Details for: TNFAIP6

Gene ID: 7130

Symbol: TNFAIP6

Ensembl ID: ENSG00000123610

Description: TNF alpha induced protein 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 69.4975
    Cell Significance Index: -10.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.8160
    Cell Significance Index: -10.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 27.6006
    Cell Significance Index: -11.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.7134
    Cell Significance Index: -10.0400
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 18.3195
    Cell Significance Index: 105.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 13.7956
    Cell Significance Index: 395.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.5473
    Cell Significance Index: -10.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.7838
    Cell Significance Index: -10.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4886
    Cell Significance Index: -9.8200
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.3728
    Cell Significance Index: 11.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9373
    Cell Significance Index: -4.2400
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.2878
    Cell Significance Index: 3.8300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.9006
    Cell Significance Index: 9.8300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.7075
    Cell Significance Index: 7.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3197
    Cell Significance Index: 15.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2638
    Cell Significance Index: 34.0800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1365
    Cell Significance Index: 1.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1271
    Cell Significance Index: 2.6600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0851
    Cell Significance Index: 1.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0790
    Cell Significance Index: 1.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0578
    Cell Significance Index: 1.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0514
    Cell Significance Index: 2.6000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0511
    Cell Significance Index: 0.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0467
    Cell Significance Index: 5.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0215
    Cell Significance Index: 0.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0066
    Cell Significance Index: 1.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0044
    Cell Significance Index: 2.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0037
    Cell Significance Index: -0.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -6.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0045
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0058
    Cell Significance Index: -9.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0073
    Cell Significance Index: -3.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0078
    Cell Significance Index: -10.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0125
    Cell Significance Index: -2.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0130
    Cell Significance Index: -8.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0130
    Cell Significance Index: -9.8100
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0175
    Cell Significance Index: -0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0207
    Cell Significance Index: -9.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0209
    Cell Significance Index: -7.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0212
    Cell Significance Index: -4.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0227
    Cell Significance Index: -1.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0361
    Cell Significance Index: -4.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0375
    Cell Significance Index: -6.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0395
    Cell Significance Index: -7.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0455
    Cell Significance Index: -4.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0517
    Cell Significance Index: -7.5200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0588
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0668
    Cell Significance Index: -7.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0703
    Cell Significance Index: -8.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0868
    Cell Significance Index: -10.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0873
    Cell Significance Index: -6.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0895
    Cell Significance Index: -10.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0913
    Cell Significance Index: -6.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0981
    Cell Significance Index: -11.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1023
    Cell Significance Index: -10.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1121
    Cell Significance Index: -5.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1223
    Cell Significance Index: -9.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1399
    Cell Significance Index: -3.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1411
    Cell Significance Index: -3.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1420
    Cell Significance Index: -3.6500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1456
    Cell Significance Index: -2.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1467
    Cell Significance Index: -6.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1528
    Cell Significance Index: -10.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1750
    Cell Significance Index: -11.0300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1778
    Cell Significance Index: -1.1000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1784
    Cell Significance Index: -1.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1790
    Cell Significance Index: -11.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1987
    Cell Significance Index: -8.1400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2052
    Cell Significance Index: -1.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2061
    Cell Significance Index: -10.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2085
    Cell Significance Index: -10.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2114
    Cell Significance Index: -11.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2138
    Cell Significance Index: -5.7100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2342
    Cell Significance Index: -1.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2343
    Cell Significance Index: -8.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2358
    Cell Significance Index: -10.4300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2424
    Cell Significance Index: -3.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2662
    Cell Significance Index: -9.3300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2693
    Cell Significance Index: -4.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2773
    Cell Significance Index: -10.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2789
    Cell Significance Index: -4.7800
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2843
    Cell Significance Index: -1.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2857
    Cell Significance Index: -9.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2923
    Cell Significance Index: -8.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3039
    Cell Significance Index: -9.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3202
    Cell Significance Index: -11.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3457
    Cell Significance Index: -6.7600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3506
    Cell Significance Index: -11.0900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3530
    Cell Significance Index: -1.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3703
    Cell Significance Index: -10.0800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3716
    Cell Significance Index: -9.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3753
    Cell Significance Index: -10.7100
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.3780
    Cell Significance Index: -2.7200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3871
    Cell Significance Index: -9.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3910
    Cell Significance Index: -6.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3916
    Cell Significance Index: -11.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3925
    Cell Significance Index: -11.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TNFAIP6 is a multifunctional protein that exhibits a wide range of characteristics, including: 1. **Calcium ion binding**: TNFAIP6 has a high affinity for calcium ions, which is essential for its regulatory functions. 2. **Carboxylesterase activity**: TNFAIP6 possesses carboxylesterase activity, which allows it to hydrolyze ester bonds and regulate protein function. 3. **Cell-cell signaling**: TNFAIP6 participates in cell-cell signaling pathways, influencing cell migration, adhesion, and differentiation. 4. **Fibronectin binding**: TNFAIP6 interacts with fibronectin, a glycoprotein that plays a critical role in cell adhesion and tissue organization. **Pathways and Functions** TNFAIP6 is involved in various signaling pathways, including: 1. **Negative regulation of BMP signaling pathway**: TNFAIP6 inhibits the BMP (Bone Morphogenetic Protein) signaling pathway, which is essential for osteoblast differentiation and bone formation. 2. **Negative regulation of inflammatory response**: TNFAIP6 modulates the inflammatory response by inhibiting the production of pro-inflammatory cytokines and chemokines. 3. **Negative regulation of neutrophil chemotaxis**: TNFAIP6 reduces neutrophil migration and activation, which is essential for preventing tissue damage during inflammation. 4. **Negative regulation of osteoclast differentiation**: TNFAIP6 inhibits osteoclast formation, which is critical for maintaining bone homeostasis. In addition to its regulatory functions, TNFAIP6 also participates in various cellular processes, including: 1. **Cell migration**: TNFAIP6 promotes cell migration by interacting with fibronectin and other extracellular matrix proteins. 2. **Receptor clustering**: TNFAIP6 facilitates receptor clustering, which is essential for signal transduction and cellular response. 3. **Protein binding**: TNFAIP6 interacts with various proteins, including receptors, signaling molecules, and extracellular matrix proteins. **Clinical Significance** TNFAIP6 has been implicated in various diseases, including: 1. **Osteoarthritis**: TNFAIP6 has been shown to play a role in osteoarthritis, a degenerative joint disease characterized by cartilage degradation and bone remodeling. 2. **Rheumatoid Arthritis**: TNFAIP6 has been implicated in rheumatoid arthritis, an autoimmune disease characterized by inflammation and joint destruction. 3. **Cancer**: TNFAIP6 has been shown to play a role in cancer progression, including metastasis and tumor growth. 4. **Neurological disorders**: TNFAIP6 has been implicated in neurological disorders, including Alzheimer's disease and multiple sclerosis. In conclusion, TNFAIP6 is a multifunctional protein that plays a critical role in regulating various physiological and pathological processes. Its involvement in inflammation, immune response, and tissue homeostasis highlights its significance in different diseases, including osteoarthritis, rheumatoid arthritis, cancer, and neurological disorders. Further research is necessary to fully understand the mechanisms of TNFAIP6 and its potential therapeutic applications.

