Details for: TNNI2

Gene ID: 7136

Symbol: TNNI2

Ensembl ID: ENSG00000130598

Description: troponin I2, fast skeletal type

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 31.6950
    Cell Significance Index: -4.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.4762
    Cell Significance Index: -4.9400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 12.9004
    Cell Significance Index: 208.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.3475
    Cell Significance Index: -4.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 9.8564
    Cell Significance Index: -5.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.8495
    Cell Significance Index: -4.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.9904
    Cell Significance Index: -4.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.5547
    Cell Significance Index: 63.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3922
    Cell Significance Index: 124.2700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.1952
    Cell Significance Index: 13.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6849
    Cell Significance Index: 47.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6594
    Cell Significance Index: 22.6400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.3418
    Cell Significance Index: 32.7400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.1843
    Cell Significance Index: 2.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0929
    Cell Significance Index: 29.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5714
    Cell Significance Index: 56.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5688
    Cell Significance Index: 108.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5004
    Cell Significance Index: 451.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4677
    Cell Significance Index: 8.6500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.4104
    Cell Significance Index: 5.7600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.2962
    Cell Significance Index: 3.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2895
    Cell Significance Index: 7.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2861
    Cell Significance Index: 14.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2176
    Cell Significance Index: 26.7600
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.2018
    Cell Significance Index: 2.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1570
    Cell Significance Index: 4.0100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1560
    Cell Significance Index: 2.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1461
    Cell Significance Index: 15.9000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1416
    Cell Significance Index: 0.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1189
    Cell Significance Index: 21.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0780
    Cell Significance Index: 2.0900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0765
    Cell Significance Index: 0.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0667
    Cell Significance Index: 4.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0589
    Cell Significance Index: 9.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0475
    Cell Significance Index: 1.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0378
    Cell Significance Index: 1.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0277
    Cell Significance Index: 3.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0135
    Cell Significance Index: 0.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0130
    Cell Significance Index: 0.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0086
    Cell Significance Index: 0.3900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0017
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0040
    Cell Significance Index: -0.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0046
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0070
    Cell Significance Index: -0.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0072
    Cell Significance Index: -3.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0090
    Cell Significance Index: -5.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0092
    Cell Significance Index: -0.2000
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: -0.0101
    Cell Significance Index: -0.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0104
    Cell Significance Index: -4.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0107
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0122
    Cell Significance Index: -2.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0127
    Cell Significance Index: -5.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0131
    Cell Significance Index: -2.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0144
    Cell Significance Index: -5.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0155
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0165
    Cell Significance Index: -1.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0190
    Cell Significance Index: -1.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0196
    Cell Significance Index: -1.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0250
    Cell Significance Index: -5.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0303
    Cell Significance Index: -4.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0303
    Cell Significance Index: -4.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0310
    Cell Significance Index: -3.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0331
    Cell Significance Index: -2.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0399
    Cell Significance Index: -5.1500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0544
    Cell Significance Index: -0.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0547
    Cell Significance Index: -3.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0592
    Cell Significance Index: -1.2600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0661
    Cell Significance Index: -0.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0670
    Cell Significance Index: -3.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0691
    Cell Significance Index: -5.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0701
    Cell Significance Index: -5.3800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0748
    Cell Significance Index: -0.7100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0868
    Cell Significance Index: -1.3200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0870
    Cell Significance Index: -1.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0896
    Cell Significance Index: -1.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0918
    Cell Significance Index: -5.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0920
    Cell Significance Index: -4.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0958
    Cell Significance Index: -5.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1040
    Cell Significance Index: -2.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1079
    Cell Significance Index: -3.7500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1095
    Cell Significance Index: -2.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1194
    Cell Significance Index: -3.1400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1216
    Cell Significance Index: -1.2700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1238
    Cell Significance Index: -2.4200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1260
    Cell Significance Index: -2.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1280
    Cell Significance Index: -4.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1344
    Cell Significance Index: -5.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1376
    Cell Significance Index: -4.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1443
    Cell Significance Index: -4.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1513
    Cell Significance Index: -4.8200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1517
    Cell Significance Index: -2.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1518
    Cell Significance Index: -4.9700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1519
    Cell Significance Index: -3.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1580
    Cell Significance Index: -2.6500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1702
    Cell Significance Index: -2.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1720
    Cell Significance Index: -5.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1758
    Cell Significance Index: -5.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TNNI2 is predominantly expressed in skeletal muscle, with significant expression in other tissues such as the colon, cornea, and small intestine. 2. **Protein Function:** Troponin I2 is a fast skeletal type, which distinguishes it from other troponin isoforms. Its primary function is to regulate muscle contraction and relaxation by binding to tropomyosin and modulating the interaction between actin and myosin filaments. 3. **Cellular Localization:** TNNI2 is found in the cytosol of muscle cells, as well as in the nucleus, where it may play a role in gene transcription regulation. **Pathways and Functions:** 1. **Muscle Contraction:** TNNI2 is integral to the regulation of skeletal muscle contraction through its interaction with tropomyosin and actin/myosin filaments. 2. **Cardiac Muscle Contraction:** Although not as well-studied as in skeletal muscle, TNNI2 has been implicated in cardiac muscle contraction, suggesting a conserved function across muscle types. 3. **DNA-templated Transcription:** TNNI2 may play a role in regulating gene transcription, given its localization to the nucleus. **Clinical Significance:** Dysregulation of TNNI2 has been implicated in various diseases and conditions, including: 1. **Muscular Dystrophy:** Mutations in the TNNI2 gene have been associated with certain forms of muscular dystrophy, highlighting the protein's critical role in muscle function. 2. **Cardiac Disease:** Aberrant TNNI2 expression has been linked to cardiac dysfunction and arrhythmias, underscoring the protein's importance in cardiac muscle contraction. 3. **Neurological Disorders:** TNNI2 has been found in the brain and may play a role in neurological disorders such as epilepsy and schizophrenia, where dysregulation of muscle contraction and relaxation may contribute to disease pathogenesis. In conclusion, TNNI2 is a multifunctional protein that plays a critical role in regulating skeletal muscle contraction and relaxation, as well as cardiac muscle function and gene transcription regulation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying TNNI2 function and its clinical significance.

Genular Protein ID: 2816138432

Symbol: TNNI2_HUMAN

Name: Troponin I, fast skeletal muscle

UniProtKB Accession Codes:

P48788 A6NIV8 A6NJU5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 Ensembl 8 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8148383

Title: Sequencing of a cDNA encoding the human fast-twitch skeletal muscle isoform of troponin I.

PubMed ID: 8148383

DOI: 10.1016/0167-4781(94)90297-6

PubMed ID: 10721725

Title: Structural characterization of the human fast skeletal muscle troponin I gene (TNNI2).

PubMed ID: 10721725

DOI: 10.1016/s0378-1119(99)00519-3

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12592607

Title: Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes.

PubMed ID: 12592607

DOI: 10.1086/368294

Sequence Information:

  • Length: 182
  • Mass: 21339
  • Checksum: A204BF5616D748BB
  • Sequence:
    • MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRREAE KQNYLAEHCP PLHIPGSMSE 
VQELCKQLHA KIDAAEEEKY DMEVRVQKTS KELEDMNQKL FDLRGKFKRP PLRRVRMSAD 
AMLKALLGSK HKVCMDLRAN LKQVKKEDTE KERDLRDVGD WRKNIEEKSG MEGRKKMFES 
ES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.