Details for: TMEM97

Gene ID: 27346

Symbol: TMEM97

Ensembl ID: ENSG00000109084

Description: transmembrane protein 97

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 99.9709
    Cell Significance Index: -15.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.8264
    Cell Significance Index: -14.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 30.9230
    Cell Significance Index: -20.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.4855
    Cell Significance Index: -17.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 9.4758
    Cell Significance Index: 87.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5779
    Cell Significance Index: -20.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.9599
    Cell Significance Index: 309.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6553
    Cell Significance Index: -18.3700
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 4.0876
    Cell Significance Index: 19.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.0088
    Cell Significance Index: 105.4100
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 3.9320
    Cell Significance Index: 22.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.4527
    Cell Significance Index: 37.5400
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 3.2813
    Cell Significance Index: 16.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6221
    Cell Significance Index: 160.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6121
    Cell Significance Index: 290.6200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.5548
    Cell Significance Index: 11.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.5151
    Cell Significance Index: 258.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4832
    Cell Significance Index: 51.5400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.4209
    Cell Significance Index: 19.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4179
    Cell Significance Index: 85.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3630
    Cell Significance Index: 28.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1352
    Cell Significance Index: 123.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0164
    Cell Significance Index: 124.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8682
    Cell Significance Index: 141.2100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8660
    Cell Significance Index: 11.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8445
    Cell Significance Index: 167.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7787
    Cell Significance Index: 16.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6669
    Cell Significance Index: 602.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6308
    Cell Significance Index: 44.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6200
    Cell Significance Index: 4.9500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.5256
    Cell Significance Index: 0.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4888
    Cell Significance Index: 266.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4193
    Cell Significance Index: 23.5300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.4138
    Cell Significance Index: 2.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3903
    Cell Significance Index: 172.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3817
    Cell Significance Index: 12.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3632
    Cell Significance Index: 19.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2849
    Cell Significance Index: 39.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2379
    Cell Significance Index: 45.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1883
    Cell Significance Index: 2.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1696
    Cell Significance Index: 60.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1594
    Cell Significance Index: 18.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1457
    Cell Significance Index: 18.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1431
    Cell Significance Index: 16.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1408
    Cell Significance Index: 106.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1270
    Cell Significance Index: 3.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1122
    Cell Significance Index: 22.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1020
    Cell Significance Index: 70.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0860
    Cell Significance Index: 11.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0304
    Cell Significance Index: 1.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0240
    Cell Significance Index: 1.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0106
    Cell Significance Index: 0.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0045
    Cell Significance Index: 0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0009
    Cell Significance Index: 0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0017
    Cell Significance Index: -1.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0068
    Cell Significance Index: -12.7700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0126
    Cell Significance Index: -0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0141
    Cell Significance Index: -26.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0164
    Cell Significance Index: -25.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0177
    Cell Significance Index: -10.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0197
    Cell Significance Index: -26.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0255
    Cell Significance Index: -16.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0364
    Cell Significance Index: -3.7200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.0374
    Cell Significance Index: -0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0399
    Cell Significance Index: -18.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0438
    Cell Significance Index: -9.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0490
    Cell Significance Index: -5.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0522
    Cell Significance Index: -1.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0522
    Cell Significance Index: -1.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0607
    Cell Significance Index: -1.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0615
    Cell Significance Index: -3.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0651
    Cell Significance Index: -18.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0804
    Cell Significance Index: -2.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0822
    Cell Significance Index: -2.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0907
    Cell Significance Index: -10.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1062
    Cell Significance Index: -1.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1091
    Cell Significance Index: -2.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1108
    Cell Significance Index: -2.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1215
    Cell Significance Index: -7.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1230
    Cell Significance Index: -17.8800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1514
    Cell Significance Index: -0.9900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1545
    Cell Significance Index: -0.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1579
    Cell Significance Index: -11.7700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1726
    Cell Significance Index: -1.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1758
    Cell Significance Index: -18.3100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1830
    Cell Significance Index: -1.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2038
    Cell Significance Index: -13.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2092
    Cell Significance Index: -16.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2093
    Cell Significance Index: -12.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2325
    Cell Significance Index: -10.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2476
    Cell Significance Index: -19.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2579
    Cell Significance Index: -6.6300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2755
    Cell Significance Index: -2.8700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2764
    Cell Significance Index: -1.6400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2780
    Cell Significance Index: -4.6800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2926
    Cell Significance Index: -2.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3098
    Cell Significance Index: -3.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEM97 is a transmembrane protein with a characteristic structure, consisting of a single membrane-spanning domain. This domain is crucial for its function, as it allows the protein to interact with other cellular components and regulate various biological processes. TMEM97 is also known to bind to oxysterols, which are oxidized cholesterol derivatives involved in cholesterol homeostasis. **Pathways and Functions:** TMEM97 is involved in several key pathways, including: 1. **Cholesterol Homeostasis:** TMEM97 regulates the transport of cholesterol within cells, influencing the balance of cholesterol levels and preventing its accumulation. 2. **Regulation of Lipid Transport:** TMEM97 is involved in the transport of lipids, including cholesterol, between the endoplasmic reticulum and the plasma membrane. 3. **Wound Healing:** TMEM97 is upregulated during wound healing, promoting the repair of damaged tissues. 4. **Cell Growth Regulation:** TMEM97 regulates cellular growth, influencing the proliferation and differentiation of cells. 5. **Protein Binding:** TMEM97 interacts with various proteins, including SGMR2, to regulate cellular processes. **Clinical Significance:** TMEM97's involvement in cholesterol homeostasis and cellular regulation makes it an important protein for understanding and treating various diseases, including: 1. **Atherosclerosis:** TMEM97's role in regulating cholesterol transport and homeostasis makes it a potential target for treating atherosclerosis. 2. **Wound Healing Disorders:** TMEM97's upregulation during wound healing makes it a potential target for treating wound healing disorders. 3. **Neurological Disorders:** TMEM97's involvement in lipid transport and cellular regulation makes it a potential target for treating neurological disorders, such as Alzheimer's disease. 4. **Cancer:** TMEM97's regulation of cellular growth and differentiation makes it a potential target for treating cancer. In conclusion, TMEM97 is a multifaceted protein that plays a crucial role in maintaining cholesterol homeostasis and regulating various cellular processes. Its involvement in disease states makes it an important protein for understanding and treating various diseases. Further research into TMEM97's functions and clinical significance will provide valuable insights into its potential as a therapeutic target.

