Details for: RAB3IL1

Gene ID: 5866

Symbol: RAB3IL1

Ensembl ID: ENSG00000167994

Description: RAB3A interacting protein like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.5798
    Cell Significance Index: -8.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.7074
    Cell Significance Index: -7.6000
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 6.0433
    Cell Significance Index: -0.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.9393
    Cell Significance Index: -6.0900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.6199
    Cell Significance Index: 58.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.0552
    Cell Significance Index: -8.1100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.3584
    Cell Significance Index: 21.5500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2607
    Cell Significance Index: 16.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9268
    Cell Significance Index: 29.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8250
    Cell Significance Index: 23.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7065
    Cell Significance Index: 17.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6664
    Cell Significance Index: 91.5200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.6401
    Cell Significance Index: 5.2200
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.5713
    Cell Significance Index: 2.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2702
    Cell Significance Index: 3.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2120
    Cell Significance Index: 40.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1949
    Cell Significance Index: 4.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1914
    Cell Significance Index: 11.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1596
    Cell Significance Index: 2.8200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.1548
    Cell Significance Index: 1.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1386
    Cell Significance Index: 7.0100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.1338
    Cell Significance Index: 0.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0963
    Cell Significance Index: 1.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0871
    Cell Significance Index: 1.8600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0842
    Cell Significance Index: 0.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0835
    Cell Significance Index: 9.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0822
    Cell Significance Index: 1.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0716
    Cell Significance Index: 4.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0644
    Cell Significance Index: 8.2500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0530
    Cell Significance Index: 0.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0359
    Cell Significance Index: 4.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0333
    Cell Significance Index: 0.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0319
    Cell Significance Index: 3.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0268
    Cell Significance Index: 14.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0247
    Cell Significance Index: 4.0100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0236
    Cell Significance Index: 0.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0216
    Cell Significance Index: 4.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0048
    Cell Significance Index: 3.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0026
    Cell Significance Index: 2.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0023
    Cell Significance Index: 4.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0003
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0047
    Cell Significance Index: -1.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0048
    Cell Significance Index: -7.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0080
    Cell Significance Index: -5.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0087
    Cell Significance Index: -3.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0102
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0106
    Cell Significance Index: -7.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0114
    Cell Significance Index: -2.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0145
    Cell Significance Index: -8.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0149
    Cell Significance Index: -6.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0169
    Cell Significance Index: -2.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0170
    Cell Significance Index: -0.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0201
    Cell Significance Index: -5.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0203
    Cell Significance Index: -0.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0219
    Cell Significance Index: -1.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0240
    Cell Significance Index: -2.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0243
    Cell Significance Index: -0.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0299
    Cell Significance Index: -0.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0300
    Cell Significance Index: -4.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0317
    Cell Significance Index: -5.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0335
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0353
    Cell Significance Index: -6.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0404
    Cell Significance Index: -8.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0444
    Cell Significance Index: -1.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0528
    Cell Significance Index: -2.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0555
    Cell Significance Index: -6.8200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0558
    Cell Significance Index: -0.8000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0574
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0581
    Cell Significance Index: -6.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0723
    Cell Significance Index: -1.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0759
    Cell Significance Index: -7.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0874
    Cell Significance Index: -6.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0912
    Cell Significance Index: -6.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1047
    Cell Significance Index: -8.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1088
    Cell Significance Index: -3.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1092
    Cell Significance Index: -5.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1207
    Cell Significance Index: -3.0100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1224
    Cell Significance Index: -1.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1226
    Cell Significance Index: -1.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1244
    Cell Significance Index: -6.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1252
    Cell Significance Index: -3.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1261
    Cell Significance Index: -8.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1263
    Cell Significance Index: -7.7600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1330
    Cell Significance Index: -1.9100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1360
    Cell Significance Index: -2.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1421
    Cell Significance Index: -9.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1445
    Cell Significance Index: -3.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1488
    Cell Significance Index: -7.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1531
    Cell Significance Index: -1.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1579
    Cell Significance Index: -6.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1586
    Cell Significance Index: -6.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1600
    Cell Significance Index: -8.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1664
    Cell Significance Index: -4.6500
  • Cell Name: reticular cell (CL0000432)
    Fold Change: -0.1711
    Cell Significance Index: -1.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1802
    Cell Significance Index: -7.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAB3IL1 exhibits several key characteristics that underscore its importance in immunological processes. Firstly, its interaction with RAB3A suggests that it is involved in regulating membrane trafficking and exocytosis, which are essential processes for immune cell function. Secondly, RAB3IL1 is a guanine nucleotide exchange factor (GEF) for RAB3A, meaning it can activate RAB3A by exchanging GDP for GTP, thereby regulating its activity. This GEF activity is critical for modulating membrane trafficking and immune responses. **Pathways and Functions** RAB3IL1 is involved in several key pathways that regulate membrane trafficking and immune responses. These include: 1. **Cytosol**: RAB3IL1 is involved in regulating the cytosolic localization of proteins and lipids, which is essential for maintaining cellular homeostasis and regulating immune responses. 2. **Exocytosis**: RAB3IL1 regulates the exocytosis of vesicles, which is critical for the release of immune-related molecules and the maintenance of immune cell function. 3. **Golgi to plasma membrane transport vesicle**: RAB3IL1 is involved in regulating the transport of vesicles from the Golgi apparatus to the plasma membrane, which is essential for the delivery of proteins and lipids to the cell surface. 4. **Guanyl-nucleotide exchange factor activity**: RAB3IL1's GEF activity for RAB3A is critical for regulating membrane trafficking and immune responses. 5. **Protein binding**: RAB3IL1 interacts with various proteins, including RAB3A, to regulate membrane trafficking and immune responses. 6. **Protein transport**: RAB3IL1 regulates the transport of proteins across the cell membrane, which is essential for maintaining cellular homeostasis and regulating immune responses. 7. **Rab regulation of trafficking**: RAB3IL1 regulates the activity of RAB3A, which is critical for modulating membrane trafficking and immune responses. 8. **Vesicle-mediated transport**: RAB3IL1 is involved in regulating vesicle-mediated transport, which is essential for the delivery of proteins and lipids to the cell surface. **Clinical Significance** RAB3IL1 has significant clinical implications, particularly in the context of immunological disorders. For example: 1. **Autoimmune diseases**: RAB3IL1 dysfunction may contribute to autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis, by disrupting membrane trafficking and immune responses. 2. **Immunodeficiency disorders**: RAB3IL1 deficiency may contribute to immunodeficiency disorders, such as DiGeorge syndrome, by disrupting membrane trafficking and immune responses. 3. **Cancer**: RAB3IL1 may play a role in cancer development and progression by regulating membrane trafficking and immune responses. 4. **Neurological disorders**: RAB3IL1 may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease, by disrupting membrane trafficking and immune responses. In conclusion, RAB3IL1 is a critical regulator of membrane trafficking and immunological functions, and its dysfunction may contribute to various immunological disorders. Further research is necessary to fully elucidate the role of RAB3IL1 in immune responses and its clinical significance.

