Details for: FOLR2

Gene ID: 2350

Symbol: FOLR2

Ensembl ID: ENSG00000165457

Description: folate receptor beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 4.46
    Marker Score: 4462
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.45
    Marker Score: 1347
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.95
    Marker Score: 2232
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.81
    Marker Score: 738
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169491
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251808
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.99
    Marker Score: 2510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5329
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.83
    Marker Score: 1697
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 632
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.82
    Marker Score: 411
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.78
    Marker Score: 388
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.77
    Marker Score: 1400
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1186
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.72
    Marker Score: 803
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.6
    Marker Score: 1567
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.6
    Marker Score: 724
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 454
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.54
    Marker Score: 1596
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.51
    Marker Score: 1407
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 198
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.44
    Marker Score: 2679
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.38
    Marker Score: 189
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.35
    Marker Score: 867
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.35
    Marker Score: 145
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.35
    Marker Score: 310
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.34
    Marker Score: 169
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.34
    Marker Score: 644
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.33
    Marker Score: 356
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.32
    Marker Score: 192
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 83
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.31
    Marker Score: 292
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.31
    Marker Score: 81.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.3
    Marker Score: 580
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.28
    Marker Score: 15790
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.27
    Marker Score: 83
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.27
    Marker Score: 115
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.26
    Marker Score: 4080
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.25
    Marker Score: 984
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.25
    Marker Score: 170
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.24
    Marker Score: 185
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.24
    Marker Score: 229
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.24
    Marker Score: 77
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.22
    Marker Score: 134
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.22
    Marker Score: 903
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.21
    Marker Score: 507
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.2
    Marker Score: 134.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.2
    Marker Score: 114
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.19
    Marker Score: 53
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 114
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.19
    Marker Score: 45
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.19
    Marker Score: 4834
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.18
    Marker Score: 110
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.18
    Marker Score: 64
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.17
    Marker Score: 303
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.17
    Marker Score: 220
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.16
    Marker Score: 95
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.16
    Marker Score: 1031
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.15
    Marker Score: 461
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.14
    Marker Score: 1422
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 68
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.14
    Marker Score: 141
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.12
    Marker Score: 88
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.12
    Marker Score: 120
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.12
    Marker Score: 81
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.12
    Marker Score: 1338
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.11
    Marker Score: 81
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.11
    Marker Score: 66
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.11
    Marker Score: 24
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 99
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.11
    Marker Score: 133
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.11
    Marker Score: 132
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1
    Marker Score: 177
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.1
    Marker Score: 95
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.1
    Marker Score: 91
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.1
    Marker Score: 94
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.1
    Marker Score: 19
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 29

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Other Information

**Key characteristics:** * FolR2 is a transmembrane protein that is expressed in the plasma membrane of cells. * It is a member of the folate receptor family of proteins. * FolR2 is a high-affinity receptor for folic acid. * It is involved in the regulation of cell population proliferation and the maintenance of tissue integrity. * FolR2 is also involved in the inflammatory response and the metabolism of folate and pterines. **Pathways and functions:** * FolR2 is involved in cell adhesion by binding to folic acid and promoting the interaction between the cytoplasmic domain of the protein and the extracellular matrix protein fibronectin. * FolR2 is involved in the cellular response to folic acid by regulating the expression of genes that are involved in cell cycle regulation, cell growth, and migration. * FolR2 is involved in the regulation of cell population proliferation by binding to folic acid and promoting the assembly of a complex of signaling proteins that regulate cell cycle progression. * FolR2 is involved in the inflammatory response by binding to inflammatory cytokines and promoting the production of inflammatory cytokines. * FolR2 is involved in the metabolism of folate and pterines by regulating the uptake of these nutrients into cells. **Clinical significance:** Mutations in the FOLR2 gene have been linked to a number of human diseases, including colorectal cancer, breast cancer, and neural tube defects. These diseases are caused by mutations that disrupt the function of FolR2, which can lead to the accumulation of folate and pterines in cells. This can result in the activation of signaling pathways that promote cell proliferation and survival, which can lead to cancer. **Additional information:** * FolR2 is a highly conserved protein that is found in humans, mice, and rats. * It is a transmembrane protein that is expressed on the surface of cells. * It is a glycoprotein that is composed of 120 amino acids. * It is a high-affinity receptor for folic acid. * It is involved in the regulation of cell population proliferation and the maintenance of tissue integrity.

Genular Protein ID: 4046357496

Symbol: FOLR2_HUMAN

Name: Folate receptor beta

UniProtKB Accession Codes:

P14207 Q05CA5 Q6GTE8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 5 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 4 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8445646

Title: Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene.

PubMed ID: 8445646

DOI: 10.1006/jmbi.1993.1116

PubMed ID: 2605182

Title: Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA.

PubMed ID: 2605182

DOI: 10.1021/bi00446a042

PubMed ID: 8106441

Title: Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein.

PubMed ID: 8106441

DOI: 10.1016/s0021-9258(17)37605-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2561247

Title: Folate coenzyme and antifolate transport proteins in normal and neoplastic cells.

PubMed ID: 2561247

DOI: 10.1016/0065-2571(89)90091-5

PubMed ID: 4066659

Title: Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells.

PubMed ID: 4066659

DOI: 10.1016/s0021-9258(18)95679-6

PubMed ID: 7578066

Title: Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal.

PubMed ID: 7578066

DOI: 10.1021/bi00044a039

PubMed ID: 9398177

Title: Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion.

PubMed ID: 9398177

DOI: 10.1021/bi970845w

PubMed ID: 20632143

Title: All-trans retinoic acid is capable of inducing folate receptor beta expression in KG-1 cells.

PubMed ID: 20632143

DOI: 10.1007/s13277-010-0074-0

PubMed ID: 23934049

Title: Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.

PubMed ID: 23934049

DOI: 10.1073/pnas.1308827110

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 255
  • Mass: 29280
  • Checksum: F585715CF5631C98
  • Sequence:
    • MVWKWMPLLL LLVCVATMCS AQDRTDLLNV CMDAKHHKTK PGPEDKLHDQ CSPWKKNACC 
TASTSQELHK DTSRLYNFNW DHCGKMEPAC KRHFIQDTCL YECSPNLGPW IQQVNQSWRK 
ERFLDVPLCK EDCQRWWEDC HTSHTCKSNW HRGWDWTSGV NKCPAGALCR TFESYFPTPA 
ALCEGLWSHS YKVSNYSRGS GRCIQMWFDS AQGNPNEEVA RFYAAAMHVN AGEMLHGTGG 
LLLSLALMLQ LWLLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.