Details for: FZD1

Gene ID: 8321

Symbol: FZD1

Ensembl ID: ENSG00000157240

Description: frizzled class receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.9703
    Cell Significance Index: -14.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.7081
    Cell Significance Index: -14.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.9588
    Cell Significance Index: -13.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 24.3300
    Cell Significance Index: -12.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.5819
    Cell Significance Index: -14.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5707
    Cell Significance Index: -14.0900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.3102
    Cell Significance Index: 35.1700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.1433
    Cell Significance Index: 13.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7076
    Cell Significance Index: 324.9600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.5092
    Cell Significance Index: 24.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2873
    Cell Significance Index: 35.0400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.1018
    Cell Significance Index: 17.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6235
    Cell Significance Index: 562.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5712
    Cell Significance Index: 34.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5280
    Cell Significance Index: 57.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5204
    Cell Significance Index: 51.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4895
    Cell Significance Index: 216.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4635
    Cell Significance Index: 75.3800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4421
    Cell Significance Index: 3.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3115
    Cell Significance Index: 6.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2774
    Cell Significance Index: 2.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2559
    Cell Significance Index: 17.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2389
    Cell Significance Index: 32.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1909
    Cell Significance Index: 24.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1906
    Cell Significance Index: 4.1300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1857
    Cell Significance Index: 1.7900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.1727
    Cell Significance Index: 1.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1480
    Cell Significance Index: 80.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1395
    Cell Significance Index: 25.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1387
    Cell Significance Index: 17.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1245
    Cell Significance Index: 3.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1227
    Cell Significance Index: 5.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1186
    Cell Significance Index: 5.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0979
    Cell Significance Index: 2.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0959
    Cell Significance Index: 6.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0624
    Cell Significance Index: 10.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0564
    Cell Significance Index: 6.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0538
    Cell Significance Index: 2.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0406
    Cell Significance Index: 0.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0382
    Cell Significance Index: 4.9400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0062
    Cell Significance Index: 0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0038
    Cell Significance Index: -5.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0047
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0049
    Cell Significance Index: -3.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0050
    Cell Significance Index: -9.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0057
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0096
    Cell Significance Index: -5.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0098
    Cell Significance Index: -18.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0100
    Cell Significance Index: -1.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0101
    Cell Significance Index: -15.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0128
    Cell Significance Index: -9.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0134
    Cell Significance Index: -10.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0135
    Cell Significance Index: -1.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0138
    Cell Significance Index: -8.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0158
    Cell Significance Index: -3.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0255
    Cell Significance Index: -0.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0266
    Cell Significance Index: -12.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0296
    Cell Significance Index: -0.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0320
    Cell Significance Index: -11.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0393
    Cell Significance Index: -8.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0541
    Cell Significance Index: -1.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0568
    Cell Significance Index: -11.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0608
    Cell Significance Index: -1.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0680
    Cell Significance Index: -3.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0718
    Cell Significance Index: -0.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0822
    Cell Significance Index: -11.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0861
    Cell Significance Index: -4.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0880
    Cell Significance Index: -6.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0941
    Cell Significance Index: -10.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1069
    Cell Significance Index: -3.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1107
    Cell Significance Index: -13.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1110
    Cell Significance Index: -4.5500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1117
    Cell Significance Index: -1.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1221
    Cell Significance Index: -7.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1298
    Cell Significance Index: -9.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1348
    Cell Significance Index: -14.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1472
    Cell Significance Index: -11.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1484
    Cell Significance Index: -3.7100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1530
    Cell Significance Index: -1.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1530
    Cell Significance Index: -10.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1548
    Cell Significance Index: -5.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1655
    Cell Significance Index: -1.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1874
    Cell Significance Index: -11.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1882
    Cell Significance Index: -11.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1973
    Cell Significance Index: -11.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2390
    Cell Significance Index: -7.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2488
    Cell Significance Index: -3.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2590
    Cell Significance Index: -13.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2695
    Cell Significance Index: -7.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2808
    Cell Significance Index: -7.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2909
    Cell Significance Index: -6.3700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3095
    Cell Significance Index: -13.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3128
    Cell Significance Index: -13.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3128
    Cell Significance Index: -8.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3157
    Cell Significance Index: -11.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3475
    Cell Significance Index: -9.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3593
    Cell Significance Index: -6.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3634
    Cell Significance Index: -9.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3673
    Cell Significance Index: -13.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FZD1 is a G protein-coupled receptor that binds to Wnt proteins, which are secreted signaling molecules that interact with Frizzled receptors to activate downstream signaling pathways. FZD1 is a class B/2 receptor, which is distinct from class A receptors, and it exhibits unique characteristics, including: 1. **Asymmetric localization of PCP proteins**: FZD1 is involved in the asymmetric localization of Paraxis-1 (PCP1) and Paraxis-2 (PCP2) proteins, which are essential for planar cell polarity (PCP) signaling. 2. **Negative regulation of BMP signaling pathway**: FZD1 negatively regulates the BMP (Bone Morphogenetic Protein) signaling pathway, which is involved in cell differentiation and development. 3. **Positive regulation of DNA-binding transcription factor activity**: FZD1 positively regulates the activity of DNA-binding transcription factors, such as TCF/LEF, which are essential for Wnt signaling. 4. **Regulation of mesenchymal stem cell differentiation**: FZD1 is involved in the regulation of mesenchymal stem cell differentiation, which is essential for tissue repair and development. **Pathways and Functions** FZD1 is involved in several signaling pathways, including: 1. **Canonical Wnt signaling pathway**: FZD1 is involved in the canonical Wnt signaling pathway, which is a key pathway involved in cell differentiation, proliferation, and survival. 2. **Non-canonical Wnt signaling pathway**: FZD1 is also involved in the non-canonical Wnt signaling pathway, which is involved in cell migration, polarity, and differentiation. 3. **PCP pathway**: FZD1 is involved in the planar cell polarity (PCP) pathway, which is essential for cell polarization and tissue morphogenesis. 4. **Endothelial cell differentiation**: FZD1 is involved in the regulation of endothelial cell differentiation, which is essential for vascular development and maintenance. **Clinical Significance** FZD1 has been implicated in various diseases and disorders, including: 1. **Neurological disorders**: FZD1 has been implicated in neurological disorders, such as autism, schizophrenia, and Alzheimer's disease. 2. **Cancer**: FZD1 has been implicated in cancer, including colorectal cancer, breast cancer, and lung cancer. 3. **Cardiovascular disease**: FZD1 has been implicated in cardiovascular disease, including atherosclerosis and heart failure. 4. **Musculoskeletal disorders**: FZD1 has been implicated in musculoskeletal disorders, including osteoarthritis and muscular dystrophy. Overall, FZD1 plays a critical role in various cellular processes, including cell signaling, differentiation, and development. Its dysregulation has been implicated in various diseases and disorders, highlighting its importance as a potential therapeutic target.

