Details for: KCNJ2

Gene ID: 3759

Symbol: KCNJ2

Ensembl ID: ENSG00000123700

Description: potassium inwardly rectifying channel subfamily J member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.9808
    Cell Significance Index: -12.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.3782
    Cell Significance Index: 31.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1222
    Cell Significance Index: 111.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7162
    Cell Significance Index: 43.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7115
    Cell Significance Index: 91.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6481
    Cell Significance Index: 70.5000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.6289
    Cell Significance Index: 5.5400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5864
    Cell Significance Index: 4.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5667
    Cell Significance Index: 92.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5446
    Cell Significance Index: 41.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4725
    Cell Significance Index: 20.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4463
    Cell Significance Index: 16.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4245
    Cell Significance Index: 19.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3319
    Cell Significance Index: 22.9600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.2260
    Cell Significance Index: 2.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2150
    Cell Significance Index: 40.9100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1861
    Cell Significance Index: 4.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1656
    Cell Significance Index: 4.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1613
    Cell Significance Index: 71.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1456
    Cell Significance Index: 52.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1452
    Cell Significance Index: 29.1300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1092
    Cell Significance Index: 0.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0884
    Cell Significance Index: 2.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0843
    Cell Significance Index: 1.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0632
    Cell Significance Index: 1.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0336
    Cell Significance Index: 0.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0266
    Cell Significance Index: 0.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0245
    Cell Significance Index: 0.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0164
    Cell Significance Index: 1.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0108
    Cell Significance Index: 0.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0023
    Cell Significance Index: 1.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0023
    Cell Significance Index: 0.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0003
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0047
    Cell Significance Index: -2.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0053
    Cell Significance Index: -3.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0077
    Cell Significance Index: -14.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0095
    Cell Significance Index: -14.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0109
    Cell Significance Index: -14.8400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0149
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0152
    Cell Significance Index: -8.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0161
    Cell Significance Index: -11.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0181
    Cell Significance Index: -11.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0209
    Cell Significance Index: -3.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0235
    Cell Significance Index: -4.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0281
    Cell Significance Index: -12.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0325
    Cell Significance Index: -5.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0366
    Cell Significance Index: -10.5400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0451
    Cell Significance Index: -0.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0541
    Cell Significance Index: -10.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0589
    Cell Significance Index: -7.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0682
    Cell Significance Index: -4.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0688
    Cell Significance Index: -8.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0694
    Cell Significance Index: -1.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0724
    Cell Significance Index: -9.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0799
    Cell Significance Index: -11.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0804
    Cell Significance Index: -4.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0819
    Cell Significance Index: -11.2500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0868
    Cell Significance Index: -9.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0883
    Cell Significance Index: -4.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0904
    Cell Significance Index: -9.2300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0960
    Cell Significance Index: -1.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1028
    Cell Significance Index: -1.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1109
    Cell Significance Index: -13.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1172
    Cell Significance Index: -13.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1177
    Cell Significance Index: -12.2600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1260
    Cell Significance Index: -2.5300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1302
    Cell Significance Index: -2.1000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1332
    Cell Significance Index: -1.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1377
    Cell Significance Index: -4.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1422
    Cell Significance Index: -6.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1428
    Cell Significance Index: -2.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1428
    Cell Significance Index: -7.5000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1434
    Cell Significance Index: -2.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1521
    Cell Significance Index: -12.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1703
    Cell Significance Index: -12.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1981
    Cell Significance Index: -12.7800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2001
    Cell Significance Index: -8.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2236
    Cell Significance Index: -4.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2251
    Cell Significance Index: -12.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2337
    Cell Significance Index: -12.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2445
    Cell Significance Index: -6.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2629
    Cell Significance Index: -7.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2639
    Cell Significance Index: -6.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3004
    Cell Significance Index: -8.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3067
    Cell Significance Index: -10.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3090
    Cell Significance Index: -2.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3107
    Cell Significance Index: -9.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3111
    Cell Significance Index: -11.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3266
    Cell Significance Index: -11.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3284
    Cell Significance Index: -8.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3334
    Cell Significance Index: -11.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3361
    Cell Significance Index: -8.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3449
    Cell Significance Index: -10.1600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3453
    Cell Significance Index: -4.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3480
    Cell Significance Index: -14.2600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3642
    Cell Significance Index: -4.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3656
    Cell Significance Index: -18.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Potassium Channel Function:** KCNJ2 encodes for a potassium inwardly rectifying channel, which regulates the influx of potassium ions into the cell, maintaining the resting membrane potential and influencing various cellular processes. 2. **Cellular Expression:** KCNJ2 is expressed in cardiac muscle cells, gut endothelial cells, and other cell types, including cerebral cortex GABAergic interneurons and forebrain radial glial cells. 3. **Signaling Pathways:** KCNJ2 is involved in several signaling pathways, including the activation of GABA receptors, the regulation of cardiac conduction, and the transmission of sensory information. **Pathways and Functions:** 1. **Cardiac Conduction:** KCNJ2 plays a critical role in regulating the cardiac muscle cell action potential, influencing cardiac conduction and heart rate. 2. **Muscle Contraction:** KCNJ2 is involved in regulating muscle contraction, particularly in cardiac muscle cells, by influencing the cardiac muscle cell action potential. 3. **Sensory Perception:** KCNJ2 is involved in the regulation of sensory perception, particularly in the transmission of sensory information from the taste buds to the brain. 4. **Regulation of Membrane Potential:** KCNJ2 helps regulate the resting membrane potential and the membrane repolarization during the cardiac muscle cell action potential. 5. **Cellular Response to Mechanical Stimulus:** KCNJ2 is involved in the cellular response to mechanical stimuli, influencing the contraction and relaxation of cardiac and skeletal muscle cells. **Clinical Significance:** 1. **Arrhythmias:** Mutations in the KCNJ2 gene have been associated with arrhythmias, including long QT syndrome and Brugada syndrome. 2. **Cardiac Conduction Disorders:** KCNJ2 dysfunction can lead to cardiac conduction disorders, including heart block and cardiac arrest. 3. **Sensory Perception Disorders:** KCNJ2 mutations have been linked to sensory perception disorders, including taste disorders and altered perception of sour taste. 4. **Neurological Disorders:** KCNJ2 has been implicated in neurological disorders, including epilepsy and migraines. In conclusion, the KCNJ2 gene plays a critical role in regulating cardiac conduction, muscle contraction, and sensory perception. Its dysfunction can lead to various clinical disorders, highlighting the importance of this gene in maintaining proper cellular function and overall health.

