Details for: TNNI2

Gene ID: 7136

Symbol: TNNI2

Ensembl ID: ENSG00000130598

Description: troponin I2, fast skeletal type

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 7.25
    Marker Score: 5519
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1163
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.4
    Marker Score: 1541
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 848
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.18
    Marker Score: 30298
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.16
    Marker Score: 1226
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 482
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.05
    Marker Score: 1552
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.98
    Marker Score: 1112
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.94
    Marker Score: 469
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5217
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.87
    Marker Score: 2178.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.83
    Marker Score: 383
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.83
    Marker Score: 1022
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.79
    Marker Score: 3092
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.76
    Marker Score: 2136
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3073
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 558
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.73
    Marker Score: 876
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.7
    Marker Score: 212
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.64
    Marker Score: 3904
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 352
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.54
    Marker Score: 265
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.53
    Marker Score: 1041
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.5
    Marker Score: 333
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.49
    Marker Score: 215
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.47
    Marker Score: 884
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.45
    Marker Score: 298
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.43
    Marker Score: 127
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.42
    Marker Score: 136
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.42
    Marker Score: 290
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.41
    Marker Score: 22994
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.41
    Marker Score: 171
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 107
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.4
    Marker Score: 956
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.39
    Marker Score: 643
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.38
    Marker Score: 242
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.38
    Marker Score: 121
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.37
    Marker Score: 112
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.37
    Marker Score: 1375
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.36
    Marker Score: 200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.33
    Marker Score: 1143
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.32
    Marker Score: 111
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.31
    Marker Score: 309
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.31
    Marker Score: 145
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.3
    Marker Score: 783
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.3
    Marker Score: 309
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.29
    Marker Score: 198
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.29
    Marker Score: 465
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 162
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.28
    Marker Score: 120.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.28
    Marker Score: 94
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.28
    Marker Score: 281
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.27
    Marker Score: 114
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.27
    Marker Score: 146
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.27
    Marker Score: 181
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.27
    Marker Score: 87.5
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.26
    Marker Score: 2295
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.25
    Marker Score: 67
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.25
    Marker Score: 51
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.25
    Marker Score: 111
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.25
    Marker Score: 2874
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.25
    Marker Score: 86
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.24
    Marker Score: 149
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.24
    Marker Score: 159.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.23
    Marker Score: 253
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.23
    Marker Score: 942
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.21
    Marker Score: 77
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.21
    Marker Score: 360
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.2
    Marker Score: 262
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.2
    Marker Score: 136
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.19
    Marker Score: 361
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.19
    Marker Score: 244
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.19
    Marker Score: 107
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.18
    Marker Score: 214
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.18
    Marker Score: 42
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.18
    Marker Score: 88
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.18
    Marker Score: 61

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Other Information

**Key Characteristics:** 1. **Expression Pattern:** TNNI2 is predominantly expressed in skeletal muscle, with significant expression in other tissues such as the colon, cornea, and small intestine. 2. **Protein Function:** Troponin I2 is a fast skeletal type, which distinguishes it from other troponin isoforms. Its primary function is to regulate muscle contraction and relaxation by binding to tropomyosin and modulating the interaction between actin and myosin filaments. 3. **Cellular Localization:** TNNI2 is found in the cytosol of muscle cells, as well as in the nucleus, where it may play a role in gene transcription regulation. **Pathways and Functions:** 1. **Muscle Contraction:** TNNI2 is integral to the regulation of skeletal muscle contraction through its interaction with tropomyosin and actin/myosin filaments. 2. **Cardiac Muscle Contraction:** Although not as well-studied as in skeletal muscle, TNNI2 has been implicated in cardiac muscle contraction, suggesting a conserved function across muscle types. 3. **DNA-templated Transcription:** TNNI2 may play a role in regulating gene transcription, given its localization to the nucleus. **Clinical Significance:** Dysregulation of TNNI2 has been implicated in various diseases and conditions, including: 1. **Muscular Dystrophy:** Mutations in the TNNI2 gene have been associated with certain forms of muscular dystrophy, highlighting the protein's critical role in muscle function. 2. **Cardiac Disease:** Aberrant TNNI2 expression has been linked to cardiac dysfunction and arrhythmias, underscoring the protein's importance in cardiac muscle contraction. 3. **Neurological Disorders:** TNNI2 has been found in the brain and may play a role in neurological disorders such as epilepsy and schizophrenia, where dysregulation of muscle contraction and relaxation may contribute to disease pathogenesis. In conclusion, TNNI2 is a multifunctional protein that plays a critical role in regulating skeletal muscle contraction and relaxation, as well as cardiac muscle function and gene transcription regulation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying TNNI2 function and its clinical significance.

Genular Protein ID: 2816138432

Symbol: TNNI2_HUMAN

Name: Troponin I, fast skeletal muscle

UniProtKB Accession Codes:

P48788 A6NIV8 A6NJU5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 Ensembl 8 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8148383

Title: Sequencing of a cDNA encoding the human fast-twitch skeletal muscle isoform of troponin I.

PubMed ID: 8148383

DOI: 10.1016/0167-4781(94)90297-6

PubMed ID: 10721725

Title: Structural characterization of the human fast skeletal muscle troponin I gene (TNNI2).

PubMed ID: 10721725

DOI: 10.1016/s0378-1119(99)00519-3

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12592607

Title: Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes.

PubMed ID: 12592607

DOI: 10.1086/368294

Sequence Information:

  • Length: 182
  • Mass: 21339
  • Checksum: A204BF5616D748BB
  • Sequence:
    • MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRREAE KQNYLAEHCP PLHIPGSMSE 
VQELCKQLHA KIDAAEEEKY DMEVRVQKTS KELEDMNQKL FDLRGKFKRP PLRRVRMSAD 
AMLKALLGSK HKVCMDLRAN LKQVKKEDTE KERDLRDVGD WRKNIEEKSG MEGRKKMFES 
ES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.