Details for: IBSP

Gene ID: 3381

Symbol: IBSP

Ensembl ID: ENSG00000029559

Description: integrin binding sialoprotein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 38.5486
    Cell Significance Index: -15.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.3320
    Cell Significance Index: -8.2600
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.9199
    Cell Significance Index: 26.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.0464
    Cell Significance Index: 16.1900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.2179
    Cell Significance Index: 2.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1295
    Cell Significance Index: 2.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0057
    Cell Significance Index: -10.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0068
    Cell Significance Index: -0.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0095
    Cell Significance Index: -0.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0169
    Cell Significance Index: -9.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0220
    Cell Significance Index: -9.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0265
    Cell Significance Index: -9.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0442
    Cell Significance Index: -7.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0456
    Cell Significance Index: -9.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0465
    Cell Significance Index: -9.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0486
    Cell Significance Index: -13.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0525
    Cell Significance Index: -10.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0541
    Cell Significance Index: -7.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0634
    Cell Significance Index: -10.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0657
    Cell Significance Index: -8.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0669
    Cell Significance Index: -8.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0835
    Cell Significance Index: -9.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0977
    Cell Significance Index: -9.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1229
    Cell Significance Index: -3.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1288
    Cell Significance Index: -17.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1445
    Cell Significance Index: -9.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1586
    Cell Significance Index: -8.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1746
    Cell Significance Index: -10.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2028
    Cell Significance Index: -9.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2030
    Cell Significance Index: -9.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2080
    Cell Significance Index: -5.3000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2555
    Cell Significance Index: -4.3400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2626
    Cell Significance Index: -2.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2764
    Cell Significance Index: -8.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3116
    Cell Significance Index: -8.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3129
    Cell Significance Index: -10.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3286
    Cell Significance Index: -10.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3297
    Cell Significance Index: -9.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3347
    Cell Significance Index: -10.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3348
    Cell Significance Index: -8.9400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3379
    Cell Significance Index: -8.4400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3441
    Cell Significance Index: -8.5800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3494
    Cell Significance Index: -5.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3522
    Cell Significance Index: -9.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3579
    Cell Significance Index: -15.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3685
    Cell Significance Index: -17.1800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3699
    Cell Significance Index: -2.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3745
    Cell Significance Index: -19.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3886
    Cell Significance Index: -8.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4182
    Cell Significance Index: -10.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4212
    Cell Significance Index: -15.9500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4215
    Cell Significance Index: -9.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4280
    Cell Significance Index: -15.7100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4335
    Cell Significance Index: -6.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4396
    Cell Significance Index: -8.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4762
    Cell Significance Index: -11.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4795
    Cell Significance Index: -10.3600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4869
    Cell Significance Index: -8.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4961
    Cell Significance Index: -10.5300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5186
    Cell Significance Index: -7.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5204
    Cell Significance Index: -8.7100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5260
    Cell Significance Index: -10.5600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5267
    Cell Significance Index: -10.5000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5447
    Cell Significance Index: -10.7700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5533
    Cell Significance Index: -10.8900
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.5657
    Cell Significance Index: -4.2900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.5813
    Cell Significance Index: -6.9100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5820
    Cell Significance Index: -9.5900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5957
    Cell Significance Index: -10.3000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5975
    Cell Significance Index: -11.6800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.6143
    Cell Significance Index: -5.9600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.6266
    Cell Significance Index: -7.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6271
    Cell Significance Index: -8.9800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.6339
    Cell Significance Index: -8.0200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.6437
    Cell Significance Index: -7.6000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.6561
    Cell Significance Index: -6.9700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.6582
    Cell Significance Index: -10.6600
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.6584
    Cell Significance Index: -7.8400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.6590
    Cell Significance Index: -7.4600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.6655
    Cell Significance Index: -9.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.6794
    Cell Significance Index: -9.5400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.6856
    Cell Significance Index: -8.2700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.6862
    Cell Significance Index: -9.4100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.6866
    Cell Significance Index: -8.8900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.6900
    Cell Significance Index: -8.1300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6976
    Cell Significance Index: -17.0200
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.7000
    Cell Significance Index: -8.0300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.7008
    Cell Significance Index: -9.8000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7030
    Cell Significance Index: -9.8600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.7031
    Cell Significance Index: -17.0300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.7069
    Cell Significance Index: -7.9000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.7083
    Cell Significance Index: -8.3700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.7092
    Cell Significance Index: -10.6100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.7116
    Cell Significance Index: -7.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7200
    Cell Significance Index: -8.1800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7295
    Cell Significance Index: -9.2100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.7322
    Cell Significance Index: -9.7300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.7343
    Cell Significance Index: -8.8200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.7349
    Cell Significance Index: -9.5300
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.7375
    Cell Significance Index: -8.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** IBSP is expressed in various cell types, including progenitor cells, osteoblasts, and endothelial cells. 2. **Protein structure:** IBSP is a member of the sialoprotein family, characterized by the presence of sialic acid residues. 3. **Integrin binding:** IBSP interacts with integrins, a family of transmembrane receptors involved in cell adhesion. 4. **Extracellular matrix organization:** IBSP regulates the organization of the ECM, which is essential for bone mineralization and tissue development. **Pathways and Functions:** IBSP is involved in several signaling pathways, including: 1. **Cell adhesion:** IBSP regulates cell adhesion through its interaction with integrins, which is essential for the formation and maintenance of tissue structure. 2. **Osteoblast differentiation:** IBSP promotes osteoblast differentiation, which is a critical process for bone formation and mineralization. 3. **Extracellular matrix organization:** IBSP regulates the organization of the ECM, which is essential for bone mineralization and tissue development. 4. **Growth factor signaling:** IBSP interacts with growth factors, such as transforming growth factor-beta (TGF-β), which regulates cell growth and differentiation. **Clinical Significance:** IBSP's role in bone-related disorders has significant clinical implications. Alterations in IBSP expression or function have been implicated in various bone diseases, including: 1. **Osteoporosis:** IBSP's role in osteoblast differentiation and bone mineralization makes it a potential therapeutic target for osteoporosis treatment. 2. **Bone fractures:** IBSP's involvement in cell adhesion and ECM organization makes it a potential therapeutic target for bone fracture repair. 3. **Growth disorders:** IBSP's role in cell growth and differentiation makes it a potential therapeutic target for growth disorders, such as dwarfism. In conclusion, IBSP is a key regulator of cell adhesion and bone mineralization. Its role in various cellular processes makes it a potential therapeutic target for bone-related disorders. Further research is needed to fully understand IBSP's function and its potential applications in clinical practice.

