Details for: GPR34

Gene ID: 2857

Symbol: GPR34

Ensembl ID: ENSG00000171659

Description: G protein-coupled receptor 34

Associated with

  • G protein-coupled purinergic nucleotide receptor activity
    (GO:0045028)
  • G protein-coupled purinergic nucleotide receptor signaling pathway
    (GO:0035589)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Plasma membrane
    (GO:0005886)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.21
    Marker Score: 15442.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.95
    Marker Score: 4748
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.88
    Marker Score: 11137
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.56
    Marker Score: 30138
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.06
    Marker Score: 3056
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.58
    Marker Score: 7365
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.32
    Marker Score: 947
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.21
    Marker Score: 1219
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.86
    Marker Score: 924
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.65
    Marker Score: 598
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169138
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.39
    Marker Score: 1585
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.37
    Marker Score: 1527
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.25
    Marker Score: 560
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.23
    Marker Score: 3197.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 482
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4808
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.02
    Marker Score: 486
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5341
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.89
    Marker Score: 409.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 617
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.75
    Marker Score: 363
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.74
    Marker Score: 828
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.68
    Marker Score: 1084
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1343
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.62
    Marker Score: 347
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.6
    Marker Score: 1101
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.59
    Marker Score: 15069
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.52
    Marker Score: 270
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.49
    Marker Score: 1354
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 128
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.45
    Marker Score: 2738
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.42
    Marker Score: 511
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 389
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.4
    Marker Score: 263
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.38
    Marker Score: 2303
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 217
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.36
    Marker Score: 205
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.33
    Marker Score: 335
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.31
    Marker Score: 94
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3
    Marker Score: 127
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3
    Marker Score: 175
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.3
    Marker Score: 82
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.3
    Marker Score: 150
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.29
    Marker Score: 144
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.28
    Marker Score: 139
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.27
    Marker Score: 113
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.26
    Marker Score: 58
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.26
    Marker Score: 117
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.25
    Marker Score: 79
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.25
    Marker Score: 1050
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.25
    Marker Score: 183
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.24
    Marker Score: 456
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.24
    Marker Score: 182
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.24
    Marker Score: 142
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.22
    Marker Score: 933
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.22
    Marker Score: 2909
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.22
    Marker Score: 526
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.22
    Marker Score: 65
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.22
    Marker Score: 215
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.21
    Marker Score: 406
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.2
    Marker Score: 105
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 121
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.2
    Marker Score: 487
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.19
    Marker Score: 1917
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 173
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.18
    Marker Score: 448
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.18
    Marker Score: 167
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 56
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.17
    Marker Score: 60
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.17
    Marker Score: 209
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.17
    Marker Score: 146
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 80
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.17
    Marker Score: 57

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GPR34 is a transmembrane protein with a single extracellular domain and a single transmembrane domain. * It is a member of the G protein-coupled purinergic receptor family. * It is expressed in high levels in the retina and other tissues where it is involved in retinal function. **Pathways and functions:** * GPR34 is a key regulator of retinal cell survival and function. * It is essential for the development and maintenance of the retina. * It is involved in the regulation of retinal cell migration, proliferation, and differentiation. * It is also involved in the regulation of retinal inflammation. * It is a potential therapeutic target for retinal diseases. **Clinical significance:** * Mutations in GPR34 have been linked to several eye diseases, including macular degeneration, retinitis, and diabetic retinopathy. * G protein-coupled purinergic receptor agonists have been shown to be effective in treating these diseases. * Therefore, GPR34 is a promising target for the treatment of eye diseases. **Additional information:** * The gene encoding GPR34 is located on chromosome 11p15.1. * It is a single-exon gene. * It is expressed in high levels in the retina of humans and other primates. * It is a highly conserved gene.

Genular Protein ID: 4164374540

Symbol: GPR34_HUMAN

Name: Probable G-protein coupled receptor 34

UniProtKB Accession Codes:

Q9UPC5 O95853

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10395919

Title: A novel subgroup of class I G-protein-coupled receptors.

PubMed ID: 10395919

DOI: 10.1016/s0167-4781(99)00081-0

PubMed ID: 10036181

Title: Discovery of three novel orphan G-protein-coupled receptors.

PubMed ID: 10036181

DOI: 10.1006/geno.1998.5655

PubMed ID: 10982042

Title: Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1.

PubMed ID: 10982042

DOI: 10.1007/s004390000337

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16460680

Title: Identification of a lysophosphatidylserine receptor on mast cells.

PubMed ID: 16460680

DOI: 10.1016/j.bbrc.2006.01.069

PubMed ID: 27086875

Title: Topogenesis and cell surface trafficking of GPR34 are facilitated by positive-inside rule that effects through a tri-basic motif in the first intracellular loop.

PubMed ID: 27086875

DOI: 10.1016/j.bbamcr.2016.04.010

Sequence Information:

  • Length: 381
  • Mass: 43860
  • Checksum: 491FC016E5624379
  • Sequence:
    • MRSHTITMTT TSVSSWPYSS HRMRFITNHS DQPPQNFSAT PNVTTCPMDE KLLSTVLTTS 
YSVIFIVGLV GNIIALYVFL GIHRKRNSIQ IYLLNVAIAD LLLIFCLPFR IMYHINQNKW 
TLGVILCKVV GTLFYMNMYI SIILLGFISL DRYIKINRSI QQRKAITTKQ SIYVCCIVWM 
LALGGFLTMI ILTLKKGGHN STMCFHYRDK HNAKGEAIFN FILVVMFWLI FLLIILSYIK 
IGKNLLRISK RRSKFPNSGK YATTARNSFI VLIIFTICFV PYHAFRFIYI SSQLNVSSCY 
WKEIVHKTNE IMLVLSSFNS CLDPVMYFLM SSNIRKIMCQ LLFRRFQGEP SRSESTSEFK 
PGYSLHDTSV AVKIQSSSKS T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.