Genular Protein ID: 4057105842

Symbol: R3GEF_HUMAN

Name: Guanine nucleotide exchange factor for Rab-3A

UniProtKB Accession Codes:

Q8TBN0 Q86V32 Q9P1Q8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20937701

Title: Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.

PubMed ID: 20937701

DOI: 10.1083/jcb.201008051

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 382
  • Mass: 42637
  • Checksum: 952C14B47CAEC7F9
  • Sequence:
    • MWSGPPQPDQ GLPPPLAAVP VPWKSTDPCQ GHRESPGALV ETSAGEEAQG QEGPAAAQLD 
VLRLRSSSME IREKGSEFLK EELHRAQKEL KLKDEECERL SKVREQLEQE LEELTASLFE 
EAHKMVREAN MKQAASEKQL KEARGKIDML QAEVTALKTL VITSTPASPN RELHPQLLSP 
TKAGPRKGHS RHKSTSSTLC PAVCPAAGHT LTPDREGKEV DTILFAEFQA WRESPTLDKT 
CPFLERVYRE DVGPCLDFTM QELSVLVRAA VEDNTLTIEP VASQTLPTVK VAEVDCSSTN 
TCALSGLTRT CRHRIRLGDS KSHYYISPSS RARITAVCNF FTYIRYIQQG LVRQDAEPMF 
WEIMRLRKEM SLAKLGFFPQ EA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.