Details for: C11orf96

Gene ID: 387763

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: C11orf96

Ensembl ID: ENSG00000187479

Description: chromosome 11 open reading frame 96

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cerebral cortex endothelial cell CL1001602
    CSI 18.73
    rCSI 32.39%
    PRS 90.3
  • fibroblast of lung CL0002553
    CSI 18.32
    rCSI 17.05%
    PRS 95.1
  • skin fibroblast CL0002620
    CSI 17.29
    rCSI 14.9%
    PRS 93.49
  • smooth muscle cell CL0000192
    CSI 16.87
    rCSI 40.22%
    PRS 89.34
  • stromal cell of ovary CL0002132
    CSI 16.79
    rCSI 46.14%
    PRS 95.93
  • interneuron CL0000099
    CSI 16.42
    rCSI 32.97%
    PRS 89.67
  • periportal region hepatocyte CL0019026
    CSI 15.72
    rCSI 61.15%
    PRS 90.8
  • conjunctival epithelial cell CL1000432
    CSI 15.46
    rCSI 23.61%
    PRS 93.06
  • microcirculation associated smooth muscle cell CL0008035
    CSI 14.36
    rCSI 41.57%
    PRS 93.4
  • alveolar type 1 fibroblast cell CL4028004
    CSI 14.19
    rCSI 15.54%
    PRS 95.28
  • myofibroblast cell CL0000186
    CSI 12.98
    rCSI 17.97%
    PRS 91.59
  • bronchus fibroblast of lung CL2000093
    CSI 11.31
    rCSI 9.19%
    PRS 93.68
  • retinal blood vessel endothelial cell CL0002585
    CSI 10.8
    rCSI 17.25%
    PRS 95.6
  • smooth muscle cell of prostate CL1000487
    CSI 10.35
    rCSI 60.86%
    PRS 96.05
  • vascular associated smooth muscle cell CL0000359
    CSI 10.22
    rCSI 33.15%
    PRS 92.69
  • pulmonary alveolar type 2 cell CL0002063
    CSI 9.84
    rCSI 15.26%
    PRS 94.34
  • pulmonary capillary endothelial cell CL4028001
    CSI 9.68
    rCSI 18.46%
    PRS 97.19
  • Kupffer cell CL0000091
    CSI 9.63
    rCSI 22.03%
    PRS 94.84
  • alveolar adventitial fibroblast CL4028006
    CSI 8.71
    rCSI 13.76%
    PRS 94.82
  • pancreatic stellate cell CL0002410
    CSI 8.61
    rCSI 50.08%
    PRS 95.06
  • capillary endothelial cell CL0002144
    CSI 8
    rCSI 14.66%
    PRS 93.26
  • myeloid leukocyte CL0000766
    CSI 7.87
    rCSI 7.26%
    PRS 95.09
  • vascular leptomeningeal cell CL4023051
    CSI 7.58
    rCSI 13.29%
    PRS 91.82
  • endothelial cell of lymphatic vessel CL0002138
    CSI 7.48
    rCSI 14.83%
    PRS 94.34
  • hepatic stellate cell CL0000632
    CSI 7.18
    rCSI 26.9%
    PRS 91.18
  • stromal cell CL0000499
    CSI 7.01
    rCSI 19.72%
    PRS 90.98
  • lung pericyte CL0009089
    CSI 6.79
    rCSI 17.91%
    PRS 96.62
  • blood vessel endothelial cell CL0000071
    CSI 6.78
    rCSI 14.06%
    PRS 92.63
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 6.54
    rCSI 29.99%
    PRS 95.57
  • pericyte CL0000669
    CSI 6.42
    rCSI 17.1%
    PRS 73.69
  • skeletal muscle satellite stem cell CL0008011
    CSI 6.22
    rCSI 27.72%
    PRS 97.39
  • vein endothelial cell CL0002543
    CSI 6.04
    rCSI 16.47%
    PRS 95.57
  • epithelial cell of lower respiratory tract CL0002632
    CSI 5.54
    rCSI 4.29%
    PRS 95.78
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 5.42
    rCSI 16%
    PRS 93.66
  • pancreatic acinar cell CL0002064
    CSI 5.36
    rCSI 7.13%
    PRS 95.76
  • peripheral nervous system neuron CL2000032
    CSI 5.28
    rCSI 7.2%
    PRS 88.92
  • respiratory suprabasal cell CL4033048
    CSI 5.18
    rCSI 6.64%
    PRS 95
  • progenitor cell CL0011026
    CSI 4.97
    rCSI 10.56%
    PRS 88.4
  • adventitial cell CL0002503
    CSI 4.61
    rCSI 11%
    PRS 95.75
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI 4.49
