Details for: TNFAIP6

Gene ID: 7130

Symbol: TNFAIP6

Ensembl ID: ENSG00000123610

Description: TNF alpha induced protein 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.96
    Marker Score: 134890
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 3.06
    Marker Score: 1745
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.99
    Marker Score: 1093
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.53
    Marker Score: 1089
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.03
    Marker Score: 2788
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.88
    Marker Score: 784
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.86
    Marker Score: 1583
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.69
    Marker Score: 420
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.67
    Marker Score: 420
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.64
    Marker Score: 581
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168974
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.43
    Marker Score: 900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.21
    Marker Score: 1489
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.08
    Marker Score: 578
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.01
    Marker Score: 227
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2464
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.94
    Marker Score: 2459
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5308
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.83
    Marker Score: 235
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 623
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.79
    Marker Score: 273
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.74
    Marker Score: 182
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.73
    Marker Score: 246
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.71
    Marker Score: 4250
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.65
    Marker Score: 629
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1313
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.62
    Marker Score: 34874
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.61
    Marker Score: 2995
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.6
    Marker Score: 289
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.56
    Marker Score: 1743
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 445
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.55
    Marker Score: 2277
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.51
    Marker Score: 247
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5
    Marker Score: 951
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.5
    Marker Score: 1225.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.49
    Marker Score: 524
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 128.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.48
    Marker Score: 292
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.45
    Marker Score: 2744
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.43
    Marker Score: 192
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.41
    Marker Score: 94
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.41
    Marker Score: 99
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 388.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.38
    Marker Score: 952
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.37
    Marker Score: 156
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.37
    Marker Score: 109
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 215
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.35
    Marker Score: 225
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.35
    Marker Score: 454
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.35
    Marker Score: 4600.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.34
    Marker Score: 5304
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.33
    Marker Score: 141
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.31
    Marker Score: 210
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.31
    Marker Score: 387
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.31
    Marker Score: 76
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.31
    Marker Score: 107
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.3
    Marker Score: 463
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.29
    Marker Score: 119
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.28
    Marker Score: 588
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.28
    Marker Score: 312
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.28
    Marker Score: 234
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.28
    Marker Score: 327
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.28
    Marker Score: 199
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.27
    Marker Score: 70
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 130
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.27
    Marker Score: 120
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.27
    Marker Score: 70
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.27
    Marker Score: 309
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.26
    Marker Score: 115
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.25
    Marker Score: 278
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.24
    Marker Score: 76
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.24
    Marker Score: 396.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.24
    Marker Score: 165
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.24
    Marker Score: 247
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.24
    Marker Score: 235
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 134
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.23
    Marker Score: 130
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.23
    Marker Score: 369
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.23
    Marker Score: 227
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.22
    Marker Score: 5672.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.22
    Marker Score: 56
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.22
    Marker Score: 523
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 136
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.2
    Marker Score: 200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2
    Marker Score: 451
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.2
    Marker Score: 384
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2
    Marker Score: 176
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.19
    Marker Score: 125

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Other Information

**Key Characteristics** TNFAIP6 is a multifunctional protein that exhibits a wide range of characteristics, including: 1. **Calcium ion binding**: TNFAIP6 has a high affinity for calcium ions, which is essential for its regulatory functions. 2. **Carboxylesterase activity**: TNFAIP6 possesses carboxylesterase activity, which allows it to hydrolyze ester bonds and regulate protein function. 3. **Cell-cell signaling**: TNFAIP6 participates in cell-cell signaling pathways, influencing cell migration, adhesion, and differentiation. 4. **Fibronectin binding**: TNFAIP6 interacts with fibronectin, a glycoprotein that plays a critical role in cell adhesion and tissue organization. **Pathways and Functions** TNFAIP6 is involved in various signaling pathways, including: 1. **Negative regulation of BMP signaling pathway**: TNFAIP6 inhibits the BMP (Bone Morphogenetic Protein) signaling pathway, which is essential for osteoblast differentiation and bone formation. 2. **Negative regulation of inflammatory response**: TNFAIP6 modulates the inflammatory response by inhibiting the production of pro-inflammatory cytokines and chemokines. 3. **Negative regulation of neutrophil chemotaxis**: TNFAIP6 reduces neutrophil migration and activation, which is essential for preventing tissue damage during inflammation. 4. **Negative regulation of osteoclast differentiation**: TNFAIP6 inhibits osteoclast formation, which is critical for maintaining bone homeostasis. In addition to its regulatory functions, TNFAIP6 also participates in various cellular processes, including: 1. **Cell migration**: TNFAIP6 promotes cell migration by interacting with fibronectin and other extracellular matrix proteins. 2. **Receptor clustering**: TNFAIP6 facilitates receptor clustering, which is essential for signal transduction and cellular response. 3. **Protein binding**: TNFAIP6 interacts with various proteins, including receptors, signaling molecules, and extracellular matrix proteins. **Clinical Significance** TNFAIP6 has been implicated in various diseases, including: 1. **Osteoarthritis**: TNFAIP6 has been shown to play a role in osteoarthritis, a degenerative joint disease characterized by cartilage degradation and bone remodeling. 2. **Rheumatoid Arthritis**: TNFAIP6 has been implicated in rheumatoid arthritis, an autoimmune disease characterized by inflammation and joint destruction. 3. **Cancer**: TNFAIP6 has been shown to play a role in cancer progression, including metastasis and tumor growth. 4. **Neurological disorders**: TNFAIP6 has been implicated in neurological disorders, including Alzheimer's disease and multiple sclerosis. In conclusion, TNFAIP6 is a multifunctional protein that plays a critical role in regulating various physiological and pathological processes. Its involvement in inflammation, immune response, and tissue homeostasis highlights its significance in different diseases, including osteoarthritis, rheumatoid arthritis, cancer, and neurological disorders. Further research is necessary to fully understand the mechanisms of TNFAIP6 and its potential therapeutic applications.

