Details for: KCNJ2

Gene ID: 3759

Symbol: KCNJ2

Ensembl ID: ENSG00000123700

Description: potassium inwardly rectifying channel subfamily J member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.76
    Marker Score: 36753
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 2.1
    Marker Score: 754
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169162
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.29
    Marker Score: 3089
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16730
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 787
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5297
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.89
    Marker Score: 19918
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.83
    Marker Score: 1697
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 302
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 682
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.71
    Marker Score: 26833.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.71
    Marker Score: 1462
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2934
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.69
    Marker Score: 666
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.61
    Marker Score: 195
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.59
    Marker Score: 557
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.57
    Marker Score: 1040
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.55
    Marker Score: 330
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 346
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 129
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.48
    Marker Score: 1774
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 224
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.46
    Marker Score: 457
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.46
    Marker Score: 258
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.46
    Marker Score: 456
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.45
    Marker Score: 3471
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.43
    Marker Score: 3775
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 426.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.43
    Marker Score: 136
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.43
    Marker Score: 23879
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.42
    Marker Score: 838
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.42
    Marker Score: 2719
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.41
    Marker Score: 1118
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.4
    Marker Score: 146
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.39
    Marker Score: 280
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.38
    Marker Score: 460
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.37
    Marker Score: 288
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.36
    Marker Score: 345
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.36
    Marker Score: 852
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.35
    Marker Score: 1363
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.35
    Marker Score: 1211
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.35
    Marker Score: 948
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.34
    Marker Score: 5061
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.34
    Marker Score: 214
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.34
    Marker Score: 154
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.34
    Marker Score: 227
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.32
    Marker Score: 514
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.31
    Marker Score: 97
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.31
    Marker Score: 128
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.31
    Marker Score: 153
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.3
    Marker Score: 733
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.3
    Marker Score: 171
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.29
    Marker Score: 260.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.28
    Marker Score: 278
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.28
    Marker Score: 128
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.27
    Marker Score: 165
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.27
    Marker Score: 834
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.26
    Marker Score: 503
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.26
    Marker Score: 68
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.25
    Marker Score: 783.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 112
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.25
    Marker Score: 133
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.25
    Marker Score: 124
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.25
    Marker Score: 1020
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.25
    Marker Score: 474
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.25
    Marker Score: 1228
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.25
    Marker Score: 79
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 71
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 136
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.24
    Marker Score: 12612
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.24
    Marker Score: 110
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.24
    Marker Score: 103
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.23
    Marker Score: 197
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.23
    Marker Score: 278
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.23
    Marker Score: 85
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.23
    Marker Score: 440
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.22
    Marker Score: 192
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.22
    Marker Score: 146
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.22
    Marker Score: 51
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.22
    Marker Score: 85
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.22
    Marker Score: 107
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.21
    Marker Score: 215

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Other Information

**Key characteristics:** * KCNJ2 is a member of the inwardly rectifying potassium channel family. * It is a highly conserved gene with a similar sequence in mammals. * It is expressed in a variety of cell types, suggesting a role in regulating potassium homeostasis and signaling. **Pathways and functions:** * KCNJ2 is involved in various cellular processes, including cardiac conduction, classical Kir channels, gaba b receptor activation, and muscle contraction. * It plays a role in regulating cardiac conduction by modulating the activity of cardiac sodium channels. * It is involved in classical Kir channels by mediating the inhibition of voltage-gated calcium channels. * It is involved in gaba b receptor activation by facilitating the opening of gaba b receptors. * It is involved in muscle contraction by modulating the opening of inotropic potassium channels. **Clinical significance:** * Mutations in KCNJ2 have been linked to several neurological disorders, including autism, schizophrenia, and epilepsy. * KCNJ2 is a potential therapeutic target for these disorders. * The development of drugs targeting KCNJ2 is an active area of research.

Genular Protein ID: 2670464955

Symbol: KCNJ2_HUMAN

Name: Inward rectifier potassium channel 2

UniProtKB Accession Codes:

P63252 O15110 P48049

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 8 EMDB 1 Ensembl 2 GO 33 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7696590

Title: Molecular cloning and expression of a human heart inward rectifier potassium channel.

PubMed ID: 7696590

DOI: 10.1097/00001756-199412000-00024

PubMed ID: 7590287

Title: Cloning and functional expression of a human gene, hIRK1, encoding the heart inward rectifier K+-channel.

PubMed ID: 7590287

DOI: 10.1016/0378-1119(95)00244-z

PubMed ID: 9490857

Title: Inwardly rectifying whole cell potassium current in human blood eosinophils.

PubMed ID: 9490857

DOI: 10.1111/j.1469-7793.1998.303bw.x

PubMed ID: 11240146

Title: Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits.

PubMed ID: 11240146

DOI: 10.1016/s0014-5793(01)02202-5

PubMed ID: 7840300

Title: Inward rectifier K+ channel from human heart and brain: cloning and stable expression in a human cell line.

PubMed ID: 7840300

DOI: 10.1152/ajpheart.1995.268.1.h506

PubMed ID: 12032359

Title: Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.

PubMed ID: 12032359

DOI: 10.1073/pnas.102609499

PubMed ID: 19608980

Title: Nitric oxide increases cardiac IK1 by nitrosylation of cysteine 76 of Kir2.1 channels.

PubMed ID: 19608980

DOI: 10.1161/circresaha.109.197558

PubMed ID: 25043870

Title: Cell-free identification of novel N-myristoylated proteins from complementary DNA resources using bioorthogonal myristic acid analogues.

PubMed ID: 25043870

DOI: 10.1016/j.ab.2014.07.006

PubMed ID: 36149965

Title: Cryo-electron microscopy unveils unique structural features of the human Kir2.1 channel.

PubMed ID: 36149965

DOI: 10.1126/sciadv.abq8489

PubMed ID: 11371347

Title: Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome.

PubMed ID: 11371347

DOI: 10.1016/s0092-8674(01)00342-7

PubMed ID: 12148092

Title: KCNJ2 mutation results in Andersen syndrome with sex-specific cardiac and skeletal muscle phenotypes.

PubMed ID: 12148092

DOI: 10.1086/342360

PubMed ID: 12163457

Title: Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome).

PubMed ID: 12163457

DOI: 10.1172/jci15183

PubMed ID: 15922306

Title: A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation.

PubMed ID: 15922306

DOI: 10.1016/j.bbrc.2005.05.054

PubMed ID: 15761194

Title: A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene.

PubMed ID: 15761194

DOI: 10.1161/01.res.0000162101.76263.8c

PubMed ID: 16571646

Title: Functional and clinical characterization of a mutation in KCNJ2 associated with Andersen-Tawil syndrome.

PubMed ID: 16571646

DOI: 10.1136/jmg.2006.040816

PubMed ID: 17324964

Title: Corticosteroid-exacerbated symptoms in an Andersen's syndrome kindred.

PubMed ID: 17324964

DOI: 10.1093/hmg/ddm034

Sequence Information:

  • Length: 427
  • Mass: 48288
  • Checksum: AB37CAD4B99B4050
  • Sequence:
    • MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK DGHCNVQFIN 
VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG CVFWLIALLH GDLDASKEGK 
ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV TDECPIAVFM VVFQSIVGCI IDAFIIGAVM 
AKMAKPKKRN ETLVFSHNAV IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG 
EYIPLDQIDI NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDIDNA DFEIVVILEG 
MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKHYYKVD YSRFHKTYEV PNTPLCSARD 
LAEKKYILSN ANSFCYENEV ALTSKEEDDS ENGVPESTST DTPPDIDLHN QASVPLEPRP 
LRRESEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.