Genular Protein ID: 2734901782

Symbol: SGMR2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5BJF2 B4DS02 Q07823

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7694637

Title: Identification and characterization of genes differentially expressed in meningiomas.

PubMed ID: 7694637

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15375745

Title: Expression analysis of MAC30 in human pancreatic cancer and tumors of the gastrointestinal tract.

PubMed ID: 15375745

DOI: 10.14670/hh-19.1021

PubMed ID: 18070364

Title: Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer.

PubMed ID: 18070364

DOI: 10.1186/1471-2407-7-223

PubMed ID: 19583955

Title: Identification of cholesterol-regulating genes by targeted RNAi screening.

PubMed ID: 19583955

DOI: 10.1016/j.cmet.2009.05.009

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22292588

Title: S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling.

PubMed ID: 22292588

DOI: 10.1517/17425255.2012.658367

PubMed ID: 25566323

Title: TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease.

PubMed ID: 25566323

DOI: 10.3389/fgene.2014.00439

PubMed ID: 23922215

Title: Sigma-2 receptor ligands and their perspectives in cancer diagnosis and therapy.

PubMed ID: 23922215

DOI: 10.1002/med.21297

PubMed ID: 25620095

Title: Sigma-2 receptor ligands: neurobiological effects.

PubMed ID: 25620095

DOI: 10.2174/0929867322666150114163607

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27378690

Title: Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells.

PubMed ID: 27378690

DOI: 10.1093/hmg/ddw204

PubMed ID: 28559337

Title: Identification of the gene that codes for the sigma2 receptor.

PubMed ID: 28559337

DOI: 10.1073/pnas.1705154114

PubMed ID: 28007569

Title: Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1.

PubMed ID: 28007569

DOI: 10.1016/j.phrs.2016.12.023

PubMed ID: 30443021

Title: Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex.

PubMed ID: 30443021

DOI: 10.1038/s41598-018-35430-3

PubMed ID: 34233061

Title: Histatin-1 is an endogenous ligand of the sigma-2 receptor.

PubMed ID: 34233061

DOI: 10.1111/febs.16108

PubMed ID: 34799735

Title: A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes.

PubMed ID: 34799735

DOI: 10.1038/s41589-021-00907-2

PubMed ID: 34880501

Title: Structures of the sigma2 receptor enable docking for bioactive ligand discovery.

PubMed ID: 34880501

DOI: 10.1038/s41586-021-04175-x

PubMed ID: 35970844

Title: GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1.

PubMed ID: 35970844

DOI: 10.1038/s41368-022-00181-5

PubMed ID: 37047353

Title: Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97.

PubMed ID: 37047353

DOI: 10.3390/ijms24076381

Sequence Information:

  • Length: 176
  • Mass: 20848
  • Checksum: 685248D421877F84
  • Sequence:
    • MGAPATRRCV EWLLGLYFLS HIPITLFMDL QAVLPRELYP VEFRNLLKWY AKEFKDPLLQ 
EPPAWFKSFL FCELVFQLPF FPIATYAFLK GSCKWIRTPA IIYSVHTMTT LIPILSTFLF 
EDFSKASGFK GQRPETLHER LTLVSVYAPY LLIPFILLIF MLRSPYYKYE EKRKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.