Details for: LTC4S

Gene ID: 4056

Symbol: LTC4S

Ensembl ID: ENSG00000213316

Description: leukotriene C4 synthase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 5.3
    Marker Score: 7615
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.41
    Marker Score: 1621
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.92
    Marker Score: 3970
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.87
    Marker Score: 765
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.49
    Marker Score: 739
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.36
    Marker Score: 1168
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.25
    Marker Score: 2108
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.25
    Marker Score: 1802.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.11
    Marker Score: 1112
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.06
    Marker Score: 773.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.05
    Marker Score: 2671.5
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.05
    Marker Score: 243
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251780
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48023
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.96
    Marker Score: 527
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.92
    Marker Score: 296
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.89
    Marker Score: 3163
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.87
    Marker Score: 1737
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.87
    Marker Score: 7618.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.86
    Marker Score: 183
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.79
    Marker Score: 458
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.78
    Marker Score: 1133
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.75
    Marker Score: 234
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.73
    Marker Score: 5439
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.71
    Marker Score: 812
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.69
    Marker Score: 166
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.69
    Marker Score: 198
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.69
    Marker Score: 217
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.67
    Marker Score: 678
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2821.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 216
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.65
    Marker Score: 269
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.62
    Marker Score: 656
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.61
    Marker Score: 1439
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.6
    Marker Score: 1667.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6
    Marker Score: 379
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.56
    Marker Score: 723
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.52
    Marker Score: 1347
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 322
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.5
    Marker Score: 452
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.49
    Marker Score: 281
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.49
    Marker Score: 154.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.49
    Marker Score: 324
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.48
    Marker Score: 121
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.48
    Marker Score: 213
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.47
    Marker Score: 189
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.47
    Marker Score: 1273
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.46
    Marker Score: 683
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.46
    Marker Score: 126
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.46
    Marker Score: 116
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.45
    Marker Score: 405
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.45
    Marker Score: 144
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.45
    Marker Score: 279
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.44
    Marker Score: 779
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.44
    Marker Score: 712
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.43
    Marker Score: 471
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.42
    Marker Score: 466
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.42
    Marker Score: 207
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.41
    Marker Score: 189.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.41
    Marker Score: 173
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.41
    Marker Score: 497
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.4
    Marker Score: 274
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.4
    Marker Score: 272.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.39
    Marker Score: 1032
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.39
    Marker Score: 86
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.39
    Marker Score: 222
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.39
    Marker Score: 104
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.39
    Marker Score: 177
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.39
    Marker Score: 941
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.37
    Marker Score: 144
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.37
    Marker Score: 366
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.35
    Marker Score: 140
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.35
    Marker Score: 364
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.34
    Marker Score: 248
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.34
    Marker Score: 773
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.34
    Marker Score: 140
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 223
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.33
    Marker Score: 88
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.33
    Marker Score: 1304
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.33
    Marker Score: 224
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.33
    Marker Score: 1739
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.33
    Marker Score: 90
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.32
    Marker Score: 190
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.32
    Marker Score: 334
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.32
    Marker Score: 577
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.31
    Marker Score: 716
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.31
    Marker Score: 131
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.31
    Marker Score: 1200
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.31
    Marker Score: 100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.3
    Marker Score: 913
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.3
    Marker Score: 309
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.3
    Marker Score: 84

