Details for: FOLR2

Gene ID: 2350

Symbol: FOLR2

Ensembl ID: ENSG00000165457

Description: folate receptor beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.0182
    Cell Significance Index: -9.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.6657
    Cell Significance Index: -9.3000
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 18.9769
    Cell Significance Index: 50.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.4374
    Cell Significance Index: -9.1700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 4.9636
    Cell Significance Index: 40.4800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.4722
    Cell Significance Index: 53.7200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.6728
    Cell Significance Index: 5.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3402
    Cell Significance Index: 40.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0225
    Cell Significance Index: 2.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0142
    Cell Significance Index: 0.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0093
    Cell Significance Index: 1.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0022
    Cell Significance Index: 0.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0035
    Cell Significance Index: -2.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0048
    Cell Significance Index: -9.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0095
    Cell Significance Index: -17.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0112
    Cell Significance Index: -17.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0119
    Cell Significance Index: -7.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0128
    Cell Significance Index: -17.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0151
    Cell Significance Index: -9.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0160
    Cell Significance Index: -9.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0182
    Cell Significance Index: -9.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0220
    Cell Significance Index: -9.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0254
    Cell Significance Index: -9.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0303
    Cell Significance Index: -8.7300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0311
    Cell Significance Index: -0.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0316
    Cell Significance Index: -5.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0489
    Cell Significance Index: -9.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0501
    Cell Significance Index: -8.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0525
    Cell Significance Index: -7.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0556
    Cell Significance Index: -2.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0599
    Cell Significance Index: -7.6800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0606
    Cell Significance Index: -0.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0611
    Cell Significance Index: -7.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0615
    Cell Significance Index: -8.4400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0617
    Cell Significance Index: -0.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0691
    Cell Significance Index: -8.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0900
    Cell Significance Index: -9.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0908
    Cell Significance Index: -2.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0909
    Cell Significance Index: -10.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0910
    Cell Significance Index: -2.4300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0931
    Cell Significance Index: -0.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0972
    Cell Significance Index: -4.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1163
    Cell Significance Index: -7.5000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1164
    Cell Significance Index: -1.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1208
    Cell Significance Index: -9.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1209
    Cell Significance Index: -9.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1242
    Cell Significance Index: -5.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1259
    Cell Significance Index: -7.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1329
    Cell Significance Index: -6.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1372
    Cell Significance Index: -8.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1450
    Cell Significance Index: -9.7500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1501
    Cell Significance Index: -2.5500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1641
    Cell Significance Index: -2.0300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1656
    Cell Significance Index: -1.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1747
    Cell Significance Index: -7.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1813
    Cell Significance Index: -2.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2067
    Cell Significance Index: -11.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2105
    Cell Significance Index: -9.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2338
    Cell Significance Index: -10.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2412
    Cell Significance Index: -8.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2424
    Cell Significance Index: -9.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2482
    Cell Significance Index: -6.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2534
    Cell Significance Index: -6.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2709
    Cell Significance Index: -9.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3007
    Cell Significance Index: -11.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3071
    Cell Significance Index: -9.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3079
    Cell Significance Index: -10.0800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3100
    Cell Significance Index: -7.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3103
    Cell Significance Index: -9.1400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3114
    Cell Significance Index: -2.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3146
    Cell Significance Index: -10.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3206
    Cell Significance Index: -9.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3315
    Cell Significance Index: -8.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3429
    Cell Significance Index: -12.0500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3431
    Cell Significance Index: -9.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3452
    Cell Significance Index: -6.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3543
    Cell Significance Index: -9.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3594
    Cell Significance Index: -9.4500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3674
    Cell Significance Index: -2.2200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3710
    Cell Significance Index: -6.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3744
    Cell Significance Index: -9.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3918
    Cell Significance Index: -8.5800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3966
    Cell Significance Index: -5.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3973
    Cell Significance Index: -9.9100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.4015
    Cell Significance Index: -3.6300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4030
    Cell Significance Index: -8.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4070
    Cell Significance Index: -9.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4217
    Cell Significance Index: -8.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4220
    Cell Significance Index: -12.1600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4240
    Cell Significance Index: -10.5900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4334
    Cell Significance Index: -7.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4453
    Cell Significance Index: -9.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4562
    Cell Significance Index: -7.6400
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.4569
    Cell Significance Index: -4.9900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.4571
    Cell Significance Index: -1.9900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4660
    Cell Significance Index: -6.0300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4661
    Cell Significance Index: -5.4800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.4684
    Cell Significance Index: -4.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** FOLR2 is a transmembrane receptor composed of two extracellular domains and a single transmembrane domain. 2. **Function:** FOLR2 is a high-affinity folate receptor that binds to folate, facilitating its uptake into cells. 3. **Expression:** FOLR2 is expressed in various cell types, including immune cells, such as Kupffer cells, macrophages, and GABAergic interneurons. 4. **Signaling:** FOLR2 activates downstream signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which regulate cell proliferation, survival, and migration. **Pathways and Functions:** 1. **Folate Metabolism:** FOLR2 plays a crucial role in the uptake of folate, which is essential for DNA synthesis, repair, and methylation. 2. **Cell Adhesion:** FOLR2 mediates cell adhesion to the extracellular matrix, influencing cell migration, invasion, and angiogenesis. 3. **Signaling:** FOLR2 activates various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which regulate cell proliferation, survival, and migration. 4. **Immune Response:** FOLR2 is expressed on immune cells, such as macrophages and dendritic cells, and plays a role in the regulation of immune responses, including monocyte chemotaxis and inflammatory response. **Clinical Significance:** 1. **Cancer:** FOLR2 is overexpressed in various types of cancer, including colon, breast, and ovarian cancer, and has been identified as a potential therapeutic target. 2. **Pregnancy Complications:** FOLR2 has been implicated in pregnancy complications, such as preeclampsia and gestational trophoblastic disease. 3. **Neurological Disorders:** FOLR2 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where folate metabolism is impaired. 4. **Infectious Diseases:** FOLR2 has been identified as a potential target for the treatment of infectious diseases, such as toxoplasmosis and malaria. In conclusion, the Folate Receptor Beta (FOLR2) is a multifunctional receptor that plays a critical role in folate metabolism, cell adhesion, and signaling. Its dysregulation has been implicated in various diseases, including cancer, pregnancy complications, and neurological disorders. Further research is needed to fully elucidate the mechanisms underlying FOLR2's functions and its potential therapeutic applications.