    rCSI 34.39%
    PRS 94.73
  • type EC enteroendocrine cell CL0000577
    CSI 4.48
    rCSI 15.9%
    PRS 94.58
  • contractile cell CL0000183
    CSI 4.44
    rCSI 13.1%
    PRS 93.73
  • mononuclear phagocyte CL0000113
    CSI 4.33
    rCSI 9.53%
    PRS 95.91
  • tracheobronchial smooth muscle cell CL0019019
    CSI 4.31
    rCSI 7.6%
    PRS 95.84
  • granulocyte CL0000094
    CSI 4.29
    rCSI 6.56%
    PRS 96.6
  • epithelial cell of lung CL0000082
    CSI 4.16
    rCSI 3.45%
    PRS 94.99
  • chondrocyte CL0000138
    CSI 4.12
    rCSI 6.55%
    PRS 90.66
  • centrilobular region hepatocyte CL0019029
    CSI 4.01
    rCSI 10.46%
    PRS 90.2
  • pancreatic PP cell CL0002275
    CSI 3.88
    rCSI 15.44%
    PRS 95.61
  • blood vessel smooth muscle cell CL0019018
    CSI 3.63
    rCSI 29.54%
    PRS 92.74
  • enteric smooth muscle cell CL0002504
    CSI 3.33
    rCSI 4.76%
    PRS 93.94
  • interstitial cell of Cajal CL0002088
    CSI 3.26
    rCSI 4.15%
    PRS 96.31
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 3.08
    rCSI 9.49%
    PRS 94.92
  • tendon cell CL0000388
    CSI 2.88
    rCSI 7.5%
    PRS 95.48
  • ciliated epithelial cell CL0000067
    CSI 2.88
    rCSI 2.53%
    PRS 87.11
  • fibroblast of cardiac tissue CL0002548
    CSI 2.86
    rCSI 13.68%
    PRS 94.8
  • mesenchymal cell CL0008019
    CSI 2.82
    rCSI 7.16%
    PRS 90.42
  • glandular epithelial cell CL0000150
    CSI 2.81
    rCSI 7.4%
    PRS 97.97
  • endothelial cell of arteriole CL1000412
    CSI 2.79
    rCSI 15.46%
    PRS 97.41
  • bronchiolar smooth muscle cell CL4033017
    CSI 2.75
    rCSI 41.22%
    PRS 96.78
  • mesodermal cell CL0000222
    CSI 2.66
    rCSI 3.19%
    PRS 93.26
  • retinal ganglion cell CL0000740
    CSI 2.66
    rCSI 5.87%
    PRS 86.03
  • mesenchymal stem cell of adipose tissue CL0002570
    CSI 2.57
    rCSI 14.35%
    PRS 94.93
  • renal interstitial pericyte CL1001318
    CSI 2.18
    rCSI 6%
    PRS 92.57
  • neural progenitor cell CL0011020
    CSI 2.05
    rCSI 9.03%
    PRS 84.94
  • stem cell CL0000034
    CSI 1.99
    rCSI 1.92%
    PRS 91.3
  • endothelial cell of uterus CL0009095
    CSI 1.95
    rCSI 14.24%
    PRS 97.04
  • vein endothelial cell of respiratory system CL4033008
    CSI 1.93
    rCSI 13.22%
    PRS 96.16
  • uterine smooth muscle cell CL0002601
    CSI 1.76
    rCSI 11.58%
    PRS 95.89
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.72
    rCSI 9.93%
    PRS 91.8
  • prostate gland microvascular endothelial cell CL2000059
    CSI 1.7
    rCSI 40.58%
    PRS 96.1
  • odontoblast CL0000060
    CSI 1.52
    rCSI 34.39%
    PRS 96.99
  • kidney interstitial cell CL1000500
    CSI 1.51
    rCSI 24.82%
    PRS 95.96
  • lung microvascular endothelial cell CL2000016
    CSI 1.47
    rCSI 28.3%
    PRS 96.35
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.44
    rCSI 2.55%
    PRS 84.04
  • fibroblast of breast CL4006000
    CSI 1.24
    rCSI 5.21%
    PRS 95.64
  • tracheobronchial serous cell CL0019001
    CSI 1.11
    rCSI 4.81%
    PRS 95.52
  • forebrain radial glial cell CL0013000
    CSI 1.11
    rCSI 3.55%
    PRS 93.59
  • vasa recta ascending limb cell CL1001131
    CSI 1.08
    rCSI 4.88%
    PRS 96.62
  • kidney granular cell CL0000648
    CSI 0.9
    rCSI 13.08%
    PRS 94.78
  • enteroglial cell CL4040002
    CSI 0.78
    rCSI 4.09%
    PRS 94.02
  • respiratory goblet cell CL0002370
    CSI 0.37
    rCSI 4.07%
    PRS 95.85
  • mesenchymal stem cell CL0000134
    CSI 0.22
    rCSI 2.36%
    PRS 95.2

