Details for: IGFBP1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 8.6143
Cell Significance Index: 302.7000 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 8.1618
Cell Significance Index: 137.4900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 6.9094
Cell Significance Index: 172.7200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 5.2924
Cell Significance Index: 152.4900 - Cell Name: chorionic trophoblast cell (CL0011101)
Fold Change: 4.9904
Cell Significance Index: 15.4800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 3.8016
Cell Significance Index: 233.0800 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 2.5474
Cell Significance Index: 6.7200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.3412
Cell Significance Index: 464.6200 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 2.3243
Cell Significance Index: 13.3900 - Cell Name: plasmablast (CL0000980)
Fold Change: 1.6572
Cell Significance Index: 15.3800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.5440
Cell Significance Index: 22.7900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.5419
Cell Significance Index: 49.3900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4228
Cell Significance Index: 64.4900 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.4085
Cell Significance Index: 23.6900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.3040
Cell Significance Index: 19.6500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0744
Cell Significance Index: 204.4600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7156
Cell Significance Index: 70.7900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6029
Cell Significance Index: 544.3400 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.5602
Cell Significance Index: 2.1100 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.5264
Cell Significance Index: 5.4500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3681
Cell Significance Index: 59.8600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3442
Cell Significance Index: 7.3300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2547
Cell Significance Index: 27.7100 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.2457
Cell Significance Index: 1.9400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1746
Cell Significance Index: 12.0800 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.0896
Cell Significance Index: 0.2400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0241
Cell Significance Index: 1.4500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.0239
Cell Significance Index: 1.0400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0099
Cell Significance Index: 1.3600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0028
Cell Significance Index: -0.0600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0056
Cell Significance Index: -0.2900 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0058
Cell Significance Index: -0.2400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0065
Cell Significance Index: -0.1000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0102
Cell Significance Index: -7.5600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0102
Cell Significance Index: -0.2600 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0109
Cell Significance Index: -0.1200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0112
Cell Significance Index: -8.1800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0127
Cell Significance Index: -1.4800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0129
Cell Significance Index: -7.2700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0148
Cell Significance Index: -4.2600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0154
Cell Significance Index: -1.9700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0163
Cell Significance Index: -5.8400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0163
Cell Significance Index: -10.1700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0168
Cell Significance Index: -9.2000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0267
Cell Significance Index: -0.3000 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0352
Cell Significance Index: -0.2400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0410
Cell Significance Index: -7.3900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0482
Cell Significance Index: -1.0000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0486
Cell Significance Index: -10.2400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0492
Cell Significance Index: -9.8600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0574
Cell Significance Index: -9.8000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0607
Cell Significance Index: -7.8400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0609
Cell Significance Index: -7.4900 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0637
Cell Significance Index: -1.0500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0685
Cell Significance Index: -7.0000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0710
Cell Significance Index: -8.1300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0743
Cell Significance Index: -8.7600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0750
Cell Significance Index: -1.5700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0871
Cell Significance Index: -1.7000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1043
Cell Significance Index: -6.4100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1064
Cell Significance Index: -7.9300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1108
Cell Significance Index: -8.7800 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.1219
Cell Significance Index: -0.9700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1275
Cell Significance Index: -8.5700 - Cell Name: chondrocyte (CL0000138)
Fold Change: -0.1371
Cell Significance Index: -1.5800 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.1399
Cell Significance Index: -1.9400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1417
Cell Significance Index: -1.5400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1589
Cell Significance Index: -7.4700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1614
Cell Significance Index: -4.3100 - Cell Name: osteoblast (CL0000062)
Fold Change: -0.1629
Cell Significance Index: -1.5800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1836
Cell Significance Index: -4.9200 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.1943
Cell Significance Index: -2.5100 - Cell Name: monocyte (CL0000576)
Fold Change: -0.1981
Cell Significance Index: -2.2800 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.1998
Cell Significance Index: -2.4300 - Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.2164
Cell Significance Index: -1.9800 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.2278
Cell Significance Index: -2.3500 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.2279
Cell Significance Index: -1.0900 - Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.2432
Cell Significance Index: -1.4900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2561
Cell Significance Index: -8.9000 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.2573
Cell Significance Index: -3.5700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2683
Cell Significance Index: -7.6900 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.2686
Cell Significance Index: -4.3100 - Cell Name: chondroblast (CL0000058)
Fold Change: -0.2692
Cell Significance Index: -1.5800 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2714
Cell Significance Index: -6.9200 - Cell Name: peg cell (CL4033014)
Fold Change: -0.2744
Cell Significance Index: -6.3400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2782
Cell Significance Index: -9.7500 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: -0.2860
Cell Significance Index: -1.0000 - Cell Name: articular chondrocyte (CL1001607)
Fold Change: -0.2897
Cell Significance Index: -1.5700 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2911
Cell Significance Index: -7.2600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3010
Cell Significance Index: -8.5900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3101
Cell Significance Index: -6.7900 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.3103
Cell Significance Index: -2.9500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3127
Cell Significance Index: -9.2100 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.3147
Cell Significance Index: -3.1700 - Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.3162
Cell Significance Index: -3.1200 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.3175
Cell Significance Index: -4.5500 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.3179
Cell Significance Index: -2.4500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3187
Cell Significance Index: -10.4400 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.3194
Cell Significance Index: -6.5000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3247
Cell Significance Index: -10.3400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2938113013
Symbol: IBP1_HUMAN
Name: Insulin-like growth factor-binding protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2461294
Title: Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1).
PubMed ID: 2461294
PubMed ID: 2454104
Title: Cloning, characterization, and expression of a human insulin-like growth factor binding protein.
PubMed ID: 2454104
PubMed ID: 3419931
Title: Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin.
PubMed ID: 3419931
PubMed ID: 2457513
Title: Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA.
PubMed ID: 2457513
PubMed ID: 2458522
Title: Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors.
PubMed ID: 2458522
DOI: 10.1210/mend-2-5-404
PubMed ID: 2474129
Title: Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein.
PubMed ID: 2474129
DOI: 10.1210/mend-3-5-846
PubMed ID: 2849945
Title: Organization of the gene encoding the insulin-like growth factor binding protein IBP-1.
PubMed ID: 2849945
PubMed ID: 1373120
Title: Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7.
PubMed ID: 1373120
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19765076
Title: Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms.
PubMed ID: 19765076
PubMed ID: 2466665
Title: Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning.
PubMed ID: 2466665
PubMed ID: 2971653
Title: Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions.
PubMed ID: 2971653
PubMed ID: 1718783
Title: Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability.
PubMed ID: 1718783
PubMed ID: 7678248
Title: Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101.
PubMed ID: 7678248
PubMed ID: 10329650
Title: The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry.
PubMed ID: 10329650
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
PubMed ID: 15972819
Title: Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid.
PubMed ID: 15972819
PubMed ID: 16924115
Title: Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
PubMed ID: 16924115
Sequence Information:
- Length: 259
- Mass: 27904
- Checksum: 8AA75AF7DC966012
- Sequence:
MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE VTRSAGCGCC PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG QGACVQESDA SAPHAAEAGS PESPESTEIT EEELLDNFHL MAPSEEDHSI LWDAISTYDG SKALHVTNIK KWKEPCRIEL YRVVESLAKA QETSGEEISK FYLPNCNKNG FYHSRQCETS MDGEAGLCWC VYPWNGKRIP GSPEIRGDPN CQIYFNVQN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.