Details for: LTC4S

Gene ID: 4056

Symbol: LTC4S

Ensembl ID: ENSG00000213316

Description: leukotriene C4 synthase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.1556
    Cell Significance Index: -13.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.5758
    Cell Significance Index: -11.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.7749
    Cell Significance Index: -11.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.6835
    Cell Significance Index: -13.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.9668
    Cell Significance Index: -12.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.6005
    Cell Significance Index: -13.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7819
    Cell Significance Index: -12.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4275
    Cell Significance Index: -9.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.3595
    Cell Significance Index: 77.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3394
    Cell Significance Index: -13.1800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.0141
    Cell Significance Index: 33.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.5981
    Cell Significance Index: 28.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3491
    Cell Significance Index: 133.4600
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.2590
    Cell Significance Index: 4.3800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.2423
    Cell Significance Index: 19.2200
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 1.1658
    Cell Significance Index: 4.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.1396
    Cell Significance Index: 24.2700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 1.1051
    Cell Significance Index: 15.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0822
    Cell Significance Index: 56.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9489
    Cell Significance Index: 856.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8172
    Cell Significance Index: 11.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6797
    Cell Significance Index: 110.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6583
    Cell Significance Index: 71.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5123
    Cell Significance Index: 13.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4806
    Cell Significance Index: 28.8500
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.4573
    Cell Significance Index: 2.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3359
    Cell Significance Index: 41.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3325
    Cell Significance Index: 63.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3155
    Cell Significance Index: 21.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2814
    Cell Significance Index: 14.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2142
    Cell Significance Index: 27.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2029
    Cell Significance Index: 9.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1840
    Cell Significance Index: 2.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1249
    Cell Significance Index: 55.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1195
    Cell Significance Index: 21.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1090
    Cell Significance Index: 5.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1046
    Cell Significance Index: 12.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0818
    Cell Significance Index: 6.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0440
    Cell Significance Index: 24.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0324
    Cell Significance Index: 1.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0124
    Cell Significance Index: 2.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0017
    Cell Significance Index: -0.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0017
    Cell Significance Index: -0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0084
    Cell Significance Index: -0.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0088
    Cell Significance Index: -6.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.5200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0094
    Cell Significance Index: -0.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0105
    Cell Significance Index: -16.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0111
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0115
    Cell Significance Index: -8.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0129
    Cell Significance Index: -4.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0159
    Cell Significance Index: -11.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0171
    Cell Significance Index: -10.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0183
    Cell Significance Index: -3.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0200
    Cell Significance Index: -14.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0258
    Cell Significance Index: -14.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0301
    Cell Significance Index: -13.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0304
    Cell Significance Index: -19.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0350
    Cell Significance Index: -1.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0454
    Cell Significance Index: -6.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0466
    Cell Significance Index: -13.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0662
    Cell Significance Index: -4.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0674
    Cell Significance Index: -9.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0722
    Cell Significance Index: -15.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0723
    Cell Significance Index: -12.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0834
    Cell Significance Index: -9.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1243
    Cell Significance Index: -12.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1381
    Cell Significance Index: -16.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1391
    Cell Significance Index: -7.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1580
    Cell Significance Index: -12.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1650
    Cell Significance Index: -12.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1659
    Cell Significance Index: -4.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1694
    Cell Significance Index: -4.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1733
    Cell Significance Index: -11.1800
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.1820
    Cell Significance Index: -1.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2179
    Cell Significance Index: -13.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2215
    Cell Significance Index: -9.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2301
    Cell Significance Index: -7.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2345
    Cell Significance Index: -13.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2366
    Cell Significance Index: -14.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2498
    Cell Significance Index: -8.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2668
    Cell Significance Index: -9.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2674
    Cell Significance Index: -14.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2715
    Cell Significance Index: -12.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2885
    Cell Significance Index: -7.3700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3141
    Cell Significance Index: -4.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3142
    Cell Significance Index: -9.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3157
    Cell Significance Index: -11.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3222
    Cell Significance Index: -11.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3428
    Cell Significance Index: -9.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3484
    Cell Significance Index: -5.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3520
    Cell Significance Index: -11.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3561
    Cell Significance Index: -11.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3573
    Cell Significance Index: -3.2900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.3578
    Cell Significance Index: -4.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3605
    Cell Significance Index: -10.3400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3605
    Cell Significance Index: -2.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LTC4S exhibits distinct characteristics that enable its function in leukotriene biosynthesis. These include: 1. **Arachidonic acid specificity**: LTC4S selectively converts arachidonic acid into LTC4, highlighting its specificity for this particular fatty acid. 2. **Leukotriene C4 production**: The enzyme's primary function is to produce LTC4, which is then further processed into other leukotrienes, such as LTC5 and LTD4. 3. **Regulation of inflammation**: LTC4S is involved in the regulation of inflammatory responses, as LTC4 and other leukotrienes can induce bronchoconstriction, increase mucus production, and recruit inflammatory cells. 4. **Tissue regeneration**: LTC4S is also implicated in tissue regeneration, particularly in the context of lung injury, where it helps to resolve inflammation and promote tissue repair. **Pathways and Functions** LTC4S is integrated into multiple cellular pathways, including: 1. **Arachidonic acid metabolism**: LTC4S is involved in the conversion of arachidonic acid into LTC4, which is then further processed into other leukotrienes. 2. **Biosynthesis of dha-derived spms**: LTC4S is part of the biosynthetic pathway for specialized proresolving mediators (spms), which are involved in resolving inflammation. 3. **Biosynthesis of protectin and resolvin conjugates**: LTC4S is also involved in the production of protectin and resolvin conjugates, which are involved in tissue regeneration and anti-inflammatory responses. 4. **Cellular oxidant detoxification**: LTC4S has been shown to have glutathione peroxidase activity, which helps to detoxify cellular oxidants. **Clinical Significance** LTC4S has significant clinical implications in various diseases, including: 1. **Asthma**: LTC4S plays a crucial role in the regulation of inflammatory responses in asthma, and its inhibition has been explored as a potential therapeutic strategy. 2. **Allergic reactions**: LTC4S is involved in the production of leukotrienes, which are key mediators of allergic reactions, such as anaphylaxis. 3. **Inflammatory diseases**: LTC4S is implicated in the pathogenesis of various inflammatory diseases, including arthritis, inflammatory bowel disease, and cardiovascular disease. 4. **Tissue regeneration**: LTC4S is involved in tissue regeneration, particularly in the context of lung injury, where it helps to resolve inflammation and promote tissue repair. In conclusion, LTC4S is a critical enzyme involved in the biosynthesis of leukotrienes, which play a significant role in various physiological and pathological processes. Further research on LTC4S and its downstream targets may provide new insights into the development of therapeutic strategies for inflammatory and tissue regeneration disorders.