Genular Protein ID: 2242421511

Symbol: TSG6_HUMAN

Name: Tumor necrosis factor-inducible gene 6 protein

UniProtKB Accession Codes:

P98066 Q53TI7 Q8WWI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 7 VEuPathDB 1 eggNOG 2 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1730767

Title: A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.

PubMed ID: 1730767

DOI: 10.1083/jcb.116.2.545

PubMed ID: 11854277

Title: A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression.

PubMed ID: 11854277

DOI: 10.1074/jbc.m110765200

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7516184

Title: TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor.

PubMed ID: 7516184

DOI: 10.1021/bi00189a049

PubMed ID: 15060082

Title: TSG-6 modulates the interaction between hyaluronan and cell surface CD44.

PubMed ID: 15060082

DOI: 10.1074/jbc.m313319200

PubMed ID: 15917224

Title: Characterization of the interaction between tumor necrosis factor-stimulated gene-6 and heparin: implications for the inhibition of plasmin in extracellular matrix microenvironments.

PubMed ID: 15917224

DOI: 10.1074/jbc.m502068200

PubMed ID: 16771708

Title: Tumour necrosis factor alpha-stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by osteogenic differentiation medium and BMP-2.

PubMed ID: 16771708

DOI: 10.1042/bj20060027

PubMed ID: 16873769

Title: TSG-6 potentiates the antitissue kallikrein activity of inter-alpha-inhibitor through bikunin release.

PubMed ID: 16873769

DOI: 10.1165/rcmb.2006-0018oc

PubMed ID: 18586671

Title: TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation.

PubMed ID: 18586671

DOI: 10.1074/jbc.m802138200

PubMed ID: 18042364

Title: TSG-6 binds via its CUB_C domain to the cell-binding domain of fibronectin and increases fibronectin matrix assembly.

PubMed ID: 18042364

DOI: 10.1016/j.matbio.2007.10.003

PubMed ID: 20463016

Title: The TSG-6/HC2-mediated transfer is a dynamic process shuffling heavy chains between glycosaminoglycans.

PubMed ID: 20463016

DOI: 10.1074/jbc.m109.041046

PubMed ID: 24501198

Title: TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8.

PubMed ID: 24501198

DOI: 10.4049/jimmunol.1300194

PubMed ID: 26823460

Title: Binding of Hyaluronan to the Native Lymphatic Vessel Endothelial Receptor LYVE-1 Is Critically Dependent on Receptor Clustering and Hyaluronan Organization.

PubMed ID: 26823460

DOI: 10.1074/jbc.m115.708305

PubMed ID: 27044744

Title: The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.

PubMed ID: 27044744

DOI: 10.1074/jbc.m116.720953

PubMed ID: 8797823

Title: Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration.

PubMed ID: 8797823

DOI: 10.1016/s0092-8674(00)80151-8

PubMed ID: 26468290

Title: Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix.

PubMed ID: 26468290

DOI: 10.1074/jbc.m115.669838

Sequence Information:

  • Length: 277
  • Mass: 31203
  • Checksum: E2B3AEB76353A782
  • Sequence:
    • MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT YAEAKAVCEF 
EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNCGFGKTGI IDYGIRLNRS 
ERWDAYCYNP HAKECGGVFT DPKQIFKSPG FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF 
DLEDDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF 
QIKYVAMDPV SKSSQGKNTS TTSTGNKNFL AGRFSHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.