Details for: FZD1

Gene ID: 8321

Symbol: FZD1

Ensembl ID: ENSG00000157240

Description: frizzled class receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 3.82
    Marker Score: 4612
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 3.07
    Marker Score: 4402
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.37
    Marker Score: 2777
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16319
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.03
    Marker Score: 391
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48022
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.99
    Marker Score: 2336
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Marker Score: 1862
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.98
    Marker Score: 695
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.97
    Marker Score: 306
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.96
    Marker Score: 1475
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5254
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.88
    Marker Score: 843
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5275
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.85
    Marker Score: 196
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.83
    Marker Score: 646
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.8
    Marker Score: 2833
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.74
    Marker Score: 1024
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 668
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.72
    Marker Score: 1884
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.72
    Marker Score: 9489
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.69
    Marker Score: 221
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.68
    Marker Score: 214
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.66
    Marker Score: 441
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.65
    Marker Score: 2422
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.64
    Marker Score: 687
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.63
    Marker Score: 580
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.62
    Marker Score: 333
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.62
    Marker Score: 1564
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.61
    Marker Score: 368
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.58
    Marker Score: 1428
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.58
    Marker Score: 604
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.57
    Marker Score: 540
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.57
    Marker Score: 699
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.56
    Marker Score: 184
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.55
    Marker Score: 7308
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.55
    Marker Score: 155
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 259
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.49
    Marker Score: 324
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.49
    Marker Score: 307.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.49
    Marker Score: 2383
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.47
    Marker Score: 461
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 193
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.45
    Marker Score: 2945
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.45
    Marker Score: 198
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.44
    Marker Score: 470
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 440
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 415
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.43
    Marker Score: 415
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.43
    Marker Score: 14498
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.42
    Marker Score: 147
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.42
    Marker Score: 1028
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.42
    Marker Score: 98
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.42
    Marker Score: 981.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.41
    Marker Score: 238
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.4
    Marker Score: 421
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4
    Marker Score: 269
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.4
    Marker Score: 98
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.39
    Marker Score: 213
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.39
    Marker Score: 1296
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.38
    Marker Score: 183
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.38
    Marker Score: 175
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.38
    Marker Score: 237
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.37
    Marker Score: 527
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.37
    Marker Score: 4985
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.37
    Marker Score: 98
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.37
    Marker Score: 196
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.37
    Marker Score: 391
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.36
    Marker Score: 81
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.36
    Marker Score: 343
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.35
    Marker Score: 408
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.35
    Marker Score: 130
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.34
    Marker Score: 783
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.34
    Marker Score: 97
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.33
    Marker Score: 3698
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.32
    Marker Score: 357
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.31
    Marker Score: 81
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.31
    Marker Score: 10653
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.31
    Marker Score: 271
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.3
    Marker Score: 775
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.3
    Marker Score: 528
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 299.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.29
    Marker Score: 291
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.29
    Marker Score: 115
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.29
    Marker Score: 597

