Details for: ITGB1

Gene ID: 3688

Symbol: ITGB1

Ensembl ID: ENSG00000150093

Description: integrin subunit beta 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.91
    Marker Score: 5,088
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.75
    Marker Score: 127,608
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.63
    Marker Score: 17,828
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.52
    Marker Score: 8,600
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.48
    Marker Score: 2,478
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.47
    Marker Score: 4,774
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.47
    Marker Score: 30,435
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.45
    Marker Score: 3,291
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.37
    Marker Score: 6,325
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.17
    Marker Score: 3,388
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.09
    Marker Score: 2,631
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.02
    Marker Score: 3,723
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.01
    Marker Score: 7,658
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.99
    Marker Score: 8,266
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.85
    Marker Score: 1,187
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.84
    Marker Score: 98,515
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.82
    Marker Score: 2,430
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.79
    Marker Score: 2,996
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.78
    Marker Score: 1,583
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.73
    Marker Score: 3,958
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.72
    Marker Score: 1,788
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.71
    Marker Score: 1,582
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.7
    Marker Score: 1,021
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.7
    Marker Score: 7,058
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.68
    Marker Score: 5,360
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.68
    Marker Score: 35,289
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.65
    Marker Score: 896
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.63
    Marker Score: 2,766
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.62
    Marker Score: 29,561
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.61
    Marker Score: 11,270
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.59
    Marker Score: 2,504
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.58
    Marker Score: 5,669
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.56
    Marker Score: 1,501
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.53
    Marker Score: 6,381
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.52
    Marker Score: 1,807
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.51
    Marker Score: 3,236
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.46
    Marker Score: 10,568
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.46
    Marker Score: 2,967
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.46
    Marker Score: 2,967
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.45
    Marker Score: 15,924
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.43
    Marker Score: 2,179
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.42
    Marker Score: 1,223
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.42
    Marker Score: 562
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.41
    Marker Score: 2,273
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.4
    Marker Score: 611
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.37
    Marker Score: 1,867
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.35
    Marker Score: 755
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.34
    Marker Score: 2,375
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.34
    Marker Score: 3,444
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.31
    Marker Score: 5,436
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.29
    Marker Score: 1,242
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.29
    Marker Score: 570
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.29
    Marker Score: 1,444
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.28
    Marker Score: 4,047
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.28
    Marker Score: 22,600
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.28
    Marker Score: 794
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.27
    Marker Score: 3,345
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.27
    Marker Score: 570
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.26
    Marker Score: 3,487
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.26
    Marker Score: 640
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.26
    Marker Score: 16,803
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.24
    Marker Score: 3,262
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.23
    Marker Score: 1,334
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.23
    Marker Score: 632
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.22
    Marker Score: 2,008
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.19
    Marker Score: 1,756
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.16
    Marker Score: 3,949
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.16
    Marker Score: 2,022
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.16
    Marker Score: 3,056
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.15
    Marker Score: 786
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.15
    Marker Score: 2,522
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.14
    Marker Score: 494
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.14
    Marker Score: 4,467
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.13
    Marker Score: 921
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.13
    Marker Score: 828
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.13
    Marker Score: 858
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.09
    Marker Score: 3,532
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.07
    Marker Score: 1,007
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.07
    Marker Score: 5,554
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.07
    Marker Score: 465
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.07
    Marker Score: 2,319
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.06
    Marker Score: 1,406
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.05
    Marker Score: 1,503
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.05
    Marker Score: 7,595
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.05
    Marker Score: 1,368
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.04
    Marker Score: 3,933
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.04
    Marker Score: 488
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.04
    Marker Score: 8,022
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.04
    Marker Score: 495
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.04
    Marker Score: 2,332
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.04
    Marker Score: 20,508
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.04
    Marker Score: 6,395
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 2.03
    Marker Score: 559
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.02
    Marker Score: 500
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.02
    Marker Score: 748
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.01
    Marker Score: 51,596
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 2.01
    Marker Score: 1,153
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2
    Marker Score: 699
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2
    Marker Score: 1,172
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2
    Marker Score: 586

