index: -10.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3788
    Cell Significance Index: -13.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4028
    Cell Significance Index: -15.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4144
    Cell Significance Index: -19.3200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4339
    Cell Significance Index: -10.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4363
    Cell Significance Index: -15.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4446
    Cell Significance Index: -12.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4765
    Cell Significance Index: -5.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4805
    Cell Significance Index: -15.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4845
    Cell Significance Index: -13.8300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4928
    Cell Significance Index: -12.2900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5036
    Cell Significance Index: -7.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5459
    Cell Significance Index: -16.0800
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.5527
    Cell Significance Index: -5.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5734
    Cell Significance Index: -21.0500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5825
    Cell Significance Index: -14.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5833
    Cell Significance Index: -14.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6138
    Cell Significance Index: -16.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6144
    Cell Significance Index: -21.5900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6229
    Cell Significance Index: -19.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6285
    Cell Significance Index: -13.3400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.6462
    Cell Significance Index: -8.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6570
    Cell Significance Index: -13.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6589
    Cell Significance Index: -17.6600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.6634
    Cell Significance Index: -7.6400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6660
    Cell Significance Index: -14.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6774
    Cell Significance Index: -18.1200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.6877
    Cell Significance Index: -8.8900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.7027
    Cell Significance Index: -7.6700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7029
    Cell Significance Index: -14.6700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.7043
    Cell Significance Index: -6.7900
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.7080
    Cell Significance Index: -7.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7083
    Cell Significance Index: -15.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7175
    Cell Significance Index: -19.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7283
    Cell Significance Index: -19.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7293
    Cell Significance Index: -14.4200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7455
    Cell Significance Index: -18.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7490
    Cell Significance Index: -21.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7518
    Cell Significance Index: -18.0300
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.7528
    Cell Significance Index: -6.3700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.7731
    Cell Significance Index: -15.7300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7762
    Cell Significance Index: -13.4200
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.7821
    Cell Significance Index: -7.9400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7822
    Cell Significance Index: -5.3000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.7897
    Cell Significance Index: -10.8300
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.7897
    Cell Significance Index: -7.7600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7974
    Cell Significance Index: -15.7000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.8049
    Cell Significance Index: -10.4200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.8056
    Cell Significance Index: -15.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulator:** MEOX2 is a transcription factor that binds to specific DNA sequences, influencing the expression of target genes involved in various developmental and immune processes. 2. **Developmental Expression:** MEOX2 is highly expressed in embryonic tissues, including limb buds, somites, and skeletal muscle, suggesting its critical role in developmental processes. 3. **Immune Cell Development:** MEOX2 is expressed in hematopoietic stem cells, megakaryocyte-erythroid progenitor cells, and granulocyte monocyte progenitor cells, indicating its involvement in immune cell development. 4. **Angiogenesis:** MEOX2 is also implicated in the regulation of angiogenesis, a process critical for tissue development and immune responses. **Pathways and Functions:** MEOX2 interacts with RNA polymerase II to regulate gene expression, influencing the development and function of multiple cell types. The gene is involved in the following pathways: 1. **Angiogenesis:** MEOX2 modulates the expression of genes involved in angiogenesis, influencing the formation of new blood vessels. 2. **Limb Development:** MEOX2 regulates the expression of genes involved in limb development, including the specification of mesenchymal cells. 3. **Somite Specification:** MEOX2 plays a critical role in the specification of somites, which give rise to skeletal muscle and other tissues. 4. **Skeletal Muscle Tissue Development:** MEOX2 regulates the expression of genes involved in skeletal muscle development, influencing the formation of muscle fibers. 5. **Negative Regulation of Cell Migration:** MEOX2 modulates the expression of genes involved in cell migration, influencing the formation of new blood vessels. **Clinical Significance:** Dysregulation of MEOX2 has been implicated in various diseases, including: 1. **Cancer:** MEOX2 is often downregulated in cancer cells, suggesting its role as a tumor suppressor. 2. **Immune Disorders:** MEOX2 is involved in the regulation of immune cell development and function, and dysregulation may contribute to immune disorders, such as autoimmune diseases. 3. **Developmental Disorders:** MEOX2 is critical for normal development, and dysregulation may contribute to developmental disorders, such as limb abnormalities. In conclusion, MEOX2 is a critical transcription factor involved in regulating developmental processes and immune function. Further studies are necessary to elucidate the mechanisms by which MEOX2 influences gene expression and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3959716872

Symbol: MEOX2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P50222 A4D127 B2R8I7 O75263 Q9UPL6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7607679

Title: Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3.

PubMed ID: 7607679

DOI: 10.1016/0888-7543(95)80174-k

PubMed ID: 7713505

Title: Molecular cloning and localization of the human GAX gene to 7p21.

PubMed ID: 7713505

DOI: 10.1006/geno.1994.1663

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16335786

Title: Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10.

PubMed ID: 16335786

DOI: 10.1007/s11010-005-0823-3

PubMed ID: 17074759

Title: The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences.

PubMed ID: 17074759

DOI: 10.1074/jbc.m606604200

PubMed ID: 19760604

Title: Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilms tumor.

PubMed ID: 19760604

DOI: 10.1002/gcc.20705

PubMed ID: 19266028

Title: Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.

PubMed ID: 19266028

DOI: 10.1371/journal.pgen.1000397

PubMed ID: 20516212

Title: Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221.

PubMed ID: 20516212

DOI: 10.1128/mcb.01237-09

PubMed ID: 22206000

Title: Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.

PubMed ID: 22206000

DOI: 10.1371/journal.pone.0029099

Sequence Information:

  • Length: 304
  • Mass: 33594
  • Checksum: 0C008479D6995389
  • Sequence:
    • MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII AGYPNEEGMF 
ASQHHRGHHH HHHHHHHHHH QQQQHQALQT NWHLPQMSSP PSAARHSLCL QPDSGGPPEL 
GSSPPVLCSN SSSLGSSTPT GAACAPGDYG RQALSPAEAE KRSGGKRKSD SSDSQEGNYK 
SEVNSKPRKE RTAFTKEQIR ELEAEFAHHN YLTRLRRYEI AVNLDLTERQ VKVWFQNRRM 
KWKRVKGGQQ GAAAREKELV NVKKGTLLPS ELSGIGAATL QQTGDSIANE DSHDSDHSSE 
HAHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.