Details for: ADGRE1

Gene ID: 2015

Symbol: ADGRE1

Ensembl ID: ENSG00000174837

Description: adhesion G protein-coupled receptor E1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.26
    Marker Score: 2566
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.17
    Marker Score: 523
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.91
    Marker Score: 1103
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.91
    Marker Score: 509
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.75
    Marker Score: 451
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.65
    Marker Score: 1239
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.59
    Marker Score: 418
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.58
    Marker Score: 1391
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.57
    Marker Score: 1101.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.53
    Marker Score: 8310
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.43
    Marker Score: 1775
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.4
    Marker Score: 398
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 383.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 210
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.37
    Marker Score: 20472
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 172
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 90.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.33
    Marker Score: 8451
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.32
    Marker Score: 110
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.31
    Marker Score: 571.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.31
    Marker Score: 489
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.24
    Marker Score: 487
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.23
    Marker Score: 100
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.23
    Marker Score: 152.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.23
    Marker Score: 2696
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.21
    Marker Score: 84
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 137
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.21
    Marker Score: 126
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 91
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.19
    Marker Score: 81
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.19
    Marker Score: 130
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.19
    Marker Score: 465
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.19
    Marker Score: 319
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 108
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.17
    Marker Score: 2274
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.16
    Marker Score: 114
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.15
    Marker Score: 88
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.15
    Marker Score: 385
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.13
    Marker Score: 135
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.13
    Marker Score: 563
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.13
    Marker Score: 68
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.13
    Marker Score: 801
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.12
    Marker Score: 350
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.12
    Marker Score: 123
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.12
    Marker Score: 78
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.11
    Marker Score: 149
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.11
    Marker Score: 71
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 669
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 59.5
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.11
    Marker Score: 177
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.11
    Marker Score: 84
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.11
    Marker Score: 155
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.11
    Marker Score: 116
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.1
    Marker Score: 86
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.1
    Marker Score: 319
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 112
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.1
    Marker Score: 111
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.1
    Marker Score: 102
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.1
    Marker Score: 65
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 95
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.1
    Marker Score: 595
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 84
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.09
    Marker Score: 212
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.09
    Marker Score: 57
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.09
    Marker Score: 58
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.09
    Marker Score: 52

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Other Information

**Key characteristics:** - ADGRE1 is a single-pass membrane protein with a molecular weight of approximately 140 kDa. - It is expressed in high levels in epithelial cells of the lung, including the alveoli, goblet cells, and epithelial cells of the colon. - ADGRE1 is also expressed in immature innate lymphoid cells, myeloid leukocytes, and CD4-positive thymocytes. **Pathways and functions:** - ADGRE1 is a key receptor for epidermal growth factor-beta (EGF-beta), a cytokine that is produced by epithelial cells. - It is involved in cell adhesion, migration, and signaling through the activation of its intracellular signaling cascade. - ADGRE1 is also involved in the regulation of epithelial cell migration and differentiation. **Clinical significance:** - Mutations in the ADGRE1 gene have been linked to several human diseases, including asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease (IBD). - ADGRE1 is a potential therapeutic target for these diseases, as it is expressed in cells that are involved in their pathogenesis. - Inhibition of ADGRE1 signaling has been shown to suppress cell migration and proliferation, and to improve lung function in animal models of asthma and COPD.

Genular Protein ID: 3573759261

Symbol: AGRE1_HUMAN

Name: EGF-like module receptor 1

UniProtKB Accession Codes:

Q14246 A6NHV2 B7Z486 B7Z489 E7EPX9 E9PD45 H9KV79 Q2I7G5 Q6ZMN0 Q8NGA7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 5 ExpressionAtlas 1 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 7 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 1 RefSeq 5 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7601460

Title: EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments.

PubMed ID: 7601460

DOI: 10.1016/0888-7543(95)80218-b

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17823986

Title: EMR1, the human homolog of F4/80, is an eosinophil-specific receptor.

PubMed ID: 17823986

DOI: 10.1002/eji.200737553

PubMed ID: 24530099

Title: The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders.

PubMed ID: 24530099

DOI: 10.1016/j.jaci.2013.11.041

PubMed ID: 25713288

Title: International union of basic and clinical pharmacology. XCIV. Adhesion G protein-coupled receptors.

PubMed ID: 25713288

DOI: 10.1124/pr.114.009647

Sequence Information:

  • Length: 886
  • Mass: 97683
  • Checksum: 07322996EEF5A6F1
  • Sequence:
    • MRGFNLLLFW GCCVMHSWEG HIRPTRKPNT KGNNCRDSTL CPAYATCTNT VDSYYCACKQ 
GFLSSNGQNH FKDPGVRCKD IDECSQSPQP CGPNSSCKNL SGRYKCSCLD GFSSPTGNDW 
VPGKPGNFSC TDINECLTSS VCPEHSDCVN SMGSYSCSCQ VGFISRNSTC EDVDECADPR 
ACPEHATCNN TVGNYSCFCN PGFESSSGHL SFQGLKASCE DIDECTEMCP INSTCTNTPG 
SYFCTCHPGF APSNGQLNFT DQGVECRDID ECRQDPSTCG PNSICTNALG SYSCGCIAGF 
HPNPEGSQKD GNFSCQRVLF KCKEDVIPDN KQIQQCQEGT AVKPAYVSFC AQINNIFSVL 
DKVCENKTTV VSLKNTTESF VPVLKQISTW TKFTKEETSS LATVFLESVE SMTLASFWKP 
SANITPAVRT EYLDIESKVI NKECSEENVT LDLVAKGDKM KIGCSTIEES ESTETTGVAF 
VSFVGMESVL NERFFKDHQA PLTTSEIKLK MNSRVVGGIM TGEKKDGFSD PIIYTLENIQ 
PKQKFERPIC VSWSTDVKGG RWTSFGCVIL EASETYTICS CNQMANLAVI MASGELTMDF 
SLYIISHVGI IISLVCLVLA IATFLLCRSI RNHNTYLHLH LCVCLLLAKT LFLAGIHKTD 
NKMGCAIIAG FLHYLFLACF FWMLVEAVIL FLMVRNLKVV NYFSSRNIKM LHICAFGYGL 
PMLVVVISAS VQPQGYGMHN RCWLNTETGF IWSFLGPVCT VIVINSLLLT WTLWILRQRL 
SSVNAEVSTL KDTRLLTFKA FAQLFILGCS WVLGIFQIGP VAGVMAYLFT IINSLQGAFI 
FLIHCLLNGQ VREEYKRWIT GKTKPSSQSQ TSRILLSSMP SASKTG