Genular Protein ID: 2670464955

Symbol: KCNJ2_HUMAN

Name: Inward rectifier potassium channel 2

UniProtKB Accession Codes:

P63252 O15110 P48049

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 8 EMDB 1 Ensembl 2 GO 33 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7696590

Title: Molecular cloning and expression of a human heart inward rectifier potassium channel.

PubMed ID: 7696590

DOI: 10.1097/00001756-199412000-00024

PubMed ID: 7590287

Title: Cloning and functional expression of a human gene, hIRK1, encoding the heart inward rectifier K+-channel.

PubMed ID: 7590287

DOI: 10.1016/0378-1119(95)00244-z

PubMed ID: 9490857

Title: Inwardly rectifying whole cell potassium current in human blood eosinophils.

PubMed ID: 9490857

DOI: 10.1111/j.1469-7793.1998.303bw.x

PubMed ID: 11240146

Title: Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits.

PubMed ID: 11240146

DOI: 10.1016/s0014-5793(01)02202-5

PubMed ID: 7840300

Title: Inward rectifier K+ channel from human heart and brain: cloning and stable expression in a human cell line.

PubMed ID: 7840300

DOI: 10.1152/ajpheart.1995.268.1.h506

PubMed ID: 12032359

Title: Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.

PubMed ID: 12032359

DOI: 10.1073/pnas.102609499

PubMed ID: 19608980

Title: Nitric oxide increases cardiac IK1 by nitrosylation of cysteine 76 of Kir2.1 channels.

PubMed ID: 19608980

DOI: 10.1161/circresaha.109.197558

PubMed ID: 25043870

Title: Cell-free identification of novel N-myristoylated proteins from complementary DNA resources using bioorthogonal myristic acid analogues.

PubMed ID: 25043870

DOI: 10.1016/j.ab.2014.07.006

PubMed ID: 36149965

Title: Cryo-electron microscopy unveils unique structural features of the human Kir2.1 channel.

PubMed ID: 36149965

DOI: 10.1126/sciadv.abq8489

PubMed ID: 11371347

Title: Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome.

PubMed ID: 11371347

DOI: 10.1016/s0092-8674(01)00342-7

PubMed ID: 12148092

Title: KCNJ2 mutation results in Andersen syndrome with sex-specific cardiac and skeletal muscle phenotypes.

PubMed ID: 12148092

DOI: 10.1086/342360

PubMed ID: 12163457

Title: Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome).

PubMed ID: 12163457

DOI: 10.1172/jci15183

PubMed ID: 15922306

Title: A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation.

PubMed ID: 15922306

DOI: 10.1016/j.bbrc.2005.05.054

PubMed ID: 15761194

Title: A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene.

PubMed ID: 15761194

DOI: 10.1161/01.res.0000162101.76263.8c

PubMed ID: 16571646

Title: Functional and clinical characterization of a mutation in KCNJ2 associated with Andersen-Tawil syndrome.

PubMed ID: 16571646

DOI: 10.1136/jmg.2006.040816

PubMed ID: 17324964

Title: Corticosteroid-exacerbated symptoms in an Andersen's syndrome kindred.

PubMed ID: 17324964

DOI: 10.1093/hmg/ddm034

Sequence Information:

  • Length: 427
  • Mass: 48288
  • Checksum: AB37CAD4B99B4050
  • Sequence:
    • MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK DGHCNVQFIN 
VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG CVFWLIALLH GDLDASKEGK 
ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV TDECPIAVFM VVFQSIVGCI IDAFIIGAVM 
AKMAKPKKRN ETLVFSHNAV IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG 
EYIPLDQIDI NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDIDNA DFEIVVILEG 
MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKHYYKVD YSRFHKTYEV PNTPLCSARD 
LAEKKYILSN ANSFCYENEV ALTSKEEDDS ENGVPESTST DTPPDIDLHN QASVPLEPRP 
LRRESEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.