Details for: HBM

Gene ID: 3042

Symbol: HBM

Ensembl ID: ENSG00000206177

Description: hemoglobin subunit mu

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 75.6687
    Cell Significance Index: 34.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 8.6763
    Cell Significance Index: 145.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.9783
    Cell Significance Index: -1.7700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 6.0359
    Cell Significance Index: 86.5000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 2.8302
    Cell Significance Index: 32.0400
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 2.0378
    Cell Significance Index: 10.7200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.1295
    Cell Significance Index: 9.7700
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.1025
    Cell Significance Index: 4.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.5753
    Cell Significance Index: -2.2700
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.4466
    Cell Significance Index: 1.2800
  • Cell Name: enucleate erythrocyte (CL0000595)
    Fold Change: 0.3790
    Cell Significance Index: 1.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1426
    Cell Significance Index: 3.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0849
    Cell Significance Index: 2.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0712
    Cell Significance Index: 1.0200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.0607
    Cell Significance Index: 0.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0557
    Cell Significance Index: 1.3900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0449
    Cell Significance Index: 0.5800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0392
    Cell Significance Index: 0.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0207
    Cell Significance Index: 4.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0118
    Cell Significance Index: 2.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0110
    Cell Significance Index: 0.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0017
    Cell Significance Index: 0.1800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0003
    Cell Significance Index: -0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0011
    Cell Significance Index: -0.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0017
    Cell Significance Index: -2.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0027
    Cell Significance Index: -0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0027
    Cell Significance Index: -0.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0036
    Cell Significance Index: -2.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0038
    Cell Significance Index: -2.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0049
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0049
    Cell Significance Index: -0.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0061
    Cell Significance Index: -0.1600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0102
    Cell Significance Index: -0.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0103
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0116
    Cell Significance Index: -2.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0133
    Cell Significance Index: -1.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0135
    Cell Significance Index: -1.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0139
    Cell Significance Index: -0.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0184
    Cell Significance Index: -2.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0203
    Cell Significance Index: -2.3300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0212
    Cell Significance Index: -0.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0219
    Cell Significance Index: -2.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0221
    Cell Significance Index: -0.3700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0259
    Cell Significance Index: -0.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0292
    Cell Significance Index: -1.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0309
    Cell Significance Index: -2.3700
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0317
    Cell Significance Index: -0.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0344
    Cell Significance Index: -2.3100
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0351
    Cell Significance Index: -0.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0354
    Cell Significance Index: -0.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0388
    Cell Significance Index: -1.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0401
    Cell Significance Index: -2.5900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0402
    Cell Significance Index: -0.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0415
    Cell Significance Index: -1.9500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0420
    Cell Significance Index: -0.6200
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0427
    Cell Significance Index: -0.5800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.0440
    Cell Significance Index: -0.2600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0440
    Cell Significance Index: -0.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0446
    Cell Significance Index: -2.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0457
    Cell Significance Index: -1.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0461
    Cell Significance Index: -0.6800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0467
    Cell Significance Index: -0.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0481
    Cell Significance Index: -2.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0484
    Cell Significance Index: -2.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0497
    Cell Significance Index: -2.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0519
    Cell Significance Index: -1.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0539
    Cell Significance Index: -2.0400
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0560
    Cell Significance Index: -0.5500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0571
    Cell Significance Index: -0.5500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0572
    Cell Significance Index: -0.3900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0593
    Cell Significance Index: -0.8200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0620
    Cell Significance Index: -0.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0634
    Cell Significance Index: -2.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0670
    Cell Significance Index: -2.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0679
    Cell Significance Index: -2.3600
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0715
    Cell Significance Index: -0.9200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0736
    Cell Significance Index: -1.2400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0744
    Cell Significance Index: -1.7900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0748
    Cell Significance Index: -0.5700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0752
    Cell Significance Index: -2.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0756
    Cell Significance Index: -0.8600
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.0801
    Cell Significance Index: -0.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0808
    Cell Significance Index: -2.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0816
    Cell Significance Index: -2.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0827
    Cell Significance Index: -2.3600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0841
    Cell Significance Index: -1.0400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.0850
    Cell Significance Index: -0.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0858
    Cell Significance Index: -2.1400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0869
    Cell Significance Index: -0.5100
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0877
    Cell Significance Index: -0.8400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0878
    Cell Significance Index: -0.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Expression:** The HBM gene is highly expressed in cells involved in oxygen transport, such as erythroblasts, promyelocytes, and hepatoblasts. Its expression is also observed in neurons, indicating a potential role in neurological functions. 2. **Protein Structure:** The HBM protein is a subunit of hemoglobin, which is a tetrameric complex composed of two alpha and two beta subunits. The HBM subunit plays a crucial role in oxygen binding and transport. 3. **Cellular Localization:** HBM is primarily localized in the plasma membrane of erythrocytes, where it interacts with other hemoglobin subunits and oxygen-binding proteins. **Pathways and Functions:** 1. **Oxygen Transport:** The HBM protein is essential for oxygen binding and transport in the bloodstream. Its interactions with other hemoglobin subunits and oxygen-binding proteins enable the efficient delivery of oxygen to tissues. 2. **Antioxidant Defense:** The HBM protein possesses peroxidase activity, which allows it to detoxify hydrogen peroxide and other reactive oxygen species (ROS). This function is critical for maintaining cellular homeostasis and preventing oxidative damage. 3. **Cell Signaling:** HBM has been implicated in cell signaling pathways, including the regulation of GABAergic neurotransmission in the brain. Its expression in neurons suggests a potential role in modulating neural activity. 4. **Inflammation:** HBM has been shown to interact with haptoglobin, a protein involved in the clearance of hemoglobin from the circulation. This interaction may play a role in modulating the inflammatory response. **Clinical Significance:** 1. **Hemoglobinopathies:** Mutations in the HBM gene can lead to hemoglobinopathies, such as beta-thalassemia and sickle cell disease. These conditions are characterized by impaired oxygen transport and tissue hypoxia. 2. **Neurological Disorders:** The expression of HBM in neurons suggests a potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. Further research is needed to elucidate the relationship between HBM and these conditions. 3. **Cancer:** HBM has been implicated in cancer cell metabolism and survival. Its expression in certain cancer types may indicate a potential target for therapeutic intervention. 4. **Infectious Diseases:** The HBM protein's peroxidase activity may play a role in the defense against oxidative stress caused by pathogens. Further research is needed to elucidate the relationship between HBM and infectious diseases. In conclusion, the Hemoglobin Subunit Mu (HBM) gene is a multifaceted gene with significant implications for our understanding of oxygen transport, antioxidant defense, cell signaling, and clinical disease. Further research is needed to fully elucidate the role of HBM in various cellular processes and its clinical significance.

Genular Protein ID: 3163829699

Symbol: HBM_HUMAN

Name: Hemoglobin subunit mu

UniProtKB Accession Codes:

Q6B0K9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15855277

Title: A newly discovered human alpha-globin gene.

PubMed ID: 15855277

DOI: 10.1182/blood-2005-03-0948

PubMed ID: 16728641

Title: A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.

PubMed ID: 16728641

DOI: 10.1126/science.1126431

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 141
  • Mass: 15618
  • Checksum: 6864266BBE841516
  • Sequence:
    • MLSAQERAQI AQVWDLIAGH EAQFGAELLL RLFTVYPSTK VYFPHLSACQ DATQLLSHGQ 
RMLAAVGAAV QHVDNLRAAL SPLADLHALV LRVDPANFPL LIQCFHVVLA SHLQDEFTVQ 
MQAAWDKFLT GVAVVLTEKY R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.