Details for: DEK
Gene ID: 7913
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DEK
Ensembl ID: ENSG00000124795
Description: DEK proto-oncogene
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 94.59rCSI 76.48%PRS 9.09
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CSI 93.55rCSI 81%PRS 10.25
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CSI 93.39rCSI 62.08%PRS 10.99
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CSI 90.5rCSI 81.72%PRS 8.14
-
CSI 85.83rCSI 71.07%PRS 9.21
-
CSI 80.57rCSI 77.56%PRS 9.52
-
CSI 70.6rCSI 59.18%PRS 11
-
CSI 66.95rCSI 78.63%PRS 10.93
-
CSI 66.76rCSI 77.1%PRS 8.15
-
CSI 65.41rCSI 63.07%PRS 6.04
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CSI 62.36rCSI 78.27%PRS 11.75
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CSI 56.26rCSI 64.4%PRS 19.03
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CSI 54.18rCSI 75.26%PRS 9.51
-
CSI 53.47rCSI 77.12%PRS 12.87
-
CSI 51.4rCSI 38.62%PRS 9.52
-
CSI 50.87rCSI 44.68%PRS 10.34
-
CSI 47.55rCSI 81.47%PRS 12.36
-
CSI 46.16rCSI 55.41%PRS 9.13
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CSI 44.03rCSI 33.93%PRS 8.31
-
CSI 41.87rCSI 34.71%PRS 8.73
-
CSI 41.67rCSI 36.64%PRS 6.66
-
CSI 41.46rCSI 51.29%PRS 8.07
-
CSI 39.97rCSI 41.77%PRS 9.7
-
CSI 38.04rCSI 54.29%PRS 10.4
-
CSI 36.75rCSI 56.78%PRS 8.61
-
CSI 35.49rCSI 54.28%PRS 14.95
-
CSI 34.51rCSI 27.28%PRS 6.33
-
CSI 32.91rCSI 22.88%PRS 10.78
-
CSI 32.65rCSI 93.22%PRS 16.2
-
CSI 31.31rCSI 26.13%PRS 28.23
-
CSI 30.77rCSI 32.23%PRS 8.55
-
CSI 29.51rCSI 30.08%PRS 13.12
-
CSI 28.91rCSI 33.43%PRS 6.74
-
CSI 27.68rCSI 52.25%PRS 11.41
-
CSI 24.94rCSI 72.21%PRS 10.42
-
CSI 23.77rCSI 64.07%PRS 11.88
-
CSI 22.93rCSI 89.25%PRS 15.23
-
CSI 22.77rCSI 73.06%PRS 13.67
-
CSI 22.32rCSI 61.34%PRS 15.3
-
CSI 22.26rCSI 19.5%PRS 12.32
-
CSI 22.04rCSI 17.34%PRS 10.96
-
CSI 21.92rCSI 89.34%PRS 12.9
-
CSI 21.91rCSI 65.35%PRS 23.7
-
CSI 21.85rCSI 22.37%PRS 17.34
-
CSI 21.62rCSI 42.06%PRS 9.37
-
CSI 19.77rCSI 20.71%PRS 9.8
-
CSI 19.56rCSI 14.8%PRS 12.79
-
CSI 19.41rCSI 46.14%PRS 13.82
-
CSI 18.45rCSI 64.72%PRS 16.69
-
CSI 18.4rCSI 28.27%PRS 13.2
-
CSI 17.79rCSI 17.76%PRS 7.9