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ITGB1 is a non-catalytic subunit that interacts with alpha subunits to form functional integrins. The ITGB1 subunit is a 40-kDa protein that contains four immunoglobulin-like domains and a short cytoplasmic tail. ITGB1 is expressed in various cell types, including immune cells, fibroblasts, and smooth muscle cells. The protein is highly conserved across species, suggesting its essential role in maintaining tissue homeostasis and immune function. **Pathways and Functions:** ITGB1 plays a crucial role in various cellular processes, including: 1. **Cell-ECM interactions:** ITGB1 interacts with the ECM to facilitate cell adhesion, migration, and signaling. 2. **Immune response:** ITGB1 is expressed on immune cells, such as T cells and B cells, and plays a role in immune cell adhesion, migration, and signaling. 3. **Signaling pathways:** ITGB1 interacts with various signaling molecules, including growth factors, cytokines, and chemokines, to regulate cellular responses. 4. **Cell migration:** ITGB1 is involved in cell migration, including angiogenesis, wound healing, and immune cell migration. **Clinical Significance:** ITGB1 has been implicated in various diseases, including: 1. **Autoimmune disorders:** ITGB1 has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, where it plays a role in immune cell adhesion and signaling. 2. **Cancer:** ITGB1 has been linked to cancer, including metastasis, where it facilitates cell migration and invasion. 3. **Infectious diseases:** ITGB1 has been implicated in infectious diseases, such as HIV and SARS, where it plays a role in viral entry and replication. 4. **Vascular diseases:** ITGB1 has been associated with vascular diseases, including atherosclerosis and thrombosis, where it facilitates cell adhesion and signaling. **Signaling Pathways:** ITGB1 interacts with various signaling molecules, including: 1. **Growth factors:** ITGB1 interacts with growth factors, such as fibroblast growth factor (FGF) and epidermal growth factor (EGF), to regulate cellular responses. 2. **Cytokines:** ITGB1 interacts with cytokines, such as interleukin-4 (IL-4) and interleukin-13 (IL-13), to regulate immune responses. 3. **Chemokines:** ITGB1 interacts with chemokines, such as C-X3-C chemokine (CX3CL1), to regulate immune cell migration and signaling. **Conclusion:** ITGB1 is a crucial component of the integrin family, which plays a pivotal role in cell adhesion, migration, and signaling. Its expression in various cell types and its interaction with signaling molecules make it an essential molecule in maintaining tissue homeostasis and immune function. Understanding the role of ITGB1 in immune response and disease is crucial for developing novel therapeutic strategies for various diseases.

Genular Protein ID: 2214488798

Symbol: ITB1_HUMAN

Name: Fibronectin receptor subunit beta

UniProtKB Accession Codes:

P05556 A8K6N2 D3DRX9 D3DRY3 D3DRY4 D3DRY5 P78466 P78467 Q13089 Q13090 Q13091 Q13212 Q14622 Q14647 Q29RW2 Q7Z3V1 Q8WUM6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 12 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 DrugCentral 1 ELM 1 EMBL 29 EMDB 3 EPD 1 Ensembl 14 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 13 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 27 RefSeq 3 SABIO-RK 1 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2958481

Title: Amino acid sequence of the human fibronectin receptor.

PubMed ID: 2958481

DOI: 10.1083/jcb.105.3.1183

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

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PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7681433

Title: Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit.

PubMed ID: 7681433

DOI: 10.1083/jcb.121.1.171

PubMed ID: 7523423

Title: Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility.

PubMed ID: 7523423

DOI: 10.1083/jcb.127.2.557

PubMed ID: 2249781

Title: A human integrin beta 1 subunit with a unique cytoplasmic domain generated by alternative mRNA processing.

PubMed ID: 2249781

DOI: 10.1016/0378-1119(90)90369-3

PubMed ID: 1551917

Title: An alternative form of the integrin beta 1 subunit with a variant cytoplasmic domain.

PubMed ID: 1551917

DOI: 10.1016/s0021-9258(19)50545-2

PubMed ID: 7545396

Title: Novel isoform of beta 1 integrin expressed in skeletal and cardiac muscle.

PubMed ID: 7545396

DOI: 10.1006/bbrc.1995.2285

PubMed ID: 7544298

Title: A novel beta 1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle.

PubMed ID: 7544298

DOI: 10.1016/0014-5793(95)00814-p

PubMed ID: 9494094

Title: Identification of beta1C-2, a novel variant of the integrin beta1 subunit generated by utilization of an alternative splice acceptor site in exon C.

PubMed ID: 9494094

DOI: 10.1042/bj3301255

PubMed ID: 15276642

Title: Interaction of ACE2 and integrin beta1 in failing human heart.

PubMed ID: 15276642

DOI: 10.1016/j.bbadis.2004.05.005

PubMed ID: 8411387

Title: Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2.