Genular Protein ID: 1703682246

Symbol: SIAL_HUMAN

Name: Bone sialoprotein II

UniProtKB Accession Codes:

P21815

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 9 Ensembl 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2404984

Title: Human bone sialoprotein. Deduced protein sequence and chromosomal localization.

PubMed ID: 2404984

DOI: 10.1016/s0021-9258(19)39982-x

PubMed ID: 8406493

Title: The human bone sialoprotein gene (IBSP): genomic localization and characterization.

PubMed ID: 8406493

DOI: 10.1006/geno.1993.1340

PubMed ID: 8061918

Title: Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence.

PubMed ID: 8061918

DOI: 10.1016/0945-053x(94)90027-2

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 3597437

Title: Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone.

PubMed ID: 3597437

DOI: 10.1016/s0021-9258(18)47991-4

PubMed ID: 11459848

Title: Structural characterization of human recombinant and bone-derived bone sialoprotein. Functional implications for cell attachment and hydroxyapatite binding.

PubMed ID: 11459848

DOI: 10.1074/jbc.m105689200

PubMed ID: 1818768

Title: Expression of bone sialoprotein (BSP) in developing human tissues.

PubMed ID: 1818768

DOI: 10.1007/bf02555854

PubMed ID: 10640428

Title: Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein.

PubMed ID: 10640428

DOI: 10.1006/excr.1999.4765

PubMed ID: 11669636

Title: Posttranslational modifications to human bone sialoprotein determined by mass spectrometry.

PubMed ID: 11669636

DOI: 10.1021/bi010887r

PubMed ID: 24103036

Title: Structure-activity relationship of human bone sialoprotein peptides.

PubMed ID: 24103036

DOI: 10.1111/eos.12081

PubMed ID: 36261010

Title: A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration.

PubMed ID: 36261010

DOI: 10.1016/j.celrep.2022.111511

Sequence Information:

  • Length: 317
  • Mass: 35148
  • Checksum: 736CB6B8C3716FE7
  • Sequence:
    • MKTALILLSI LGMACAFSMK NLHRRVKIED SEENGVFKYR PRYYLYKHAY FYPHLKRFPV 
QGSSDSSEEN GDDSSEEEEE EEETSNEGEN NEESNEDEDS EAENTTLSAT TLGYGEDATP 
GTGYTGLAAI QLPKKAGDIT NKATKEKESD EEEEEEEEGN ENEESEAEVD ENEQGINGTS 
TNSTEAENGN GSSGGDNGEE GEEESVTGAN AEDTTETGRQ GKGTSKTTTS PNGGFEPTTP 
PQVYRTTSPP FGKTTTVEYE GEYEYTGANE YDNGYEIYES ENGEPRGDNY RAYEDEYSYF 
KGQGYDGYDG QNYYHHQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.