Details for: LOXL1

Gene ID: 4016

Symbol: LOXL1

Ensembl ID: ENSG00000129038

Description: lysyl oxidase like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 106.5928
    Cell Significance Index: -16.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.8002
    Cell Significance Index: -16.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 37.6990
    Cell Significance Index: -15.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.0423
    Cell Significance Index: -15.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3012
    Cell Significance Index: -16.8800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 5.1513
    Cell Significance Index: 31.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1776
    Cell Significance Index: -16.4900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.3791
    Cell Significance Index: 47.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.2809
    Cell Significance Index: 139.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4635
    Cell Significance Index: 15.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3852
    Cell Significance Index: 11.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2933
    Cell Significance Index: 27.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8197
    Cell Significance Index: 155.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7977
    Cell Significance Index: 41.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6563
    Cell Significance Index: 84.1400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.6555
    Cell Significance Index: 10.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6046
    Cell Significance Index: 59.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5994
    Cell Significance Index: 12.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4591
    Cell Significance Index: 25.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4191
    Cell Significance Index: 8.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3725
    Cell Significance Index: 28.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3716
    Cell Significance Index: 335.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3350
    Cell Significance Index: 11.6400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.3322
    Cell Significance Index: 1.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3112
    Cell Significance Index: 137.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3092
    Cell Significance Index: 50.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2975
    Cell Significance Index: 32.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2724
    Cell Significance Index: 31.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2431
    Cell Significance Index: 6.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2426
    Cell Significance Index: 373.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2421
    Cell Significance Index: 17.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2354
    Cell Significance Index: 14.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1769
    Cell Significance Index: 24.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1719
    Cell Significance Index: 8.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1466
    Cell Significance Index: 5.1500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1094
    Cell Significance Index: 0.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1072
    Cell Significance Index: 7.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0949
    Cell Significance Index: 175.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0842
    Cell Significance Index: 4.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0822
    Cell Significance Index: 44.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0762
    Cell Significance Index: 143.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0742
    Cell Significance Index: 26.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0688
    Cell Significance Index: 1.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0625
    Cell Significance Index: 39.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0606
    Cell Significance Index: 12.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0529
    Cell Significance Index: 0.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0474
    Cell Significance Index: 5.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0272
    Cell Significance Index: 17.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0190
    Cell Significance Index: 0.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0163
    Cell Significance Index: 2.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0149
    Cell Significance Index: 0.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0107
    Cell Significance Index: 0.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0069
    Cell Significance Index: 0.1500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0010
    Cell Significance Index: 1.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0051
    Cell Significance Index: -3.5400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0056
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0111
    Cell Significance Index: -1.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0123
    Cell Significance Index: -5.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0131
    Cell Significance Index: -1.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0172
    Cell Significance Index: -12.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0174
    Cell Significance Index: -9.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0198
    Cell Significance Index: -15.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0275
    Cell Significance Index: -1.2500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0304
    Cell Significance Index: -0.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0348
    Cell Significance Index: -10.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0392
    Cell Significance Index: -8.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0623
    Cell Significance Index: -12.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0748
    Cell Significance Index: -8.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0759
    Cell Significance Index: -9.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0989
    Cell Significance Index: -10.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1110
    Cell Significance Index: -12.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1421
    Cell Significance Index: -16.7600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1422
    Cell Significance Index: -0.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1468
    Cell Significance Index: -15.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1567
    Cell Significance Index: -5.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1600
    Cell Significance Index: -7.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1602
    Cell Significance Index: -3.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1644
    Cell Significance Index: -12.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1824
    Cell Significance Index: -14.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2027
    Cell Significance Index: -5.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2082
    Cell Significance Index: -12.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2104
    Cell Significance Index: -6.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2403
    Cell Significance Index: -16.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2448
    Cell Significance Index: -12.7500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2524
    Cell Significance Index: -1.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2531
    Cell Significance Index: -16.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2612
    Cell Significance Index: -12.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2665
    Cell Significance Index: -11.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2689
    Cell Significance Index: -7.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2881
    Cell Significance Index: -10.9100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2955
    Cell Significance Index: -1.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3172
    Cell Significance Index: -4.7800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3228
    Cell Significance Index: -8.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3354
    Cell Significance Index: -8.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3758
    Cell Significance Index: -10.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3849
    Cell Significance Index: -12.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3946
    Cell Significance Index: -12.9200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4012
    Cell Significance Index: -3.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** LOXL1 is predominantly expressed in cells of the ECM, including fibroblasts, endothelial cells, and epithelial cells. It is also found in immune cells, such as T-helper 17 cells and immature innate lymphoid cells. 2. **Function:** LOXL1 catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen, leading to the formation of advanced glycosylation end-products (AGEs) and the crosslinking of collagen fibrils. 3. **Substrate Specificity:** LOXL1 has a broad substrate specificity, recognizing and oxidizing various lysine and hydroxylysine residues in ECM proteins. 4. **Cofactor Requirements:** LOXL1 requires copper ions as cofactors for its enzymatic activity. **Pathways and Functions:** 1. **Collagen Fibril Organization:** LOXL1 plays a critical role in the organization and crosslinking of collagen fibrils, which is essential for maintaining ECM integrity and structure. 2. **Extracellular Matrix Organization:** LOXL1 contributes to the organization and remodeling of the ECM, including the formation of basement membranes, elastic fibers, and other multimeric structures. 3. **Cell Signaling:** LOXL1 has been implicated in various cell signaling pathways, including the regulation of cell growth, differentiation, and survival. 4. **Immune Response:** LOXL1 has been shown to have immunomodulatory effects, regulating the activity of immune cells, such as T-helper 17 cells and immature innate lymphoid cells. **Clinical Significance:** 1. **Ocular Diseases:** Mutations in LOXL1 have been associated with various ocular disorders, including Fuchs' endothelial corneal dystrophy and glaucoma. 2. **Cardiovascular Diseases:** LOXL1 has been implicated in the pathogenesis of cardiovascular diseases, including atherosclerosis and hypertension. 3. **Cancer:** LOXL1 has been shown to have oncogenic properties, promoting tumor growth and metastasis. 4. **Musculoskeletal Disorders:** LOXL1 has been implicated in the pathogenesis of musculoskeletal disorders, including osteoarthritis and fibrosis. In conclusion, LOXL1 is a critical gene involved in the maintenance of ECM integrity and organization. Its dysregulation has been implicated in various clinical contexts, including ocular, cardiovascular, and musculoskeletal disorders. Further research is necessary to fully understand the mechanisms by which LOXL1 regulates ECM homeostasis and to explore its potential as a therapeutic target for the treatment of these diseases.

