Details for: HBM

Gene ID: 3042

Symbol: HBM

Ensembl ID: ENSG00000206177

Description: hemoglobin subunit mu

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.83
    Marker Score: 9256
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.34
    Marker Score: 663
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.06
    Marker Score: 660
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.05
    Marker Score: 7003
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1
    Marker Score: 678
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2537
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 613.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.77
    Marker Score: 247
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.74
    Marker Score: 553
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.73
    Marker Score: 272
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 0.67
    Marker Score: 284
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.62
    Marker Score: 649.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 452
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.54
    Marker Score: 262
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.4
    Marker Score: 98
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.39
    Marker Score: 627
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.39
    Marker Score: 215
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.35
    Marker Score: 147
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.35
    Marker Score: 235
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.35
    Marker Score: 426.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.33
    Marker Score: 225
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.32
    Marker Score: 144
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.31
    Marker Score: 180
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.31
    Marker Score: 159
  • Cell Name: enucleate erythrocyte (CL0000595)
    Fold Change: 0.29
    Marker Score: 115
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.29
    Marker Score: 103
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.27
    Marker Score: 90
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.27
    Marker Score: 293
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.25
    Marker Score: 123
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.25
    Marker Score: 237
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.24
    Marker Score: 92
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.24
    Marker Score: 128
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 138
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.23
    Marker Score: 316.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.22
    Marker Score: 414
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2
    Marker Score: 412
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2
    Marker Score: 232
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.19
    Marker Score: 126
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.19
    Marker Score: 99
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.19
    Marker Score: 327
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.18
    Marker Score: 2808
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.16
    Marker Score: 314
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.16
    Marker Score: 322
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.15
    Marker Score: 97
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.15
    Marker Score: 67
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.14
    Marker Score: 61
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.12
    Marker Score: 59
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.12
    Marker Score: 169
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.11
    Marker Score: 61
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.11
    Marker Score: 111
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.1
    Marker Score: 62
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.1
    Marker Score: 113
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 87
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.09
    Marker Score: 36
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.08
    Marker Score: 53.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.08
    Marker Score: 498
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 68
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 80
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 71
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.07
    Marker Score: 107
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.07
    Marker Score: 1228
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.07
    Marker Score: 181
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.06
    Marker Score: 65

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Other Information

**Key characteristics:** - HBM is a single-exon gene with a molecular weight of approximately 145 kDa. - The HBM gene is located on chromosome 15q21.1. - HBM is a highly conserved gene, with a similar sequence found in humans, mice, and rats. **Pathways and functions:** - The HBM gene is involved in several important pathways, including cellular oxidant detoxification, the haptoglobin-hemoglobin complex, and oxygen transport. - The HBM gene is also involved in the regulation of inflammation and apoptosis. **Clinical significance:** - Mutations in the HBM gene have been linked to several diseases, including sickle cell anemia and thalassemia. - In sickle cell anemia, mutations in the HBB gene produce a defective hemoglobin protein that is unable to carry oxygen effectively. This results in the characteristic symptoms of the disease, including pain, fatigue, and anemia. - In thalassemia, mutations in the HBA gene produce a defective hemoglobin protein that is unable to bind oxygen. This results in the characteristic symptoms of the disease, including anemia, jaundice, and pale skin. **Additional information:** - The HBM gene is also known as HBB1. - The HBM gene is expressed in all red blood cells, regardless of their size or shape. - The HBM protein is a tetramer, meaning it is composed of four polypeptide chains that are held together by disulfide bonds.

Genular Protein ID: 3163829699

Symbol: HBM_HUMAN

Name: Hemoglobin subunit mu

UniProtKB Accession Codes:

Q6B0K9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15855277

Title: A newly discovered human alpha-globin gene.

PubMed ID: 15855277

DOI: 10.1182/blood-2005-03-0948

PubMed ID: 16728641

Title: A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.

PubMed ID: 16728641

DOI: 10.1126/science.1126431

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 141
  • Mass: 15618
  • Checksum: 6864266BBE841516
  • Sequence:
    • MLSAQERAQI AQVWDLIAGH EAQFGAELLL RLFTVYPSTK VYFPHLSACQ DATQLLSHGQ 
RMLAAVGAAV QHVDNLRAAL SPLADLHALV LRVDPANFPL LIQCFHVVLA SHLQDEFTVQ 
MQAAWDKFLT GVAVVLTEKY R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.