Details for: DEK

Gene ID: 7913

Symbol: DEK

Ensembl ID: ENSG00000124795

Description: DEK proto-oncogene

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 425.5997
    Cell Significance Index: -66.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 330.5921
    Cell Significance Index: -83.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 267.1820
    Cell Significance Index: -110.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 231.7194
    Cell Significance Index: -109.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 221.1407
    Cell Significance Index: -89.8400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 197.1285
    Cell Significance Index: -101.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 163.7651
    Cell Significance Index: -109.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 94.7794
    Cell Significance Index: -90.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 81.3168
    Cell Significance Index: -100.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.0700
    Cell Significance Index: -88.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 26.6976
    Cell Significance Index: -105.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.0244
    Cell Significance Index: -73.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.3889
    Cell Significance Index: -33.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 5.9299
    Cell Significance Index: 158.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.5423
    Cell Significance Index: 123.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.2453
    Cell Significance Index: 382.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.6235
    Cell Significance Index: 322.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3794
    Cell Significance Index: 326.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9817
    Cell Significance Index: 357.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9768
    Cell Significance Index: 873.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9378
    Cell Significance Index: 1058.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.8941
    Cell Significance Index: 122.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8829
    Cell Significance Index: 51.2500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.8636
    Cell Significance Index: 20.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.8152
    Cell Significance Index: 33.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7582
    Cell Significance Index: 98.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7501
    Cell Significance Index: 46.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7079
    Cell Significance Index: 80.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6754
    Cell Significance Index: 182.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3970
    Cell Significance Index: 98.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3772
    Cell Significance Index: 273.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1989
    Cell Significance Index: 55.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1869
    Cell Significance Index: 53.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.0903
    Cell Significance Index: 313.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9266
    Cell Significance Index: 19.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8802
    Cell Significance Index: 112.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8626
    Cell Significance Index: 9.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8495
    Cell Significance Index: 109.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6934
    Cell Significance Index: 68.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5701
    Cell Significance Index: 14.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3985
    Cell Significance Index: 29.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3759
    Cell Significance Index: 71.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3281
    Cell Significance Index: 65.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2634
    Cell Significance Index: 6.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2474
    Cell Significance Index: 42.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2251
    Cell Significance Index: 155.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2017
    Cell Significance Index: 72.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1996
    Cell Significance Index: 12.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1586
    Cell Significance Index: 143.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0848
    Cell Significance Index: 5.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0482
    Cell Significance Index: 2.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0245
    Cell Significance Index: 0.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0238
    Cell Significance Index: 36.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0148
    Cell Significance Index: 0.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0097
    Cell Significance Index: 7.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0045
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0022
    Cell Significance Index: -1.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0124
    Cell Significance Index: -22.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0153
    Cell Significance Index: -11.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0353
    Cell Significance Index: -1.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0400
    Cell Significance Index: -54.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0595
    Cell Significance Index: -37.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0667
    Cell Significance Index: -6.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0715
    Cell Significance Index: -32.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0902
    Cell Significance Index: -56.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1297
    Cell Significance Index: -73.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1583
    Cell Significance Index: -8.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1812
    Cell Significance Index: -29.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1991
    Cell Significance Index: -4.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2420
    Cell Significance Index: -50.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3082
    Cell Significance Index: -35.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3155
    Cell Significance Index: -9.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3718
    Cell Significance Index: -10.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3981
    Cell Significance Index: -13.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4255
    Cell Significance Index: -61.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5160
    Cell Significance Index: -10.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5435
    Cell Significance Index: -13.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5938
    Cell Significance Index: -17.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5950
    Cell Significance Index: -69.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6404
    Cell Significance Index: -16.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7245
    Cell Significance Index: -55.6000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7531
    Cell Significance Index: -4.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7729
    Cell Significance Index: -88.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9005
    Cell Significance Index: -19.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9345
    Cell Significance Index: -12.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9350
    Cell Significance Index: -74.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9425
    Cell Significance Index: -98.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.0729
    Cell Significance Index: -74.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2076
    Cell Significance Index: -31.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.2244
    Cell Significance Index: -61.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.3330
    Cell Significance Index: -23.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.3643
    Cell Significance Index: -23.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4936
    Cell Significance Index: -100.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5454
    Cell Significance Index: -94.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7758
    Cell Significance Index: -52.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.8741
    Cell Significance Index: -22.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.9107
    Cell Significance Index: -78.2900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.9953
    Cell Significance Index: -16.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.1815
    Cell Significance Index: -80.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** DEK is expressed in a wide range of cell types, including immune cells, neural crest cells, and supporting cells. 2. **Proto-Oncogenic Potential:** DEK has been implicated in oncogenesis, particularly in certain types of leukemia and lymphoma. 3. **Multifunctional Protein:** DEK exhibits a range of biochemical activities, including protein binding, RNA binding, and histone binding, which contribute to its diverse roles. 4. **Regulation of Transcription:** DEK modulates transcriptional activity through interactions with RNA polymerases and transcription factors, influencing the expression of target genes. **Pathways and Functions:** 1. **B-Cell Receptor Complex:** DEK is part of the B-cell receptor complex, which regulates B-cell development and function. 2. **Chromatin Remodeling:** DEK interacts with chromatin remodeling complexes, facilitating the regulation of gene expression and DNA repair. 3. **RNA Binding:** DEK binds to specific RNA sequences, influencing RNA processing, translation, and stability. 4. **Histone Binding:** DEK interacts with histones, modulating chromatin structure and transcriptional activity. 5. **Signaling Pathways:** DEK is involved in various signaling pathways, including those mediated by transcription factors, cytokines, and growth factors. **Clinical Significance:** DEK's dysregulation has been implicated in several diseases, including: 1. **Leukemia:** DEK overexpression has been observed in certain types of leukemia, suggesting its potential as a therapeutic target. 2. **Lymphoma:** DEK's involvement in lymphoma development and progression highlights its importance in immune regulation. 3. **Autoimmune Diseases:** DEK's role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, underscores its potential as a therapeutic target. 4. **Cancer Progression:** DEK's involvement in cancer progression and metastasis suggests its potential as a prognostic biomarker. In conclusion, DEK is a complex and multifunctional protein that plays a crucial role in immune regulation, cell proliferation, and survival. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 1451792518