Genular Protein ID: 4132469281

Symbol: LOXL1_HUMAN

Name: Lysyl oxidase homolog 1

UniProtKB Accession Codes:

Q08397 Q6NUL3 Q96BW7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7689553

Title: A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25.

PubMed ID: 7689553

DOI: 10.1016/s0021-9258(17)46643-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27339457

Title: Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.

PubMed ID: 27339457

DOI: 10.1016/j.matbio.2016.06.003

PubMed ID: 35328709

Title: Cleavage of LOXL1 by BMP1 and ADAMTS14 Proteases Suggests a Role for Proteolytic Processing in the Regulation of LOXL1 Function.

PubMed ID: 35328709

DOI: 10.3390/ijms23063285

PubMed ID: 17690259

Title: Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.

PubMed ID: 17690259

DOI: 10.1126/science.1146554

PubMed ID: 18037624

Title: Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people.

PubMed ID: 18037624

DOI: 10.1093/hmg/ddm342

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19343041

Title: Association of LOXL1 gene with Finnish exfoliation syndrome patients.

PubMed ID: 19343041

DOI: 10.1038/jhg.2009.28

Sequence Information:

  • Length: 574
  • Mass: 63110
  • Checksum: 7570FEFB3E09066D
  • Sequence:
    • MALARGSRQL GALVWGACLC VLVHGQQAQP GQGSDPARWR QLIQWENNGQ VYSLLNSGSE 
YVPAGPQRSE SSSRVLLAGA PQAQQRRSHG SPRRRQAPSL PLPGRVGSDT VRGQARHPFG 
FGQVPDNWRE VAVGDSTGMA RARTSVSQQR HGGSASSVSA SAFASTYRQQ PSYPQQFPYP 
QAPFVSQYEN YDPASRTYDQ GFVYYRPAGG GVGAGAAAVA SAGVIYPYQP RARYEEYGGG 
EELPEYPPQG FYPAPERPYV PPPPPPPDGL DRRYSHSLYS EGTPGFEQAY PDPGPEAAQA 
HGGDPRLGWY PPYANPPPEA YGPPRALEPP YLPVRSSDTP PPGGERNGAQ QGRLSVGSVY 
RPNQNGRGLP DLVPDPNYVQ ASTYVQRAHL YSLRCAAEEK CLASTAYAPE ATDYDVRVLL 
RFPQRVKNQG TADFLPNRPR HTWEWHSCHQ HYHSMDEFSH YDLLDAATGK KVAEGHKASF 
CLEDSTCDFG NLKRYACTSH TQGLSPGCYD TYNADIDCQW IDITDVQPGN YILKVHVNPK 
YIVLESDFTN NVVRCNIHYT GRYVSATNCK IVQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.