Genular Protein ID: 2702111616

Symbol: A8K653_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K653

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 3 GenomeRNAi 1 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 9 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 3 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 821
  • Mass: 90334
  • Checksum: 0DD2C0AF81639AFA
  • Sequence:
    • MRGFNLLLFW GCCVMHSWEG HIRPTRKPNT KGNNCRDSTL CPAYATCTNT VDSYYCACKQ 
GFLSSNGQNH FKDPGVRCKD IDECSQSPQP CGPNSSCKNL SGRYKCSCLD GFSSPTGNDW 
VPGKPGNFSC TDINECLTSS VCPEHSDCVN SMGSYSCICQ VGFISRNSTC EDVDECADPR 
ACPEHATCNS TVGNFSCFCN PGFESSSGHL SFQGLKASCE DIDECTEMCP INSTCTNTPG 
SYFCTCHPGF APSNGQLNFT DQGVECRDID ECRQDPSTCG PNSICTNALG SYSCGCIAGF 
HPNPEGSQKD GNFSCQRVLF KCKEDVIPDN KQIQQCQEGT AVKPAYVSFC AQINNIFSVL 
DKVCENKTTV VSLKNTTESF VPVLKQISMW TKFTKEETSS LATVFLESVE SMTLASFWKP 
SANVTPAVRT EYLDIESKVI NKECSEENVT LDLVAKGDKM KIGCSTIEES ESTETTGVAF 
VSFVGMESVL NERFFQDHQA PLTTSEIKLK MNSRVVGGIM TGEKKDGFSD PIIYTLENVQ 
PKQKFERPIC VSWSTDVKGG RWTSFGCVIL EASETYTICS CNQMANLAVI MASGELTTGC 
AIIAGFLHYL FLACFFWMLV EAVILFLMVR NLKVVNYFSS RNIKMLHICA FGYGLPMLVV 
VISASVQPQG YGMHNRCWLN TETGFIWSFL GPVCTVIVIN SLLLTWTLWI LRQRLSSVNA 
EVSTLKDTRL LTFKAFAQLF ILGCSWVLGI FQIGPVAGVM AYLFTIINSL QGAFIFLIHC 
LLNGQVREEY KRWITGKTKP SSQSQTSRIL LSSMPSASKT G

Genular Protein ID: 1205474800

Symbol: A8K2Y6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K2Y6

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 3 GenomeRNAi 1 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 9 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 3 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 889
  • Mass: 97998
  • Checksum: E61DE6022E5A961E
  • Sequence:
    • MRGFNLLLFW GCCVMHSWEG HIRPTRKPNT KGNNCRDSTL CPAYATCTNT VDSYYCACKQ 
GFLSSNGQNH FKDPGVRCKD IDECSQSPQP CGPNSSCKNL SGRYKCSCLD GFSSPTGNDW 
VPGKPGNFSC TDINECLTSS VCPEHSDCVN SMGSYSCSCQ VGFISRNSTC EDVDECADPR 
ACPEHATCNN TVGNYSCFCN PGFESSSGHL SFQGLKASCE DIDECTEMCP INSTCTNTPG 
SYFCTCHPGF APSNGQLNFT DQGVECRDID ECRQDPSTCG PNSICTNALG SYSCGCIAGF 
HPNPEGSQKD GNFSCQRVLF KCKEDVIPDN KQIQQCQEGT AVKPAYVSFC AQINNIFSVL 
DKVCENKTTV VSLKNTTESF VPVLKQISTW TKFTKEETSS LATVFLESVE SMTLASFWKP 
SANVTPAVRT EYLDIESKVI NKECSEENVT LDLVAKGDKM KIGCSTIEES ESTETTGVAF 
VSFVGMESVL NERFFQDHQA PLTTSEIKLK MNSRVVGGIM TGEKKDGFSD PIIYTLENVQ 
PKQKFERPIC VSWSTDVKGG RWTSFGCVIL EASETYTICS CNQMANLAVI MASGELTMDF 
SLYIISHVGI IISLVCLVLA IATFLLCRSI RNHNTYLHLH LCVCLLLAKT LFLAGIHKTD 
NKMGCAIIAG FLHYLFLACF FWMLVEAVIL FLMVRNLKVV NYFSSRNIKM LHICAFGYGL 
PMLVVVISAS VQPQGYGMHN RCWLNTETGF IWSFLGPVCT VIVTLQINSL LLTWTLWILR 
QRLSSVNAEV STLKDTRLLT FKAFAQLFIL GCSWVLGIFQ IGPVAGVMAY LFTIINSLQG 
AFIFLIHCLL NGQVREEYKR WITGKTKPSS QSQTSRILLS SMPSASKTG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.