Details for: TULP2

Gene ID: 7288

Symbol: TULP2

Ensembl ID: ENSG00000104804

Description: TUB like protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 19.8013
    Cell Significance Index: -3.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.2219
    Cell Significance Index: -3.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 6.7199
    Cell Significance Index: -2.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 2.9301
    Cell Significance Index: -2.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.5062
    Cell Significance Index: -3.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0061
    Cell Significance Index: 181.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9996
    Cell Significance Index: 9.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.5443
    Cell Significance Index: 7.8000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.3128
    Cell Significance Index: 3.9600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2722
    Cell Significance Index: 3.8800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1925
    Cell Significance Index: 2.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1692
    Cell Significance Index: 2.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1661
    Cell Significance Index: 20.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1603
    Cell Significance Index: 8.3300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1246
    Cell Significance Index: 1.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1111
    Cell Significance Index: 5.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0583
    Cell Significance Index: 11.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0580
    Cell Significance Index: 1.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0539
    Cell Significance Index: 6.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0166
    Cell Significance Index: 5.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0086
    Cell Significance Index: 1.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0047
    Cell Significance Index: 0.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0013
    Cell Significance Index: 0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0015
    Cell Significance Index: -0.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0022
    Cell Significance Index: -0.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0027
    Cell Significance Index: -1.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0041
    Cell Significance Index: -3.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0045
    Cell Significance Index: -2.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0045
    Cell Significance Index: -0.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0055
    Cell Significance Index: -3.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0056
    Cell Significance Index: -0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0077
    Cell Significance Index: -2.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0125
    Cell Significance Index: -0.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0127
    Cell Significance Index: -1.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0136
    Cell Significance Index: -0.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0149
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0149
    Cell Significance Index: -3.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0152
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0203
    Cell Significance Index: -2.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0235
    Cell Significance Index: -3.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0246
    Cell Significance Index: -1.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0251
    Cell Significance Index: -0.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0256
    Cell Significance Index: -2.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0272
    Cell Significance Index: -0.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0288
    Cell Significance Index: -3.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0325
    Cell Significance Index: -0.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0329
    Cell Significance Index: -3.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0352
    Cell Significance Index: -2.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0381
    Cell Significance Index: -1.7900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0389
    Cell Significance Index: -0.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0411
    Cell Significance Index: -1.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0427
    Cell Significance Index: -3.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0461
    Cell Significance Index: -2.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0465
    Cell Significance Index: -3.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0477
    Cell Significance Index: -2.9300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0491
    Cell Significance Index: -0.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0491
    Cell Significance Index: -2.1700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0535
    Cell Significance Index: -0.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0542
    Cell Significance Index: -1.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0545
    Cell Significance Index: -1.7400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0549
    Cell Significance Index: -0.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0556
    Cell Significance Index: -3.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0580
    Cell Significance Index: -1.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0602
    Cell Significance Index: -2.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0602
    Cell Significance Index: -3.1600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0611
    Cell Significance Index: -0.9700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0624
    Cell Significance Index: -0.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0689
    Cell Significance Index: -2.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0769
    Cell Significance Index: -1.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0802
    Cell Significance Index: -4.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0804
    Cell Significance Index: -2.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0820
    Cell Significance Index: -2.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0838
    Cell Significance Index: -1.8100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0842
    Cell Significance Index: -1.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0854
    Cell Significance Index: -2.4600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0859
    Cell Significance Index: -2.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0866
    Cell Significance Index: -2.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0872
    Cell Significance Index: -3.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0879
    Cell Significance Index: -2.3500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0882
    Cell Significance Index: -1.3200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0930
    Cell Significance Index: -0.7400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0946
    Cell Significance Index: -1.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0947
    Cell Significance Index: -1.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0947
    Cell Significance Index: -2.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0973
    Cell Significance Index: -4.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0978
    Cell Significance Index: -3.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0987
    Cell Significance Index: -2.8300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1001
    Cell Significance Index: -2.0100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1010
    Cell Significance Index: -1.6200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1012
    Cell Significance Index: -2.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1022
    Cell Significance Index: -3.0100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1038
    Cell Significance Index: -1.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TULP2 is a member of the TULP family of proteins, which are characterized by their tubby-related domain. This domain is involved in protein-protein interactions and is essential for the localization of TULP2 to the cilium, a specialized organelle involved in sensory perception and motility. The TULP2 protein is a multifunctional protein that interacts with various proteins, including those involved in the regulation of cilia structure and function, visual perception, and immune responses. **Pathways and Functions** TULP2 is involved in several cellular pathways, including: 1. **Cilium formation and function**: TULP2 is essential for the localization of cilia to the cilium and maintaining their structure and function. Cilia play a crucial role in sensory perception, motility, and immune responses. 2. **Visual perception**: TULP2 is involved in the regulation of photoreceptor cell function and visual perception. Mutations in TULP2 have been associated with visual impairments and blindness. 3. **Immune system function**: TULP2 is expressed in immune cells, including macrophages and neutrophils, and is involved in the regulation of immune responses. 4. **Cell signaling**: TULP2 interacts with various signaling proteins, including those involved in the regulation of cell growth, differentiation, and survival. **Clinical Significance** TULP2 mutations have been associated with several human diseases, including: 1. **Visual impairment**: Mutations in TULP2 have been associated with visual impairments and blindness, including retinitis pigmentosa and cone-rod dystrophy. 2. **Immune system disorders**: TULP2 mutations have been associated with immune system disorders, including chronic granulomatous disease and neutrophil dysfunction. 3. **Ciliopathy**: TULP2 mutations have been associated with ciliopathies, a group of disorders characterized by defects in cilia structure and function. In conclusion, TULP2 is a multifunctional protein that plays a crucial role in maintaining cellular homeostasis and regulating the function of cilia. Mutations in TULP2 have been associated with several human diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the functions of TULP2 and its role in human disease.

Genular Protein ID: 1225215804

Symbol: TULP2_HUMAN

Name: Tubby-related protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9096357

Title: Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases.

PubMed ID: 9096357

DOI: 10.1073/pnas.94.7.3128

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15905330

Title: Identification of cancer/testis-antigen genes by massively parallel signature sequencing.

PubMed ID: 15905330

DOI: 10.1073/pnas.0502583102

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 520
  • Mass: 58664
  • Checksum: 6876323948101845
  • Sequence:
  • MSQDNDTLMR DILGHELAAM RLQKLEQQRR LFEKKQRQKR QELLMVQANP DASPWLWRSC 
    LREERLLGDR GLGNPFLRKK VSEAHLPSGI HSALGTVSCG GDGRGERGLP TPRTEAVFRN 
    LGLQSPFLSW LPDNSDAELE EVSVENGSVS PPPFKQSPRI RRKGWQAHQR PGTRAEGESD 
    SQDMGDAHKS PNMGPNPGMD GDCVYENLAF QKEEDLEKKR EASESTGTNS SAAHNEELSK 
    ALKGEGGTDS DHMRHEASLA IRSPCPGLEE DMEAYVLRPA LPGTMMQCYL TRDKHGVDKG 
    LFPLYYLYLE TSDSLQRFLL AGRKRRRSKT SNYLISLDPT HLSRDGDNFV GKVRSNVFST 
    KFTIFDNGVN PDREHLTRNT ARIRQELGAV CYEPNVLGYL GPRKMTVILP GTNSQNQRIN 
    VQPLNEQESL LSRYQRGDKQ GLLLLHNKTP SWDKENGVYT LNFHGRVTRA SVKNFQIVDP 
    KHQEHLVLQF GRVGPDTFTM DFCFPFSPLQ AFSICLSSFN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.