Details for: PWP2

Gene ID: 5822

Symbol: PWP2

Ensembl ID: ENSG00000241945

Description: PWP2 small subunit processome component

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 22.4372
    Cell Significance Index: -3.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.9710
    Cell Significance Index: -3.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 10.0192
    Cell Significance Index: 150.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 8.7383
    Cell Significance Index: -3.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.8806
    Cell Significance Index: -3.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.0311
    Cell Significance Index: 75.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.9320
    Cell Significance Index: -3.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.9276
    Cell Significance Index: -2.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7353
    Cell Significance Index: 139.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5854
    Cell Significance Index: 15.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4162
    Cell Significance Index: 21.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4123
    Cell Significance Index: 40.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3503
    Cell Significance Index: 316.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.3153
    Cell Significance Index: -0.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2945
    Cell Significance Index: 32.0400
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.2796
    Cell Significance Index: 2.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2555
    Cell Significance Index: 7.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2538
    Cell Significance Index: 73.0300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2396
    Cell Significance Index: 3.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2284
    Cell Significance Index: 37.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2281
    Cell Significance Index: 5.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1625
    Cell Significance Index: 11.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1378
    Cell Significance Index: 3.9700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1257
    Cell Significance Index: 1.2600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0975
    Cell Significance Index: 1.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0974
    Cell Significance Index: 2.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0745
    Cell Significance Index: 40.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0724
    Cell Significance Index: 3.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0636
    Cell Significance Index: 2.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0621
    Cell Significance Index: 1.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0535
    Cell Significance Index: 1.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0394
    Cell Significance Index: 1.1000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0386
    Cell Significance Index: 0.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0297
    Cell Significance Index: 0.5000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0253
    Cell Significance Index: 0.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0202
    Cell Significance Index: 0.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0124
    Cell Significance Index: 1.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0111
    Cell Significance Index: 1.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0077
    Cell Significance Index: 0.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0065
    Cell Significance Index: 0.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0058
    Cell Significance Index: 1.1700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0031
    Cell Significance Index: 0.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0024
    Cell Significance Index: 0.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0021
    Cell Significance Index: -0.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0023
    Cell Significance Index: -0.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0029
    Cell Significance Index: -0.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0030
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0036
    Cell Significance Index: -0.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0042
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0045
    Cell Significance Index: -3.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0051
    Cell Significance Index: -3.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0055
    Cell Significance Index: -0.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0055
    Cell Significance Index: -3.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0062
    Cell Significance Index: -3.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0062
    Cell Significance Index: -3.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0070
    Cell Significance Index: -0.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0078
    Cell Significance Index: -0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0079
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0110
    Cell Significance Index: -1.2600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0130
    Cell Significance Index: -0.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0166
    Cell Significance Index: -1.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0173
    Cell Significance Index: -2.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0176
    Cell Significance Index: -3.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0178
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0179
    Cell Significance Index: -3.7800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0192
    Cell Significance Index: -0.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0259
    Cell Significance Index: -3.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0292
    Cell Significance Index: -3.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0322
    Cell Significance Index: -0.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0340
    Cell Significance Index: -3.5400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0353
    Cell Significance Index: -0.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0369
    Cell Significance Index: -0.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0430
    Cell Significance Index: -3.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0430
    Cell Significance Index: -3.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0447
    Cell Significance Index: -3.0000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0463
    Cell Significance Index: -0.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0511
    Cell Significance Index: -4.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0520
    Cell Significance Index: -2.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0525
    Cell Significance Index: -3.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0540
    Cell Significance Index: -2.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0546
    Cell Significance Index: -3.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0570
    Cell Significance Index: -2.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0578
    Cell Significance Index: -0.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0579
    Cell Significance Index: -3.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0610
    Cell Significance Index: -2.5000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0625
    Cell Significance Index: -0.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0626
    Cell Significance Index: -2.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0643
    Cell Significance Index: -0.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0644
    Cell Significance Index: -2.2600
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0679
    Cell Significance Index: -0.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0708
    Cell Significance Index: -1.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0713
    Cell Significance Index: -2.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0736
    Cell Significance Index: -2.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0739
    Cell Significance Index: -2.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PWP2 is a small subunit processome component that plays a pivotal role in the maturation of ssu-rRNA. This process involves the processing of a tricistronic rRNA transcript (ssu-rRNA, 5.8s rRNA, and lsu-rRNA) into mature ssu-rRNA. PWP2's function is tightly linked to the assembly and biogenesis of the ribosomal small subunit, which is a complex process requiring precise coordination of multiple proteins and RNAs. **Pathways and Functions:** PWP2 is involved in several key pathways, including: 1. **RNA processing:** PWP2 is essential for the maturation of ssu-rRNA, which is a critical step in the biogenesis of the ribosomal small subunit. 2. **Ribosomal small subunit assembly:** PWP2 contributes to the assembly of the ribosomal small subunit, which is a complex process involving the coordination of multiple proteins and RNAs. 3. **Ribosomal small subunit biogenesis:** PWP2 is involved in the biogenesis of the ribosomal small subunit, which is essential for protein synthesis. 4. **RNA binding:** PWP2 interacts with RNA molecules, including ssu-rRNA, to facilitate the maturation process. 5. **RNA modification:** PWP2 is involved in the modification of ssu-rRNA, which is a critical step in the maturation process. **Clinical Significance:** Dysregulation or mutations in the PWP2 gene have been implicated in various human diseases, including: 1. **Congenital disorders:** Mutations in PWP2 have been linked to congenital disorders, such as ribosomal disorders and intellectual disability. 2. **Neurological disorders:** PWP2 mutations have been associated with neurological disorders, including epilepsy and autism spectrum disorder. 3. **Cancer:** Aberrant PWP2 expression has been observed in certain types of cancer, including colon cancer and leukemia. In conclusion, the PWP2 gene plays a critical role in RNA processing and the biogenesis of the ribosomal small subunit. Its dysregulation or mutations can have significant implications for human health and disease, highlighting the importance of further research into the functions and mechanisms of PWP2.