PubMed ID: 8411387

DOI: 10.1128/jvi.67.11.6847-6852.1993

PubMed ID: 8567725

Title: Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells.

PubMed ID: 8567725

DOI: 10.1083/jcb.132.1.211

PubMed ID: 9501082

Title: Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.

PubMed ID: 9501082

DOI: 10.1093/emboj/17.6.1606

PubMed ID: 10397733

Title: The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.

PubMed ID: 10397733

PubMed ID: 10455171

Title: A novel protease-docking function of integrin at invadopodia.

PubMed ID: 10455171

DOI: 10.1074/jbc.274.35.24947

PubMed ID: 10613898

Title: A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation.

PubMed ID: 10613898

DOI: 10.1083/jcb.147.7.1391

PubMed ID: 11741838

Title: Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation.

PubMed ID: 11741838

DOI: 10.1093/hmg/10.25.2953

PubMed ID: 11919189

Title: Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement.

PubMed ID: 11919189

DOI: 10.1074/jbc.m200200200

PubMed ID: 11807098

Title: Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits.

PubMed ID: 11807098

DOI: 10.1083/jcb.200103037

PubMed ID: 11807099

Title: The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.

PubMed ID: 11807099

DOI: 10.1083/jcb.200108030

PubMed ID: 12907437

Title: Alpha5beta1 integrin as a cellular coreceptor for human parvovirus B19: requirement of functional activation of beta1 integrin for viral entry.

PubMed ID: 12907437

DOI: 10.1182/blood-2003-05-1522

PubMed ID: 12473654

Title: Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha.

PubMed ID: 12473654

DOI: 10.1074/jbc.m211258200

PubMed ID: 12695522

Title: CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family.

PubMed ID: 12695522

DOI: 10.1074/jbc.m302028200

PubMed ID: 12807887

Title: Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins.

PubMed ID: 12807887

DOI: 10.1074/jbc.m303159200

PubMed ID: 12941907

Title: Integrin-using rotaviruses bind alpha2beta1 integrin alpha2 I domain via VP4 DGE sequence and recognize alphaXbeta2 and alphaVbeta3 by using VP7 during cell entry.

PubMed ID: 12941907

DOI: 10.1128/jvi.77.18.9969-9978.2003

PubMed ID: 14722085

Title: RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1.

PubMed ID: 14722085

DOI: 10.1074/jbc.m313515200

PubMed ID: 15466886

Title: alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.

PubMed ID: 15466886

DOI: 10.1242/jcs.01423

PubMed ID: 15181153

Title: NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.

PubMed ID: 15181153

DOI: 10.1091/mbc.e04-03-0236

PubMed ID: 15156152

Title: Myosin-X provides a motor-based link between integrins and the cytoskeleton.

PubMed ID: 15156152

DOI: 10.1038/ncb1136

PubMed ID: 16256741

Title: Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration.

PubMed ID: 16256741

DOI: 10.1016/j.devcel.2005.09.012

PubMed ID: 16076904

Title: The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.

PubMed ID: 16076904

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PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16754960

Title: Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.

PubMed ID: 16754960

DOI: 10.1083/jcb.200509019

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16501085

Title: Beta1 integrin mediates internalization of mammalian reovirus.

PubMed ID: 16501085

DOI: 10.1128/jvi.80.6.2760-2770.2006

PubMed ID: 17956333

Title: Interaction of integrin beta1 with cytokeratin 1 in neuroblastoma NMB7 cells.

PubMed ID: 17956333

DOI: 10.1042/bst0351292

PubMed ID: 17925226

Title: Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.

PubMed ID: 17925226

DOI: 10.1016/j.devcel.2007.08.012

PubMed ID: 17158881

Title: alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity.

PubMed ID: 17158881

DOI: 10.1074/jbc.m607008200

PubMed ID: 17643115

Title: A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration.

PubMed ID: 17643115

DOI: 10.1038/ncb1622

PubMed ID: 18804435

Title: Integrin trafficking regulated by Rab21 is necessary for cytokinesis.

PubMed ID: 18804435

DOI: 10.1016/j.devcel.2008.08.001

PubMed ID: 18635536

Title: Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.

PubMed ID: 18635536

DOI: 10.1074/jbc.m804835200

PubMed ID: 19064666

Title: JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation.

PubMed ID: 19064666

DOI: 10.1083/jcb.200805061

PubMed ID: 17945327

Title: The Epstein-Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cells.

PubMed ID: 17945327

DOI: 10.1016/j.virol.2007.09.012

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20660204

Title: The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry.

