Details for: LINC02802

Gene ID: 100996732

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC02802

Ensembl ID: ENSG00000232527

Description: long intergenic non-protein coding RNA 2802

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • colon goblet cell CL0009039
    CSI 3.92
    rCSI 9.32%
    PRS 97.9
  • retinal ganglion cell CL0000740
    CSI 3.44
    rCSI 7.61%
    PRS 93.25
  • myofibroblast cell CL0000186
    CSI 3.05
    rCSI 4.22%
    PRS 96.61
  • colonocyte CL1000347
    CSI 2.93
    rCSI 4.19%
    PRS 96.97
  • stem cell CL0000034
    CSI 2.93
    rCSI 2.82%
    PRS 96.83
  • myeloid leukocyte CL0000766
    CSI 2.92
    rCSI 2.69%
    PRS 98.47
  • ciliated epithelial cell CL0000067
    CSI 2.83
    rCSI 2.49%
    PRS 93.98
  • intestine goblet cell CL0019031
    CSI 2.81
    rCSI 2.5%
    PRS 96.9
  • intestinal epithelial cell CL0002563
    CSI 2.61
    rCSI 2.73%
    PRS 96.71
  • adventitial cell CL0002503
    CSI 2.59
    rCSI 6.18%
    PRS 98.67
  • enteric smooth muscle cell CL0002504
    CSI 2.58
    rCSI 3.68%
    PRS 98.22
  • smooth muscle cell CL0000192
    CSI 2.57
    rCSI 6.12%
    PRS 95.68
  • retina horizontal cell CL0000745
    CSI 2.51
    rCSI 3.83%
    PRS 96.2
  • mesodermal cell CL0000222
    CSI 2.49
    rCSI 2.99%
    PRS 98.19
  • extravillous trophoblast CL0008036
    CSI 2.45
    rCSI 3.03%
    PRS 97
  • placental villous trophoblast CL2000060
    CSI 2.43
    rCSI 3.76%
    PRS 96.96
  • alveolar adventitial fibroblast CL4028006
    CSI 2.37
    rCSI 3.74%
    PRS 98.49
  • colon epithelial cell CL0011108
    CSI 2.36
    rCSI 2.47%
    PRS 97
  • enteroendocrine cell CL0000164
    CSI 2.3
    rCSI 3.14%
    PRS 96.48
  • epithelial cell of proximal tubule CL0002306
    CSI 2.16
    rCSI 5.27%
    PRS 94.57
  • type L enteroendocrine cell CL0002279
    CSI 2.11
    rCSI 3.97%
    PRS 97.5
  • transit amplifying cell CL0009010
    CSI 2.08
    rCSI 3.19%
    PRS 98.48
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 2.07
    rCSI 6.11%
    PRS 97.49
  • peripheral nervous system neuron CL2000032
    CSI 2.02
    rCSI 2.75%
    PRS 95.24
  • paneth cell CL0000510
    CSI 1.96
    rCSI 2.9%
    PRS 98.89
  • intestinal tuft cell CL0019032
    CSI 1.94
    rCSI 2.96%
    PRS 97.66
  • amacrine cell CL0000561
    CSI 1.55
    rCSI 4.5%
    PRS 94.03
  • stromal cell CL0000499
    CSI 1.46
    rCSI 4.11%
    PRS 96.59
  • glial cell CL0000125
    CSI 1.21
    rCSI 4.62%
    PRS 94.7
  • type EC enteroendocrine cell CL0000577
    CSI 1.07
    rCSI 3.81%
    PRS 97.41
  • mesenchymal cell CL0008019
    CSI 1.03
    rCSI 2.61%
    PRS 96.69
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.88
    rCSI 2.56%
    PRS 97.38
  • pancreatic stellate cell CL0002410
    CSI 0.66
    rCSI 3.84%
    PRS 97.99

