Details for: HTRA1

Gene ID: 5654

Symbol: HTRA1

Ensembl ID: ENSG00000166033

Description: HtrA serine peptidase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 146.4507
    Cell Significance Index: -60.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 114.1229
    Cell Significance Index: -53.8800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 3.7949
    Cell Significance Index: 42.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1331
    Cell Significance Index: 292.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.4576
    Cell Significance Index: 91.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.9523
    Cell Significance Index: 58.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9251
    Cell Significance Index: 26.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6995
    Cell Significance Index: 133.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6434
    Cell Significance Index: 230.7900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.5400
    Cell Significance Index: 7.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5134
    Cell Significance Index: 226.9700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5026
    Cell Significance Index: 5.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4721
    Cell Significance Index: 60.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3319
    Cell Significance Index: 8.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2713
    Cell Significance Index: 19.1900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2146
    Cell Significance Index: 3.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1956
    Cell Significance Index: 176.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1715
    Cell Significance Index: 7.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1051
    Cell Significance Index: 18.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0862
    Cell Significance Index: 10.6100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0660
    Cell Significance Index: 0.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0489
    Cell Significance Index: 7.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0440
    Cell Significance Index: 4.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0281
    Cell Significance Index: 15.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0056
    Cell Significance Index: 7.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0168
    Cell Significance Index: -11.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0252
    Cell Significance Index: -47.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0341
    Cell Significance Index: -25.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0357
    Cell Significance Index: -65.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0370
    Cell Significance Index: -56.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0480
    Cell Significance Index: -36.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0503
    Cell Significance Index: -31.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0684
    Cell Significance Index: -50.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0685
    Cell Significance Index: -7.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0732
    Cell Significance Index: -33.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0737
    Cell Significance Index: -46.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0750
    Cell Significance Index: -12.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0800
    Cell Significance Index: -2.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0834
    Cell Significance Index: -47.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1079
    Cell Significance Index: -11.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1442
    Cell Significance Index: -3.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1528
    Cell Significance Index: -30.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1649
    Cell Significance Index: -47.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1761
    Cell Significance Index: -34.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1824
    Cell Significance Index: -3.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2264
    Cell Significance Index: -47.6800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2482
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2829
    Cell Significance Index: -32.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2841
    Cell Significance Index: -17.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2888
    Cell Significance Index: -19.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3061
    Cell Significance Index: -8.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3067
    Cell Significance Index: -44.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3227
    Cell Significance Index: -5.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3460
    Cell Significance Index: -7.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3487
    Cell Significance Index: -45.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3500
    Cell Significance Index: -16.3200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3830
    Cell Significance Index: -4.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3872
    Cell Significance Index: -9.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3924
    Cell Significance Index: -45.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4140
    Cell Significance Index: -13.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4228
    Cell Significance Index: -5.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4808
    Cell Significance Index: -56.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4856
    Cell Significance Index: -24.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5104
    Cell Significance Index: -39.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5171
    Cell Significance Index: -53.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5207
    Cell Significance Index: -59.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5821
    Cell Significance Index: -27.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6412
    Cell Significance Index: -47.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6607
    Cell Significance Index: -52.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6918
    Cell Significance Index: -14.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7817
    Cell Significance Index: -52.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8759
    Cell Significance Index: -49.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8835
    Cell Significance Index: -24.6900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.0035
    Cell Significance Index: -15.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0049
    Cell Significance Index: -52.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0207
    Cell Significance Index: -53.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0224
    Cell Significance Index: -21.7800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0758
    Cell Significance Index: -18.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0833
    Cell Significance Index: -14.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1192
    Cell Significance Index: -22.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.2223
    Cell Significance Index: -50.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.2928
    Cell Significance Index: -22.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2930
    Cell Significance Index: -44.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3144
    Cell Significance Index: -58.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.3462
    Cell Significance Index: -19.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.3637
    Cell Significance Index: -43.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.3956
    Cell Significance Index: -48.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.4069
    Cell Significance Index: -33.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.5219
    Cell Significance Index: -57.6300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.5371
    Cell Significance Index: -32.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.5408
    Cell Significance Index: -43.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5721
    Cell Significance Index: -51.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.5746
    Cell Significance Index: -33.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5843
    Cell Significance Index: -58.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.6346
    Cell Significance Index: -43.7300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.6471
    Cell Significance Index: -17.6600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.6563
    Cell Significance Index: -32.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.6986
    Cell Significance Index: -54.1000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.7118
    Cell Significance Index: -41.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.7625
    Cell Significance Index: -38.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HTRA1 is a serine protease that belongs to the HtrA family of proteins, which are characterized by their ability to regulate cellular processes through proteolytic activity. HTRA1 is specifically involved in the degradation of the extracellular matrix, regulation of growth factor signaling, and modulation of apoptosis. Its expression is widespread, with significant levels found in various cell types, including immune cells, such as macrophages and microglia, as well as non-immune cells like astrocytes and stromal cells. **Pathways and Functions:** HTRA1's functions are mediated through its ability to regulate various signaling pathways, including: 1. **Negative regulation of BMP signaling pathway:** HTRA1 negatively regulates the BMP (Bone Morphogenetic Protein) signaling pathway, which is essential for cell differentiation and development. 2. **Negative regulation of TGF-β receptor signaling pathway:** HTRA1 also negatively regulates the TGF-β (Transforming Growth Factor-beta) receptor signaling pathway, which is involved in cell growth, differentiation, and apoptosis. 3. **Programmed cell death:** HTRA1 promotes programmed cell death, also known as apoptosis, which is a critical process for eliminating damaged or unwanted cells. 4. **Extracellular matrix organization:** HTRA1 regulates the degradation of the extracellular matrix, which is essential for tissue development and remodeling. 5. **Growth factor binding:** HTRA1 interacts with growth factors, such as TGF-β and BMP, to regulate their signaling pathways. **Clinical Significance:** HTRA1's dysregulation has been implicated in various diseases, including: 1. **Retinal degeneration:** HTRA1 has been associated with retinal degeneration, a leading cause of blindness in older adults. 2. **Neurodegenerative diseases:** HTRA1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** HTRA1's dysregulation has been linked to cancer, particularly in the context of tumor growth and metastasis. 4. **Immune disorders:** HTRA1's role in immune regulation makes it a potential target for the treatment of immune disorders, such as autoimmune diseases. In conclusion, HTRA1 is a serine protease with multiple functions in immune regulation, cell differentiation, and programmed cell death. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in different cellular processes. Further research is necessary to fully elucidate HTRA1's functions and its clinical significance.

