Details for: SLC2A5

Gene ID: 6518

Symbol: SLC2A5

Ensembl ID: ENSG00000142583

Description: solute carrier family 2 member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 47.5103
    Cell Significance Index: -7.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.0428
    Cell Significance Index: -7.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.9673
    Cell Significance Index: -4.0500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 7.8459
    Cell Significance Index: 18.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9937
    Cell Significance Index: -7.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0759
    Cell Significance Index: -8.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.3077
    Cell Significance Index: 66.4900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.1977
    Cell Significance Index: 32.9300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.1087
    Cell Significance Index: 32.6300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.7999
    Cell Significance Index: 11.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4306
    Cell Significance Index: 141.5200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.1462
    Cell Significance Index: 11.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0551
    Cell Significance Index: 63.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9650
    Cell Significance Index: 104.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9324
    Cell Significance Index: 20.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9323
    Cell Significance Index: 841.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7766
    Cell Significance Index: 126.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7400
    Cell Significance Index: 19.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6095
    Cell Significance Index: 71.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6037
    Cell Significance Index: 41.7500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.5178
    Cell Significance Index: 12.6400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.4763
    Cell Significance Index: 3.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4448
    Cell Significance Index: 12.4300
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.4230
    Cell Significance Index: 4.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3165
    Cell Significance Index: 6.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2144
    Cell Significance Index: 9.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1436
    Cell Significance Index: 3.5900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1400
    Cell Significance Index: 3.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1192
    Cell Significance Index: 22.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1067
    Cell Significance Index: 2.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1066
    Cell Significance Index: 6.8800
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.0820
    Cell Significance Index: 0.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0310
    Cell Significance Index: 5.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0273
    Cell Significance Index: 5.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0176
    Cell Significance Index: 0.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0068
    Cell Significance Index: 2.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0034
    Cell Significance Index: 6.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0047
    Cell Significance Index: -0.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0064
    Cell Significance Index: -4.0600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0092
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0099
    Cell Significance Index: -0.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0103
    Cell Significance Index: -7.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0103
    Cell Significance Index: -7.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0110
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0125
    Cell Significance Index: -7.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0129
    Cell Significance Index: -7.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0131
    Cell Significance Index: -5.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0132
    Cell Significance Index: -7.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0144
    Cell Significance Index: -6.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0177
    Cell Significance Index: -5.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0235
    Cell Significance Index: -1.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0250
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0271
    Cell Significance Index: -4.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0294
    Cell Significance Index: -3.0100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0354
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0368
    Cell Significance Index: -7.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0369
    Cell Significance Index: -2.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0390
    Cell Significance Index: -1.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0404
    Cell Significance Index: -4.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0430
    Cell Significance Index: -5.9100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0497
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0574
    Cell Significance Index: -6.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0603
    Cell Significance Index: -1.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0620
    Cell Significance Index: -8.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0655
    Cell Significance Index: -6.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0742
    Cell Significance Index: -8.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0749
    Cell Significance Index: -9.6000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0790
    Cell Significance Index: -1.1900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0841
    Cell Significance Index: -0.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0873
    Cell Significance Index: -5.8700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0876
    Cell Significance Index: -1.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0884
    Cell Significance Index: -6.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0917
    Cell Significance Index: -7.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0953
    Cell Significance Index: -5.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1083
    Cell Significance Index: -8.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1148
    Cell Significance Index: -5.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1170
    Cell Significance Index: -6.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1199
    Cell Significance Index: -7.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1271
    Cell Significance Index: -1.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1328
    Cell Significance Index: -7.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1442
    Cell Significance Index: -6.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1467
    Cell Significance Index: -7.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1526
    Cell Significance Index: -7.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1539
    Cell Significance Index: -5.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1615
    Cell Significance Index: -3.3500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1665
    Cell Significance Index: -2.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1679
    Cell Significance Index: -7.8300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1683
    Cell Significance Index: -7.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1724
    Cell Significance Index: -6.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1775
    Cell Significance Index: -5.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1799
    Cell Significance Index: -5.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1816
    Cell Significance Index: -4.4000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1852
    Cell Significance Index: -1.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1922
    Cell Significance Index: -5.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2087
    Cell Significance Index: -7.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2151
    Cell Significance Index: -7.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Fructose Transport:** SLC2A5 is a fructose transporter that facilitates the uptake of fructose across cell membranes. It is highly expressed in enterocytes, which are responsible for the absorption of nutrients from the gut. 2. **Widespread Expression:** SLC2A5 is expressed in various tissues, including the central nervous system, immune cells, and epithelial cells of the intestinal tract. 3. **Structural Homology:** SLC2A5 shares structural homology with other members of the SLC2A family, including SLC2A1 (glucose transporter 1) and SLC2A2 (glucose transporter 2). 4. **Regulation of Systemic Arterial Blood Pressure:** SLC2A5 has been implicated in the regulation of systemic arterial blood pressure, suggesting a potential role in cardiovascular disease. **Pathways and Functions:** 1. **Carbohydrate Metabolism:** SLC2A5 plays a critical role in the uptake and metabolism of fructose, a key energy source for cells. 2. **Immune System:** SLC2A5 is involved in the regulation of neutrophil degranulation and the innate immune system, suggesting a potential role in immune responses. 3. **Fructose Binding and Transport:** SLC2A5 binds to fructose and facilitates its transport across cell membranes, allowing for the uptake of this simple sugar by cells. 4. **Glucose Transport:** SLC2A5 also facilitates the transport of glucose across cell membranes, although its role in glucose metabolism is less well understood. **Clinical Significance:** 1. **Fructose Intolerance:** Mutations in the SLC2A5 gene have been associated with fructose intolerance, a condition characterized by impaired fructose metabolism. 2. **Immune-Mediated Diseases:** Alterations in SLC2A5 expression and function may contribute to the development of immune-mediated diseases, such as inflammatory bowel disease and multiple sclerosis. 3. **Cardiovascular Disease:** SLC2A5's role in regulating systemic arterial blood pressure may contribute to the development of cardiovascular disease. 4. **Neurological Disorders:** SLC2A5's expression in the central nervous system and its potential role in regulating glucose metabolism suggest a potential link to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SLC2A5 is a critical gene that plays a multifaceted role in fructose transport, carbohydrate metabolism, and immune regulation. Further research is needed to fully elucidate the functions and clinical significance of this gene.

