Details for: IGFBP1

Gene ID: 3484

Symbol: IGFBP1

Ensembl ID: ENSG00000146678

Description: insulin like growth factor binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 8.6143
    Cell Significance Index: 302.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.1618
    Cell Significance Index: 137.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 6.9094
    Cell Significance Index: 172.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 5.2924
    Cell Significance Index: 152.4900
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: 4.9904
    Cell Significance Index: 15.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.8016
    Cell Significance Index: 233.0800
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.5474
    Cell Significance Index: 6.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3412
    Cell Significance Index: 464.6200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.3243
    Cell Significance Index: 13.3900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.6572
    Cell Significance Index: 15.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.5440
    Cell Significance Index: 22.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.5419
    Cell Significance Index: 49.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4228
    Cell Significance Index: 64.4900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.4085
    Cell Significance Index: 23.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.3040
    Cell Significance Index: 19.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0744
    Cell Significance Index: 204.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7156
    Cell Significance Index: 70.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6029
    Cell Significance Index: 544.3400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.5602
    Cell Significance Index: 2.1100
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.5264
    Cell Significance Index: 5.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3681
    Cell Significance Index: 59.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3442
    Cell Significance Index: 7.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2547
    Cell Significance Index: 27.7100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.2457
    Cell Significance Index: 1.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1746
    Cell Significance Index: 12.0800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0896
    Cell Significance Index: 0.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0241
    Cell Significance Index: 1.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0239
    Cell Significance Index: 1.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0099
    Cell Significance Index: 1.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0056
    Cell Significance Index: -0.2900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0058
    Cell Significance Index: -0.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0065
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0102
    Cell Significance Index: -0.2600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0109
    Cell Significance Index: -0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0112
    Cell Significance Index: -8.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0127
    Cell Significance Index: -1.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0129
    Cell Significance Index: -7.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0148
    Cell Significance Index: -4.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0154
    Cell Significance Index: -1.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0163
    Cell Significance Index: -5.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0163
    Cell Significance Index: -10.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0168
    Cell Significance Index: -9.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0267
    Cell Significance Index: -0.3000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0352
    Cell Significance Index: -0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0410
    Cell Significance Index: -7.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0482
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0486
    Cell Significance Index: -10.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0492
    Cell Significance Index: -9.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0574
    Cell Significance Index: -9.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0607
    Cell Significance Index: -7.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0609
    Cell Significance Index: -7.4900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0637
    Cell Significance Index: -1.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0685
    Cell Significance Index: -7.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0710
    Cell Significance Index: -8.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0743
    Cell Significance Index: -8.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0750
    Cell Significance Index: -1.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0871
    Cell Significance Index: -1.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1043
    Cell Significance Index: -6.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1064
    Cell Significance Index: -7.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1108
    Cell Significance Index: -8.7800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1219
    Cell Significance Index: -0.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1275
    Cell Significance Index: -8.5700
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1371
    Cell Significance Index: -1.5800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1399
    Cell Significance Index: -1.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1417
    Cell Significance Index: -1.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1589
    Cell Significance Index: -7.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1614
    Cell Significance Index: -4.3100
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1629
    Cell Significance Index: -1.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1836
    Cell Significance Index: -4.9200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1943
    Cell Significance Index: -2.5100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1981
    Cell Significance Index: -2.2800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1998
    Cell Significance Index: -2.4300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2164
    Cell Significance Index: -1.9800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2278
    Cell Significance Index: -2.3500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.2279
    Cell Significance Index: -1.0900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2432
    Cell Significance Index: -1.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2561
    Cell Significance Index: -8.9000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2573
    Cell Significance Index: -3.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2683
    Cell Significance Index: -7.6900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2686
    Cell Significance Index: -4.3100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2692
    Cell Significance Index: -1.5800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2714
    Cell Significance Index: -6.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2744
    Cell Significance Index: -6.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2782
    Cell Significance Index: -9.7500
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.2860
    Cell Significance Index: -1.0000
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.2897
    Cell Significance Index: -1.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2911
    Cell Significance Index: -7.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3010
    Cell Significance Index: -8.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3101
    Cell Significance Index: -6.7900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.3103
    Cell Significance Index: -2.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3127
    Cell Significance Index: -9.2100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.3147
    Cell Significance Index: -3.1700
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.3162
    Cell Significance Index: -3.1200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3175
    Cell Significance Index: -4.5500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3179
    Cell Significance Index: -2.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3187
    Cell Significance Index: -10.4400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3194
    Cell Significance Index: -6.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3247
    Cell Significance Index: -10.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGFBP1 is a secreted protein that belongs to the insulin-like growth factor binding protein (IGFBP) family. It is characterized by its ability to bind to IGFs, modulating their activity and availability to cells. IGFBP1 has a high affinity for IGF-I and IGF-II, with a lower affinity for IGF-III. Its binding to IGFs inhibits their biological activity, while also influencing the activity of various signaling pathways. IGFBP1 has a unique structure, consisting of three Ig-like domains and a single fibronectin type III domain. Its expression is tightly regulated by various cellular processes, including cell growth, differentiation, and stress responses. **Pathways and Functions:** IGFBP1 plays a critical role in regulating IGF signaling, which is involved in various cellular processes, including cell growth, differentiation, and survival. Its binding to IGFs modulates their activity and availability to cells, influencing the activity of various signaling pathways. Some of the key pathways and functions of IGFBP1 include: 1. **Insulin-like Growth Factor Signaling Pathway:** IGFBP1 binds to IGFs, modulating their activity and availability to cells. This binding influences the activity of various signaling pathways, including those involved in cell growth, differentiation, and survival. 2. **Endoplasmic Reticulum Stress Response:** IGFBP1 has been implicated in the regulation of endoplasmic reticulum stress, a condition characterized by the accumulation of unfolded proteins in the endoplasmic reticulum. 3. **Oxidative Stress Response:** IGFBP1 has been shown to regulate the activity of various transcription factors involved in oxidative stress response, including Foxo. 4. **Unfolded Protein Response (UPR):** IGFBP1 has been implicated in the regulation of UPR, a cellular response to endoplasmic reticulum stress. 5. **Cellular Stress Response:** IGFBP1 has been shown to regulate the activity of various signaling pathways involved in cellular stress responses, including those involved in cell growth, differentiation, and survival. **Clinical Significance:** IGFBP1 has been implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders. Its dysregulation has been linked to various pathological processes, including tumor growth, insulin resistance, and neuronal degeneration. Some of the key clinical implications of IGFBP1 include: 1. **Cancer:** IGFBP1 has been implicated in the regulation of tumor growth and metastasis, with altered expression levels observed in various types of cancer. 2. **Diabetes:** IGFBP1 has been shown to regulate insulin sensitivity and glucose metabolism, with altered expression levels observed in diabetes. 3. **Neurodegenerative Disorders:** IGFBP1 has been implicated in the regulation of neuronal growth and survival, with altered expression levels observed in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, IGFBP1 is a multifunctional protein that plays a critical role in regulating IGF signaling and cellular stress responses. Its dysregulation has been linked to various pathological processes, including cancer, diabetes, and neurodegenerative disorders. Further research is needed to fully elucidate the mechanisms by which IGFBP1 regulates IGF signaling and cellular stress responses, with potential implications for the development of novel therapeutic strategies.

