Details for: PRELP

Gene ID: 5549

Symbol: PRELP

Ensembl ID: ENSG00000188783

Description: proline and arginine rich end leucine rich repeat protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 105.1784
    Cell Significance Index: -16.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.5000
    Cell Significance Index: -16.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.3780
    Cell Significance Index: -13.8700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 6.3958
    Cell Significance Index: 43.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1003
    Cell Significance Index: -16.1800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 3.1062
    Cell Significance Index: 49.2800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.4255
    Cell Significance Index: 20.4700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.3311
    Cell Significance Index: 7.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1654
    Cell Significance Index: 28.2300
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 1.1485
    Cell Significance Index: 11.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1451
    Cell Significance Index: 22.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6886
    Cell Significance Index: 14.7200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6128
    Cell Significance Index: 7.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4983
    Cell Significance Index: 14.2900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.4185
    Cell Significance Index: 3.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3442
    Cell Significance Index: 44.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2892
    Cell Significance Index: 13.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2500
    Cell Significance Index: 47.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2500
    Cell Significance Index: 12.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1928
    Cell Significance Index: 122.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1715
    Cell Significance Index: 3.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1505
    Cell Significance Index: 3.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1428
    Cell Significance Index: 128.9100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1235
    Cell Significance Index: 1.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1101
    Cell Significance Index: 68.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0973
    Cell Significance Index: 9.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0865
    Cell Significance Index: 162.9100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0571
    Cell Significance Index: 0.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0350
    Cell Significance Index: 5.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0262
    Cell Significance Index: 3.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0240
    Cell Significance Index: 10.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0130
    Cell Significance Index: 5.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0039
    Cell Significance Index: 0.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0065
    Cell Significance Index: -0.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0065
    Cell Significance Index: -2.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0084
    Cell Significance Index: -1.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0099
    Cell Significance Index: -18.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0120
    Cell Significance Index: -0.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0122
    Cell Significance Index: -18.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0142
    Cell Significance Index: -19.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0157
    Cell Significance Index: -2.8300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0171
    Cell Significance Index: -0.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0196
    Cell Significance Index: -14.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0250
    Cell Significance Index: -5.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0294
    Cell Significance Index: -16.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0333
    Cell Significance Index: -0.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0356
    Cell Significance Index: -0.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0368
    Cell Significance Index: -10.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0380
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0404
    Cell Significance Index: -6.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0428
    Cell Significance Index: -6.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0575
    Cell Significance Index: -7.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0645
    Cell Significance Index: -12.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0833
    Cell Significance Index: -2.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0845
    Cell Significance Index: -5.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0989
    Cell Significance Index: -11.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1023
    Cell Significance Index: -11.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1114
    Cell Significance Index: -8.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1154
    Cell Significance Index: -5.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1169
    Cell Significance Index: -8.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1209
    Cell Significance Index: -12.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1271
    Cell Significance Index: -13.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1275
    Cell Significance Index: -15.0400
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.1288
    Cell Significance Index: -0.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1440
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1510
    Cell Significance Index: -17.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1518
    Cell Significance Index: -2.5400
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.1624
    Cell Significance Index: -0.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1706
    Cell Significance Index: -10.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1836
    Cell Significance Index: -11.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1840
    Cell Significance Index: -13.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2043
    Cell Significance Index: -9.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2045
    Cell Significance Index: -13.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2107
    Cell Significance Index: -10.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2404
    Cell Significance Index: -7.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2405
    Cell Significance Index: -14.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2412
    Cell Significance Index: -6.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2882
    Cell Significance Index: -16.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3165
    Cell Significance Index: -16.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3303
    Cell Significance Index: -17.1600
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.3351
    Cell Significance Index: -3.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3389
    Cell Significance Index: -10.8000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3544
    Cell Significance Index: -3.7000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3558
    Cell Significance Index: -15.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3730
    Cell Significance Index: -16.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3854
    Cell Significance Index: -13.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3874
    Cell Significance Index: -14.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4017
    Cell Significance Index: -13.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4142
    Cell Significance Index: -13.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4392
    Cell Significance Index: -16.6300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.4492
    Cell Significance Index: -4.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4595
    Cell Significance Index: -12.2700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4779
    Cell Significance Index: -5.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4813
    Cell Significance Index: -10.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4839
    Cell Significance Index: -12.0700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4852
    Cell Significance Index: -12.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4864
    Cell Significance Index: -13.8800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.4896
    Cell Significance Index: -5.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PRELP is a type II end leucine-rich repeat (ELRR) protein, which means it contains two LRR domains separated by a proline-rich region. This unique structure allows PRELP to interact with other proteins and the extracellular matrix, facilitating its role in collagen synthesis and glycosaminoglycan metabolism. The protein is also characterized by its high content of proline and arginine residues, which are essential for its stability and function. **Pathways and Functions** PRELP is involved in several key biological pathways, including: 1. **Collagen synthesis**: PRELP plays a crucial role in the synthesis of collagen, a key structural protein in the extracellular matrix. It interacts with collagen-related proteins, such as collagen type III, to facilitate the formation of collagen fibrils. 2. **Glycosaminoglycan metabolism**: PRELP is involved in the metabolism of glycosaminoglycans (GAGs), which are important components of the extracellular matrix. It interacts with enzymes involved in GAG synthesis and degradation, regulating the balance of these processes. 3. **Cellular senescence**: PRELP has been implicated in the regulation of cellular senescence, a state of cell cycle arrest that occurs in response to DNA damage or other forms of cellular stress. PRELP may play a role in modulating the senescence response, influencing cell survival and proliferation. 4. **Extracellular matrix structural constituent**: PRELP is a key component of the extracellular matrix, providing structural support and compression resistance to tissues. **Clinical Significance** Dysregulation of PRELP has been implicated in several diseases, including: 1. **Mucopolysaccharidoses**: PRELP is involved in the metabolism of glycosaminoglycans, and mutations in the PRELP gene have been associated with mucopolysaccharidoses, a group of disorders characterized by the accumulation of GAGs. 2. **Keratan sulfate disorders**: PRELP is involved in the synthesis and degradation of keratan sulfate, a glycosaminoglycan that plays a critical role in tissue development and maintenance. Mutations in the PRELP gene have been associated with keratan sulfate disorders, which can cause a range of symptoms, including skeletal abnormalities and vision problems. 3. **Atherosclerosis**: PRELP has been implicated in the development of atherosclerosis, a disease characterized by the accumulation of lipids and inflammatory cells in the arterial wall. PRELP may play a role in modulating the inflammatory response and regulating the formation of atherosclerotic plaques. In conclusion, PRELP is a critical protein involved in various biological processes, including collagen synthesis, glycosaminoglycan metabolism, and cellular senescence. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 2473859461