Genular Protein ID: 394096384

Symbol: GTR5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1695905

Title: Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).

PubMed ID: 1695905

DOI: 10.1016/s0021-9258(19)38295-x

PubMed ID: 8037665

Title: Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP.

PubMed ID: 8037665

DOI: 10.1042/bj3010169

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8333543

Title: Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5.

PubMed ID: 8333543

DOI: 10.1152/ajpgi.1993.264.6.g1169

PubMed ID: 7619085

Title: The GLUT5 hexose transporter is also localized to the basolateral membrane of the human jejunum.

PubMed ID: 7619085

DOI: 10.1042/bj3090007

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 16186102

Title: Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7).

PubMed ID: 16186102

DOI: 10.1074/jbc.m508678200

PubMed ID: 29548810

Title: Differential patterns of inhibition of the sugar transporters GLUT2, GLUT5 and GLUT7 by flavonoids.

PubMed ID: 29548810

DOI: 10.1016/j.bcp.2018.03.011

PubMed ID: 17710649

Title: A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity.

PubMed ID: 17710649

DOI: 10.1080/09687680701298143

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 28083649

Title: Reassessment of GLUT7 and GLUT9 as putative fructose and glucose transporters.

PubMed ID: 28083649

DOI: 10.1007/s00232-016-9945-7

Sequence Information:

  • Length: 501
  • Mass: 54974
  • Checksum: 090B12F529C7B857
  • Sequence:
  • MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY NETYYGRTGE 
    FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG ALLFNNIFSI VPAILMGCSR 
    VATSFELIII SRLLVGICAG VSSNVVPMYL GELAPKNLRG ALGVVPQLFI TVGILVAQIF 
    GLRNLLANVD GWPILLGLTG VPAALQLLLL PFFPESPRYL LIQKKDEAAA KKALQTLRGW 
    DSVDREVAEI RQEDEAEKAA GFISVLKLFR MRSLRWQLLS IIVLMGGQQL SGVNAIYYYA 
    DQIYLSAGVP EEHVQYVTAG TGAVNVVMTF CAVFVVELLG RRLLLLLGFS ICLIACCVLT 
    AALALQDTVS WMPYISIVCV ISYVIGHALG PSPIPALLIT EIFLQSSRPS AFMVGGSVHW 
    LSNFTVGLIF PFIQEGLGPY SFIVFAVICL LTTIYIFLIV PETKAKTFIE INQIFTKMNK 
    VSEVYPEKEE LKELPPVTSE Q

Genular Protein ID: 3762680667

Symbol: B4DG19_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 457
  • Mass: 50132
  • Checksum: 0026813A00D61375
  • Sequence:
  • MGTTWLLSTP QHWTGEFMED FPLTLLWSVT VSMFPFGGFI GSLLVGPLVN KFGRKGALLF 
    NNIFSIVPAI LMGCSRVATS FELIIISRLL VGICAGVSSN VVPMYLGELA PKNLRGALGV 
    VPQLFITVGI LVAQIFGLRN LLANVDGWPI LLGLTGVPAA LQLLLLPFFP ESPRYLLIQK 
    KDEAAAKKAL QTLRGWDSVD REVAEIRQED EAEKAAGFIS VLKLFRMRSL RWQLLSIIVL 
    MGGQQLSGVN AIYYYADQIY LSAGVPEEHV QYVTAGTGAV NVVMTFCAVF VVELLGRRLL 
    LLLGFSICLI ACCVLTAALA LQDTVSWMPY ISIVCVISYV IGHALGPSPI PALLITEIFL 
    QSSRPSAFMV GGSVHWLSNF TVGLIFPFIQ EGLGPYSFIV FAVICLLTTI YIFLIVPETK 
    AKTFIEINQI FTKMNKVSEV YPEKEELKEL PPVTSEQ

Genular Protein ID: 2497695527

Symbol: A0A140VJK5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 244
  • Mass: 26519
  • Checksum: 310B5F011D6CEA71
  • Sequence:
  • MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY NETYYGRTGE 
    FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG ALLFNNIFSI VPAILMGCSR 
    VATSFELIII SRLLVGICAG VSSNVVPMYL GELAPKNLRG ALGVVPQLFI TVGILVAQIF 
    GLRNLLANVD GEFRTSREHP HPFTTTLGPL LVFQSHHHRT GLSADWSLLT GWMSLGGPSC 
    PEPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.