Genular Protein ID: 2938113013

Symbol: IBP1_HUMAN

Name: Insulin-like growth factor-binding protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2461294

Title: Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1).

PubMed ID: 2461294

DOI: 10.1002/j.1460-2075.1988.tb03087.x

PubMed ID: 2454104

Title: Cloning, characterization, and expression of a human insulin-like growth factor binding protein.

PubMed ID: 2454104

DOI: 10.1016/s0006-291x(88)80425-x

PubMed ID: 3419931

Title: Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin.

PubMed ID: 3419931

DOI: 10.1093/nar/16.17.8711

PubMed ID: 2457513

Title: Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA.

PubMed ID: 2457513

DOI: 10.1016/0014-5793(88)80041-3

PubMed ID: 2458522

Title: Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors.

PubMed ID: 2458522

DOI: 10.1210/mend-2-5-404

PubMed ID: 2474129

Title: Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein.

PubMed ID: 2474129

DOI: 10.1210/mend-3-5-846

PubMed ID: 2849945

Title: Organization of the gene encoding the insulin-like growth factor binding protein IBP-1.

PubMed ID: 2849945

DOI: 10.1016/s0006-291x(88)80959-8

PubMed ID: 1373120

Title: Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7.

PubMed ID: 1373120

DOI: 10.1016/0888-7543(92)90440-4

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19765076

Title: Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms.

PubMed ID: 19765076

DOI: 10.1111/j.1742-4658.2009.07318.x

PubMed ID: 2466665

Title: Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning.

PubMed ID: 2466665

DOI: 10.1111/j.1432-1033.1989.tb14641.x

PubMed ID: 2971653

Title: Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions.

PubMed ID: 2971653

DOI: 10.1016/s0021-9258(18)68206-7

PubMed ID: 1718783

Title: Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability.

PubMed ID: 1718783

DOI: 10.1016/0014-5793(91)81298-m

PubMed ID: 7678248

Title: Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101.

PubMed ID: 7678248

DOI: 10.1016/s0021-9258(18)54050-3

PubMed ID: 10329650

Title: The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry.

PubMed ID: 10329650

DOI: 10.1074/jbc.274.21.14587

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 15972819

Title: Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid.

PubMed ID: 15972819

DOI: 10.1074/jbc.m504304200

PubMed ID: 16924115

Title: Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.

PubMed ID: 16924115

DOI: 10.1073/pnas.0605652103

Sequence Information:

  • Length: 259
  • Mass: 27904
  • Checksum: 8AA75AF7DC966012
  • Sequence:
  • MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE VTRSAGCGCC 
    PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG QGACVQESDA SAPHAAEAGS 
    PESPESTEIT EEELLDNFHL MAPSEEDHSI LWDAISTYDG SKALHVTNIK KWKEPCRIEL 
    YRVVESLAKA QETSGEEISK FYLPNCNKNG FYHSRQCETS MDGEAGLCWC VYPWNGKRIP 
    GSPEIRGDPN CQIYFNVQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.