Genular Protein ID: 2242421511

Symbol: TSG6_HUMAN

Name: Tumor necrosis factor-inducible gene 6 protein

UniProtKB Accession Codes:

P98066 Q53TI7 Q8WWI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 7 VEuPathDB 1 eggNOG 2 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1730767

Title: A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.

PubMed ID: 1730767

DOI: 10.1083/jcb.116.2.545

PubMed ID: 11854277

Title: A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression.

PubMed ID: 11854277

DOI: 10.1074/jbc.m110765200

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7516184

Title: TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor.

PubMed ID: 7516184

DOI: 10.1021/bi00189a049

PubMed ID: 15060082

Title: TSG-6 modulates the interaction between hyaluronan and cell surface CD44.

PubMed ID: 15060082

DOI: 10.1074/jbc.m313319200

PubMed ID: 15917224

Title: Characterization of the interaction between tumor necrosis factor-stimulated gene-6 and heparin: implications for the inhibition of plasmin in extracellular matrix microenvironments.

PubMed ID: 15917224

DOI: 10.1074/jbc.m502068200

PubMed ID: 16771708

Title: Tumour necrosis factor alpha-stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by osteogenic differentiation medium and BMP-2.

PubMed ID: 16771708

DOI: 10.1042/bj20060027

PubMed ID: 16873769

Title: TSG-6 potentiates the antitissue kallikrein activity of inter-alpha-inhibitor through bikunin release.

PubMed ID: 16873769

DOI: 10.1165/rcmb.2006-0018oc

PubMed ID: 18586671

Title: TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation.

PubMed ID: 18586671

DOI: 10.1074/jbc.m802138200

PubMed ID: 18042364

Title: TSG-6 binds via its CUB_C domain to the cell-binding domain of fibronectin and increases fibronectin matrix assembly.

PubMed ID: 18042364

DOI: 10.1016/j.matbio.2007.10.003

PubMed ID: 20463016

Title: The TSG-6/HC2-mediated transfer is a dynamic process shuffling heavy chains between glycosaminoglycans.

PubMed ID: 20463016

DOI: 10.1074/jbc.m109.041046

PubMed ID: 24501198

Title: TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8.

PubMed ID: 24501198

DOI: 10.4049/jimmunol.1300194

PubMed ID: 26823460

Title: Binding of Hyaluronan to the Native Lymphatic Vessel Endothelial Receptor LYVE-1 Is Critically Dependent on Receptor Clustering and Hyaluronan Organization.

PubMed ID: 26823460

DOI: 10.1074/jbc.m115.708305

PubMed ID: 27044744

Title: The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.

PubMed ID: 27044744

DOI: 10.1074/jbc.m116.720953

PubMed ID: 8797823

Title: Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration.

PubMed ID: 8797823

DOI: 10.1016/s0092-8674(00)80151-8

PubMed ID: 26468290

Title: Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix.

PubMed ID: 26468290

DOI: 10.1074/jbc.m115.669838

Sequence Information:

  • Length: 277
  • Mass: 31203
  • Checksum: E2B3AEB76353A782
  • Sequence:
    • MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT YAEAKAVCEF 
EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNCGFGKTGI IDYGIRLNRS 
ERWDAYCYNP HAKECGGVFT DPKQIFKSPG FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF 
DLEDDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF 
QIKYVAMDPV SKSSQGKNTS TTSTGNKNFL AGRFSHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.