Genular Protein ID: 4046357496

Symbol: FOLR2_HUMAN

Name: Folate receptor beta

UniProtKB Accession Codes:

P14207 Q05CA5 Q6GTE8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 4 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8445646

Title: Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene.

PubMed ID: 8445646

DOI: 10.1006/jmbi.1993.1116

PubMed ID: 2605182

Title: Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA.

PubMed ID: 2605182

DOI: 10.1021/bi00446a042

PubMed ID: 8106441

Title: Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein.

PubMed ID: 8106441

DOI: 10.1016/s0021-9258(17)37605-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2561247

Title: Folate coenzyme and antifolate transport proteins in normal and neoplastic cells.

PubMed ID: 2561247

DOI: 10.1016/0065-2571(89)90091-5

PubMed ID: 4066659

Title: Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells.

PubMed ID: 4066659

DOI: 10.1016/s0021-9258(18)95679-6

PubMed ID: 7578066

Title: Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal.

PubMed ID: 7578066

DOI: 10.1021/bi00044a039

PubMed ID: 9398177

Title: Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion.

PubMed ID: 9398177

DOI: 10.1021/bi970845w

PubMed ID: 20632143

Title: All-trans retinoic acid is capable of inducing folate receptor beta expression in KG-1 cells.

PubMed ID: 20632143

DOI: 10.1007/s13277-010-0074-0

PubMed ID: 23934049

Title: Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.

PubMed ID: 23934049

DOI: 10.1073/pnas.1308827110

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 255
  • Mass: 29280
  • Checksum: F585715CF5631C98
  • Sequence:
    • MVWKWMPLLL LLVCVATMCS AQDRTDLLNV CMDAKHHKTK PGPEDKLHDQ CSPWKKNACC 
TASTSQELHK DTSRLYNFNW DHCGKMEPAC KRHFIQDTCL YECSPNLGPW IQQVNQSWRK 
ERFLDVPLCK EDCQRWWEDC HTSHTCKSNW HRGWDWTSGV NKCPAGALCR TFESYFPTPA 
ALCEGLWSHS YKVSNYSRGS GRCIQMWFDS AQGNPNEEVA RFYAAAMHVN AGEMLHGTGG 
LLLSLALMLQ LWLLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.