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [C11orf96](/details-gene/387763) is a largely uncharacterized protein-coding gene located on human chromosome 11. Although its precise molecular function remains to be elucidated, expression data indicate a significant role within mesenchymal and vascular cell lineages. **Overall**, the gene shows prominent and high-significance expression in diverse structural and lining cells, including various types of fibroblasts, smooth muscle cells, and endothelial cells. The protein product has been identified in several large-scale proteomic and phosphoproteomic studies, suggesting it may be a regulated component of cellular signaling pathways involved in development and disease ([Link](https://doi.org/10.1126/scisignal.2001570), [Link](https://pubmed.ncbi.nlm.nih.gov/23186163)). ## Cellular Roles and Expression Landscape The expression profile of [C11orf96](/details-gene/387763) points towards a fundamental role in tissues of mesenchymal origin. An analysis of its **Overall** expression landscape reveals its highest significance in a range of vascular, stromal, and contractile cell types. The gene is a particularly strong marker for: * **Endothelial Cells:** It is most significantly expressed in [cerebral cortex endothelial cell](/details-cell/CL1001602) (CSI: 18.73) and is also prominent in [retinal blood vessel endothelial cell](/details-cell/CL0002585) (CSI: 10.80), suggesting a potential function in the maintenance or regulation of the microvasculature and blood-brain barrier. * **Fibroblasts:** High significance is observed in [fibroblast of lung](/details-cell/CL0002553) (CSI: 18.32), [skin fibroblast](/details-cell/CL0002620) (CSI: 17.29), and related cells like [myofibroblast cell](/details-cell/CL0000186) (CSI: 12.98), implicating it in extracellular matrix synthesis and tissue architecture. * **Smooth Muscle Cells:** The gene is highly significant across multiple smooth muscle populations, including generalized [smooth muscle cell](/details-cell/CL0000192) (CSI: 16.87) and those associated with the vasculature like [microcirculation associated smooth muscle cell](/details-cell/CL0008035) (CSI: 14.36) and [vascular associated smooth muscle cell](/details-cell/CL0000359) (CSI: 10.22). This pattern is consistent with a role in regulating vascular tone and structural integrity. Beyond these core cell types, significant expression is also noted in [interneuron](/details-cell/CL0000099) (CSI: 16.42) and [periportal region hepatocyte](/details-cell/CL0019026) (CSI: 15.72), indicating its functional relevance may extend to specialized roles within the nervous system and liver. ## Pathways and Molecular Function The specific biological pathways and molecular functions involving [C11orf96](/details-gene/387763) are not yet well-defined, and it is not currently associated with any specific GO or Reactome annotations in the provided data. However, proteomic evidence offers initial clues. The protein has been detected in phosphoproteomic screens of differentiating human embryonic stem cells, human cancer cells, and liver tissue ([Link](https://doi.org/10.1126/scisignal.2001570), [Link](https://pubmed.ncbi.nlm.nih.gov/23186163), [Link](https://doi.org/10.1016/j.jprot.2013.11.014)). This recurring identification as a phosphoprotein strongly suggests that [C11orf96](/details-gene/387763) may be a substrate for one or more protein kinases and could function as a downstream effector or regulator in intracellular signaling cascades. Its involvement in such pathways would be consistent with the diverse cellular contexts in which it is expressed. ## Research Directions The uncharacterized nature of [C11orf96](/details-gene/387763), combined with its specific expression pattern, presents several avenues for future investigation. **Proposed Hypotheses:** 1. Given its high significance in multiple fibroblast populations ([fibroblast of lung](/details-cell/CL0002553), [skin fibroblast](/details-cell/CL0002620)) and [myofibroblast cell](/details-cell/CL0000186), [C11orf96](/details-gene/387763) may be a key regulator of fibroblast activation and extracellular matrix (ECM) deposition, potentially playing a pro-fibrotic role in tissue injury and repair. 2. Based on its consistent expression across various endothelial and smooth muscle cells, [C11orf96](/details-gene/387763) could be integral to maintaining vascular homeostasis, with potential roles in regulating endothelial barrier function, vascular tone, or angiogenic processes. 3. The detection of phosphorylated C11orf96 protein in cancer cells ([Link](https://pubmed.ncbi.nlm.nih.gov/23186163)) suggests its activity could be dysregulated in malignancy. Its phosphorylation may be part of a signaling pathway that promotes cell survival, proliferation, or migration in certain cancer types. **Proposed Key Experiment:** To test the hypothesis that [C11orf96](/details-gene/387763) is involved in fibrosis (Hypothesis 1), a loss-of-function study could be performed. Primary human [fibroblast of lung](/details-cell/CL0002553) could be transfected with CRISPR-Cas9 constructs to knock out [C11orf96](/details-gene/387763). These knockout cells, alongside non-targeting controls, would be stimulated with the pro-fibrotic cytokine TGF-β. The functional consequences could be evaluated by quantifying the expression of key fibrotic markers (e.g., *COL1A1*, *ACTA2*) via qPCR, assessing protein levels of collagen and alpha-smooth muscle actin by Western blot, and performing a collagen gel contraction assay to measure the cells' ability to remodel the ECM. **Therapeutic Potential:** The therapeutic potential of [C11orf96](/details-gene/387763) is currently speculative. If it is validated as a pro-fibrotic factor, it could become a novel target for **inhibition** in diseases characterized by excessive fibrosis, such as idiopathic pulmonary fibrosis or scleroderma. However, its widespread expression in healthy vascular and stromal tissues suggests that systemic inhibition could lead to significant off-target effects. A more viable strategy might involve targeting a specific post-translational modification, such as a disease-relevant phosphorylation site, or developing therapies for localized delivery to affected tissues.