Genular Protein ID: 492647807

Symbol: FZD1_HUMAN

Name: Frizzled-1

UniProtKB Accession Codes:

Q9UP38 A4D1E8 O94815 Q549T8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 2 Ensembl 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10557084

Title: Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.

PubMed ID: 10557084

DOI: 10.1038/sj.onc.1202985

PubMed ID: 9813155

Title: Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.

PubMed ID: 9813155

DOI: 10.1006/bbrc.1998.9607

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9707618

Title: A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.

PubMed ID: 9707618

DOI: 10.1073/pnas.95.17.10164

PubMed ID: 19188438

Title: Myocilin is a modulator of Wnt signaling.

PubMed ID: 19188438

DOI: 10.1128/mcb.01274-08

PubMed ID: 27680706

Title: Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

PubMed ID: 27680706

DOI: 10.1038/nature19799

Sequence Information:

  • Length: 647
  • Mass: 71158
  • Checksum: 7FC916A736482826
  • Sequence:
    • MAEEEAPKKS RAAGGGASWE LCAGALSARL AEEGSGDAGG RRRPPVDPRR LARQLLLLLW 
LLEAPLLLGV RAQAAGQGPG QGPGPGQQPP PPPQQQQSGQ QYNGERGISV PDHGYCQPIS 
IPLCTDIAYN QTIMPNLLGH TNQEDAGLEV HQFYPLVKVQ CSAELKFFLC SMYAPVCTVL 
EQALPPCRSL CERARQGCEA LMNKFGFQWP DTLKCEKFPV HGAGELCVGQ NTSDKGTPTP 
SLLPEFWTSN PQHGGGGHRG GFPGGAGASE RGKFSCPRAL KVPSYLNYHF LGEKDCGAPC 
EPTKVYGLMY FGPEELRFSR TWIGIWSVLC CASTLFTVLT YLVDMRRFSY PERPIIFLSG 
CYTAVAVAYI AGFLLEDRVV CNDKFAEDGA RTVAQGTKKE GCTILFMMLY FFSMASSIWW 
VILSLTWFLA AGMKWGHEAI EANSQYFHLA AWAVPAIKTI TILALGQVDG DVLSGVCFVG 
LNNVDALRGF VLAPLFVYLF IGTSFLLAGF VSLFRIRTIM KHDGTKTEKL EKLMVRIGVF 
SVLYTVPATI VIACYFYEQA FRDQWERSWV AQSCKSYAIP CPHLQAGGGA PPHPPMSPDF 
TVFMIKYLMT LIVGITSGFW IWSGKTLNSW RKFYTRLTNS KQGETTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.