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Other Information

**Key Characteristics** FZD1 is a G protein-coupled receptor that binds to Wnt proteins, which are secreted signaling molecules that interact with Frizzled receptors to activate downstream signaling pathways. FZD1 is a class B/2 receptor, which is distinct from class A receptors, and it exhibits unique characteristics, including: 1. **Asymmetric localization of PCP proteins**: FZD1 is involved in the asymmetric localization of Paraxis-1 (PCP1) and Paraxis-2 (PCP2) proteins, which are essential for planar cell polarity (PCP) signaling. 2. **Negative regulation of BMP signaling pathway**: FZD1 negatively regulates the BMP (Bone Morphogenetic Protein) signaling pathway, which is involved in cell differentiation and development. 3. **Positive regulation of DNA-binding transcription factor activity**: FZD1 positively regulates the activity of DNA-binding transcription factors, such as TCF/LEF, which are essential for Wnt signaling. 4. **Regulation of mesenchymal stem cell differentiation**: FZD1 is involved in the regulation of mesenchymal stem cell differentiation, which is essential for tissue repair and development. **Pathways and Functions** FZD1 is involved in several signaling pathways, including: 1. **Canonical Wnt signaling pathway**: FZD1 is involved in the canonical Wnt signaling pathway, which is a key pathway involved in cell differentiation, proliferation, and survival. 2. **Non-canonical Wnt signaling pathway**: FZD1 is also involved in the non-canonical Wnt signaling pathway, which is involved in cell migration, polarity, and differentiation. 3. **PCP pathway**: FZD1 is involved in the planar cell polarity (PCP) pathway, which is essential for cell polarization and tissue morphogenesis. 4. **Endothelial cell differentiation**: FZD1 is involved in the regulation of endothelial cell differentiation, which is essential for vascular development and maintenance. **Clinical Significance** FZD1 has been implicated in various diseases and disorders, including: 1. **Neurological disorders**: FZD1 has been implicated in neurological disorders, such as autism, schizophrenia, and Alzheimer's disease. 2. **Cancer**: FZD1 has been implicated in cancer, including colorectal cancer, breast cancer, and lung cancer. 3. **Cardiovascular disease**: FZD1 has been implicated in cardiovascular disease, including atherosclerosis and heart failure. 4. **Musculoskeletal disorders**: FZD1 has been implicated in musculoskeletal disorders, including osteoarthritis and muscular dystrophy. Overall, FZD1 plays a critical role in various cellular processes, including cell signaling, differentiation, and development. Its dysregulation has been implicated in various diseases and disorders, highlighting its importance as a potential therapeutic target.

Genular Protein ID: 492647807

Symbol: FZD1_HUMAN

Name: Frizzled-1

UniProtKB Accession Codes:

Q9UP38 A4D1E8 O94815 Q549T8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 GO 38 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10557084

Title: Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.

PubMed ID: 10557084

DOI: 10.1038/sj.onc.1202985

PubMed ID: 9813155

Title: Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.

PubMed ID: 9813155

DOI: 10.1006/bbrc.1998.9607

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9707618

Title: A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.

PubMed ID: 9707618

DOI: 10.1073/pnas.95.17.10164

PubMed ID: 19188438

Title: Myocilin is a modulator of Wnt signaling.

PubMed ID: 19188438

DOI: 10.1128/mcb.01274-08

PubMed ID: 27680706

Title: Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

PubMed ID: 27680706

DOI: 10.1038/nature19799

Sequence Information:

  • Length: 647
  • Mass: 71158
  • Checksum: 7FC916A736482826
  • Sequence:
    • MAEEEAPKKS RAAGGGASWE LCAGALSARL AEEGSGDAGG RRRPPVDPRR LARQLLLLLW 
LLEAPLLLGV RAQAAGQGPG QGPGPGQQPP PPPQQQQSGQ QYNGERGISV PDHGYCQPIS 
IPLCTDIAYN QTIMPNLLGH TNQEDAGLEV HQFYPLVKVQ CSAELKFFLC SMYAPVCTVL 
EQALPPCRSL CERARQGCEA LMNKFGFQWP DTLKCEKFPV HGAGELCVGQ NTSDKGTPTP 
SLLPEFWTSN PQHGGGGHRG GFPGGAGASE RGKFSCPRAL KVPSYLNYHF LGEKDCGAPC 
EPTKVYGLMY FGPEELRFSR TWIGIWSVLC CASTLFTVLT YLVDMRRFSY PERPIIFLSG 
CYTAVAVAYI AGFLLEDRVV CNDKFAEDGA RTVAQGTKKE GCTILFMMLY FFSMASSIWW 
VILSLTWFLA AGMKWGHEAI EANSQYFHLA AWAVPAIKTI TILALGQVDG DVLSGVCFVG 
LNNVDALRGF VLAPLFVYLF IGTSFLLAGF VSLFRIRTIM KHDGTKTEKL EKLMVRIGVF 
SVLYTVPATI VIACYFYEQA FRDQWERSWV AQSCKSYAIP CPHLQAGGGA PPHPPMSPDF 
TVFMIKYLMT LIVGITSGFW IWSGKTLNSW RKFYTRLTNS KQGETTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.