-
CSI 17.73rCSI 42.67%PRS 14.66
-
CSI 17.65rCSI 37.53%PRS 16.81
-
CSI 17.17rCSI 22.95%PRS 17.63
-
CSI 16.39rCSI 19.8%PRS 10.83
-
CSI 15.89rCSI 42.18%PRS 15.44
-
CSI 15.48rCSI 76.29%PRS 12.52
-
CSI 15.45rCSI 40.15%PRS 26.48
-
CSI 15.39rCSI 79.44%PRS 18.47
-
CSI 15.03rCSI 15.46%PRS 15.05
-
CSI 15rCSI 53.31%PRS 29.35
-
CSI 14.8rCSI 79.87%PRS 17.48
-
CSI 13.64rCSI 10.58%PRS 8.78
-
CSI 13.41rCSI 19.33%PRS 14.84
-
CSI 13.35rCSI 11.85%PRS 9.2
-
CSI 13.16rCSI 86.39%PRS 24.12
-
CSI 13.15rCSI 70.15%PRS 34.19
-
CSI 13.06rCSI 57.32%PRS 17.19
-
CSI 12.95rCSI 19.78%PRS 9.22
-
CSI 12.1rCSI 19.3%PRS 7.92
-
CSI 12.07rCSI 39.51%PRS 27.12
-
CSI 11.99rCSI 18.09%PRS 9.06
-
CSI 11.73rCSI 15.99%PRS 8.25
-
CSI 11.69rCSI 27.25%PRS 22.59
-
CSI 11.65rCSI 30.66%PRS 18.03
-
CSI 11.54rCSI 10.64%PRS 9.37
-
CSI 11.43rCSI 11.25%PRS 9.99
-
CSI 11.27rCSI 11.98%PRS 16.42
-
CSI 11.22rCSI 39.82%PRS 15.09
-
CSI 11.1rCSI 31.11%PRS 14.28
-
CSI 10.94rCSI 66.17%PRS 20.91
-
CSI 10.9rCSI 62.47%PRS 14.46
-
CSI 10.27rCSI 13.08%PRS 10.7
-
CSI 10.24rCSI 8.9%PRS 11.36
-
CSI 10.12rCSI 18.05%PRS 15.68
-
CSI 9.97rCSI 56.11%PRS 29.27
-
CSI 9.82rCSI 7.8%PRS 16.21
-
CSI 9.8rCSI 7.62%PRS 13.23
-
CSI 9.68rCSI 14.87%PRS 10.74
-
CSI 9.51rCSI 11.95%PRS 14.08
-
CSI 9.28rCSI 9.68%PRS 9.44
-
CSI 9.26rCSI 9.14%PRS 37.21
-
CSI 9.2rCSI 21.43%PRS 20.63
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CSI 9.07rCSI 52.8%PRS 13.85
-
CSI 8.76rCSI 12.7%PRS 13.57
-
CSI 8.7rCSI 17.34%PRS 15.41
-
CSI 8.66rCSI 8.97%PRS 10.82
-
CSI 8.64rCSI 39.92%PRS 19.57
-
CSI 8.28rCSI 7.82%PRS 9.6
-
CSI 8.27rCSI 10.19%PRS 30.25
-
CSI -10.4rCSI -23.3%PRS 5.7%
-
CSI -9.7rCSI -25.1%PRS 12.8%
-
CSI -6.7rCSI -15.9%PRS 11.3%
-
CSI -4.1rCSI -13.2%PRS 6.6%
-
CSI -4.0rCSI -4.3%PRS 10.6%
-
CSI -3.7rCSI -4.3%PRS 13.1%
-
CSI -3.3rCSI -20.8%PRS 7.3%
-
CSI -3.0rCSI -4.4%PRS 10.6%
-
CSI -2.8rCSI -7.8%PRS 9.1%
-
CSI -2.6rCSI -12.5%PRS 5.8%
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CSI -2.4rCSI -4.1%PRS 7.0%
-
CSI -2.3rCSI -4.5%PRS 25.3%
-
CSI -2.1rCSI -3.4%PRS 6.1%
-
CSI -1.8rCSI -11.2%PRS 40.0%
-
CSI -1.6rCSI -6.7%PRS 22.1%
-
CSI -1.3rCSI -3.5%PRS 9.1%
-
CSI -1.3rCSI -2.6%PRS 9.9%
-