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Other Information

## Summary The LTC4S gene encodes a protein involved in the biosynthesis of leukotrienes (LTs), a class of bioactive lipid mediators with diverse effects on inflammation and tissue repair. It is significantly expressed in various cell types, with highest expression in respiratory epithelial cells, macrophages, and endothelial cells. ## Key characteristics * **Function:** The protein is an enzyme that catalyzes the formation of leukotrienes from arachidonic acid, a product of the arachidonic acid metabolism pathway. * **Location:** The gene is located on chromosome 1p31.1 and encodes a protein of 136 amino acids. * **Expression:** It is highly expressed in various cell types, with highest levels in respiratory epithelial cells, macrophages, and endothelial cells. * **Regulation:** The expression of the gene is regulated by various factors, including cytokines, growth factors, and metabolic signals. ## Pathways and functions The LTC4S protein is involved in multiple pathways involved in inflammation and tissue regeneration: * **Arachidonic acid metabolism:** It catalyzes the formation of LTs from arachidonic acid, a precursor molecule in the arachidonic acid metabolism pathway. * **Thromboregulatory pathway:** LTs produced by LTC4S can modulate the inflammatory response by interacting with G protein-coupled receptors on immune cells. * **Tissue regeneration:** It is involved in tissue repair and regeneration by promoting the formation of new blood vessels and collagen fibers. * **Immune regulation:** LTs have immunomodulatory effects, promoting inflammation and tissue remodeling. ## Clinical significance Mutations in the LTC4S gene have been linked to various inflammatory diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease. These mutations can disrupt the regulation of the arachidonic acid metabolism pathway, leading to the production of excessive LTs and inflammation. Therefore, targeting the LTC4S gene or its signaling pathway is a potential therapeutic strategy for inflammatory diseases characterized by LT overproduction.

Genular Protein ID: 4213866900

Symbol: LTC4S_HUMAN

Name: Leukotriene C4 synthase

UniProtKB Accession Codes:

Q16873 Q8N6P0 Q9UC73 Q9UD18

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 16 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 4 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8052639

Title: Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4.

PubMed ID: 8052639

DOI: 10.1073/pnas.91.16.7663

PubMed ID: 7937884

Title: Molecular cloning and expression of human leukotriene-C4 synthase.

PubMed ID: 7937884

DOI: 10.1073/pnas.91.21.9745

PubMed ID: 8626689

Title: Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35.

PubMed ID: 8626689

DOI: 10.1074/jbc.271.19.11356

PubMed ID: 8898379

Title: Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35.

PubMed ID: 8898379

DOI: 10.1007/bf03401647

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8446623

Title: Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits.

PubMed ID: 8446623

DOI: 10.1073/pnas.90.5.2015

PubMed ID: 7599836

Title: Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody.

PubMed ID: 7599836

DOI: 10.1164/ajrccm.152.1.7599836

PubMed ID: 7766706

Title: Two step purification of human and murine leukotriene C4 synthase.

PubMed ID: 7766706

DOI: 10.1016/0005-2760(95)00031-7

PubMed ID: 9153254

Title: Site-directed mutagenesis of human leukotriene C4 synthase.

PubMed ID: 9153254

DOI: 10.1074/jbc.272.21.13923

PubMed ID: 9820300

Title: Leukotriene C4-synthesis deficiency: a new inborn error of metabolism linked to a fatal developmental syndrome.

PubMed ID: 9820300

DOI: 10.1016/s0140-6736(98)01186-6

PubMed ID: 10896305

Title: Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism.

PubMed ID: 10896305

DOI: 10.1023/a:1005664204956

PubMed ID: 12023288

Title: Membrane localization and topology of leukotriene C4 synthase.

PubMed ID: 12023288

DOI: 10.1074/jbc.m203074200

PubMed ID: 19233132

Title: Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein.

PubMed ID: 19233132

DOI: 10.1016/j.bbrc.2009.02.074

PubMed ID: 17632548

Title: Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis.

PubMed ID: 17632548

DOI: 10.1038/nature05936

PubMed ID: 17632546

Title: Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase.

PubMed ID: 17632546

DOI: 10.1038/nature06009

PubMed ID: 23409838

Title: Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps.

PubMed ID: 23409838

DOI: 10.1021/bi3014104

PubMed ID: 27791009

Title: Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages.

PubMed ID: 27791009

DOI: 10.1073/pnas.1607003113

PubMed ID: 27365393

Title: Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.

PubMed ID: 27365393

DOI: 10.1074/jbc.m116.735647

Sequence Information:

  • Length: 150
  • Mass: 16567
  • Checksum: 04E269B475063037
  • Sequence:
    • MKDEVALLAA VTLLGVLLQA YFSLQVISAR RAFRVSPPLT TGPPEFERVY RAQVNCSEYF 
PLFLATLWVA GIFFHEGAAA LCGLVYLFAR LRYFQGYARS AQLRLAPLYA SARALWLLVA 
LAALGLLAHF LPAALRAALL GRLRTLLPWA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.