Details for: LOXL1

Gene ID: 4016

Symbol: LOXL1

Ensembl ID: ENSG00000129038

Description: lysyl oxidase like 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.1
    Marker Score: 2538
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1158
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.52
    Marker Score: 2089
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.49
    Marker Score: 3903
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.37
    Marker Score: 308
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.32
    Marker Score: 995
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.3
    Marker Score: 853
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.24
    Marker Score: 1668
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2327
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17665
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.13
    Marker Score: 2134
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.05
    Marker Score: 268
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251785
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 786
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1
    Marker Score: 1070
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71803
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.96
    Marker Score: 1083
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.95
    Marker Score: 599.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.92
    Marker Score: 2177
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 365
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.9
    Marker Score: 5413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5133
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.88
    Marker Score: 2071
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.87
    Marker Score: 509
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.87
    Marker Score: 548
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.87
    Marker Score: 11485
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5277
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.84
    Marker Score: 7142.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.84
    Marker Score: 790
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.8
    Marker Score: 226
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.78
    Marker Score: 3271
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.75
    Marker Score: 1444
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 699
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2817
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.66
    Marker Score: 2450
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.65
    Marker Score: 184
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.65
    Marker Score: 432
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.65
    Marker Score: 308
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 377
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.62
    Marker Score: 5888
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.62
    Marker Score: 21057
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.58
    Marker Score: 705
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.58
    Marker Score: 187
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.58
    Marker Score: 133
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.58
    Marker Score: 342
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.57
    Marker Score: 4929
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.57
    Marker Score: 177
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.56
    Marker Score: 1051
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.55
    Marker Score: 6246
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.54
    Marker Score: 173
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.52
    Marker Score: 917
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.52
    Marker Score: 3838
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.5
    Marker Score: 186
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.49
    Marker Score: 607
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.49
    Marker Score: 750
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.48
    Marker Score: 141
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.48
    Marker Score: 1846
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.47
    Marker Score: 117
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.47
    Marker Score: 203
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.47
    Marker Score: 693
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.45
    Marker Score: 215
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.44
    Marker Score: 433
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.44
    Marker Score: 98
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.43
    Marker Score: 228
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.42
    Marker Score: 4320
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 181
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.41
    Marker Score: 347
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.4
    Marker Score: 463
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.39
    Marker Score: 856
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.39
    Marker Score: 114
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.39
    Marker Score: 385
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.39
    Marker Score: 140
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.39
    Marker Score: 98
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.38
    Marker Score: 464
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.38
    Marker Score: 188
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.37
    Marker Score: 2406
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.37
    Marker Score: 233
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.36
    Marker Score: 148
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.35
    Marker Score: 239
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 151
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.33
    Marker Score: 113
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.33
    Marker Score: 87
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.33
    Marker Score: 216
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.33
    Marker Score: 174.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.32
    Marker Score: 188
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 85

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Other Information

# Summary LOXL1 is a lysyl oxidase that is expressed in a variety of cell types. It is involved in the assembly of collagen fibrils and other multimeric structures, the basement membrane, and the extracellular matrix. LOXL1 is also involved in the regulation of copper ion binding, the crosslinking of collagen fibrils, and the formation of elastic fibers. # Key characteristics * LOXL1 is a transmembrane protein that is expressed in the extracellular matrix. * It is a homotrimer, meaning that it is made up of four identical subunits that are held together by disulfide bonds. * LOXL1 is a glycoprotein that is expressed on the surface of cells. * It is a key regulator of the assembly of collagen fibrils and other multimeric structures. * LOXL1 is also involved in the regulation of copper ion binding, the crosslinking of collagen fibrils, and the formation of elastic fibers. # Pathways and functions * LOXL1 is involved in the assembly of collagen fibrils and other multimeric structures. This is essential for the integrity of the extracellular matrix and for the proper function of tissues that are composed of collagen. * LOXL1 is also involved in the regulation of copper ion binding. Copper is a necessary for the assembly of collagen fibrils, and LOXL1 helps to regulate the levels of copper in the extracellular matrix. * LOXL1 is also involved in the crosslinking of collagen fibrils. This is a critical step in the assembly of collagen fibrils, and LOXL1 is essential for this process. * LOXL1 is also involved in the formation of elastic fibers. Elastic fibers are a type of collagen that is found in the skin and cartilage. LOXL1 helps to regulate the formation of elastic fibers, and this is essential for the maintenance of tissue integrity. # Clinical significance LOXL1 is a gene that is involved in a number of human diseases. Mutations in the LOXL1 gene have been linked to a number of diseases, including rheumatoid arthritis, osteoarthritis, and skin disorders. LOXL1 is also a target for therapy in some types of cancer.

Genular Protein ID: 4132469281

Symbol: LOXL1_HUMAN

Name: Lysyl oxidase homolog 1

UniProtKB Accession Codes:

Q08397 Q6NUL3 Q96BW7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7689553

Title: A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25.

PubMed ID: 7689553

DOI: 10.1016/s0021-9258(17)46643-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27339457

Title: Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.

PubMed ID: 27339457

DOI: 10.1016/j.matbio.2016.06.003

PubMed ID: 17690259

Title: Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.

PubMed ID: 17690259

DOI: 10.1126/science.1146554

PubMed ID: 18037624

Title: Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people.

PubMed ID: 18037624

DOI: 10.1093/hmg/ddm342

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19343041

Title: Association of LOXL1 gene with Finnish exfoliation syndrome patients.

PubMed ID: 19343041

DOI: 10.1038/jhg.2009.28

Sequence Information:

  • Length: 574
  • Mass: 63110
  • Checksum: 7570FEFB3E09066D
  • Sequence:
    • MALARGSRQL GALVWGACLC VLVHGQQAQP GQGSDPARWR QLIQWENNGQ VYSLLNSGSE 
YVPAGPQRSE SSSRVLLAGA PQAQQRRSHG SPRRRQAPSL PLPGRVGSDT VRGQARHPFG 
FGQVPDNWRE VAVGDSTGMA RARTSVSQQR HGGSASSVSA SAFASTYRQQ PSYPQQFPYP 
QAPFVSQYEN YDPASRTYDQ GFVYYRPAGG GVGAGAAAVA SAGVIYPYQP RARYEEYGGG 
EELPEYPPQG FYPAPERPYV PPPPPPPDGL DRRYSHSLYS EGTPGFEQAY PDPGPEAAQA 
HGGDPRLGWY PPYANPPPEA YGPPRALEPP YLPVRSSDTP PPGGERNGAQ QGRLSVGSVY 
RPNQNGRGLP DLVPDPNYVQ ASTYVQRAHL YSLRCAAEEK CLASTAYAPE ATDYDVRVLL 
RFPQRVKNQG TADFLPNRPR HTWEWHSCHQ HYHSMDEFSH YDLLDAATGK KVAEGHKASF 
CLEDSTCDFG NLKRYACTSH TQGLSPGCYD TYNADIDCQW IDITDVQPGN YILKVHVNPK 
YIVLESDFTN NVVRCNIHYT GRYVSATNCK IVQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.