Details for: IGFBP1

Gene ID: 3484

Symbol: IGFBP1

Ensembl ID: ENSG00000146678

Description: insulin like growth factor binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.41
    Marker Score: 10383
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1998
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.65
    Marker Score: 1135.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.46
    Marker Score: 6299
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.4
    Marker Score: 7509
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.3
    Marker Score: 3582
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4818
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.13
    Marker Score: 427
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.13
    Marker Score: 6845
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.07
    Marker Score: 6891
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.06
    Marker Score: 1011
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1
    Marker Score: 3269
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 651.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.81
    Marker Score: 472
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.76
    Marker Score: 351
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.7
    Marker Score: 388
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.7
    Marker Score: 475.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1264
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 427.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.6
    Marker Score: 349.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 475
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.59
    Marker Score: 658
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.58
    Marker Score: 226
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.56
    Marker Score: 8821
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.55
    Marker Score: 593.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1073
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.5
    Marker Score: 3297
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.46
    Marker Score: 1128
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 411.5
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.4
    Marker Score: 124.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.38
    Marker Score: 226
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.37
    Marker Score: 595
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.36
    Marker Score: 360
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.33
    Marker Score: 104
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: 0.31
    Marker Score: 121
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.29
    Marker Score: 105
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.29
    Marker Score: 107
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.28
    Marker Score: 143
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.25
    Marker Score: 424
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.24
    Marker Score: 65
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 120
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.2
    Marker Score: 329
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 86.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.19
    Marker Score: 89
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.18
    Marker Score: 239
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 367
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.15
    Marker Score: 83
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.15
    Marker Score: 83
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.14
    Marker Score: 59
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.14
    Marker Score: 50
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.13
    Marker Score: 79
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.13
    Marker Score: 112
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.13
    Marker Score: 66
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.11
    Marker Score: 96
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.11
    Marker Score: 145
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.1
    Marker Score: 86
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.09
    Marker Score: 65
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 195
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.08
    Marker Score: 99
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.08
    Marker Score: 61
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.08
    Marker Score: 22

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Other Information

## Summary IGFBP1 is a key regulator of various cellular processes, including metabolism, proliferation, and differentiation. It is highly expressed in the developing and regenerating tissues of the body, and its expression is often associated with cellular health and homeostasis. ## Key characteristics * IGFBP1 is a secreted protein that acts as a decoy receptor for IGFs. * It is a member of the IGF superfamily of proteins, which are characterized by a conserved IGF binding domain. * IGFBP1 is a key regulator of insulin-like growth factor (IGF) signaling. * It is expressed in high levels in various cell types, including endothelial cells, hepatocytes, and immune cells. * It is involved in the regulation of cell growth, differentiation, and metabolism. ## Pathways and functions * IGFBP1 is a key regulator of the insulin/IGF signaling pathway. * It binds to IGFs and prevents their interaction with their receptors, thereby inhibiting IGF signaling. * This leads to the inhibition of various downstream signaling pathways that are stimulated by IGFs, including the MAPK pathway, PI3K/AKT pathway, and mTOR pathway. * As a result, IGFBP1 helps to maintain cellular homeostasis and prevent the growth of tumors. ## Clinical significance * Mutations in IGFBP1 have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. * Overexpression of IGFBP1 has been observed in many tumor cells, suggesting that it may play a role in tumor growth and metastasis. * Inhibition of IGFBP1 has been shown to suppress tumor growth in animal models. ## Additional information * IGFBP1 is a highly conserved protein that is found in humans, mice, and rats. * It is produced by a variety of cell types, including endothelial cells, hepatocytes, and immune cells. * It is a key regulator of angiogenesis, cell growth, and differentiation. * It is a potential therapeutic target for cancer and other diseases that are characterized by abnormal cell growth.

Genular Protein ID: 2938113013

Symbol: IBP1_HUMAN

Name: Insulin-like growth factor-binding protein 1

UniProtKB Accession Codes:

P08833 A4D2F4 D3DVL9 Q8IYP5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 18 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2461294

Title: Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1).

PubMed ID: 2461294

DOI: 10.1002/j.1460-2075.1988.tb03087.x

PubMed ID: 2454104

Title: Cloning, characterization, and expression of a human insulin-like growth factor binding protein.

PubMed ID: 2454104

DOI: 10.1016/s0006-291x(88)80425-x

PubMed ID: 3419931

Title: Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin.

PubMed ID: 3419931

DOI: 10.1093/nar/16.17.8711

PubMed ID: 2457513

Title: Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA.

PubMed ID: 2457513

DOI: 10.1016/0014-5793(88)80041-3

PubMed ID: 2458522

Title: Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors.

PubMed ID: 2458522

DOI: 10.1210/mend-2-5-404

PubMed ID: 2474129

Title: Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein.

PubMed ID: 2474129

DOI: 10.1210/mend-3-5-846

PubMed ID: 2849945

Title: Organization of the gene encoding the insulin-like growth factor binding protein IBP-1.

PubMed ID: 2849945

DOI: 10.1016/s0006-291x(88)80959-8

PubMed ID: 1373120

Title: Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7.

PubMed ID: 1373120

DOI: 10.1016/0888-7543(92)90440-4

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19765076

Title: Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms.

PubMed ID: 19765076

DOI: 10.1111/j.1742-4658.2009.07318.x

PubMed ID: 2466665

Title: Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning.

PubMed ID: 2466665

DOI: 10.1111/j.1432-1033.1989.tb14641.x

PubMed ID: 2971653

Title: Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions.

PubMed ID: 2971653

DOI: 10.1016/s0021-9258(18)68206-7

PubMed ID: 1718783

Title: Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability.

PubMed ID: 1718783

DOI: 10.1016/0014-5793(91)81298-m

PubMed ID: 7678248

Title: Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101.

PubMed ID: 7678248

DOI: 10.1016/s0021-9258(18)54050-3

PubMed ID: 10329650

Title: The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry.

PubMed ID: 10329650

DOI: 10.1074/jbc.274.21.14587

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 15972819

Title: Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid.

PubMed ID: 15972819

DOI: 10.1074/jbc.m504304200

PubMed ID: 16924115

Title: Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.

PubMed ID: 16924115

DOI: 10.1073/pnas.0605652103

Sequence Information:

  • Length: 259
  • Mass: 27904
  • Checksum: 8AA75AF7DC966012
  • Sequence:
    • MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE VTRSAGCGCC 
PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG QGACVQESDA SAPHAAEAGS 
PESPESTEIT EEELLDNFHL MAPSEEDHSI LWDAISTYDG SKALHVTNIK KWKEPCRIEL 
YRVVESLAKA QETSGEEISK FYLPNCNKNG FYHSRQCETS MDGEAGLCWC VYPWNGKRIP 
GSPEIRGDPN CQIYFNVQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.