CSI -1.2rCSI -2.7%PRS 8.9%
-
CSI -1.0rCSI -2.5%PRS 26.8%
-
CSI -0.7rCSI -1.0%PRS 12.6%
-
CSI -0.7rCSI -1.9%PRS 11.0%
-
CSI -0.7rCSI -0.7%PRS 14.6%
-
CSI -0.4rCSI -0.5%PRS 5.3%
-
CSI -0.3rCSI -0.8%PRS 11.5%
-
CSI -0.2rCSI -0.3%PRS 14.1%
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CSI -0.2rCSI -0.6%PRS 19.4%
-
CSI -0.1rCSI -0.2%PRS 12.2%
-
CSI 0.0rCSI 0.1%PRS 8.4%
-
CSI 0.1rCSI 1.8%PRS 39.4%
-
CSI 0.1rCSI 0.4%PRS 5.8%
-
CSI 0.2rCSI 1.0%PRS 12.6%
-
CSI 0.2rCSI 0.3%PRS 13.7%
-
CSI 0.2rCSI 2.4%PRS 38.7%
-
CSI 0.2rCSI 0.7%PRS 7.5%
-
CSI 0.2rCSI 0.3%PRS 5.8%
-
CSI 0.2rCSI 7.5%PRS 80.3%
-
CSI 0.2rCSI 4.6%PRS 56.6%
-
CSI 0.3rCSI 1.3%PRS 12.8%
-
CSI 0.3rCSI 0.9%PRS 6.3%
-
CSI 0.3rCSI 0.5%PRS 10.3%
-
CSI 0.3rCSI 3.0%PRS 34.8%
-
CSI 0.3rCSI 1.8%PRS 13.8%
-
CSI 0.3rCSI 0.9%PRS 15.3%
-
CSI 0.4rCSI 0.7%PRS 20.9%
-
CSI 0.4rCSI 1.6%PRS 6.9%
-
CSI 0.4rCSI 5.5%PRS 39.3%
-
CSI 0.4rCSI 2.1%PRS 22.4%
-
CSI 0.5rCSI 1.1%PRS 11.9%
-
CSI 0.5rCSI 1.9%PRS 8.7%
-
CSI 0.5rCSI 0.8%PRS 9.2%
-
CSI 0.5rCSI 2.9%PRS 31.4%
-
CSI 0.6rCSI 5.9%PRS 75.2%
-
CSI 0.6rCSI 1.2%PRS 6.6%
-
CSI 0.6rCSI 0.9%PRS 11.9%
-
CSI 0.6rCSI 2.9%PRS 12.1%
-
CSI 0.6rCSI 0.8%PRS 15.4%
-
CSI 0.6rCSI 2.0%PRS 38.1%
-
CSI 0.6rCSI 2.8%PRS 36.5%
-
CSI 0.6rCSI 1.5%PRS 9.3%
-
CSI 0.6rCSI 0.9%PRS 9.6%
-
CSI 0.7rCSI 1.7%PRS 14.1%
-
CSI 0.7rCSI 5.3%PRS 38.8%
-
CSI 0.7rCSI 5.1%PRS 39.1%
-
CSI 0.7rCSI 2.6%PRS 7.9%
-
CSI 0.7rCSI 3.3%PRS 28.3%
-
CSI 0.7rCSI 2.3%PRS 15.5%
-
CSI 0.8rCSI 1.1%PRS 13.1%
-
CSI 0.8rCSI 1.6%PRS 18.7%
-
CSI 0.8rCSI 15.0%PRS 30.6%
-
CSI 0.8rCSI 2.0%PRS 9.6%
-
CSI 0.8rCSI 2.0%PRS 5.3%
-
CSI 0.8rCSI 1.5%PRS 5.4%
-
CSI 0.9rCSI 1.7%PRS 18.2%
-
CSI 0.9rCSI 1.9%PRS 22.0%
-
CSI 0.9rCSI 1.5%PRS 5.4%
-
CSI 0.9rCSI 0.9%PRS 19.5%
-
CSI 0.9rCSI 1.7%PRS 6.8%
-
CSI 1.0rCSI 7.7%PRS 9.7%
-
CSI 1.0rCSI 2.4%PRS 8.5%
-
CSI 1.0rCSI 1.6%PRS 10.6%
-
CSI 1.0rCSI 6.1%PRS 42.0%
-
CSI 1.1rCSI 3.0%PRS 18.3%
-
CSI 1.1rCSI 1.9%PRS 14.0%
-
CSI 1.1rCSI 27.4%PRS 30.7%
-
CSI 1.1rCSI 2.5%PRS 10.1%
-
CSI 1.1rCSI 2.0%PRS 6.8%
-
CSI 1.2rCSI 1.4%PRS 16.0%
-
CSI 1.2rCSI 11.7%PRS 27.0%
-
CSI 1.2rCSI 5.8%PRS 21.1%
-
CSI 1.3rCSI 3.2%PRS 8.6%
-
CSI 1.3rCSI 12.3%PRS 28.1%
-
CSI 1.3rCSI 6.9%PRS 16.7%