Genular Protein ID: 4213866900

Symbol: LTC4S_HUMAN

Name: Leukotriene C4 synthase

UniProtKB Accession Codes:

Q16873 Q8N6P0 Q9UC73 Q9UD18

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 4 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8052639

Title: Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4.

PubMed ID: 8052639

DOI: 10.1073/pnas.91.16.7663

PubMed ID: 7937884

Title: Molecular cloning and expression of human leukotriene-C4 synthase.

PubMed ID: 7937884

DOI: 10.1073/pnas.91.21.9745

PubMed ID: 8626689

Title: Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35.

PubMed ID: 8626689

DOI: 10.1074/jbc.271.19.11356

PubMed ID: 8898379

Title: Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35.

PubMed ID: 8898379

DOI: 10.1007/bf03401647

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8446623

Title: Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits.

PubMed ID: 8446623

DOI: 10.1073/pnas.90.5.2015

PubMed ID: 7599836

Title: Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody.

PubMed ID: 7599836

DOI: 10.1164/ajrccm.152.1.7599836

PubMed ID: 7766706

Title: Two step purification of human and murine leukotriene C4 synthase.

PubMed ID: 7766706

DOI: 10.1016/0005-2760(95)00031-7

PubMed ID: 9153254

Title: Site-directed mutagenesis of human leukotriene C4 synthase.

PubMed ID: 9153254

DOI: 10.1074/jbc.272.21.13923

PubMed ID: 9820300

Title: Leukotriene C4-synthesis deficiency: a new inborn error of metabolism linked to a fatal developmental syndrome.

PubMed ID: 9820300

DOI: 10.1016/s0140-6736(98)01186-6

PubMed ID: 10896305

Title: Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism.

PubMed ID: 10896305

DOI: 10.1023/a:1005664204956

PubMed ID: 12023288

Title: Membrane localization and topology of leukotriene C4 synthase.

PubMed ID: 12023288

DOI: 10.1074/jbc.m203074200

PubMed ID: 19233132

Title: Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein.

PubMed ID: 19233132

DOI: 10.1016/j.bbrc.2009.02.074

PubMed ID: 17632548

Title: Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis.

PubMed ID: 17632548

DOI: 10.1038/nature05936

PubMed ID: 17632546

Title: Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase.

PubMed ID: 17632546

DOI: 10.1038/nature06009

PubMed ID: 23409838

Title: Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps.

PubMed ID: 23409838

DOI: 10.1021/bi3014104

PubMed ID: 27791009

Title: Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages.

PubMed ID: 27791009

DOI: 10.1073/pnas.1607003113

PubMed ID: 27365393

Title: Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.

PubMed ID: 27365393

DOI: 10.1074/jbc.m116.735647

Sequence Information:

  • Length: 150
  • Mass: 16567
  • Checksum: 04E269B475063037
  • Sequence:
    • MKDEVALLAA VTLLGVLLQA YFSLQVISAR RAFRVSPPLT TGPPEFERVY RAQVNCSEYF 
PLFLATLWVA GIFFHEGAAA LCGLVYLFAR LRYFQGYARS AQLRLAPLYA SARALWLLVA 
LAALGLLAHF LPAALRAALL GRLRTLLPWA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.