Symbol: DEK_HUMAN

Name: Protein DEK

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1549122

Title: The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.

PubMed ID: 1549122

DOI: 10.1128/mcb.12.4.1687-1697.1992

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11118221

Title: The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.

PubMed ID: 11118221

DOI: 10.1093/emboj/19.24.6860

PubMed ID: 12140263

Title: Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.

PubMed ID: 12140263

DOI: 10.1242/jcs.115.16.3319

PubMed ID: 15199154

Title: Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK.

PubMed ID: 15199154

DOI: 10.1128/mcb.24.13.6011-6020.2004

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16603771

Title: The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.

PubMed ID: 16603771

DOI: 10.1074/jbc.m600233200

PubMed ID: 17524367

Title: The distribution of the DEK protein in mammalian chromatin.

PubMed ID: 17524367

DOI: 10.1016/j.bbrc.2007.05.019

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19695025

Title: Proteome analysis of human nuclear insoluble fractions.

PubMed ID: 19695025

DOI: 10.1111/j.1365-2443.2009.01324.x

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 15238633

Title: Solution NMR structure of the C-terminal domain of the human protein DEK.

PubMed ID: 15238633

DOI: 10.1110/ps.04797104

PubMed ID: 18227428

Title: Solution NMR structure of the N-terminal domain of the human DEK protein.

PubMed ID: 18227428

DOI: 10.1110/ps.073244108

Sequence Information:

  • Length: 375
  • Mass: 42674
  • Checksum: C07D22B37B719A23
  • Sequence:
  • MSASAPAAEG EGTPTQPASE KEPEMPGPRE ESEEEEDEDD EEEEEEEKEK SLIVEGKREK 
    KKVERLTMQV SSLQREPFTI AQGKGQKLCE IERIHFFLSK KKTDELRNLH KLLYNRPGTV 
    SSLKKNVGQF SGFPFEKGSV QYKKKEEMLK KFRNAMLKSI CEVLDLERSG VNSELVKRIL 
    NFLMHPKPSG KPLPKSKKTC SKGSKKERNS SGMARKAKRT KCPEILSDES SSDEDEKKNK 
    EESSDDEDKE SEEEPPKKTA KREKPKQKAT SKSKKSVKSA NVKKADSSTT KKNQNSSKKE 
    SESEDSSDDE PLIKKLKKPP TDEELKETIK KLLASANLEE VTMKQICKKV YENYPTYDLT 
    ERKDFIKTTV KELIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.