-
CSI 1.3rCSI 6.1%PRS 24.9%
-
CSI 1.4rCSI 12.0%PRS 41.6%
-
CSI 1.4rCSI 5.9%PRS 17.9%
-
CSI 1.4rCSI 2.0%PRS 8.6%
-
CSI 1.5rCSI 2.2%PRS 8.6%
-
CSI 1.5rCSI 4.9%PRS 11.3%
-
CSI 1.5rCSI 6.9%PRS 28.9%
-
CSI 1.5rCSI 3.7%PRS 52.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1451792518
Symbol: DEK_HUMAN
Name: Protein DEK
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1549122
Title: The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.
PubMed ID: 1549122
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11118221
Title: The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.
PubMed ID: 11118221
PubMed ID: 12140263
Title: Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
PubMed ID: 12140263
PubMed ID: 15199154
Title: Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK.
PubMed ID: 15199154
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16603771
Title: The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.
PubMed ID: 16603771
PubMed ID: 17524367
Title: The distribution of the DEK protein in mammalian chromatin.
PubMed ID: 17524367
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19695025
Title: Proteome analysis of human nuclear insoluble fractions.
PubMed ID: 19695025
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28190768
Title: Serine ADP-ribosylation depends on HPF1.
PubMed ID: 28190768
PubMed ID: 15238633
Title: Solution NMR structure of the C-terminal domain of the human protein DEK.
PubMed ID: 15238633
DOI: 10.1110/ps.04797104
PubMed ID: 18227428
Title: Solution NMR structure of the N-terminal domain of the human DEK protein.
PubMed ID: 18227428
DOI: 10.1110/ps.073244108
Sequence Information:
- Length: 375
- Mass: 42674
- Checksum: C07D22B37B719A23
- Sequence:
MSASAPAAEG EGTPTQPASE KEPEMPGPRE ESEEEEDEDD EEEEEEEKEK SLIVEGKREK KKVERLTMQV SSLQREPFTI AQGKGQKLCE IERIHFFLSK KKTDELRNLH KLLYNRPGTV SSLKKNVGQF SGFPFEKGSV QYKKKEEMLK KFRNAMLKSI CEVLDLERSG VNSELVKRIL NFLMHPKPSG KPLPKSKKTC SKGSKKERNS SGMARKAKRT KCPEILSDES SSDEDEKKNK EESSDDEDKE SEEEPPKKTA KREKPKQKAT SKSKKSVKSA NVKKADSSTT KKNQNSSKKE SESEDSSDDE PLIKKLKKPP TDEELKETIK KLLASANLEE VTMKQICKKV YENYPTYDLT ERKDFIKTTV KELIS