Genular Protein ID: 3903138163

Symbol: HTRA1_HUMAN

Name: Serine protease HTRA1

UniProtKB Accession Codes:

Q92743 D3DRE4 Q9UNS5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 EMDB 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8977104

Title: Primary structure of a putative serine protease specific for IGF-binding proteins.

PubMed ID: 8977104

DOI: 10.1016/s0014-5793(96)01229-x

PubMed ID: 9852107

Title: Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage.

PubMed ID: 9852107

DOI: 10.1074/jbc.273.51.34406

PubMed ID: 15208355

Title: The serine protease HtrA1 is upregulated in the human placenta during pregnancy.

PubMed ID: 15208355

DOI: 10.1369/jhc.3a6186.2004

PubMed ID: 16377621

Title: The role of human HtrA1 in arthritic disease.

PubMed ID: 16377621

DOI: 10.1074/jbc.m500361200

PubMed ID: 17053108

Title: HTRA1 promoter polymorphism in wet age-related macular degeneration.

PubMed ID: 17053108

DOI: 10.1126/science.1133807

PubMed ID: 17053109

Title: A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.

PubMed ID: 17053109

DOI: 10.1126/science.1133811

PubMed ID: 20671064

Title: The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein.

PubMed ID: 20671064

DOI: 10.1158/1541-7786.mcr-09-0473

PubMed ID: 26063658

Title: Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease.

PubMed ID: 26063658

DOI: 10.1093/brain/awv155

PubMed ID: 21297635

Title: Substrate-induced remodeling of the active site regulates human HTRA1 activity.

PubMed ID: 21297635

DOI: 10.1038/nsmb.2013

PubMed ID: 19387015

Title: Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease.

PubMed ID: 19387015

DOI: 10.1056/nejmoa0801560

Sequence Information:

  • Length: 480
  • Mass: 51287
  • Checksum: CA20A99480FB2330
  • Sequence:
    • MQIPRAALLP LLLLLLAAPA SAQLSRAGRS APLAAGCPDR CEPARCPPQP EHCEGGRARD 
ACGCCEVCGA PEGAACGLQE GPCGEGLQCV VPFGVPASAT VRRRAQAGLC VCASSEPVCG 
SDANTYANLC QLRAASRRSE RLHRPPVIVL QRGACGQGQE DPNSLRHKYN FIADVVEKIA 
PAVVHIELFR KLPFSKREVP VASGSGFIVS EDGLIVTNAH VVTNKHRVKV ELKNGATYEA 
KIKDVDEKAD IALIKIDHQG KLPVLLLGRS SELRPGEFVV AIGSPFSLQN TVTTGIVSTT 
QRGGKELGLR NSDMDYIQTD AIINYGNSGG PLVNLDGEVI GINTLKVTAG ISFAIPSDKI 
KKFLTESHDR QAKGKAITKK KYIGIRMMSL TSSKAKELKD RHRDFPDVIS GAYIIEVIPD 
TPAEAGGLKE NDVIISINGQ SVVSANDVSD VIKRESTLNM VVRRGNEDIM ITVIPEEIDP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.