Genular Protein ID: 1808849636

Symbol: PWP2_HUMAN

Name: Periodic tryptophan protein 2 homolog

UniProtKB Accession Codes:

Q15269 B2RAG8 Q96A77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8661145

Title: Cloning the cDNA of human PWP2, which encodes a protein with WD repeats and maps to 21q22.3.

PubMed ID: 8661145

DOI: 10.1006/geno.1996.0363

PubMed ID: 8893822

Title: A periodic tryptophan protein 2 gene homologue (PWP2H) in the candidate region of progressive myoclonus epilepsy on 21q22.3.

PubMed ID: 8893822

DOI: 10.1159/000134402

PubMed ID: 8973917

Title: Isolation and genomic structure of a human homolog of the yeast periodic tryptophan protein 2 (PWP2) gene mapping to 21q22.3.

PubMed ID: 8973917

DOI: 10.1101/gr.6.12.1216

PubMed ID: 9205129

Title: Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21.

PubMed ID: 9205129

DOI: 10.1006/geno.1997.4761

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9196060

Title: Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3.

PubMed ID: 9196060

DOI: 10.1006/bbrc.1997.6758

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 919
  • Mass: 102452
  • Checksum: B2A94C5595DF4380
  • Sequence:
    • MKFAYRFSNL LGTVYRRGNL NFTCDGNSVI SPVGNRVTVF DLKNNKSDTL PLATRYNVKC 
VGLSPDGRLA IIVDEGGDAL LVSLVCRSVL HHFHFKGSVH SVSFSPDGRK FVVTKGNIAQ 
MYHAPGKKRE FNAFVLDKTY FGPYDETTCI DWTDDSRCFV VGSKDMSTWV FGAERWDNLI 
YYALGGHKDA IVACFFESNS LDLYSLSQDG VLCMWQCDTP PEGLRLKPPA GWKADLLQRE 
EEEEEEEDQE GDRETTIRGK ATPAEEEKTG KVKYSRLAKY FFNKEGDFNN LTAAAFHKKS 
HLLVTGFASG IFHLHELPEF NLIHSLSISD QSIASVAINS SGDWIAFGCS GLGQLLVWEW 
QSESYVLKQQ GHFNSMVALA YSPDGQYIVT GGDDGKVKVW NTLSGFCFVT FTEHSSGVTG 
VTFTATGYVV VTSSMDGTVR AFDLHRYRNF RTFTSPRPTQ FSCVAVDASG EIVSAGAQDS 
FEIFVWSMQT GRLLDVLSGH EGPISGLCFN PMKSVLASAS WDKTVRLWDM FDSWRTKETL 
ALTSDALAVT FRPDGAELAV ATLNSQITFW DPENAVQTGS IEGRHDLKTG RKELDKITAK 
HAAKGKAFTA LCYSADGHSI LAGGMSKFVC IYHVREQILM KRFEISCNLS LDAMEEFLNR 
RKMTEFGNLA LIDQDAGQED GVAIPLPGVR KGDMSSRHFK PEIRVTSLRF SPTGRCWAAT 
TTEGLLIYSL DTRVLFDPFE LDTSVTPGRV REALRQQDFT RAILMALRLN ESKLVQEALE 
AVPRGEIEVV TSSLPELYVE KVLEFLASSF EVSRHLEFYL LWTHKLLMLH GQKLKSRAGT 
LLPVIQFLQK SIQRHLDDLS KLCSWNHYNM QYALAVSKQR GTKRSLDPLG SEEEAEASED 
DSLHLLGGGG RDSEEEMLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.