Genular Protein ID: 396093082

Symbol: CK096_HUMAN

Name: Uncharacterized protein C11orf96

UniProtKB Accession Codes:

Q7Z7L8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GeneCards 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 InParanoid 1 InterPro 1 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 435
  • Mass: 46114
  • Checksum: F536980973B14478
  • Sequence:
    • MGNKQPQKVT VPTGTALQGV VLIVSTLHQP GGWICGKDPC CSLRPLSNSV QNALACKSKQ 
DYQAGILFKT RAFISRDCGS DAAEDSASKG ETYTLTLEHK GAGEGDLRPR GQPGWCRLGD 
PRRDSARPVA AIEGPCPGAA RASRVLRGRG FSRNPRGRGL PSGAGWRGAG GAGEGAVTFP 
ERRGDVRRKG AGRARFKWHS LSSELRAVWA AAGYISREPG RRGADGDSSG GERLGARRNS 
APRAPCPPTG PPARPPSRGA PARAREGRRH PAADLDPPPG EPPAAASRGA PAQRPPSESP 
GAPPPGPADA GGAMAAKPGE LMGICSSYQA VMPHFVCLAD EFPQPVRPAK LPKGRGRLRR 
PRQSRFKTQP VTFDEIQEVE EEGVSPMEEE KAKKSFLQSL ECLRRSTQSL SLQREQLSSC 
KLRNSLDSSD SDSAL

Genular Protein ID: 380964152

Symbol: A0A087WW59_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WW59

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 122
  • Mass: 13773
  • Checksum: 41536609D601CA90
  • Sequence:
    • MAAKPGELMG ICSSYQAVMP HFVCLADEFP QPVRPAKLPK GRGRLRRPRQ SRFKTQPVTF 
DEIQEVEEEG VSPMEEEKAK KSFLQSLECL RRSTQSLSLQ REQLSSCKLR NSLDSSDSDS 
AL