PubMed ID: 20660204

DOI: 10.1128/jvi.00710-10

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21471204

Title: Neisseria meningitidis adhesin NadA targets beta1 integrins: functional similarity to Yersinia invasin.

PubMed ID: 21471204

DOI: 10.1074/jbc.m110.188326

PubMed ID: 22027826

Title: ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration.

PubMed ID: 22027826

DOI: 10.1074/jbc.m111.278770

PubMed ID: 21768292

Title: Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition.

PubMed ID: 21768292

DOI: 10.1083/jcb.201007108

PubMed ID: 21325030

Title: Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins.

PubMed ID: 21325030

DOI: 10.1242/jcs.076976

PubMed ID: 22654117

Title: Polydom/SVEP1 is a ligand for integrin alpha9beta1.

PubMed ID: 22654117

DOI: 10.1074/jbc.m112.355016

PubMed ID: 23125415

Title: Integrins alphavbeta3 and alpha4beta1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.

PubMed ID: 23125415

DOI: 10.4049/jimmunol.1200889

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24814316

Title: Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells.

PubMed ID: 24814316

DOI: 10.1016/j.devcel.2014.03.024

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25398877

Title: Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins alphavbeta3, alpha4beta1, and alpha5beta1.

PubMed ID: 25398877

DOI: 10.1074/jbc.m114.579946

PubMed ID: 24789099

Title: The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.

PubMed ID: 24789099

DOI: 10.1371/journal.pone.0096372

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29030430

Title: Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta.

PubMed ID: 29030430

DOI: 10.1074/jbc.m117.818302

PubMed ID: 31331973

Title: Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.

PubMed ID: 31331973

DOI: 10.4049/jimmunol.1801630

PubMed ID: 32487760

Title: GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis.

PubMed ID: 32487760

DOI: 10.1128/mbio.01087-20

PubMed ID: 33102950

Title: The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection.

PubMed ID: 33102950

DOI: 10.1016/j.jacbts.2020.10.003

PubMed ID: 35802072

Title: The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins alpha9beta1 and alpha4beta1.

PubMed ID: 35802072

DOI: 10.1111/bph.15921

PubMed ID: 35687021

Title: PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.

PubMed ID: 35687021

DOI: 10.1083/jcb.202108027

PubMed ID: 22645133

Title: Mechanistic insights into regulated cargo binding by ACAP1 protein.

PubMed ID: 22645133

DOI: 10.1074/jbc.m112.378810

PubMed ID: 22451694

Title: Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor.

PubMed ID: 22451694

DOI: 10.1083/jcb.201111077

PubMed ID: 23317506

Title: Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.

PubMed ID: 23317506

DOI: 10.1016/j.molcel.2012.12.005

PubMed ID: 33962943

Title: Structural insights into integrin alpha5beta1 opening by fibronectin ligand.

PubMed ID: 33962943

DOI: 10.1126/sciadv.abe9716

Sequence Information:

  • Length: 798
  • Mass: 88415
  • Checksum: DE35979C1625578C
  • Sequence:
    • MNLQPIFWIG LISSVCCVFA QTDENRCLKA NAKSCGECIQ AGPNCGWCTN STFLQEGMPT 
SARCDDLEAL KKKGCPPDDI ENPRGSKDIK KNKNVTNRSK GTAEKLKPED ITQIQPQQLV 
LRLRSGEPQT FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF 
RIGFGSFVEK TVMPYISTTP AKLRNPCTSE QNCTSPFSYK NVLSLTNKGE VFNELVGKQR 
ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ 
CHLENNMYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL 
SANSSNVIQL IIDAYNSLSS EVILENGKLS EGVTISYKSY CKNGVNGTGE NGRKCSNISI 
GDEVQFEISI TSNKCPKKDS DSFKIRPLGF TEEVEVILQY ICECECQSEG IPESPKCHEG 
NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK 
RDNTNEIYSG KFCECDNFNC DRSNGLICGG NGVCKCRVCE CNPNYTGSAC DCSLDTSTCE 
ASNGQICNGR GICECGVCKC TDPKFQGQTC EMCQTCLGVC AEHKECVQCR AFNKGEKKDT 
CTQECSYFNI TKVESRDKLP QPVQPDPVSH CKEKDVDDCW FYFTYSVNGN NEVMVHVVEN 
PECPTGPDII PIVAGVVAGI VLIGLALLLI WKLLMIIHDR REFAKFEKEK MNAKWDTGEN 
PIYKSAVTTV VNPKYEGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.