Symbol: PRELP_HUMAN

Name: Prolargin

UniProtKB Accession Codes:

P51888 Q6FG38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7592739

Title: The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissues.

PubMed ID: 7592739

DOI: 10.1074/jbc.270.43.25639

PubMed ID: 8954791

Title: The gene organization, chromosome location, and expression of a 55-kDa matrix protein (PRELP) of human articular cartilage.

PubMed ID: 8954791

DOI: 10.1006/geno.1996.0605

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11007795

Title: The amino-terminal part of PRELP binds to heparin and heparan sulfate.

PubMed ID: 11007795

DOI: 10.1074/jbc.m007917200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 382
  • Mass: 43810
  • Checksum: A1C4E166B7515695
  • Sequence:
    • MRSPLCWLLP LLILASVAQG QPTRRPRPGT GPGRRPRPRP RPTPSFPQPD EPAEPTDLPP 
PLPPGPPSIF PDCPRECYCP PDFPSALYCD SRNLRKVPVI PPRIHYLYLQ NNFITELPVE 
SFQNATGLRW INLDNNRIRK IDQRVLEKLP GLVFLYMEKN QLEEVPSALP RNLEQLRLSQ 
NHISRIPPGV FSKLENLLLL DLQHNRLSDG VFKPDTFHGL KNLMQLNLAH NILRKMPPRV 
PTAIHQLYLD SNKIETIPNG YFKSFPNLAF IRLNYNKLTD RGLPKNSFNI SNLLVLHLSH 
NRISSVPAIN NRLEHLYLNN NSIEKINGTQ ICPNDLVAFH DFSSDLENVP HLRYLRLDGN 
YLKPPIPLDL MMCFRLLQSV VI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.