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LINC02802](/details-gene/100996732) is a long intergenic non-protein coding RNA (lncRNA) located on chromosome 1q21.1. As a non-coding RNA, it is presumed to function through regulatory mechanisms rather than by being translated into a protein. Expression data indicates that [LINC02802](/details-gene/100996732) has a broad but distinct expression pattern, showing high significance in a diverse array of cell types. **Overall**, it is most prominent in secretory epithelial cells such as the [colon goblet cell](/details-cell/CL0009039), specialized neurons like the [retinal ganglion cell](/details-cell/CL0000740), and contractile cells including the [myofibroblast cell](/details-cell/CL0000186). This varied expression profile suggests it may play a fundamental role in establishing or maintaining the specialized functions of disparate cell lineages across multiple tissues. ## Cellular Roles and Expression Landscape The expression pattern of [LINC02802](/details-gene/100996732) points to a multifaceted role in cellular identity and function across epithelial, neuronal, and mesenchymal lineages. * **Gastrointestinal System:** The gene shows a particularly high cell significance index in the intestinal epithelium. It is a top marker for [colon goblet cell](/details-cell/CL0009039) (CSI: 3.92) and [intestine goblet cell](/details-cell/CL0019031) (CSI: 2.81), specialized secretory cells responsible for producing the protective mucus layer. Its significance in [colonocyte](/details-cell/CL1000347) (CSI: 2.93) and general [intestinal epithelial cell](/details-cell/CL0002563) (CSI: 2.61) further suggests a role in maintaining the function and integrity of the gut lining. * **Nervous System:** [LINC02802](/details-gene/100996732) is highly significant in specific neuronal populations of the eye, including the [retinal ganglion cell](/details-cell/CL0000740) (CSI: 3.44) and [retina horizontal cell](/details-cell/CL0000745) (CSI: 2.51). This specific expression pattern within the retina suggests a potential involvement in neuronal development, survival, or the regulation of visual signal processing. * **Mesenchymal and Structural Tissues:** The gene is also a prominent marker in cells associated with tissue structure and contractility. Its high significance in [myofibroblast cell](/details-cell/CL0000186) (CSI: 3.05), [smooth muscle cell](/details-cell/CL0000192) (CSI: 2.57), and [enteric smooth muscle cell](/details-cell/CL0002504) (CSI: 2.58) may indicate a function in regulating pathways related to extracellular matrix deposition, tissue repair, or smooth muscle contraction. * **Other Cell Types:** Its notable expression in [stem cell](/details-cell/CL0000034) (CSI: 2.93), [myeloid leukocyte](/details-cell/CL0000766) (CSI: 2.92), and [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 2.83) further underscores its broad, yet cell-type specific, regulatory potential. ## Pathways and Molecular Function As a long non-coding RNA, [LINC02802](/details-gene/100996732) is predicted to exert its function by interacting with DNA, RNA, or proteins to regulate gene expression at the transcriptional or post-transcriptional level. The specific molecular mechanisms, such as acting as a scaffold for protein complexes or as a competing endogenous RNA (ceRNA), are currently unknown. Detailed functional annotations linking [LINC02802](/details-gene/100996732) to specific Gene Ontology terms or Reactome pathways are not available in the provided data, indicating that its molecular function and the pathways it modulates remain to be characterized. ## Research Directions The diverse and specific expression pattern of [LINC02802](/details-gene/100996732) offers several avenues for future investigation into its biological roles and therapeutic potential. **Testable Hypotheses:** 1. Given its high and specific expression in [colon goblet cell](/details-cell/CL0009039), [LINC02802](/details-gene/100996732) may be a critical regulator of mucin synthesis and secretion, thereby playing a role in the maintenance of the intestinal mucosal barrier. Its dysregulation could contribute to inflammatory bowel diseases. 2. The co-expression in [myofibroblast cell](/details-cell/CL0000186) and [retinal ganglion cell](/details-cell/CL0000740) suggests that [LINC02802](/details-gene/100996732) could be involved in cellular stress response pathways common to both fibrosis and neuronal survival, potentially regulating cellular adaptation to injury or disease. **Proposed Experimental Approach:** To test the first hypothesis regarding its role in intestinal barrier function, a loss-of-function study could be performed. CRISPR-interference (CRISPRi) or antisense oligonucleotides (ASOs) could be used to specifically knock down [LINC02802](/details-gene/100996732) in human colon organoid cultures. The effects could be quantified by assessing changes in the number of goblet cells (via PAS staining), the expression of key mucin genes like *MUC2* (via RT-qPCR and RNA-seq), and the overall integrity of the epithelial barrier (via transepithelial electrical resistance measurements). **Therapeutic Potential:** As a lncRNA, [LINC02802](/details-gene/100996732) represents a non-traditional but increasingly accessible drug target. Its widespread expression in essential cell types, such as neurons and intestinal epithelium, implies that systemic targeting could lead to significant off-target effects. However, should its expression be found to be aberrantly upregulated in specific pathologies like colorectal cancer, fibrotic diseases, or glaucoma, it could become a viable candidate for **inhibition**. Therapeutic strategies would likely rely on localized delivery of ASOs or siRNA (e.g., via colonoscopy for intestinal diseases or intravitreal injection for retinal disorders) to maximize efficacy while minimizing systemic exposure and toxicity.